FI104255B - Förfarande för framsätllning av fusionsproteiner innehållande N-terminalfragmenter av mänsklig serumalbumin - Google Patents
Förfarande för framsätllning av fusionsproteiner innehållande N-terminalfragmenter av mänsklig serumalbumin Download PDFInfo
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- FI104255B FI104255B FI915073A FI915073A FI104255B FI 104255 B FI104255 B FI 104255B FI 915073 A FI915073 A FI 915073A FI 915073 A FI915073 A FI 915073A FI 104255 B FI104255 B FI 104255B
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- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
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Claims (5)
1. Ett förfarande för framställning av en fusionspolypeptid omfattande, som ät-minstone en del av dess N-terminala del, en N-terminal del av HSA eller en variant därav och, som ätminstone en del av dess C-terminala del, en annan polypeptid med 5 undantag för att när nämnda N-terminala del av HSA är 1-n-delen, där n är 369-419 eller en en variant därav, sä är nämnda polypeptid (a) 585-1578-delen av humanfib-ronektin eller variant därav, (b) 1-368-delen av CD4 eller en variant därav, (c) plätt-härstammande tillväxtfaktor eller en variant därav, (d) transformerande tillväxtfaktor β eller en variant därav, (e) 1-261-delen av fullt utvecklat humanplasmafibronektin 10 eller en variant därav, (f) 278-578-delen av fullt utvecklat humanplasma-fibronektin eller en variant därav, (g) 1-272-delen av fullt utvecklat human-von Willebrandts faktor eller en variant därav eller (h) alfa-1-antitrypsin eller en variant därav, känne-tecknat av att i en transformerad värdcell uttrycks en polynukleotidsekvens, som kodar nämnda fusionspolypeptid.
2. Förfarande enligt patentkrav 1, kännetecknat av att fusionspolypeptiden des-sutom omfattar ätminstone en N-terminal aminosyra sträckande sig utöver den del som motsvarar den N-terminala delen av HSA. 20
3. Förfarande enligt patentkrav 1 eller 2, kännetecknat av att det finns en spalt- bar region vid kopplingspunkten för nämnda N-terminala eller C-terminala delar av fusionspolypeptid. • I
: 4. Förfarande enligt nägot av föregäende patentkrav, kännetecknat av att nämn- 25 da C-terminala del av fusionspolypeptid är 585-1578-delen av humanplasmafibro- : ’ * *i nektin eller varianter därav. ··· • · • · « • · · ··· ·
5. En polynukleotidsekvens uppvisande en nukleotidsekvens anordnad sä att den uttrycker en fusionspolypeptid enligt nägot av föregäende patentkrav. • · · ··· • · · • · · «aa a a a «aa a • a a a a · · a a « a < « « a a « a « « a a i i a a a a a a a a a a i a a a « a a
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB898909916A GB8909916D0 (en) | 1989-04-29 | 1989-04-29 | Polypeptides |
GB8909916 | 1989-04-29 | ||
GB9000650 | 1990-04-26 | ||
PCT/GB1990/000650 WO1990013653A1 (en) | 1989-04-29 | 1990-04-26 | Fusion proteins containing n-terminal fragments of human serum albumin |
Publications (3)
Publication Number | Publication Date |
---|---|
FI915073A0 FI915073A0 (fi) | 1991-10-28 |
FI104255B true FI104255B (sv) | 1999-12-15 |
FI104255B1 FI104255B1 (sv) | 1999-12-15 |
Family
ID=10656000
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI915073A FI104255B1 (sv) | 1989-04-29 | 1991-10-28 | Förfarande för framsätllning av fusionsproteiner innehållande N-terminalfragmenter av mänsklig serumalbumin |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0470165A1 (sv) |
