ES2137929T3 - Derivados de esteres penem antibacterianos. - Google Patents

Derivados de esteres penem antibacterianos.

Info

Publication number
ES2137929T3
ES2137929T3 ES91914618T ES91914618T ES2137929T3 ES 2137929 T3 ES2137929 T3 ES 2137929T3 ES 91914618 T ES91914618 T ES 91914618T ES 91914618 T ES91914618 T ES 91914618T ES 2137929 T3 ES2137929 T3 ES 2137929T3
Authority
ES
Spain
Prior art keywords
group
derivatives
penem
esters
tetrahydrofurylü
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91914618T
Other languages
English (en)
Inventor
Hiromitsu Iwata
Takashi Nakatsuka
Rie Tanaka
Masaji Ishiguro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Suntory Ltd
Original Assignee
Suntory Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suntory Ltd filed Critical Suntory Ltd
Application granted granted Critical
Publication of ES2137929T3 publication Critical patent/ES2137929T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/86—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/861—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hydrocarbon radical or a substituted hydrocarbon radical, directly attached in position 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/893—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hetero ring or a condensed hetero ring system, directly attached in position 3

Abstract

SE PRESENTAN COMPUESTOS ANTIBIOTICOS DE PENEM QUE SE REPRESENTAN MEDIANTE LA FORMULA (I), EN DONDE R REPRESENTA UN GRUPO DE LAS FORMULSA (II), (III), O -CH2-Z, EN LAS CUALES R1 ES UN GRUPO DE ALQUIL C1-C6 LINEAL O RAMIFICADO, R2 ES UN GRUPO DE ALQUIL, ARIL O ARALQUIL PARTICULAR, SUSTITUIDO O INSUSTITUIDO, N ES UN ENTERO ENTRE 1 Y 6, Y ES UN GRUPO ALIFATICO HETEROCICLICO DE 5 O 6 MIEMBROS QUE TIENE UNO O DOS ATOMOS DE OXIGENO EN EL ANILLO DEL MISMO, Y Z ES UN GRUPO DE 2-OXO-1,3-DIOXOLEN-4-IL ESPECIFICO SUSTITUIDO EN 5. TAMBIEN SE DESCRIBEN COMPOSICIONES ANTIBIOTICAS PARA ADMINISTRACION ORAL.
ES91914618T 1990-08-20 1991-08-16 Derivados de esteres penem antibacterianos. Expired - Lifetime ES2137929T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP21705290 1990-08-20

Publications (1)

Publication Number Publication Date
ES2137929T3 true ES2137929T3 (es) 2000-01-01

Family

ID=16698076

Family Applications (2)

Application Number Title Priority Date Filing Date
ES96117054T Expired - Lifetime ES2198455T3 (es) 1990-08-20 1991-08-16 Derivados esteres de penem antibacterianos.
ES91914618T Expired - Lifetime ES2137929T3 (es) 1990-08-20 1991-08-16 Derivados de esteres penem antibacterianos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES96117054T Expired - Lifetime ES2198455T3 (es) 1990-08-20 1991-08-16 Derivados esteres de penem antibacterianos.

Country Status (23)

