FI102678B1 - Menetelmä terapeuttisesti käyttökelpoisten 1-bentsyyli-3-hydroksimetyyli-indatsolin eettereiden valmistamiseksi ja välituoteyhdiste - Google Patents
Menetelmä terapeuttisesti käyttökelpoisten 1-bentsyyli-3-hydroksimetyyli-indatsolin eettereiden valmistamiseksi ja välituoteyhdisteInfo
- Publication number
- FI102678B1 FI102678B1 FI900577A FI900577A FI102678B1 FI 102678 B1 FI102678 B1 FI 102678B1 FI 900577 A FI900577 A FI 900577A FI 900577 A FI900577 A FI 900577A FI 102678 B1 FI102678 B1 FI 102678B1
- Authority
- FI
- Finland
- Prior art keywords
- hydroxymethylindazole
- benzyl
- preparation
- intermediate compound
- therapeutically useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8947620A IT1230441B (it) | 1989-02-07 | 1989-02-07 | Eteri della serie dell'indazolo |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI900577A0 FI900577A0 (fi) | 1990-02-06 |
| FI102678B FI102678B (fi) | 1999-01-29 |
| FI102678B1 true FI102678B1 (fi) | 1999-01-29 |
Family
ID=11261479
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI900577A FI102678B1 (fi) | 1989-02-07 | 1990-02-06 | Menetelmä terapeuttisesti käyttökelpoisten 1-bentsyyli-3-hydroksimetyyli-indatsolin eettereiden valmistamiseksi ja välituoteyhdiste |
Country Status (36)
| Country | Link |
|---|---|
| US (2) | US4999367A (pl) |
| EP (1) | EP0382276B1 (pl) |
| JP (1) | JP2870925B2 (pl) |
| KR (1) | KR0145525B1 (pl) |
| CN (2) | CN1046505C (pl) |
| AR (1) | AR247386A1 (pl) |
| AT (1) | ATE127115T1 (pl) |
| AU (1) | AU624895B2 (pl) |
| BG (1) | BG50273A3 (pl) |
| CA (1) | CA2009503C (pl) |
| CZ (1) | CZ280121B6 (pl) |
| DD (2) | DD295363A5 (pl) |
| DE (2) | DE382276T1 (pl) |
| DK (1) | DK0382276T3 (pl) |
| EG (1) | EG19170A (pl) |
| ES (1) | ES2020171T3 (pl) |
| FI (1) | FI102678B1 (pl) |
| GE (1) | GEP19971030B (pl) |
| GR (2) | GR910300073T1 (pl) |
| HU (1) | HU204793B (pl) |
| IL (1) | IL93132A (pl) |
| IN (1) | IN170957B (pl) |
| IT (1) | IT1230441B (pl) |
| LT (1) | LT3604B (pl) |
| LV (1) | LV10612B (pl) |
| NZ (1) | NZ232258A (pl) |
| PE (1) | PE25091A1 (pl) |
| PH (1) | PH26552A (pl) |
| PL (2) | PL163730B1 (pl) |
| PT (1) | PT93067B (pl) |
| RO (1) | RO106252B1 (pl) |
| RU (3) | RU2066318C1 (pl) |
| SK (1) | SK56390A3 (pl) |
| UA (1) | UA26852C2 (pl) |
| YU (1) | YU47943B (pl) |
| ZA (1) | ZA90644B (pl) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1253703B (it) * | 1991-04-22 | 1995-08-23 | Angelini Francesco Ist Ricerca | Uso di acidi metossi alcanoici dell'indazolo per preparare un farmaco attivo nel trattamento di malattie autoimmunitarie |
| IT1293795B1 (it) * | 1997-07-28 | 1999-03-10 | Angelini Ricerche Spa | Farmaco attivo nel ridurre la produzione di proteina mcp-1 |
| US5943270A (en) * | 1997-11-26 | 1999-08-24 | Intel Corporation | Two-transistor DRAM cell for logic process technology |
