FI101226B1 - Förfarande för framställning av som läkemedel användbara 2-[2-(karbonyl)pyrrolidin-4-yltio]-6-(1-hydroxietyl)-1-metylkarbapen-2-em-3-karboxylsyraderivat - Google Patents

Förfarande för framställning av som läkemedel användbara 2-[2-(karbonyl)pyrrolidin-4-yltio]-6-(1-hydroxietyl)-1-metylkarbapen-2-em-3-karboxylsyraderivat

Info

Publication number
FI101226B1
FI101226B1 FI922561A FI922561A FI101226B1 FI 101226 B1 FI101226 B1 FI 101226B1 FI 922561 A FI922561 A FI 922561A FI 922561 A FI922561 A FI 922561A FI 101226 B1 FI101226 B1 FI 101226B1
Authority
FI
Finland
Prior art keywords
methylcarbapen
ylthio
pyrrolidin
hydroxyethyl
carbonyl
Prior art date
Application number
FI922561A
Other languages
English (en)
Finnish (fi)
Other versions
FI101226B (sv
FI922561A0 (fi
FI922561A (fi
Inventor
Isao Kawamoto
Rokuro Endo
Masao Miyauchi
Katsuhiko Watanabe
Eiji Nakayama
Hiroshi Yasuda
Satoshi Ohya
Yukio Utsui
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of FI922561A0 publication Critical patent/FI922561A0/fi
Publication of FI922561A publication Critical patent/FI922561A/fi
Application granted granted Critical
Publication of FI101226B1 publication Critical patent/FI101226B1/sv
Publication of FI101226B publication Critical patent/FI101226B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Cephalosporin Compounds (AREA)
FI922561A 1991-06-04 1992-06-03 Förfarande för framställning av som läkemedel användbara 2-£2-(karbony l)pyrrolidin-4-yltio|-6-(1-hydroxietyl)-1-metylkarbapen-2-em-3-karboxy lsyraderivat FI101226B (sv)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP13154591 1991-06-04
JP13154591 1991-06-04
JP34573791 1991-12-27
JP34573791 1991-12-27
JP3052192 1992-02-18
JP3052192 1992-02-18
JP9128392 1992-04-10
JP9128392 1992-04-10

Publications (4)

Publication Number Publication Date
FI922561A0 FI922561A0 (fi) 1992-06-03
FI922561A FI922561A (fi) 1992-12-05
FI101226B1 true FI101226B1 (sv) 1998-05-15
FI101226B FI101226B (sv) 1998-05-15

Family

ID=27459269

Family Applications (1)

Application Number Title Priority Date Filing Date
FI922561A FI101226B (sv) 1991-06-04 1992-06-03 Förfarande för framställning av som läkemedel användbara 2-£2-(karbony l)pyrrolidin-4-yltio|-6-(1-hydroxietyl)-1-metylkarbapen-2-em-3-karboxy lsyraderivat

Country Status (21)

Country Link
EP (1) EP0518558B1 (sv)
JP (1) JP2559949B2 (sv)
KR (1) KR100247855B1 (sv)
CN (1) CN1030767C (sv)
AT (1) ATE170521T1 (sv)
AU (1) AU651887B2 (sv)
CA (1) CA2070305A1 (sv)
CZ (1) CZ167792A3 (sv)
DE (1) DE69226815T2 (sv)
DK (1) DK0518558T3 (sv)
ES (1) ES2120992T3 (sv)
FI (1) FI101226B (sv)
HK (1) HK1011980A1 (sv)
HU (2) HU218289B (sv)
IE (1) IE921796A1 (sv)
IL (1) IL102093A (sv)
MX (1) MX9202670A (sv)
NO (1) NO302475B1 (sv)
NZ (1) NZ243022A (sv)
RU (1) RU2093514C1 (sv)
TW (1) TW203612B (sv)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712267A (en) * 1991-06-04 1998-01-27 Sankyo Company,. Limited Carbapenem derivatives, their preparation and their use as antibiotics
GB9202298D0 (en) * 1992-02-04 1992-03-18 Ici Plc Antibiotic compounds
FI103046B (sv) * 1992-03-11 1999-04-15 Sankyo Co Förfarande för framställning av som läkemedel användbara pyrrolidinylt iokarbapenemderivater
GB9304156D0 (en) * 1992-03-26 1993-04-21 Zeneca Ltd Antibiotic compounds
CA2099818A1 (en) * 1992-07-21 1994-01-22 Frederic H. Jung Antibiotic compounds
EP0581502B1 (en) * 1992-07-21 1998-10-21 Zeneca Limited Antibiotic carbapenem compounds
AU4912393A (en) * 1993-06-15 1994-12-22 Dong Kook Pharmaceutical Co., Ltd. 1-beta-methyl-2-thiolic carbapenem derivatives
JP3848693B2 (ja) * 1994-07-06 2006-11-22 エーザイ・アール・アンド・ディー・マネジメント株式会社 新規カルバペネム誘導体
GB9515975D0 (en) 1995-08-04 1995-10-04 Zeneca Ltd Chemical compounds
KR100386993B1 (ko) * 1995-12-21 2003-12-18 상꾜 가부시키가이샤 1-메틸카르바페넴유도체
DE69714841T2 (de) * 1996-04-26 2003-05-28 Sankyo Co Ein 1-methylcarbapenem-derivat
AU4020897A (en) 1996-08-17 1998-03-06 Zeneca Limited 3-mercaptopyrrolidines as farnesyl protein transferase inhibitors
AU1415500A (en) * 1998-12-07 2000-06-26 Sankyo Company Limited 1-methylcarbapenem derivatives
GB9930318D0 (en) 1999-12-22 2000-02-09 Zeneca Ltd Novel compounds
GB9930317D0 (en) 1999-12-22 2000-02-09 Zeneca Ltd Novel compounds
WO2003024928A2 (en) 2001-09-14 2003-03-27 Novo Nordisk A/S Novel aminoazetidine, -pyrrolidine and -piperidine derivatives
US6673829B2 (en) 2001-09-14 2004-01-06 Novo Nordisk A/S Aminoazetidine,-pyrrolidine and -piperidine derivatives
CN101367814B (zh) * 2007-06-28 2010-12-15 山东轩竹医药科技有限公司 被巯基吡咯烷甲酰哌啶取代的培南衍生物
WO2009143153A1 (en) * 2008-05-23 2009-11-26 Janssen Pharmaceutica Nv Substituted pyrrolidine amides as modulators of the histamine h3 receptor
AU2017235293B2 (en) 2016-03-16 2021-02-04 Merck Sharp & Dohme Corp. Carbapenem compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1283906C (en) * 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
JPS60233076A (ja) * 1984-05-03 1985-11-19 Sumitomo Chem Co Ltd 新規なβ−ラクタム化合物およびその製造法
DE3780344T2 (de) * 1986-03-27 1993-01-28 Sumitomo Pharma Beta-lactam-verbindungen und deren herstellung.
CA2036163C (en) * 1990-02-14 2001-06-19 Makoto Sunagawa Novel beta-lactam compounds and their production
NO178498C (no) * 1990-02-23 1996-04-10 Sankyo Co Analogifremgangsmåte ved fremstilling av terapeutisk aktive karbapenemderivater
TW198034B (sv) * 1990-03-27 1993-01-11 Manyu Seiyaku Kk
AU644008B2 (en) * 1990-08-10 1993-12-02 Sumitomo Pharmaceuticals Company, Limited Beta-lactam compounds, and their production and use
FI103046B (sv) * 1992-03-11 1999-04-15 Sankyo Co Förfarande för framställning av som läkemedel användbara pyrrolidinylt iokarbapenemderivater

