FI105103B - DNA-molekyyli ja sen käyttö - Google Patents

DNA-molekyyli ja sen käyttö Download PDF

Info

Publication number
FI105103B
FI105103B FI901296A FI901296A FI105103B FI 105103 B FI105103 B FI 105103B FI 901296 A FI901296 A FI 901296A FI 901296 A FI901296 A FI 901296A FI 105103 B FI105103 B FI 105103B
Authority
FI
Finland
Prior art keywords
dna
rna
trna
ribozyme
gene
Prior art date
Application number
FI901296A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI901296A0 (fi
Inventor
Ernst Wagner
Max L Birnstiel
Hartmut Beug
Matthew Cotten
Harald Kandolf
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of FI901296A0 publication Critical patent/FI901296A0/fi
Application granted granted Critical
Publication of FI105103B publication Critical patent/FI105103B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/121—Hammerhead

Landscapes

  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
FI901296A 1989-03-16 1990-03-15 DNA-molekyyli ja sen käyttö FI105103B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT60989 1989-03-16
AT60989 1989-03-16

Publications (2)

Publication Number Publication Date
FI901296A0 FI901296A0 (fi) 1990-03-15
FI105103B true FI105103B (fi) 2000-06-15

Family

ID=3495118

Family Applications (1)

Application Number Title Priority Date Filing Date
FI901296A FI105103B (fi) 1989-03-16 1990-03-15 DNA-molekyyli ja sen käyttö

Country Status (20)