| US7514463B2 (en) | 2004-08-20 | 2009-04-07 | University Of Kansas | Lonidamine analogues and their use in male contraception and cancer treatment |
| ITMI20062254A1 (it) * | 2006-11-24 | 2008-05-25 | Acraf | Uso di un acido metossi-alcanoico dell'indazolo per preparare una composizione farmaceutca |
| BRPI0907974A2 (pt) | 2008-03-07 | 2015-08-04 | Acraf | Composto, composição farmacêutica, uso de um composto, e, método para tratar ou prevenir doenças |
| US7919518B2 (en) * | 2008-03-07 | 2011-04-05 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. | 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, CX3CR1 and p40 |
| EP2262777B8 (en) | 2008-03-07 | 2016-05-04 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A. | 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1 and cx3cr1 |
| JP5640086B2 (ja) * | 2009-08-03 | 2014-12-10 | アジェンデ・キミケ・リウニテ・アンジェリニ・フランチェスコ・ア・チ・エレ・ア・エフェ・ソシエタ・ペル・アチオニＡｚｉｅｎｄｅ Ｃｈｉｍｉｃｈｅ Ｒｉｕｎｉｔｅ Ａｎｇｅｌｉｎｉ Ｆｒａｎｃｅｓｃｏ Ａ．Ｃ．Ｒ．Ａ．Ｆ．Ｓｏｃｉｅｔａ Ｐｅｒ Ａｚｉｏｎｉ | １−ベンジル−３−ヒドロキシメチル−１ｈ−インダゾール及びその誘導体の製造方法並びに必要なマグネシウム中間体 |
| UA108742C2 (uk) * | 2009-09-23 | 2015-06-10 | Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1 | |
| WO2013163758A1 (en) | 2012-05-01 | 2013-11-07 | Boyd Shelley Romayne | Methods for treating and diagnosing blinding eye diseases |
| US8999292B2 (en) | 2012-05-01 | 2015-04-07 | Translatum Medicus Inc. | Methods for treating and diagnosing blinding eye diseases |
| RU2645344C2 (ru) | 2012-05-18 | 2018-02-21 | Санофи | Производные пиразола и их применение в качестве lpar5 антагонистов |
| EP2850062B1 (en) | 2012-05-18 | 2017-07-19 | Sanofi | Pyridine derivatives and their use in the treatment of conditions associated with pathological thrombus formation |
| CN108047136B (zh) * | 2017-12-20 | 2021-07-09 | 长春普华制药股份有限公司 | 一种苄达酸的精制方法 |
| CA3144861A1 (en) * | 2019-06-25 | 2020-12-30 | Translatum Medicus, Inc. | Processes of making 2-((1-benzyl-1h-indazol-3-yl)methoxy)-2-methylpropanoic acid and its derivatives |
| CN113929627A (zh) * | 2021-10-19 | 2022-01-14 | 吕梁学院 | 一种宾达利的合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL28032A (en) * | 1966-08-29 | 1971-08-25 | Acraf | Indazol-3-yl-oxyalkanoic acids and process for the preparation thereof |
| US3470298A (en) * | 1969-01-29 | 1969-09-30 | Acraf | Topical anti-inflammatory composition containing (indazole-3-yl)-oxyalkanoic acids |
| IT1131779B (it) | 1980-07-29 | 1986-06-25 | Acraf | Sale dell'acido (1-benzil-1h-indazol-3-il)-ossiacetico con la lisina e procedimento per la sua preparazione |
| IT1189052B (it) | 1981-11-27 | 1988-01-28 | Acraf | Trattamento della cataratta |
| IT1194564B (it) | 1983-04-18 | 1988-09-22 | Acraf | Impiego del bendazac e dei suoi sali nel trattamento della retinite pigmentosa |
| IT1197805B (it) | 1986-08-01 | 1988-12-06 | Acraf | Metodo per il tratamento di lenti a contatto |
-
1989
- 1989-02-07 IT IT8947620A patent/IT1230441B/it active
-
1990
- 1990-01-22 IL IL9313290A patent/IL93132A/en not_active IP Right Cessation