Country Link
US (2) US5830889A (es)
EP (2) EP0757050B1 (es)
JP (2) JP3148234B2 (es)
KR (1) KR0178956B1 (es)
AT (2) ATE242251T1 (es)
AU (1) AU652954B2 (es)
BR (1) BR9106789A (es)
CA (1) CA2089368C (es)
CZ (1) CZ282086B6 (es)
DE (2) DE69133273T2 (es)
DK (1) DK0544907T3 (es)
ES (2) ES2198455T3 (es)
FI (1) FI105186B (es)
GR (1) GR3032372T3 (es)
HU (1) HU213403B (es)
IE (1) IE20000929A1 (es)
IL (1) IL99243A (es)
MX (1) MX9203822A (es)
NO (1) NO302236B1 (es)
PL (1) PL169584B1 (es)
RU (1) RU2051919C1 (es)
SK (1) SK280188B6 (es)
WO (1) WO1992003442A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000076105A (ko) * 1998-01-13 2000-12-26 도리이 신이찌로 항생제를 함유한 국소 투여용 항균 조성물
AU5871000A (en) * 1999-06-11 2001-01-02 Paul G. Abrams High dose radionuclide complexes for bone marrow suppression
US7094885B2 (en) 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
WO2002062398A2 (en) 2001-01-08 2002-08-15 Neorx Corporation Radioactively labelled conjugates of phosphonates
AU2002364552A1 (en) 2001-12-13 2003-06-30 Dow Global Technologies Inc. Treatment of osteomyelitis with radiopharmaceuticals
EP1548017A4 (en) * 2002-10-02 2010-06-02 Nippon Soda Co PROCESS FOR PRODUCING ORGANIC COMPOUNDS
CN1314691C (zh) * 2005-08-22 2007-05-09 鲁南制药集团股份有限公司 法罗培南钠的制备方法
WO2007039885A1 (en) * 2005-10-05 2007-04-12 Ranbaxy Laboratories Limited A process for the preparation of faropenem
US20080125408A1 (en) * 2006-11-14 2008-05-29 Pfizer Inc Penem prodrug
CN101235044B (zh) * 2008-03-03 2010-11-03 南京华威医药科技开发有限公司 法罗培南酯的制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6019908B2 (ja) * 1980-04-30 1985-05-18 カネボウ株式会社 １，３−ジオキソレン−２−オン誘導体
CA1212105A (en) * 1980-04-30 1986-09-30 Shoji Ikeda Ampicillin esters and production thereof
US4479947A (en) * 1981-07-13 1984-10-30 Merck & Co., Inc. Oral absorption enhancement of carboxylic acid pharmaceuticals using (5-alkyl-2-oxo-1,3-dioxolen-4-yl)methyl ester group
US4654331A (en) * 1981-07-13 1987-03-31 Merck & Co., Inc. Oral absorption enhancement of carboxylic acid pharmaceuticals using (5-alkyl-2-oxo-1,3-dioxolen-4-yl)methyl ester group
JPS58159496A (ja) * 1983-03-02 1983-09-21 Kyoto Yakuhin Kogyo Kk セフエム系化合物
JPH075463B2 (ja) * 1985-03-09 1995-01-25 サントリー株式会社 抗菌剤
EP0275002A1 (en) * 1987-01-09 1988-07-20 Hoechst Aktiengesellschaft Process for the production of 7-oxo-4-thia-1-aza-bicyclo [3.2.0] hept-2-ene derivatives
GB8713515D0 (en) * 1987-06-10 1987-07-15 Erba Farmitalia Methoxymethyl compounds
GB2206578B (en) * 1987-07-07 1991-07-03 Erba Carlo Spa Process for the preparation of penems
JPH026728A (ja) 1988-06-23 1990-01-10 Japan Radio Co Ltd 弾性表面波による液体粘性測定装置
GB2220203B (en) * 1988-07-04 1991-09-11 Erba Carlo Spa Process for penems
DE3839987A1 (de) * 1988-11-26 1990-05-31 Hoechst Ag Penemderivate und verfahren zu ihrer herstellung
EP0399228A1 (de) * 1989-04-29 1990-11-28 Hoechst Aktiengesellschaft Verfahren zur Herstellung von Penemverbindungen

Also Published As

Publication number Publication date
KR930701452A (ko) 1993-06-11
WO1992003442A1 (en) 1992-03-05
ATE242251T1 (de) 2003-06-15
IL99243A0 (en) 1992-07-15
FI930682A (fi) 1993-02-16
FI105186B (fi) 2000-06-30
AU652954B2 (en) 1994-09-15
AU8333391A (en) 1992-03-17
US5885981A (en) 1999-03-23
RU2051919C1 (ru) 1996-01-10
US5830889A (en) 1998-11-03
CZ282086B6 (cs) 1997-05-14
IE20000929A1 (en) 2001-05-30
BR9106789A (pt) 1993-06-29
FI930682A0 (fi) 1993-02-16
DE69133273T2 (de) 2004-05-13
JPH06500769A (ja) 1994-01-27
JP3274854B2 (ja) 2002-04-15
CA2089368A1 (en) 1992-02-21
DE69131753D1 (de) 1999-12-02
DE69131753T2 (de) 2000-05-04
JP2000302786A (ja) 2000-10-31
CZ20993A3 (en) 1993-10-13
JP3148234B2 (ja) 2001-03-19
NO302236B1 (no) 1998-02-09
NO930588L (no) 1993-02-19
EP0544907A1 (en) 1993-06-09
ES2198455T3 (es) 2004-02-01
ATE186053T1 (de) 1999-11-15
MX9203822A (es) 1992-09-01
GR3032372T3 (en) 2000-04-27
EP0757050A1 (en) 1997-02-05
EP0544907B1 (en) 1999-10-27
IL99243A (en) 1995-07-31
CA2089368C (en) 2002-08-06
HU213403B (en) 1997-06-30
DE69133273D1 (de) 2003-07-10
HU9300461D0 (en) 1993-05-28
PL169584B1 (pl) 1996-08-30
EP0757050B1 (en) 2003-06-04
NO930588D0 (no) 1993-02-19
KR0178956B1 (ko) 1999-03-20
SK280188B6 (sk) 1999-09-10
DK0544907T3 (da) 2000-01-24
HUT64349A (en) 1993-12-28
SK10793A3 (en) 1993-09-09

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