Country Link
EP (1) EP0387775B1 (fr)
JP (1) JP3330930B2 (fr)
KR (1) KR900014591A (fr)
AT (1) ATE140961T1 (fr)
AU (1) AU637354B2 (fr)
CA (1) CA2012312C (fr)
DD (1) DD297838A5 (fr)
DE (1) DE59010432D1 (fr)
DK (1) DK0387775T3 (fr)
ES (1) ES2090049T3 (fr)
FI (1) FI105103B (fr)
GR (1) GR3020935T3 (fr)
HU (2) HU215187B (fr)
IE (1) IE74850B1 (fr)
IL (1) IL93754A (fr)
NO (1) NO306623B1 (fr)
NZ (1) NZ232917A (fr)
PT (1) PT93440B (fr)
RU (1) RU2136751C1 (fr)
ZA (1) ZA901973B (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0471796A4 (en) * 1989-05-10 1993-05-05 Sloan Kettering Institute For Cancer Research Stably transformed eucaryotic cells comprising a foreign transcribable dna under the control of a pol iii promoter
DE4091533T (fr) * 1989-08-31 1992-01-30
JP2507895B2 (ja) * 1989-12-19 1996-06-19 工業技術院長 リボザイムの新規合成系
US6008343A (en) * 1990-06-19 1999-12-28 Gene Shears Pty. Ltd. Nucleotide based endonucleases
WO1991019789A1 (fr) * 1990-06-19 1991-12-26 Commonwealth Scientific And Industrial Research Organisation Endonucleases
DE69123979T2 (de) 1990-10-12 1997-04-30 Max Planck Gesellschaft Abgeänderte ribozyme
DE4104186A1 (de) * 1991-02-12 1992-08-13 Genentech Inc Neue, ueber endozytose in hoehere eukaryotische zellen aufnehmbare, nukleinsaeure enthaltende komplexe
FR2687411A1 (fr) * 1992-02-13 1993-08-20 Nice Sophia Antipolis Universi Vecteur comportant un gene viral transcrit par l'arn polymerase iii, et procede de production intracellulaire d'arn.
AU4259193A (en) * 1992-04-28 1993-11-29 Frank Andreas Harald Meyer Medicament for the gene-therapeutic treatment of human beings, animals and plants, especially to block virus multiplication and carcinogenes and process for producing the medicament
JPH08502950A (ja) * 1992-05-14 1996-04-02 リボザイム・ファーマシューティカルズ・インコーポレイテッド 癌増殖を抑制する方法及び試薬
US5989906A (en) * 1992-05-14 1999-11-23 Ribozyme Pharmaceuticals, Inc. Method and reagent for inhibiting P-glycoprotein (mdr-1-gene)
US5610052A (en) * 1992-08-26 1997-03-11 Ribozyme Pharmaceuticals Inc. Enzymatic RNA with activity to ras
US5827935A (en) * 1992-05-27 1998-10-27 City Of Hope Chimeric tRNAlys -ribozyme molecules
CA2114312A1 (fr) * 1992-05-27 1993-12-09 John J. Rossi Molecules chimeriques arnt-ribozyme
RU94046396A (ru) * 1992-06-29 1996-11-10 Джин Ширс Пти.Лтд. (AU) Нуклеиновая кислота, днк, вектор, способ получения растения или животного, способ получения клеток, способ создания животного, животное, трансгенное животное, трансгенное растение, плоды, черенки и семена, растительные клетки, способ вмешательства в репликацию вируса
AU5968994A (en) * 1992-12-16 1994-07-04 Johanna E. Bergmann Agents for the prevention and treatment of human alzheimer's disease
DE69333216T2 (de) * 1993-07-06 2004-06-24 Université de Nice-Sophia Antipolis Vektor, enthält ein bei ARN-Polymerase-III transcriptes Virus-Gen
US5837503A (en) * 1993-07-07 1998-11-17 Universite De Nice-Sophia-Antipolis Vector containing viral gene transcribed by RNA polymerase III and methods for use
US5817635A (en) * 1993-08-09 1998-10-06 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Modified ribozymes
WO1995019788A1 (fr) * 1994-01-24 1995-07-27 City Of Hope Co-localisation d'une molecule cible et de ses inhibiteurs
DE4424761C1 (de) * 1994-07-04 1995-06-08 Max Planck Gesellschaft Expressionskassette für die Antisense- und die Ribozym-Expression
NZ308970A (en) 1995-06-07 1999-10-28 Commw Scient Ind Res Org Optimized minizymes and miniribozymes and uses thereof
FR2755976B1 (fr) * 1996-11-15 1999-01-15 Idm Immuno Designed Molecules Nouveaux complexes d'acides nucleiques et de polymere substitue par des residus entrainant la destabilisation des membranes cellulaires
US6057156A (en) 1997-01-31 2000-05-02 Robozyme Pharmaceuticals, Inc. Enzymatic nucleic acid treatment of diseases or conditions related to levels of epidermal growth factor receptors
AU1187099A (en) * 1997-10-21 1999-05-10 Ribozyme Pharmaceuticals, Inc. Peptide bond formation using nucleic acid catalysts
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
EP1857549B1 (fr) 1998-03-20 2018-10-17 Commonwealth Scientific and Industrial Research Organisation Contrôle de l'expression de gènes
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
EP1147204A1 (fr) 1999-01-28 2001-10-24 Medical College Of Georgia Research Institute, Inc. Composition et methode destinees a l'attenuation in vivo et in vitro de l'expression genique utilisant de l'arn double brin
US6423885B1 (en) 1999-08-13 2002-07-23 Commonwealth Scientific And Industrial Research Organization (Csiro) Methods for obtaining modified phenotypes in plant cells
CA2369944A1 (fr) 2001-01-31 2002-07-31 Nucleonics Inc. Utilisation de l'inhibition genetique post-transcriptionnelle pour identifier les sequences d'acides nucleiques qui modulent la fonction d'une cellule
AUPR621501A0 (en) 2001-07-06 2001-08-02 Commonwealth Scientific And Industrial Research Organisation Delivery of ds rna

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4987071A (en) * 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods

Also Published As

Publication number Publication date
IL93754A0 (en) 1990-12-23
EP0387775A1 (fr) 1990-09-19
IE900931L (en) 1990-09-16
NZ232917A (en) 1997-07-27
HUT54206A (en) 1991-01-28
DK0387775T3 (da) 1996-11-04
CA2012312A1 (fr) 1990-09-16
NO901213D0 (no) 1990-03-15
KR900014591A (ko) 1990-10-24
ATE140961T1 (de) 1996-08-15
JPH03130080A (ja) 1991-06-03
JP3330930B2 (ja) 2002-10-07
AU637354B2 (en) 1993-05-27
NO901213L (no) 1990-09-17
AU5130190A (en) 1990-11-01
CA2012312C (fr) 2001-08-14
IE74850B1 (en) 1997-08-13
RU2136751C1 (ru) 1999-09-10
GR3020935T3 (en) 1996-12-31
DD297838A5 (de) 1992-01-23
ES2090049T3 (es) 1996-10-16
HU211868A9 (en) 1995-12-28
EP0387775B1 (fr) 1996-07-31
HU901584D0 (en) 1990-06-28
HU215187B (hu) 1998-10-28
ZA901973B (en) 1991-11-27
IL93754A (en) 1995-12-31
DE59010432D1 (de) 1996-09-05
PT93440A (pt) 1990-11-07
NO306623B1 (no) 1999-11-29
FI901296A0 (fi) 1990-03-15
PT93440B (pt) 2001-07-31

Similar Documents

Publication Publication Date Title
FI105103B (fi) DNA-molekyyli ja sen käyttö
JP3316216B2 (ja) 安定化外部ガイド配列
AU687001B2 (en) Method and reagent for inhibiting cancer development
US5989906A (en) Method and reagent for inhibiting P-glycoprotein (mdr-1-gene)
US20030105051A1 (en) Nucleic acid treatment of diseases or conditions related to levels of HER2
JP2009000105A (ja) 短干渉核酸（ｓｉＮＡ）を用いた血管内皮成長因子および血管内皮成長因子レセプター遺伝子発現のＲＮＡ干渉媒介阻害
JP2009060893A (ja) 短干渉核酸（ｓｉＮＡ）を用いる遺伝子発現のＲＮＡ干渉媒介性阻害
JP2006502694A (ja) 短干渉核酸（ｓｉＮＡ）を用いるＨＩＶ遺伝子発現のＲＮＡ干渉媒介性阻害
US5599704A (en) ErbB2/neu targeted ribozymes
Levi et al. Constitutive expression of c-fos antisense RNA blocks c-fos gene induction by interferon and by phorbol ester and reduces c-myc expression in F9 embryonal carcinoma cells.
JP2003511025A (ja) インビボで製造されたｓｓＤＮＡによる遺伝子発現の改変
Zhang et al. Generation of ribozyme-adenoviral vector against K-ras mutant human lung cancer cells
US20040072783A1 (en) Nucleozymes with endonuclease activity
US6830923B1 (en) Genetics units for inhibiting the function of RNA
WO2005059134A1 (fr) Composes et procedes d'interference arn de la sous-unite p65 de nf-kappa-b
AU2006219666B2 (en) Inhibition of SPAG9 expression with siRNAs
JP2010538661A (ja) ＳＴＡＴ５ｓｉＲＮＡ含有組成物及びそれらの使用法
JP2007505605A (ja) 低分子干渉核酸（ｓｉＮＡ）を使用したＲＮＡ干渉により媒介される血管内皮増殖因子遺伝子発現および血管内皮増殖因子遺伝子受容体遺伝子発現のＲＮＡ干渉媒介性抑制
JP2007505605A6 (ja) 低分子干渉核酸（ｓｉＮＡ）を使用したＲＮＡ干渉により媒介される血管内皮増殖因子遺伝子発現および血管内皮増殖因子遺伝子受容体遺伝子発現のＲＮＡ干渉媒介性抑制
WO2001062911A2 (fr) Methode et reactif d'inhibition de grid
AU730506B2 (en) Method and reagent for inhibiting cancer development
JPH09501318A (ja) ヒト免疫不全ウイルスの複製を阻害するための方法および試薬
CA2578402A1 (fr) Inhibition du papillomavirus humain a l'aide d'un ribozyme en forme d'e ingle a cheveux

Legal Events

Date Code Title Description
FG Patent granted

Owner name: BOEHRINGER INGELHEIM INTERNATIONAL GMBH