ES8800176A1 - Procedimiento para la obtencion de compuestos de 1-(a-fenil-alquilo inferior)-1h-1,2,3-triazol - Google Patents

Procedimiento para la obtencion de compuestos de 1-(a-fenil-alquilo inferior)-1h-1,2,3-triazol

Info

Publication number
ES8800176A1
ES8800176A1 ES554024A ES554024A ES8800176A1 ES 8800176 A1 ES8800176 A1 ES 8800176A1 ES 554024 A ES554024 A ES 554024A ES 554024 A ES554024 A ES 554024A ES 8800176 A1 ES8800176 A1 ES 8800176A1
Authority
ES
Spain
Prior art keywords
lower alkyl
unsubstituted
denotes
optionally
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES554024A
Other languages
English (en)
Other versions
ES554024A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES554024A0 publication Critical patent/ES554024A0/es
Publication of ES8800176A1 publication Critical patent/ES8800176A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles

Abstract

PROCEDIMIENTO PARA OBTENER COMPUESTOS DE 1-(ALFA-FENIL-ALQUILO INFERIRO)1H-1,2,3-TRIAZOL. CONISTE EN HACER REACCIONAR A UNA AZIDA DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN BENCENO, Y ENTRE 50 Y 120GC, PARA OBTENER UN COMPUESTO DE FORMULA (I), SUS DIASTEROISOMEROS Y ENANTIOMEROS. SIENDO: ALK, ALQUILIDENO INFERIOR, PH, UN RESTO FENILO SUSTITUIDO EN LA POSICION ORTO POR F; R1, H, ALQUILO INFERIOR Y OTROS; R2, UN GRUPO CARBAMILO SUSTITUIDO POR ALQUILO INFERIOR; Y1, HIDROXI; E Y2, H. SE UTILIZAN COMO AGENTES ANTICONVULSIVOS. *FORMULA*
ES554024A 1985-04-18 1986-04-16 Procedimiento para la obtencion de compuestos de 1-(a-fenil-alquilo inferior)-1h-1,2,3-triazol Expired ES8800176A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH166385 1985-04-18

Publications (2)

Publication Number Publication Date
ES554024A0 ES554024A0 (es) 1987-10-16
ES8800176A1 true ES8800176A1 (es) 1987-10-16

Family

ID=4215715

Family Applications (2)

Application Number Title Priority Date Filing Date
ES554024A Expired ES8800176A1 (es) 1985-04-18 1986-04-16 Procedimiento para la obtencion de compuestos de 1-(a-fenil-alquilo inferior)-1h-1,2,3-triazol
ES557641A Expired ES8802501A1 (es) 1985-04-18 1987-07-31 Procedimiento para la obtencion de compuestos de 1-(<-fenil-alquilo inferior)-1h-1,2,3-triazol

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES557641A Expired ES8802501A1 (es) 1985-04-18 1987-07-31 Procedimiento para la obtencion de compuestos de 1-(<-fenil-alquilo inferior)-1h-1,2,3-triazol

Country Status (22)