- 1990-01-23 DK DK90200167.6T patent/DK0382276T3/da active
- 1990-01-23 ES ES90200167T patent/ES2020171T3/es not_active Expired - Lifetime
- 1990-01-23 DE DE199090200167T patent/DE382276T1/de active Pending
- 1990-01-23 AT AT90200167T patent/ATE127115T1/de not_active IP Right Cessation
- 1990-01-23 EP EP90200167A patent/EP0382276B1/en not_active Expired - Lifetime
- 1990-01-23 DE DE69021902T patent/DE69021902T2/de not_active Expired - Lifetime
- 1990-01-24 US US07/470,118 patent/US4999367A/en not_active Expired - Lifetime
- 1990-01-26 NZ NZ232258A patent/NZ232258A/en unknown
- 1990-01-29 ZA ZA90644A patent/ZA90644B/xx unknown
- 1990-01-30 IN IN81/CAL/90A patent/IN170957B/en unknown
- 1990-01-30 PE PE1990164654A patent/PE25091A1/es unknown
- 1990-02-02 AU AU49066/90A patent/AU624895B2/en not_active Expired
- 1990-02-05 RO RO144074A patent/RO106252B1/ro unknown
- 1990-02-05 YU YU20690A patent/YU47943B/sh unknown
- 1990-02-05 PL PL90285287A patent/PL163730B1/pl unknown
- 1990-02-05 PL PL90283638A patent/PL163720B1/pl unknown
- 1990-02-06 HU HU90689A patent/HU204793B/hu unknown
- 1990-02-06 JP JP2027007A patent/JP2870925B2/ja not_active Expired - Lifetime
- 1990-02-06 SK SK563-90A patent/SK56390A3/sk not_active IP Right Cessation
- 1990-02-06 RU SU904743128A patent/RU2066318C1/ru active
- 1990-02-06 UA UA4743128A patent/UA26852C2/uk unknown
- 1990-02-06 FI FI900577A patent/FI102678B1/fi active IP Right Grant
- 1990-02-06 EG EG6290A patent/EG19170A/xx active
- 1990-02-06 PH PH40002A patent/PH26552A/en unknown
- 1990-02-06 AR AR90316095A patent/AR247386A1/es active
- 1990-02-06 PT PT93067A patent/PT93067B/pt active IP Right Grant
- 1990-02-06 CZ CS90563A patent/CZ280121B6/cs not_active IP Right Cessation
- 1990-02-06 BG BG91122A patent/BG50273A3/xx unknown
- 1990-02-07 DD DD90342349A patent/DD295363A5/de unknown
- 1990-02-07 KR KR1019900001453A patent/KR0145525B1/ko not_active IP Right Cessation
- 1990-02-07 CA CA002009503A patent/CA2009503C/en not_active Expired - Lifetime
- 1990-02-07 CN CN90100599A patent/CN1046505C/zh not_active Expired - Fee Related
- 1990-02-07 DD DD90337657A patent/DD291995A5/de unknown
- 1990-12-20 US US07/632,117 patent/US5112986A/en not_active Expired - Lifetime
-
1991
- 1991-06-05 RU SU914895526A patent/RU2055071C1/ru active
- 1991-06-05 RU SU914895540A patent/RU2044729C1/ru active
- 1991-11-15 GR GR91300073T patent/GR910300073T1/el unknown
-
1993
- 1993-06-22 LV LVP-93-647A patent/LV10612B/lv unknown
- 1993-07-26 GE GEAP19931214A patent/GEP19971030B/en unknown
- 1993-08-17 LT LTIP872A patent/LT3604B/lt not_active IP Right Cessation
- 1993-09-15 CN CN93117740A patent/CN1034016C/zh not_active Expired - Fee Related
-
1995
- 1995-11-22 GR GR950403284T patent/GR3018165T3/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI104170B1 (fi) | Menetelmä terapeuttisesti käyttökelpoisten 3-amidopyratsolijohdannaisten valmistamiseksi | |
