FI902700A0 - VAEVNADPLASMINOGENAKTIVATORDERIVAT. - Google Patents

VAEVNADPLASMINOGENAKTIVATORDERIVAT.

Info

Publication number
FI902700A0
FI902700A0 FI902700A FI902700A FI902700A0 FI 902700 A0 FI902700 A0 FI 902700A0 FI 902700 A FI902700 A FI 902700A FI 902700 A FI902700 A FI 902700A FI 902700 A0 FI902700 A0 FI 902700A0
Authority
FI
Finland
Prior art keywords
vaevnadplasminogenaktivatorderivat
glycosylated
derivative
image
acid sequence
Prior art date
Application number
FI902700A
Other languages
Finnish (fi)
Other versions
FI101475B (en
FI101475B1 (en
Inventor
Anne Stern
Ulrich Kohnert
Rainer Rudolph
Stephen Fischer
Ulrich Martin
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of FI902700A0 publication Critical patent/FI902700A0/en
Application granted granted Critical
Publication of FI101475B publication Critical patent/FI101475B/en
Publication of FI101475B1 publication Critical patent/FI101475B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

Abstract

The tissue plasminogen activator (t-PA) derivative is not glycosylated and has the following amino-acid sequence: <IMAGE>
FI902700A 1989-05-31 1990-05-30 A method for preparing a tissue plasminogen activator derivative FI101475B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3917781 1989-05-31
DE3917781 1989-05-31
DE3923339 1989-07-14
DE3923339A DE3923339A1 (en) 1989-05-31 1989-07-14 FABRIC PLASMINOGEN ACTIVATOR DERIVATIVE

Publications (3)

Publication Number Publication Date
FI902700A0 true FI902700A0 (en) 1990-05-30
FI101475B FI101475B (en) 1998-06-30
FI101475B1 FI101475B1 (en) 1998-06-30

Family

ID=25881452

Family Applications (1)

Application Number Title Priority Date Filing Date
FI902700A FI101475B1 (en) 1989-05-31 1990-05-30 A method for preparing a tissue plasminogen activator derivative

Country Status (17)

Country Link
EP (1) EP0400545B1 (en)
JP (1) JPH0327286A (en)
AT (1) ATE119940T1 (en)
AU (1) AU623781B2 (en)
CA (1) CA2017636C (en)
CZ (1) CZ282035B6 (en)
DD (1) DD300109A5 (en)
DE (2) DE3923339A1 (en)
ES (1) ES2070210T3 (en)
FI (1) FI101475B1 (en)
HU (1) HU216870B (en)
IE (1) IE66006B1 (en)
IL (1) IL94539A (en)
NO (1) NO902405L (en)
NZ (1) NZ233796A (en)
PT (1) PT94227B (en)
ZA (1) ZA904089B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3942144A1 (en) * 1989-12-20 1991-06-27 Boehringer Mannheim Gmbh STABILIZATION OF K1K2P PRO
WO1997038123A1 (en) * 1996-04-05 1997-10-16 Board Of Regents, The University Of Texas System Methods for producing soluble, biologically-active disulfide bond-containing eukaryotic proteins in bacterial cells

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX197183A (en) * 1982-05-05 1994-02-28 Genentech Inc HUMAN TISSUE PLASMINOGEN ACTIVATOR
FR2594845B1 (en) * 1986-02-21 1989-12-01 Genetica MICROBIOLOGICAL PREPARATION OF THE HUMAN PLASMINOGEN TISSUE ACTIVATOR (T-PA) AND CONVERSION OF THE ENZYME SO OBTAINED IN ITS ACTIVE FORM
DE3643158A1 (en) * 1986-04-21 1987-11-19 Boehringer Mannheim Gmbh TISSUE PLASMINOGEN ACTIVATOR (TPA) DERIVATIVE AND ITS PRODUCTION
FI100106B (en) * 1986-12-05 1997-09-30 Novartis Ag A process for the preparation of a plasminogen single-stranded recombinant activator
IL87276A (en) * 1987-08-03 1995-07-31 Fujisawa Pharmaceutical Co Analog of tissue plasminogen activator comprising only the kringle 2 and protease domain dna encoding the same processes for the preparation thereof and pharmaceutical compositions containing the same
US5094953A (en) * 1988-03-21 1992-03-10 Genentech, Inc. Human tissue plasminogen activator variants
DE3903581A1 (en) * 1989-02-07 1990-08-16 Boehringer Mannheim Gmbh FABRIC PLASMINOGEN ACTIVATOR DERIVATIVE

Also Published As

Publication number Publication date
IL94539A0 (en) 1991-03-10
DE3923339A1 (en) 1990-12-06
ZA904089B (en) 1991-03-27
FI101475B (en) 1998-06-30
NZ233796A (en) 1992-07-28
EP0400545B1 (en) 1995-03-15
HUT54734A (en) 1991-03-28
ES2070210T3 (en) 1995-06-01
AU5600990A (en) 1990-12-06
NO902405D0 (en) 1990-05-30
NO902405L (en) 1990-12-03
ATE119940T1 (en) 1995-04-15
CZ267690A3 (en) 1997-04-16
HU216870B (en) 1999-09-28
HU903267D0 (en) 1990-10-28
AU623781B2 (en) 1992-05-21
JPH0327286A (en) 1991-02-05
EP0400545A1 (en) 1990-12-05
IE901848L (en) 1990-11-30
CA2017636A1 (en) 1990-11-30
PT94227B (en) 1997-01-31
CA2017636C (en) 2000-05-02
IE66006B1 (en) 1995-11-29
DE59008693D1 (en) 1995-04-20
IL94539A (en) 1996-08-04
CZ282035B6 (en) 1997-04-16
DD300109A5 (en) 1992-05-21
PT94227A (en) 1991-02-08
FI101475B1 (en) 1998-06-30

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Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: BOEHRINGER MANNHEIM GMBH