FI103805B1 - Förfarande för hydrolys av preproinsuliner - Google Patents

Förfarande för hydrolys av preproinsuliner

Info

Publication number
FI103805B1
FI103805B1 FI914151A FI914151A FI103805B1 FI 103805 B1 FI103805 B1 FI 103805B1 FI 914151 A FI914151 A FI 914151A FI 914151 A FI914151 A FI 914151A FI 103805 B1 FI103805 B1 FI 103805B1
Authority
FI
Finland
Prior art keywords
preproinsulins
hydrolysis
intermediates
clostripain
carboxypeptidase
Prior art date
Application number
FI914151A
Other languages
English (en)
Finnish (fi)
Other versions
FI103805B (sv
FI914151A0 (fi
FI914151A (fi
Inventor
Michael Doerschug
Klaus-Peter Koller
Ruediger Marquardt
Johannes Meiwes
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI914151A0 publication Critical patent/FI914151A0/fi
Publication of FI914151A publication Critical patent/FI914151A/fi
Application granted granted Critical
Publication of FI103805B publication Critical patent/FI103805B/sv
Publication of FI103805B1 publication Critical patent/FI103805B1/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
FI914151A 1990-09-05 1991-09-03 Förfarande för hydrolys av preproinsuliner FI103805B1 (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4028118 1990-09-05

Publications (4)

Publication Number Publication Date
FI914151A0 FI914151A0 (fi) 1991-09-03
FI914151A FI914151A (fi) 1992-03-06
FI103805B FI103805B (sv) 1999-09-30
FI103805B1 true FI103805B1 (sv) 1999-09-30

Family

ID=6413629

Family Applications (1)

Application Number Title Priority Date Filing Date
FI914151A FI103805B1 (sv) 1990-09-05 1991-09-03 Förfarande för hydrolys av preproinsuliner

Country Status (26)

Country Link
US (1) US5728543A (sv)
EP (1) EP0474212B1 (sv)
JP (1) JP3005335B2 (sv)
KR (1) KR100188800B1 (sv)
AT (1) ATE145922T1 (sv)
AU (1) AU637254B2 (sv)
CA (1) CA2050606C (sv)
CZ (1) CZ283234B6 (sv)
DE (1) DE59108392D1 (sv)
DK (1) DK0474212T3 (sv)
ES (1) ES2095891T3 (sv)
FI (1) FI103805B1 (sv)
GR (1) GR3021909T3 (sv)
HR (1) HRP940766A2 (sv)
HU (1) HU214676B (sv)
IE (1) IE75723B1 (sv)
IL (1) IL99383A (sv)
LT (1) LT3328B (sv)
LV (1) LV10508B (sv)
NO (1) NO300980B1 (sv)
NZ (1) NZ239652A (sv)
PL (1) PL167810B1 (sv)
RU (1) RU2062301C1 (sv)
SK (1) SK279686B6 (sv)
YU (1) YU147491A (sv)
ZA (1) ZA917008B (sv)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6461834B1 (en) 1998-11-06 2002-10-08 Bionebraska, Inc. Clostripain catalyzed amidation of peptides
DE19915938A1 (de) * 1999-04-09 2000-10-19 Aventis Pharma Gmbh Herstellung von pankreatischer Procarboxypeptidase B, Isoformen und Muteinen davon und ihre Verwendung
WO2003099847A2 (en) * 2002-05-24 2003-12-04 Restoragen, Inc. Method for enzymatic production of glp-1 (7-36) amide peptides
EP1513945A4 (en) * 2002-05-24 2008-12-24 Restoragen Inc PROCESS FOR UNIVERSAL ENZYMATIC PRODUCTION OF BIOACTIVE PEPTIDES
WO2003099854A2 (en) * 2002-05-24 2003-12-04 Nps Allelix Corp. Method for enzymatic production of glp-2(1-33) and glp-2-(1-34) peptides
SI1704234T1 (sl) * 2003-11-21 2012-08-31 Nps Pharma Inc Proizvodnja glukagonu podobnih peptidov 2 in analogov
WO2013015697A1 (en) * 2011-07-28 2013-01-31 Mabion S.A. A recombinant protein, a polynucleotide encoding it as well as a method of obtaining insulin or its an analogue
KR102646845B1 (ko) * 2018-08-08 2024-03-14 주식회사 대웅제약 클로스트리파인을 이용한 지속형 인슐린 아날로그 복합체의 활성형 제조방법

