AU623781B2 - Derivative of tissue-type plasminogen activator - Google Patents

Derivative of tissue-type plasminogen activator

Info

Publication number
AU623781B2
AU623781B2 AU56009/90A AU5600990A AU623781B2 AU 623781 B2 AU623781 B2 AU 623781B2 AU 56009/90 A AU56009/90 A AU 56009/90A AU 5600990 A AU5600990 A AU 5600990A AU 623781 B2 AU623781 B2 AU 623781B2
Authority
AU
Australia
Prior art keywords
derivative
plasminogen activator
tissue
type plasminogen
glycosylated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU56009/90A
Other versions
AU5600990A (en
Inventor
Stephan Fischer
Ulrich Kohnert
Ulrich Martin
Rainer Rudolph
Anne Stern
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of AU5600990A publication Critical patent/AU5600990A/en
Application granted granted Critical
Publication of AU623781B2 publication Critical patent/AU623781B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Luminescent Compositions (AREA)

Abstract

The tissue plasminogen activator (t-PA) derivative is not glycosylated and has the following amino-acid sequence: <IMAGE>
AU56009/90A 1989-05-31 1990-05-28 Derivative of tissue-type plasminogen activator Ceased AU623781B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3917781 1989-05-31
DE3917781 1989-05-31
DE3923339A DE3923339A1 (en) 1989-05-31 1989-07-14 FABRIC PLASMINOGEN ACTIVATOR DERIVATIVE
DE3923339 1989-07-14

Publications (2)

Publication Number Publication Date
AU5600990A AU5600990A (en) 1990-12-06
AU623781B2 true AU623781B2 (en) 1992-05-21

Family

ID=25881452

Family Applications (1)

Application Number Title Priority Date Filing Date
AU56009/90A Ceased AU623781B2 (en) 1989-05-31 1990-05-28 Derivative of tissue-type plasminogen activator

Country Status (17)

Country Link
EP (1) EP0400545B1 (en)
JP (1) JPH0327286A (en)
AT (1) ATE119940T1 (en)
AU (1) AU623781B2 (en)
CA (1) CA2017636C (en)
CZ (1) CZ267690A3 (en)
DD (1) DD300109A5 (en)
DE (2) DE3923339A1 (en)
ES (1) ES2070210T3 (en)
FI (1) FI101475B1 (en)
HU (1) HU216870B (en)
IE (1) IE66006B1 (en)
IL (1) IL94539A (en)
NO (1) NO902405L (en)
NZ (1) NZ233796A (en)
PT (1) PT94227B (en)
ZA (1) ZA904089B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3942144A1 (en) * 1989-12-20 1991-06-27 Boehringer Mannheim Gmbh STABILIZATION OF K1K2P PRO
WO1997038123A1 (en) * 1996-04-05 1997-10-16 Board Of Regents, The University Of Texas System Methods for producing soluble, biologically-active disulfide bond-containing eukaryotic proteins in bacterial cells

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0236209A1 (en) * 1986-02-21 1987-09-09 Genetica Preparation of human tissue plasminogen activator (t-PA) by the microbiological way and conversion of the so obtained enzyme in its active form
AU3414889A (en) * 1988-03-21 1989-10-16 Genentech Inc. Novel human tissue plasminogen activator variants and processes
AU5047090A (en) * 1989-02-07 1990-09-05 Actavis Group Ptc Ehf. Tissue plasminogene activator derivative

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1662352A3 (en) * 1982-05-05 1991-07-07 Генентек, Инк (Фирма) Strain of bacteria escherichia coli - a producer of plasminogen activator of tissue type
DE3643158A1 (en) * 1986-04-21 1987-11-19 Boehringer Mannheim Gmbh TISSUE PLASMINOGEN ACTIVATOR (TPA) DERIVATIVE AND ITS PRODUCTION
FI100106B (en) * 1986-12-05 1997-09-30 Novartis Ag A process for the preparation of a plasminogen single-stranded recombinant activator
IL87276A (en) * 1987-08-03 1995-07-31 Fujisawa Pharmaceutical Co Analog of tissue plasminogen activator comprising only the kringle 2 and protease domain dna encoding the same processes for the preparation thereof and pharmaceutical compositions containing the same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0236209A1 (en) * 1986-02-21 1987-09-09 Genetica Preparation of human tissue plasminogen activator (t-PA) by the microbiological way and conversion of the so obtained enzyme in its active form
AU3414889A (en) * 1988-03-21 1989-10-16 Genentech Inc. Novel human tissue plasminogen activator variants and processes
AU5047090A (en) * 1989-02-07 1990-09-05 Actavis Group Ptc Ehf. Tissue plasminogene activator derivative

Also Published As

Publication number Publication date
FI902700A0 (en) 1990-05-30
ES2070210T3 (en) 1995-06-01
IL94539A0 (en) 1991-03-10
PT94227B (en) 1997-01-31
EP0400545A1 (en) 1990-12-05
EP0400545B1 (en) 1995-03-15
HUT54734A (en) 1991-03-28
CA2017636A1 (en) 1990-11-30
DE59008693D1 (en) 1995-04-20
NO902405L (en) 1990-12-03
CZ282035B6 (en) 1997-04-16
NZ233796A (en) 1992-07-28
IL94539A (en) 1996-08-04
HU903267D0 (en) 1990-10-28
DE3923339A1 (en) 1990-12-06
CA2017636C (en) 2000-05-02
IE901848L (en) 1990-11-30
IE66006B1 (en) 1995-11-29
ZA904089B (en) 1991-03-27
FI101475B (en) 1998-06-30
HU216870B (en) 1999-09-28
ATE119940T1 (en) 1995-04-15
CZ267690A3 (en) 1997-04-16
NO902405D0 (en) 1990-05-30
JPH0327286A (en) 1991-02-05
FI101475B1 (en) 1998-06-30
AU5600990A (en) 1990-12-06
PT94227A (en) 1991-02-08
DD300109A5 (en) 1992-05-21

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired