FI101475B1 - Menetelmä kudosplasminogeeniaktivaattorijohdannaisen valmistamiseksi - Google Patents

Menetelmä kudosplasminogeeniaktivaattorijohdannaisen valmistamiseksi

Info

Publication number
FI101475B1
FI101475B1 FI902700A FI902700A FI101475B1 FI 101475 B1 FI101475 B1 FI 101475B1 FI 902700 A FI902700 A FI 902700A FI 902700 A FI902700 A FI 902700A FI 101475 B1 FI101475 B1 FI 101475B1
Authority
FI
Finland
Prior art keywords
plasminogen activator
tissue plasminogen
preparing
derivative
activator derivative
Prior art date
Application number
FI902700A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI101475B (fi
FI902700A0 (fi
Inventor
Anne Stern
Ulrich Kohnert
Rainer Rudolph
Stephan Fischer
Ulrich Martin
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of FI902700A0 publication Critical patent/FI902700A0/fi
Application granted granted Critical
Publication of FI101475B publication Critical patent/FI101475B/fi
Publication of FI101475B1 publication Critical patent/FI101475B1/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/6456Plasminogen activators
    • C12N9/6459Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/6456Plasminogen activators
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21069Protein C activated (3.4.21.69)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Luminescent Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI902700A 1989-05-31 1990-05-30 Menetelmä kudosplasminogeeniaktivaattorijohdannaisen valmistamiseksi FI101475B1 (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3917781 1989-05-31
DE3917781 1989-05-31
DE3923339 1989-07-14
DE3923339A DE3923339A1 (de) 1989-05-31 1989-07-14 Gewebs-plasminogen-aktivator-derivat

Publications (3)

Publication Number Publication Date
FI902700A0 FI902700A0 (fi) 1990-05-30
FI101475B FI101475B (fi) 1998-06-30
FI101475B1 true FI101475B1 (fi) 1998-06-30

Family

ID=25881452

Family Applications (1)

Application Number Title Priority Date Filing Date
FI902700A FI101475B1 (fi) 1989-05-31 1990-05-30 Menetelmä kudosplasminogeeniaktivaattorijohdannaisen valmistamiseksi

Country Status (17)

Country Link
EP (1) EP0400545B1 (cs)
JP (1) JPH0327286A (cs)
AT (1) ATE119940T1 (cs)
AU (1) AU623781B2 (cs)
CA (1) CA2017636C (cs)
CZ (1) CZ267690A3 (cs)
DD (1) DD300109A5 (cs)
DE (2) DE3923339A1 (cs)
ES (1) ES2070210T3 (cs)
FI (1) FI101475B1 (cs)
HU (1) HU216870B (cs)
IE (1) IE66006B1 (cs)
IL (1) IL94539A (cs)
NO (1) NO902405L (cs)
NZ (1) NZ233796A (cs)
PT (1) PT94227B (cs)
ZA (1) ZA904089B (cs)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3942144A1 (de) * 1989-12-20 1991-06-27 Boehringer Mannheim Gmbh Stabilisierung von k1k2p pro
US6027888A (en) * 1996-04-05 2000-02-22 Board Of Regents, The University Of Texas System Methods for producing soluble, biologically-active disulfide-bond containing eukaryotic proteins in bacterial cells

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU200615B (en) * 1982-05-05 1990-07-28 Genentech Inc Methods of preparing tissue plasiminogen activator derivative composition
FR2594845B1 (fr) * 1986-02-21 1989-12-01 Genetica Preparation par voie microbiologique de l'activateur tissulaire humain du plasminogene (t-pa) et conversion de l'enzyme ainsi obtenue en sa forme active
DE3643158A1 (de) * 1986-04-21 1987-11-19 Boehringer Mannheim Gmbh Gewebs-plasminogen-aktivator(tpa) - derivat und seine herstellung
FI100106B (fi) * 1986-12-05 1997-09-30 Novartis Ag Menetelmä plasminogeenin yksisäikeisen yhdistelmäaktivaattorin valmist amiseksi
IL87276A (en) * 1987-08-03 1995-07-31 Fujisawa Pharmaceutical Co Analog of tissue plasminogen activator comprising only the kringle 2 and protease domain dna encoding the same processes for the preparation thereof and pharmaceutical compositions containing the same
US5094953A (en) * 1988-03-21 1992-03-10 Genentech, Inc. Human tissue plasminogen activator variants
DE3903581A1 (de) * 1989-02-07 1990-08-16 Boehringer Mannheim Gmbh Gewebs-plasminogenaktivator-derivat

Also Published As

Publication number Publication date
PT94227B (pt) 1997-01-31
HU903267D0 (en) 1990-10-28
EP0400545B1 (de) 1995-03-15
FI101475B (fi) 1998-06-30
EP0400545A1 (de) 1990-12-05
IL94539A0 (en) 1991-03-10
ES2070210T3 (es) 1995-06-01
IE66006B1 (en) 1995-11-29
AU5600990A (en) 1990-12-06
NZ233796A (en) 1992-07-28
CA2017636C (en) 2000-05-02
HU216870B (hu) 1999-09-28
ATE119940T1 (de) 1995-04-15
IE901848L (en) 1990-11-30
PT94227A (pt) 1991-02-08
FI902700A0 (fi) 1990-05-30
NO902405D0 (no) 1990-05-30
CA2017636A1 (en) 1990-11-30
DE3923339A1 (de) 1990-12-06
CZ282035B6 (cs) 1997-04-16
AU623781B2 (en) 1992-05-21
DE59008693D1 (de) 1995-04-20
DD300109A5 (de) 1992-05-21
HUT54734A (en) 1991-03-28
NO902405L (no) 1990-12-03
ZA904089B (en) 1991-03-27
JPH0327286A (ja) 1991-02-05
CZ267690A3 (en) 1997-04-16
IL94539A (en) 1996-08-04

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Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: BOEHRINGER MANNHEIM GMBH