FI104894B - Menetelmä mutiliinijohdannaisen valmistamiseksi - Google Patents

Menetelmä mutiliinijohdannaisen valmistamiseksi Download PDF

Info

Publication number
FI104894B
FI104894B FI904853A FI904853A FI104894B FI 104894 B FI104894 B FI 104894B FI 904853 A FI904853 A FI 904853A FI 904853 A FI904853 A FI 904853A FI 104894 B FI104894 B FI 104894B
Authority
FI
Finland
Prior art keywords
formula
compound
alkyl
reaction
methyl ether
Prior art date
Application number
FI904853A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI904853A0 (fi
Inventor
Ingolfy Macher
Original Assignee
Biochemie Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AT0228689A external-priority patent/AT394554B/de
Priority claimed from AT2287/89A external-priority patent/AT392272B/de
Application filed by Biochemie Gmbh filed Critical Biochemie Gmbh
Publication of FI904853A0 publication Critical patent/FI904853A0/fi
Application granted granted Critical
Publication of FI104894B publication Critical patent/FI104894B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C325/00—Thioaldehydes; Thioketones; Thioquinones; Oxides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/76—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members
    • C07C2603/80—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing eight-membered rings
    • C07C2603/82—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing eight-membered rings having three condensed rings with in total fourteen carbon atoms and having a having a [5.4.3.0(1,8)] ring structure, e.g. pleuromutiline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI904853A 1989-10-03 1990-10-02 Menetelmä mutiliinijohdannaisen valmistamiseksi FI104894B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
AT228789 1989-10-03
AT0228689A AT394554B (de) 1989-10-03 1989-10-03 Neues thiazolidin, verfahren zur herstellung von thiazolidinen und ihre verwendung
AT228689 1989-10-03
AT2287/89A AT392272B (de) 1989-10-03 1989-10-03 Verfahren zur herstellung eines pleuromutilinderivats und seiner saeureadditionssalze

Publications (2)

Publication Number Publication Date
FI904853A0 FI904853A0 (fi) 1990-10-02
FI104894B true FI104894B (fi) 2000-04-28

Family

ID=25598123

Family Applications (1)

Application Number Title Priority Date Filing Date
FI904853A FI104894B (fi) 1989-10-03 1990-10-02 Menetelmä mutiliinijohdannaisen valmistamiseksi

Country Status (19)

Country Link
US (2) US5164526A (ru)
EP (1) EP0421364B1 (ru)
JP (2) JP2515427B2 (ru)
KR (1) KR0185971B1 (ru)
AT (1) ATE124037T1 (ru)
AU (1) AU638747B2 (ru)
CA (1) CA2026690C (ru)
DE (1) DE69020287T2 (ru)
DK (1) DK0421364T3 (ru)
ES (1) ES2072952T3 (ru)
FI (1) FI104894B (ru)
HK (1) HK112296A (ru)
HU (1) HU208115B (ru)
IE (1) IE68412B1 (ru)
IL (1) IL95856A (ru)
NZ (1) NZ235525A (ru)
PL (1) PL164132B1 (ru)
RU (1) RU2038350C1 (ru)
TW (1) TW217406B (ru)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT397654B (de) * 1992-05-04 1994-06-27 Biochemie Gmbh Neue pleuromutilinderivate, ihre verwendung und verfahren zu ihrer herstellung
GB9614017D0 (en) * 1996-07-04 1996-09-04 Biochemie Gmbh Organic compounds
US5932553A (en) * 1996-07-18 1999-08-03 The Regents Of The University Of California Illudin analogs useful as antitumor agents
US7141603B2 (en) 1999-02-19 2006-11-28 The Regents Of The University California Antitumor agents
GB9918037D0 (en) 1999-07-30 1999-09-29 Biochemie Gmbh Organic compounds
TWI228048B (en) * 1999-12-09 2005-02-21 Novartis Ag New formulation
GB0017031D0 (en) * 2000-07-11 2000-08-30 Biochemie Gmbh Antimicrobials
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
EP1909783B1 (en) 2005-08-03 2011-10-12 The Regents of the University of California Illudin analogs useful as anticancer agents
PE20110235A1 (es) 2006-05-04 2011-04-14 Boehringer Ingelheim Int Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
NZ573360A (en) 2006-05-04 2012-08-31 Boehringer Ingelheim Int Polymorphic forms of 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-amino-piperidin-1-yl)-xanthine
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
EP1908750A1 (en) * 2006-10-05 2008-04-09 Nabriva Therapeutics Forschungs GmbH Process for the preparation of pleuromutilins
EP2190434B1 (en) * 2007-08-17 2019-04-17 Boehringer Ingelheim International GmbH Purin derivatives for use in the treatment of fap-related diseases
AR071175A1 (es) 2008-04-03 2010-06-02 Boehringer Ingelheim Int Composicion farmaceutica que comprende un inhibidor de la dipeptidil-peptidasa-4 (dpp4) y un farmaco acompanante
PE20100156A1 (es) * 2008-06-03 2010-02-23 Boehringer Ingelheim Int Tratamiento de nafld
CN101318921B (zh) * 2008-07-04 2011-07-27 江苏赛奥生化有限公司 沃尼妙林的制备方法
KR20190016601A (ko) 2008-08-06 2019-02-18 베링거 인겔하임 인터내셔날 게엠베하 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
JP5906086B2 (ja) * 2008-08-15 2016-04-20 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｆａｂ関連疾患の治療に用いるためのプリン誘導体
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
TWI508965B (zh) 2008-12-23 2015-11-21 Boehringer Ingelheim Int 有機化合物的鹽形式
TW201036975A (en) 2009-01-07 2010-10-16 Boehringer Ingelheim Int Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy
CN101597248B (zh) * 2009-07-10 2012-08-22 河北远征药业有限公司 沃尼妙林及其盐酸盐的制备方法
CN101993400A (zh) * 2009-08-17 2011-03-30 北京中牧科技服务有限责任公司 一种沃尼妙林的合成方法
KR101124759B1 (ko) 2009-11-17 2012-03-23 삼성메디슨 주식회사 엔트로피 정보에 기초하여 초음파 영상의 화질을 개선시키는 초음파 시스템 및 방법
JP2013512229A (ja) 2009-11-27 2013-04-11 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 遺伝子型が同定された糖尿病患者のリナグリプチン等のｄｄｐ−ｉｖ阻害薬による治療
NZ602921A (en) 2010-05-05 2016-01-29 Boehringer Ingelheim Int Combination therapy comprising the administration of a glp-1 receptor agonist and a ddp-4 inhibitor
MX2012014247A (es) 2010-06-24 2013-01-18 Boehringer Ingelheim Int Terapia para la diabetes.
CN102001980B (zh) * 2010-10-27 2012-11-14 齐鲁动物保健品有限公司 一种沃尼妙林盐酸盐的出料方法
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
CN102225906B (zh) * 2011-05-12 2014-07-30 浙江国邦药业有限公司 一种沃尼妙林盐酸盐的结晶方法
EP3517539B1 (en) 2011-07-15 2022-12-14 Boehringer Ingelheim International GmbH Substituted dimeric quinazoline derivative, its preparation and its use in pharmaceutical compositions for the treatment of type i and ii diabetes
CN102344397B (zh) * 2011-08-23 2013-09-04 浙江升华拜克生物股份有限公司 一种伐奈莫林盐酸盐的提纯方法
CN102432510B (zh) * 2011-11-11 2014-02-12 山东胜利股份有限公司 一种二甲基半胱胺盐酸盐的合成方法
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
WO2013171167A1 (en) 2012-05-14 2013-11-21 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
CN103193692A (zh) * 2013-04-23 2013-07-10 河北科技大学 一种沃尼妙林及其盐酸盐的制备
US9526728B2 (en) 2014-02-28 2016-12-27 Boehringer Ingelheim International Gmbh Medical use of a DPP-4 inhibitor
CN105367467B (zh) * 2015-12-01 2017-07-14 苏利制药科技江阴有限公司 一种二甲基半胱氨盐酸盐的合成方法
EP3468562A1 (en) 2016-06-10 2019-04-17 Boehringer Ingelheim International GmbH Combinations of linagliptin and metformin

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1324510A (fr) * 1962-04-26 1963-04-19 Bayer Ag Nouveau procédé de préparation de peptides
US3919290A (en) * 1972-10-03 1975-11-11 Sandoz Ltd Substituted 14-desoxy-mutilins
US4086359A (en) * 1975-09-30 1978-04-25 E. R. Squibb & Sons, Inc. Derivatives of pleuromutilin and compositions
CH619450A5 (ru) * 1976-01-15 1980-09-30 Sandoz Ag
GB2072012B (en) * 1980-03-14 1984-07-25 Squibb & Sons Inc Veterinary compositions containing pleuromutilin derivatives
DE3172383D1 (en) * 1980-12-12 1985-10-24 Fine Organics Ltd Preparation of thiazolidine derivatives
FR2526019A1 (fr) * 1982-04-28 1983-11-04 Sandoz Sa Nouveaux derives de la pleuromutiline, leur preparation et leur utilisation comme medicaments
EP0153277B1 (de) * 1984-02-17 1987-08-26 Sandoz Ag Neue Pleuromutilinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung
DE3742265A1 (de) * 1987-12-12 1989-06-22 Basf Ag Verfahren zur herstellung von cysteamin-saeureadditionssalzen