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU81606A1 (de) 1979-08-14 1981-03-24 Arbed Verfahren und einrichtung zur wiederverwertung von kohlenstoffreichen abfallprodukten
DE3209184A1 (de) * 1982-03-13 1983-09-15 Hoechst Ag, 6230 Frankfurt Verfahren zur umwandlung von praeproinsulinanaloga zu insulinen
US4581909A (en) 1982-05-27 1986-04-15 Neiman S.A. Cylinder lock, particularly a steering-wheel lock for a motor vehicle
JPS60217894A (ja) * 1984-04-14 1985-10-31 Suntory Ltd 新規プロテア−ゼ及びその製造方法
DE3440988A1 (de) 1984-11-09 1986-07-10 Hoechst Ag, 6230 Frankfurt Verfahren zur spaltung von peptiden und proteinen an der methionyl-bindung
DK129385A (da) * 1985-03-22 1986-09-23 Novo Industri As Peptider og fremstilling deraf
IL84110A (en) 1986-10-14 1992-11-15 Lilly Co Eli Process for transforming a human insulin precursor to a human insulin
DE4012818A1 (de) * 1990-04-21 1991-10-24 Hoechst Ag Verfahren zur herstellung von fremdproteinen in streptomyceten
DE3919852A1 (de) * 1988-06-23 1989-12-28 Hoechst Ag Mini-proinsulin, seine herstellung und verwendung
DE58906966D1 (de) 1988-06-23 1994-03-24 Hoechst Ag Mini-Proinsulin, seine Herstellung und Verwendung.
ES2081826T3 (es) 1988-11-03 1996-03-16 Hoechst Ag Procedimiento para la preparacion de un producto previo de insulina en estreptomicetos.
US5617606A (en) 1996-02-29 1997-04-08 Baracuda International Corp. Fluted swimming pool cleaner discs

Also Published As

Publication number Publication date
ES2095891T3 (es) 1997-03-01
FI103805B (sv) 1999-09-30
DE59108392D1 (de) 1997-01-16
JPH04258296A (ja) 1992-09-14
EP0474212B1 (de) 1996-12-04
KR920006504A (ko) 1992-04-27
RU2062301C1 (ru) 1996-06-20
FI914151A0 (fi) 1991-09-03
IE913117A1 (en) 1992-03-11
DK0474212T3 (da) 1997-05-12
LV10508B (en) 1996-02-20
NO913474D0 (no) 1991-09-04
GR3021909T3 (en) 1997-03-31
NO913474L (no) 1992-03-06
CZ283234B6 (cs) 1998-02-18
LT3328B (en) 1995-07-25
IL99383A0 (en) 1992-08-18
AU8356791A (en) 1992-03-12
CA2050606C (en) 2002-08-13
PL167810B1 (pl) 1995-11-30
US5728543A (en) 1998-03-17
LTIP712A (en) 1995-01-31
YU147491A (sh) 1995-10-24
HU912875D0 (en) 1992-01-28
EP0474212A3 (de) 1992-04-08
IE75723B1 (en) 1997-09-24
LV10508A (lv) 1995-02-20
NZ239652A (en) 1992-09-25
CA2050606A1 (en) 1992-03-06
AU637254B2 (en) 1993-05-20
ATE145922T1 (de) 1996-12-15
CS271191A3 (en) 1992-03-18
NO300980B1 (no) 1997-08-25
IL99383A (en) 1996-01-31
JP3005335B2 (ja) 2000-01-31
KR100188800B1 (ko) 1999-06-01
HUT58823A (en) 1992-03-30
HRP940766A2 (en) 1997-08-31
FI914151A (fi) 1992-03-06
ZA917008B (en) 1992-04-29
HU214676B (hu) 1998-04-28
EP0474212A2 (de) 1992-03-11
PL291617A1 (en) 1992-03-09
SK279686B6 (sk) 1999-02-11

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Legal Events

Date Code Title Description
MA Patent expired