| NO179584C (no) | Analogifremgangsmåte for fremstilling av terapeutisk aktive 2-acylaminotiazoler | |
| FI885943A (fi) | Menetelmä uusien terapeuttisesti käyttökelpoisten adenosiinijohdannaisten valmistamiseksi ja välituotteita | |
| FI94250B (fi) | Menetelmä uusien, terapeuttisesti käyttökelpoisten eetterien valmistamiseksi | |
| FI881223A0 (fi) | Menetelmä terapeuttisesti aktiivisten substituoitujen 9-aminotetrahydroakriinien ja niille läheisten yhdisteiden valmistamiseksi | |
| FI102678B1 (fi) | Menetelmä terapeuttisesti käyttökelpoisten 1-bentsyyli-3-hydroksimetyyli-indatsolin eettereiden valmistamiseksi ja välituoteyhdiste | |
| IS1667B (is) | Hliðstæð aðferð við framleiðslu á meðferðarvirkumbis-aza-bísýklískum efnasamböndum | |
| FI895757A0 (fi) | Menetelmä terapeuttisesti käyttökelpoisten propenonioksiimieettereiden valmistamiseksi | |
| FI850654L (fi) | Menetelmä terapeuttisesti käyttökelpoisten pleuromutilinijohdannaisten valmistamiseksi | |
| FI895417A0 (fi) | Menetelmä uusien terapeuttisesti käyttökelpoisten 2'-halometylideeninukleosidien valmistamiseksi | |
| FI92696C (fi) | Menetelmä terapeuttisesti käyttökelpoisten tiatsolidiinidionijohdannaisten valmistamiseksi | |
| FI895393A0 (fi) | Menetelmä terapeuttisesti käyttökelpoisten alkyylisubstituoitujen 2-alkyyliamiinibentsopyran-6-olien valmistamiseksi | |
| FI883672A (fi) | Menetelmä terapeuttisesti käyttökelpoisten aminoalkoksifenyylijohdannaisten valmistamiseksi | |
| FI95701C (fi) | Menetelmä terapeuttisesti käyttökelpoisten kromaanijohdannaisten valmistamiseksi | |
| FI892948A0 (fi) | Menetelmä terapeuttisesti käyttökelpoisten kromaanijohdannaisten valmistamiseksi | |
| FI893003A (fi) | Menetelmä uusien terapeuttisesti käyttökelpoisten neplanosiinijohdannaisten valmistamiseksi | |
| FI911420A0 (fi) | Menetelmä terapeuttisesti käyttökelpoisten yhdisteiden valmistamiseksi | |
| FI92064C (fi) | Menetelmä terapeuttisesti käyttökelpoisten N-bentsopyranyylilaktaamien valmistamiseksi | |
| FI92825C (fi) | Menetelmä terapeuttisesti käyttökelpoisten kromaanijohdannaisten valmistamiseksi | |
| NO174203C (no) | Analogifremgangsmåte for fremstilling av terapeutisk aktive | |
| FI884473A (fi) | Menetelmä terapeuttisesti käyttökelpoisten fenoksialkyylipyrokatekolijohdannaisten valmistamiseksi | |
| PT86938A (pt) | Process for the preparation of a macrocyclic compound | |
| FI892420A (fi) | Menetelmä terapeuttisesti käyttökelpoisten 2-aminoetanolijohdannaisten valmistamiseksi | |
| FI893434A (fi) | Menetelmä uusien terapeuttisesti käyttökelpoisten sykloalkyylitiatsolijohdannaisten valmistamiseksi | |
| NO175780C (no) | Analogifremgangsmåte for fremstilling av terapeutisk aktive substituerte dibenzofuraner |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Patent granted |
Owner name: AZIENDE CHIMICHE RIUNITE ANGELINI |
|
| FG | Patent granted |
Owner name: AZIENDE CHIMICHE RIUNITE ANGELINI |