ES2070210T3 - Derivado del activador de plasminogeno de tejido. - Google Patents

Derivado del activador de plasminogeno de tejido.

Info

Publication number
ES2070210T3
ES2070210T3 ES90110096T ES90110096T ES2070210T3 ES 2070210 T3 ES2070210 T3 ES 2070210T3 ES 90110096 T ES90110096 T ES 90110096T ES 90110096 T ES90110096 T ES 90110096T ES 2070210 T3 ES2070210 T3 ES 2070210T3
Authority
ES
Spain
Prior art keywords
derivative
plasminogen activator
tissue plasminogen
glycosylated
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90110096T
Other languages
English (en)
Inventor
Anne Dr Rer Nat Stern
Ulrich Dr Rer Nat Kohnert
Rainer Dr Rer Nat Rudolph
Stephan Dr Rer Nat Fischer
Ulrich Dr Med Martin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Application granted granted Critical
Publication of ES2070210T3 publication Critical patent/ES2070210T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

NUEVO DERIVADO (T-PA) ACTIVANTE DEL PLASMINOGENO TISULAR, NO GLUCOSILADO, QUE PRESENTA UNA SECUENCIA DE AMINOACIDOS COMO LA DESCRITA EN LA MEMORIA DE LA PATENTE.
ES90110096T 1989-05-31 1990-05-28 Derivado del activador de plasminogeno de tejido. Expired - Lifetime ES2070210T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3917781 1989-05-31
DE3923339A DE3923339A1 (de) 1989-05-31 1989-07-14 Gewebs-plasminogen-aktivator-derivat

Publications (1)

Publication Number Publication Date
ES2070210T3 true ES2070210T3 (es) 1995-06-01

Family

ID=25881452

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90110096T Expired - Lifetime ES2070210T3 (es) 1989-05-31 1990-05-28 Derivado del activador de plasminogeno de tejido.

Country Status (17)

Country Link
EP (1) EP0400545B1 (es)
JP (1) JPH0327286A (es)
AT (1) ATE119940T1 (es)
AU (1) AU623781B2 (es)
CA (1) CA2017636C (es)
CZ (1) CZ267690A3 (es)
DD (1) DD300109A5 (es)
DE (2) DE3923339A1 (es)
ES (1) ES2070210T3 (es)
FI (1) FI101475B (es)
HU (1) HU216870B (es)
IE (1) IE66006B1 (es)
IL (1) IL94539A (es)
NO (1) NO902405L (es)
NZ (1) NZ233796A (es)
PT (1) PT94227B (es)
ZA (1) ZA904089B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3942144A1 (de) * 1989-12-20 1991-06-27 Boehringer Mannheim Gmbh Stabilisierung von k1k2p pro
US6027888A (en) * 1996-04-05 2000-02-22 Board Of Regents, The University Of Texas System Methods for producing soluble, biologically-active disulfide-bond containing eukaryotic proteins in bacterial cells

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX197183A (es) * 1982-05-05 1994-02-28 Genentech Inc Activador de plasminogeno de tejido humano
FR2594845B1 (fr) * 1986-02-21 1989-12-01 Genetica Preparation par voie microbiologique de l'activateur tissulaire humain du plasminogene (t-pa) et conversion de l'enzyme ainsi obtenue en sa forme active
DE3643158A1 (de) * 1986-04-21 1987-11-19 Boehringer Mannheim Gmbh Gewebs-plasminogen-aktivator(tpa) - derivat und seine herstellung
FI100106B (fi) * 1986-12-05 1997-09-30 Novartis Ag Menetelmä plasminogeenin yksisäikeisen yhdistelmäaktivaattorin valmist amiseksi
IL87276A (en) * 1987-08-03 1995-07-31 Fujisawa Pharmaceutical Co Analog of a tissue plasminogen activator containing the Pringle 2 and protease regions only, DNA encoding it, processes for its preparation, and pharmaceutical preparations containing it
US5094953A (en) * 1988-03-21 1992-03-10 Genentech, Inc. Human tissue plasminogen activator variants
DE3903581A1 (de) * 1989-02-07 1990-08-16 Boehringer Mannheim Gmbh Gewebs-plasminogenaktivator-derivat

Also Published As

Publication number Publication date
NO902405L (no) 1990-12-03
CZ282035B6 (cs) 1997-04-16
PT94227A (pt) 1991-02-08
IE66006B1 (en) 1995-11-29
DE59008693D1 (de) 1995-04-20
JPH0327286A (ja) 1991-02-05
DD300109A5 (de) 1992-05-21
AU623781B2 (en) 1992-05-21
IL94539A (en) 1996-08-04
FI101475B1 (fi) 1998-06-30
CZ267690A3 (en) 1997-04-16
AU5600990A (en) 1990-12-06
EP0400545A1 (de) 1990-12-05
ATE119940T1 (de) 1995-04-15
FI101475B (fi) 1998-06-30
CA2017636A1 (en) 1990-11-30
IL94539A0 (en) 1991-03-10
NO902405D0 (no) 1990-05-30
HU903267D0 (en) 1990-10-28
PT94227B (pt) 1997-01-31
NZ233796A (en) 1992-07-28
DE3923339A1 (de) 1990-12-06
CA2017636C (en) 2000-05-02
IE901848L (en) 1990-11-30
EP0400545B1 (de) 1995-03-15
HUT54734A (en) 1991-03-28
FI902700A0 (fi) 1990-05-30
HU216870B (hu) 1999-09-28
ZA904089B (en) 1991-03-27

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