Also Published As

Publication number Publication date
CN1069494A (zh) 1993-03-03
HU211822A9 (en) 1995-12-28
DK0518558T3 (da) 1999-05-31
EP0518558A1 (en) 1992-12-16
KR100247855B1 (ko) 2000-05-01
TW203612B (sv) 1993-04-11
NO922185L (no) 1992-12-07
HUT61551A (en) 1993-01-28
JP2559949B2 (ja) 1996-12-04
KR930000515A (ko) 1993-01-15
AU1739092A (en) 1993-03-11
ATE170521T1 (de) 1998-09-15
ES2120992T3 (es) 1998-11-16
CZ167792A3 (en) 1995-12-13
FI101226B (sv) 1998-05-15
NO302475B1 (no) 1998-03-09
IL102093A (en) 1996-12-05
IL102093A0 (en) 1993-01-14
CN1030767C (zh) 1996-01-24
RU2093514C1 (ru) 1997-10-20
FI922561A0 (fi) 1992-06-03
DE69226815D1 (de) 1998-10-08
EP0518558B1 (en) 1998-09-02
HU9201871D0 (en) 1992-08-28
MX9202670A (es) 1993-01-01
CA2070305A1 (en) 1992-12-05
DE69226815T2 (de) 1999-05-20
HK1011980A1 (en) 1999-07-23
AU651887B2 (en) 1994-08-04
JPH05339269A (ja) 1993-12-21
IE921796A1 (en) 1992-12-16
HU218289B (en) 2000-07-28
FI922561A (fi) 1992-12-05
NZ243022A (en) 1993-07-27
NO922185D0 (no) 1992-06-03

Similar Documents

Publication Publication Date Title
FI101226B1 (sv) Förfarande för framställning av som läkemedel användbara 2-[2-(karbonyl)pyrrolidin-4-yltio]-6-(1-hydroxietyl)-1-metylkarbapen-2-em-3-karboxylsyraderivat
HU911986D0 (en) Process for the production of cyclical amido-derivatives and the medical preparations containing them
GB9124513D0 (en) Novel process
ATE138571T1 (de) Verwendung von dioxabicyclo (3.3.0>octane derivaten zur herstellung eines arzneimittels zur hemmung des cholesterinmetabolismus.
FI913067A (fi) Bisfosfonsyraderivat, deras framstaellning och anvaendning.
HUT50160A (en) Process for production of derivatives of tiophene and medical compositions containing them as active substance
HUT50337A (en) Process for producing benzoxazine derivatives and pharmaceutical compositions comprising the compounds
PL290703A1 (en) Method of obtaining novel n-benzyl-n-phenyl-i-phenylalkyl thiocarbamides
RO92245A (ro) Procedeu pentru prepararea unor derivati de 1,6-naftiridina
DE69324854D1 (de) Pyridazinone-Derivate und Verfahren zur deren Herstellung
EP0555479A4 (sv)
ATE61362T1 (de) Ein thiophenderivat und verfahren zu dessen herstellung.
ES2074770T3 (es) Procedimiento de preparacion de derivados de 1,3-dioxano-4,6-diona.
ATE110376T1 (de) Biphenyl-derivate, verfahren zu deren herstellung und deren zwischenprodukte.
ATE25680T1 (de) Verfahren zur herstellung von 4-amino-5-dialkoxy- methylpyrimidinderivaten.
HUT47923A (en) Process for production of new derivatives of naphtotiazephin and medical compositions containing these substances
ATE98248T1 (de) Verfahren zur herstellung von cephalosporinderivaten.
DE69520566D1 (de) Verfahren zur herstellung eines carbonsäurederivates