JP (1) | JP2781459B2 (sv) |
KR (1) | KR100227167B1 (sv) |
AU (1) | AU630450B2 (sv) |
CA (1) | CA2015687C (sv) |
FI (1) | FI104255B1 (sv) |
GB (2) | GB8909916D0 (sv) |
HU (1) | HUT61049A (sv) |
IE (1) | IE67651B1 (sv) |
IL (1) | IL94243A (sv) |
WO (1) | WO1990013653A1 (sv) |
ZA (1) | ZA903237B (sv) |
Families Citing this family (37)
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US5610148A (en) * | 1991-01-18 | 1997-03-11 | University College London | Macroscopically oriented cell adhesion protein for wound treatment |
US5629287A (en) * | 1991-01-18 | 1997-05-13 | University College London | Depot formulations |
FR2686899B1 (fr) * | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
FR2686900B1 (fr) * | 1992-01-31 | 1995-07-21 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides ayant une activite de stimulation des colonies de granulocytes, leur preparation et compositions pharmaceutiques les contenant. |
WO1994016085A2 (en) * | 1992-12-30 | 1994-07-21 | Zymogenetics, Inc. | Hybrid proteins having cross-linking and tissue-binding activities |
GB9408466D0 (en) * | 1994-04-27 | 1994-06-22 | Univ Nottingham | Cloning and functional expression of neurotoxins |
US5543308A (en) * | 1994-10-18 | 1996-08-06 | New England Biolabs, Inc. | Isolated DNA encoding the FSEI restriction endonuclease and related methods for producing the same |
US5641483A (en) * | 1995-06-07 | 1997-06-24 | Beaulieu; Andre | Wound healing formulations containing human plasma fibronectin |
US5877149A (en) | 1995-06-07 | 1999-03-02 | Beaulieu; Andre | Deepithelialized skin diffusion cell system |
US6423512B1 (en) | 1996-07-26 | 2002-07-23 | Novartis Ag | Fusion polypeptides |
PE99498A1 (es) * | 1996-07-26 | 1999-01-21 | Novartis Ag | Polipeptidos de fusion |
US5932693A (en) * | 1996-12-10 | 1999-08-03 | Washington University | Antithrombotic peptides |
JP2003525570A (ja) | 1998-01-23 | 2003-09-02 | ノボ ノルディスク アクティーゼルスカブ | 酵母において所望のポリペプチドを産生する方法 |
AU775422B2 (en) | 1998-06-15 | 2004-07-29 | Gtc Biotherapeutics, Inc. | Erythropoietin analog-human serum albumin fusion |
EP1278544A4 (en) * | 2000-04-12 | 2004-08-18 | Human Genome Sciences Inc | ALBUMIN FUSION PROTEINS |
TW200718784A (en) | 2001-08-15 | 2007-05-16 | Takara Bio Inc | Method of extended culture for antigen-specific cytotoxic T lumphocytes |
EP2277910A1 (en) | 2001-12-21 | 2011-01-26 | Human Genome Sciences, Inc. | Albumin fusion proteins |
ATE491021T1 (de) | 2002-03-25 | 2010-12-15 | Takara Bio Inc | Verfahren zur produktion eines zytotoxischen lymphozyten |
EP1666589B1 (en) * | 2003-08-22 | 2010-02-17 | Takara Bio Inc. | Process for producing cytotoxic lymphocytes |
EP3192872A1 (en) | 2003-08-26 | 2017-07-19 | The Regents of the University of Colorado, a body corporate | Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections |
GB0329681D0 (en) | 2003-12-23 | 2004-01-28 | Delta Biotechnology Ltd | Gene expression technique |
GB0329722D0 (en) | 2003-12-23 | 2004-01-28 | Delta Biotechnology Ltd | Modified plasmid and use thereof |
JP5631533B2 (ja) | 2004-12-23 | 2014-11-26 | ノボザイムス バイオファーマ デーコー アクティーゼルスカブ | 遺伝子発現技術 |
EP1816201A1 (en) | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Modified coagulation factor VIIa with extended half-life |
EP2474318A1 (en) | 2006-06-07 | 2012-07-11 | Human Genome Sciences, Inc. | Albumin fusion proteins |