Also Published As

Publication number Publication date
US5164526A (en) 1992-11-17
DK0421364T3 (da) 1995-08-14
IE903523A1 (en) 1991-04-10
AU638747B2 (en) 1993-07-08
ES2072952T3 (es) 1995-08-01
AU6326890A (en) 1991-04-11
PL287150A1 (en) 1992-01-27
CA2026690C (en) 2003-01-21
RU2038350C1 (ru) 1995-06-27
DE69020287D1 (de) 1995-07-27
ATE124037T1 (de) 1995-07-15
DE69020287T2 (de) 1995-11-02
EP0421364A2 (en) 1991-04-10
NZ235525A (en) 1992-11-25
FI904853A0 (fi) 1990-10-02
US5284967A (en) 1994-02-08
JP2742250B2 (ja) 1998-04-22
JP2515427B2 (ja) 1996-07-10
PL164132B1 (pl) 1994-06-30
TW217406B (ru) 1993-12-11
HK112296A (en) 1996-07-05
HU208115B (en) 1993-08-30
KR910007874A (ko) 1991-05-30
JPH08225519A (ja) 1996-09-03
IE68412B1 (en) 1996-06-12
EP0421364A3 (en) 1992-01-22
KR0185971B1 (ko) 1999-05-15
IL95856A (en) 1994-05-30
HU906029D0 (en) 1991-03-28
IL95856A0 (en) 1991-07-18
CA2026690A1 (en) 1991-04-04
JPH03151356A (ja) 1991-06-27
EP0421364B1 (en) 1995-06-21

Similar Documents

Publication Publication Date Title
FI104894B (fi) Menetelmä mutiliinijohdannaisen valmistamiseksi
US20060167278A1 (en) Propanolamine derivatives, process for preparation of 3-n-methylamino-1-(2-thienyl)-1-propanols and process for preparation of propanolamine derivatives
FI59991B (fi) Foerfarande foer framstaellning av 2-arylamino-2-imidazolin-derivat och deras salter
Topal et al. Facile synthesis of mono and dibenzo N, N'‐disubstituted diaza 18‐crown‐6 derivatives
EP0054409B1 (en) Preparation of thiazolidine derivatives
De Voghel et al. Phosgene immonium salts. XIII. Dichloromalonyl cyanines and 3, 5-bis (dimethylamino) pyrazoles
CA1055509A (en) Process for the preparation of 2-(2-thienyl)-ethylamine and derivatives thereof
Turk et al. Direction of Ring Opening in the Reaction of Episulfides with Amines1
FI63231B (fi) Foerfarande foer framstaellning av n-(2-pyridyl)-2-metyl-4-hydroxi-2h-1,2-bensotiazin-3-karboxamid-1,1-dioxid
US5663365A (en) Process for the preparation of pyrazolones
FI110939B (fi) N-substituoitu-1-alkyylitio-2-nitroeteeniamiinin ja sen suolan valmistus
NZ202857A (en) Preparation of beta-((2-methylpropoxy)methyl)-n-phenyl-n-(phenylmethyl)-1-pyrrolidineethanamine hydrochloride hydrate
KR940008923B1 (ko) 아미노아세토니트릴 유도체
Fancher et al. Anomalous Ring Opening of N-aryl-2-oxazolidinones by Anhydrous Alkoxide: A Convenient Preparation of n-(alkoxyethyl)-2, 6-disubstituted Anilines
US4873343A (en) Process for the preparation of N-(2-chlorobenzyl)-2-(2-thienyl) ethylamine
EP0483674B1 (en) A process for producing an aliphatic amide and salts thereof
RU2292340C1 (ru) Способ получения r-метилпроизводных 3,5-диамино-1,2,4-триазола
US4539416A (en) Processes for making thioalkyl carboxamides and amines
EP0103840B1 (en) Method for preparing 1,2,3-trihetero 5-membered heterocyclic compounds
HU186423B (en) Process for producing pyrazole
SU941359A1 (ru) Способ получени метилентиоалкильных производных циклогексанона
FI62831C (fi) Foerfarande foer framstaellning av n-metylpyrrol-2-acetonitril
US5066813A (en) Method for production of 1,3-thiazolidin-2-ones
EP0357192A1 (en) Process for preparing substituted guanylthioureas
JPH0674250B2 (ja) チオカルバメ−ト誘導体の製法

Legal Events

Date Code Title Description
FG Patent granted

Owner name: BIOCHEMIE GESELLSCHAFT M.B.H