FI101226B1 - Process for the preparation of 2- [2- (carbonyl) pyrrolidin-4-ylthio] -6- (1-hydroxyethyl) -1-methylcarbapen-2-em-3-carboxylic acid derivatives useful as a medicament - Google Patents

Process for the preparation of 2- [2- (carbonyl) pyrrolidin-4-ylthio] -6- (1-hydroxyethyl) -1-methylcarbapen-2-em-3-carboxylic acid derivatives useful as a medicament

Info

Publication number
FI101226B1
FI101226B1 FI922561A FI922561A FI101226B1 FI 101226 B1 FI101226 B1 FI 101226B1 FI 922561 A FI922561 A FI 922561A FI 922561 A FI922561 A FI 922561A FI 101226 B1 FI101226 B1 FI 101226B1
Authority
FI
Finland
Prior art keywords
methylcarbapen
ylthio
pyrrolidin
hydroxyethyl
carbonyl
Prior art date
Application number
FI922561A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI101226B (en
FI922561A0 (en
FI922561A (en
Inventor
Isao Kawamoto
Rokuro Endo
Masao Miyauchi
Katsuhiko Watanabe
Eiji Nakayama
Hiroshi Yasuda
Satoshi Ohya
Yukio Utsui
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of FI922561A0 publication Critical patent/FI922561A0/en
Publication of FI922561A publication Critical patent/FI922561A/en
Application granted granted Critical
Publication of FI101226B publication Critical patent/FI101226B/en
Publication of FI101226B1 publication Critical patent/FI101226B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

Compounds of formula (I): <CHEM> in which: R<1> is hydrogen or an unsubstituted or substituted alkyl group; and A represents a number of cyclic or acyclic nitrogen-containing groups are valuable antibiotics which are resistant to dehydropeptidase I in vivo. Methods of preparing the compounds and of using them are also disclosed.
FI922561A 1991-06-04 1992-06-03 Process for the preparation of 2- [2- (carbonyl) pyrrolidin-4-ylthio] -6- (1-hydroxyethyl) -1-methylcarbapen-2-em-3-carboxylic acid derivatives useful as a medicament FI101226B1 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP13154591 1991-06-04
JP13154591 1991-06-04
JP34573791 1991-12-27
JP34573791 1991-12-27
JP3052192 1992-02-18
JP3052192 1992-02-18
JP9128392 1992-04-10
JP9128392 1992-04-10

Publications (4)

Publication Number Publication Date
FI922561A0 FI922561A0 (en) 1992-06-03
FI922561A FI922561A (en) 1992-12-05
FI101226B FI101226B (en) 1998-05-15
FI101226B1 true FI101226B1 (en) 1998-05-15

Family

ID=27459269

Family Applications (1)

Application Number Title Priority Date Filing Date
FI922561A FI101226B1 (en) 1991-06-04 1992-06-03 Process for the preparation of 2- [2- (carbonyl) pyrrolidin-4-ylthio] -6- (1-hydroxyethyl) -1-methylcarbapen-2-em-3-carboxylic acid derivatives useful as a medicament

Country Status (21)

Country Link
EP (1) EP0518558B1 (en)
JP (1) JP2559949B2 (en)
KR (1) KR100247855B1 (en)
CN (1) CN1030767C (en)
AT (1) ATE170521T1 (en)
AU (1) AU651887B2 (en)
CA (1) CA2070305A1 (en)
CZ (1) CZ167792A3 (en)
DE (1) DE69226815T2 (en)
DK (1) DK0518558T3 (en)
ES (1) ES2120992T3 (en)
FI (1) FI101226B1 (en)
HK (1) HK1011980A1 (en)
HU (2) HU218289B (en)
IE (1) IE921796A1 (en)
IL (1) IL102093A (en)
MX (1) MX9202670A (en)
NO (1) NO302475B1 (en)
NZ (1) NZ243022A (en)
RU (1) RU2093514C1 (en)
TW (1) TW203612B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712267A (en) * 1991-06-04 1998-01-27 Sankyo Company,. Limited Carbapenem derivatives, their preparation and their use as antibiotics
GB9202298D0 (en) * 1992-02-04 1992-03-18 Ici Plc Antibiotic compounds
CZ290002B6 (en) * 1992-03-11 2002-05-15 Sankyo Company Limited Antimicrobial carbapenem derivatives, process of their preparation and pharmaceutical preparation in which the derivatives are comprised
GB9304156D0 (en) * 1992-03-26 1993-04-21 Zeneca Ltd Antibiotic compounds
CA2099818A1 (en) * 1992-07-21 1994-01-22 Frederic H. Jung Antibiotic compounds
EP0581502B1 (en) * 1992-07-21 1998-10-21 Zeneca Limited Antibiotic carbapenem compounds
AU4912393A (en) * 1993-06-15 1994-12-22 Dong Kook Pharmaceutical Co., Ltd. 1-beta-methyl-2-thiolic carbapenem derivatives
JP3848693B2 (en) * 1994-07-06 2006-11-22 エーザイ・アール・アンド・ディー・マネジメント株式会社 New carbapenem derivatives
GB9515975D0 (en) 1995-08-04 1995-10-04 Zeneca Ltd Chemical compounds
DE69623497T2 (en) * 1995-12-21 2003-05-28 Sankyo Co 1-methylcarbapenem DERIVATIVES
CZ342098A3 (en) * 1996-04-26 1999-02-17 Sankyo Company, Limited 1-methylcarbapenem derivatives
AU4020897A (en) 1996-08-17 1998-03-06 Zeneca Limited 3-mercaptopyrrolidines as farnesyl protein transferase inhibitors
WO2000034282A1 (en) * 1998-12-07 2000-06-15 Sankyo Company, Limited 1-methylcarbapenem derivatives
GB9930318D0 (en) 1999-12-22 2000-02-09 Zeneca Ltd Novel compounds
GB9930317D0 (en) 1999-12-22 2000-02-09 Zeneca Ltd Novel compounds
US6673829B2 (en) 2001-09-14 2004-01-06 Novo Nordisk A/S Aminoazetidine,-pyrrolidine and -piperidine derivatives
ATE479655T1 (en) 2001-09-14 2010-09-15 High Point Pharmaceuticals Llc NEW AMINOAZETIDINE, AMINOPYRROLIDINE AND AMINOPIPERIDINE DERIVATIVES
CN101367814B (en) * 2007-06-28 2010-12-15 山东轩竹医药科技有限公司 Sulfhydryl pyrrolidine formyl piperidine substituted penem derivant
WO2009143153A1 (en) * 2008-05-23 2009-11-26 Janssen Pharmaceutica Nv Substituted pyrrolidine amides as modulators of the histamine h3 receptor
US11180504B2 (en) 2016-03-16 2021-11-23 Orchid Pharma Ltd. Substituted carbapenems for the treatment of bacterial infections

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1283906C (en) * 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
JPS60233076A (en) * 1984-05-03 1985-11-19 Sumitomo Chem Co Ltd Novel beta-lactam and its preparation
DE3780344T2 (en) * 1986-03-27 1993-01-28 Sumitomo Pharma BETA LACTAM COMPOUNDS AND THEIR PRODUCTION.
CA2036163C (en) * 1990-02-14 2001-06-19 Makoto Sunagawa Novel beta-lactam compounds and their production
IE910606A1 (en) * 1990-02-23 1991-08-28 Sankyo Co Carbapenem derivatives having antibiotic activity, their¹preparation and their use
TW198034B (en) * 1990-03-27 1993-01-11 Manyu Seiyaku Kk
AU644008B2 (en) * 1990-08-10 1993-12-02 Sumitomo Pharmaceuticals Company, Limited Beta-lactam compounds, and their production and use
CZ290002B6 (en) * 1992-03-11 2002-05-15 Sankyo Company Limited Antimicrobial carbapenem derivatives, process of their preparation and pharmaceutical preparation in which the derivatives are comprised

Also Published As

Publication number Publication date
FI101226B (en) 1998-05-15
DK0518558T3 (en) 1999-05-31
NZ243022A (en) 1993-07-27
CZ167792A3 (en) 1995-12-13
MX9202670A (en) 1993-01-01
KR930000515A (en) 1993-01-15
NO302475B1 (en) 1998-03-09
FI922561A0 (en) 1992-06-03
CN1030767C (en) 1996-01-24
HU9201871D0 (en) 1992-08-28
IL102093A (en) 1996-12-05
CA2070305A1 (en) 1992-12-05
JPH05339269A (en) 1993-12-21
FI922561A (en) 1992-12-05
ES2120992T3 (en) 1998-11-16
DE69226815D1 (en) 1998-10-08
AU651887B2 (en) 1994-08-04
HUT61551A (en) 1993-01-28
DE69226815T2 (en) 1999-05-20
HU218289B (en) 2000-07-28
JP2559949B2 (en) 1996-12-04
IE921796A1 (en) 1992-12-16
HK1011980A1 (en) 1999-07-23
AU1739092A (en) 1993-03-11
TW203612B (en) 1993-04-11
RU2093514C1 (en) 1997-10-20
NO922185D0 (en) 1992-06-03
ATE170521T1 (en) 1998-09-15
KR100247855B1 (en) 2000-05-01
NO922185L (en) 1992-12-07
HU211822A9 (en) 1995-12-28
CN1069494A (en) 1993-03-03
EP0518558B1 (en) 1998-09-02
IL102093A0 (en) 1993-01-14
EP0518558A1 (en) 1992-12-16

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