EP2049560B1 (en) | 2006-07-13 | 2013-05-15 | Novozymes Biopharma DK A/S | Process for preparing particles of proteinaceous material |
JP5936112B2 (ja) | 2009-02-11 | 2016-06-15 | アルブミディクス アクティーゼルスカブ | アルブミン変異体及び複合体 |
EP2493921B1 (en) | 2009-10-30 | 2018-09-26 | Albumedix Ltd | Albumin variants |
KR20130070576A (ko) | 2010-04-09 | 2013-06-27 | 노보자임스 바이오파마 디케이 에이/에스 | 알부민 유도체 및 변이체 |
US9938353B2 (en) * | 2011-06-24 | 2018-04-10 | The Regents Of The University Of Colorado, A Body Corporate | Compositions, methods and uses for alpha-1 antitrypsin fusion molecules |
US20140315817A1 (en) | 2011-11-18 | 2014-10-23 | Eleven Biotherapeutics, Inc. | Variant serum albumin with improved half-life and other properties |
PL2825556T3 (pl) | 2012-03-16 | 2018-10-31 | Albumedix A/S | Warianty albuminy |
GB2512156A (en) | 2012-11-08 | 2014-09-24 | Novozymes Biopharma Dk As | Albumin variants |
EP2968587A2 (en) | 2013-03-13 | 2016-01-20 | Bristol-Myers Squibb Company | Fibronectin based scaffold domains linked to serum albumin or a moiety binding thereto |
EP3337816B1 (en) | 2015-08-20 | 2024-02-14 | Albumedix Ltd | Albumin variants and conjugates |
WO2018089702A1 (en) | 2016-11-10 | 2018-05-17 | Keros Therapeutics, Inc. | Gdnf fusion polypeptides and methods of use thereof |
JP2022509517A (ja) * | 2018-10-29 | 2022-01-20 | スピン セラピューティクス, エルエルシー | アルファ-1-アンチトリプシン欠乏症のための組成物及び方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE459586B (sv) * | 1987-09-14 | 1989-07-17 | Mta Szegedi Biolog Koezponti | Strukturgen som kodar foer autentiskt humant serum albumin och foerfarande foer dess framstaellning |
GB8725529D0 (en) * | 1987-10-30 | 1987-12-02 | Delta Biotechnology Ltd | Polypeptides |
-
1989
- 1989-04-29 GB GB898909916A patent/GB8909916D0/en active Pending
-
1990
- 1990-04-26 HU HU904413A patent/HUT61049A/hu unknown
- 1990-04-26 WO PCT/GB1990/000650 patent/WO1990013653A1/en active IP Right Grant
- 1990-04-26 JP JP2506978A patent/JP2781459B2/ja not_active Expired - Lifetime
- 1990-04-26 AU AU55646/90A patent/AU630450B2/en not_active Expired
- 1990-04-26 EP EP90907285A patent/EP0470165A1/en active Pending
- 1990-04-27 IE IE155490A patent/IE67651B1/en not_active IP Right Cessation
- 1990-04-27 ZA ZA903237A patent/ZA903237B/xx unknown
- 1990-04-27 CA CA002015687A patent/CA2015687C/en not_active Expired - Lifetime
- 1990-04-29 IL IL9424390A patent/IL94243A/en not_active IP Right Cessation
-
1991
- 1991-09-06 GB GB9119043A patent/GB2246783B/en not_active Expired - Lifetime
- 1991-10-14 KR KR1019910701334A patent/KR100227167B1/ko not_active IP Right Cessation
- 1991-10-28 FI FI915073A patent/FI104255B1/sv active
Also Published As
Publication number | Publication date |
---|---|
HUT61049A (en) | 1992-11-30 |
GB2246783B (en) | 1992-10-14 |
EP0470165A1 (en) | 1992-02-12 |
JPH04506598A (ja) | 1992-11-19 |
IE901554L (en) | 1990-10-29 |
AU5564690A (en) | 1990-11-29 |
GB8909916D0 (en) | 1989-06-14 |
ZA903237B (en) | 1991-03-27 |
FI104255B1 (sv) | 1999-12-15 |
GB2246783A (en) | 1992-02-12 |
CA2015687C (en) | 2000-08-29 |
AU630450B2 (en) | 1992-10-29 |
KR100227167B1 (ko) | 1999-10-15 |
JP2781459B2 (ja) | 1998-07-30 |
HU904413D0 (en) | 1992-01-28 |
CA2015687A1 (en) | 1990-10-29 |
IE67651B1 (en) | 1996-04-17 |
FI915073A0 (fi) | 1991-10-28 |
IL94243A0 (en) | 1991-01-31 |
GB9119043D0 (en) | 1991-12-04 |
IL94243A (en) | 1995-10-31 |
KR920701451A (ko) | 1992-08-11 |
WO1990013653A1 (en) | 1990-11-15 |
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