Country Link
EP (1) EP0199262B1 (es)
JP (1) JPS61243068A (es)
KR (1) KR900008810B1 (es)
AU (1) AU599024B2 (es)
CA (1) CA1272201A (es)
CY (1) CY1751A (es)
DD (1) DD245874A5 (es)
DE (1) DE3677626D1 (es)
DK (1) DK169720B1 (es)
ES (2) ES8800176A1 (es)
FI (1) FI93544C (es)
GR (1) GR861004B (es)
HK (1) HK1494A (es)
HU (1) HU203327B (es)
IE (1) IE58472B1 (es)
IL (1) IL78510A (es)
MX (1) MX9203628A (es)
NO (1) NO164295C (es)
NZ (1) NZ215871A (es)
PH (1) PH22568A (es)
PT (1) PT82400B (es)
ZA (1) ZA862873B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0151528B1 (en) * 1984-02-02 1990-07-04 Merck & Co. Inc. 5-(amino or substituted amino)-1,2,3-triazoles
AU2633897A (en) * 1996-04-19 1997-11-12 Novo Nordisk A/S Solid phase and combinatorial synthesis of substituted 1,2,3-triazoles and of arrays of substituted 1,2,3-triazoles
IL127665A (en) * 1996-07-11 2004-03-28 Novartis Ag Process for the preparation of 4 cyano - 3,2,1 converted triazoles in position 1
TW403740B (en) * 1997-06-10 2000-09-01 Novartis Ag Novel crystal modifications of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide
TW513301B (en) * 1999-03-01 2002-12-11 Novartis Ag Pharmaceutical composition for treatment of neuropathic pain and affective and attention disorders
WO2004106329A2 (en) * 2003-06-03 2004-12-09 Dr. Reddy's Laboratories Ltd. Novel antiinfective compounds and their pharmaceutical compositions
IT1393368B1 (it) * 2009-03-23 2012-04-20 Dipharma Francis Srl Metodo per la preparazione di rufinamide
IT1395736B1 (it) 2009-08-04 2012-10-19 Dipharma Francis Srl Forme cristalline di rufinamide
JP2013525413A (ja) * 2010-04-30 2013-06-20 ラボラトリオス レスヴィ，エス．エル． ルフィナマイド中間体の改良された製造方法
ITMI20110718A1 (it) 2011-04-29 2012-10-30 Dipharma Francis Srl Procedimento per la purificazione di rufinamide
WO2014120994A1 (en) * 2013-01-31 2014-08-07 The Johns Hopkins University Rufinamide and derivatives and their use in modulating the gating process of human voltage-gated sodium channels
US9771335B2 (en) * 2015-07-31 2017-09-26 The Johns Hopkins University Derivatives of rufinamide and their use in inhibtion of the activation of human voltage-gated sodium channels
WO2017097311A1 (en) 2015-12-11 2017-06-15 Aarhus Universitet Rufinamide for use in the treatment of myotonia
WO2021099481A1 (en) 2019-11-20 2021-05-27 Medichem, S.A. Solid composition containing rufinamide

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1511195A (en) * 1976-10-18 1978-05-17 Ici America Inc Triazole derivatives
FI834666A (fi) * 1982-12-23 1984-06-24 Ciba Geigy Ag Foerfarande foer framstaellning av nya aralkyltriazolfoereningar.

Also Published As

Publication number Publication date
EP0199262A2 (de) 1986-10-29
JPH0564949B2 (es) 1993-09-16
HUT40792A (en) 1987-02-27
ES554024A0 (es) 1987-10-16
JPS61243068A (ja) 1986-10-29
GR861004B (en) 1986-08-12
KR900008810B1 (ko) 1990-11-30
NZ215871A (en) 1989-01-27
IE861015L (en) 1986-10-18
CA1272201A (en) 1990-07-31
DD245874A5 (de) 1987-05-20
EP0199262B1 (de) 1991-02-27
FI93544C (fi) 1995-04-25
IE58472B1 (en) 1993-09-22
FI861573A (fi) 1986-10-19
PH22568A (en) 1988-10-17
MX9203628A (es) 1992-09-01
NO861486L (no) 1986-10-20
DK175686D0 (da) 1986-04-17
FI861573A0 (fi) 1986-04-14
PT82400B (pt) 1988-08-17
FI93544B (fi) 1995-01-13
AU5631986A (en) 1986-10-23
NO164295B (no) 1990-06-11
DK169720B1 (da) 1995-01-23
IL78510A0 (en) 1986-08-31
KR860008152A (ko) 1986-11-12
ES8802501A1 (es) 1988-07-01
DK175686A (da) 1986-10-19
IL78510A (en) 1992-05-25
NO164295C (no) 1990-09-19
DE3677626D1 (de) 1991-04-04
ES557641A0 (es) 1988-07-01
HK1494A (en) 1994-01-14
EP0199262A3 (en) 1987-08-26
PT82400A (en) 1986-05-01
ZA862873B (en) 1986-12-30
HU203327B (en) 1991-07-29
AU599024B2 (en) 1990-07-12
CY1751A (en) 1994-06-03

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Legal Events

Date Code Title Description
PC1A Transfer granted
FD1A Patent lapsed

Effective date: 20070808