FI861573A - Menetelmä fluorattujen, antikonvulsiivisesti vaikuttavien 1-bentsyyli-1H-1,2,3-triatsoliyhdisteiden valmistamiseksi - Google Patents

Menetelmä fluorattujen, antikonvulsiivisesti vaikuttavien 1-bentsyyli-1H-1,2,3-triatsoliyhdisteiden valmistamiseksi Download PDF

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Publication number
FI861573A
FI861573A FI861573A FI861573A FI861573A FI 861573 A FI861573 A FI 861573A FI 861573 A FI861573 A FI 861573A FI 861573 A FI861573 A FI 861573A FI 861573 A FI861573 A FI 861573A
Authority
FI
Finland
Prior art keywords
anticonvulsant
fluorinated
benzyl
preparation
triazole compounds
Prior art date
Application number
FI861573A
Other languages
English (en)
Swedish (sv)
Other versions
FI93544C (fi
FI861573A0 (fi
FI93544B (fi
Inventor
Rene Meier
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of FI861573A0 publication Critical patent/FI861573A0/fi
Publication of FI861573A publication Critical patent/FI861573A/fi
Application granted granted Critical
Publication of FI93544B publication Critical patent/FI93544B/fi
Publication of FI93544C publication Critical patent/FI93544C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI861573A 1985-04-18 1986-04-14 Menetelmä fluorattujen, antikonvulsiivisesti vaikuttavien 1-bentsyyli-1H-1,2,3-triatsoliyhdisteiden valmistamiseksi FI93544C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH166385 1985-04-18
CH166385 1985-04-18

Publications (4)

Publication Number Publication Date
FI861573A0 FI861573A0 (fi) 1986-04-14
FI861573A true FI861573A (fi) 1986-10-19
FI93544B FI93544B (fi) 1995-01-13
FI93544C FI93544C (fi) 1995-04-25

Family

ID=4215715

Family Applications (1)

Application Number Title Priority Date Filing Date
FI861573A FI93544C (fi) 1985-04-18 1986-04-14 Menetelmä fluorattujen, antikonvulsiivisesti vaikuttavien 1-bentsyyli-1H-1,2,3-triatsoliyhdisteiden valmistamiseksi

Country Status (22)

Country Link
EP (1) EP0199262B1 (fi)
JP (1) JPS61243068A (fi)
KR (1) KR900008810B1 (fi)
AU (1) AU599024B2 (fi)
CA (1) CA1272201A (fi)
CY (1) CY1751A (fi)
DD (1) DD245874A5 (fi)
DE (1) DE3677626D1 (fi)
DK (1) DK169720B1 (fi)
ES (2) ES8800176A1 (fi)
FI (1) FI93544C (fi)
GR (1) GR861004B (fi)
HK (1) HK1494A (fi)
HU (1) HU203327B (fi)
IE (1) IE58472B1 (fi)
IL (1) IL78510A (fi)
MX (1) MX9203628A (fi)
NO (1) NO164295C (fi)
NZ (1) NZ215871A (fi)
PH (1) PH22568A (fi)
PT (1) PT82400B (fi)
ZA (1) ZA862873B (fi)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3578499D1 (de) * 1984-02-02 1990-08-09 Merck & Co Inc 5-(amino oder substituiertes amino)-1,2,3-triazole.
WO1997040025A1 (en) * 1996-04-19 1997-10-30 Novo Nordisk A/S Solid phase and combinatorial synthesis of substituted 1,2,3-triazoles and of arrays of substituted 1,2,3-triazoles
SK283990B6 (sk) * 1996-07-11 2004-07-07 Novartis Ag Spôsob prípravy 1-substituovaných 4-kyano-1,2,3-triazolov, 4-kyano-1-(2,6-difluórbenzyl)-1H-1,2,3-triazol
TW403740B (en) * 1997-06-10 2000-09-01 Novartis Ag Novel crystal modifications of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide
TW513301B (en) * 1999-03-01 2002-12-11 Novartis Ag Pharmaceutical composition for treatment of neuropathic pain and affective and attention disorders
WO2004106329A2 (en) * 2003-06-03 2004-12-09 Dr. Reddy's Laboratories Ltd. Novel antiinfective compounds and their pharmaceutical compositions
IT1393368B1 (it) * 2009-03-23 2012-04-20 Dipharma Francis Srl Metodo per la preparazione di rufinamide
IT1395736B1 (it) 2009-08-04 2012-10-19 Dipharma Francis Srl Forme cristalline di rufinamide
ES2498267T3 (es) * 2010-04-30 2014-09-24 Laboratorios Lesvi, S.L. Procedimiento mejorado para la preparación de un intermedio de rufinamida
ITMI20110718A1 (it) 2011-04-29 2012-10-30 Dipharma Francis Srl Procedimento per la purificazione di rufinamide
WO2014120994A1 (en) * 2013-01-31 2014-08-07 The Johns Hopkins University Rufinamide and derivatives and their use in modulating the gating process of human voltage-gated sodium channels
US9771335B2 (en) * 2015-07-31 2017-09-26 The Johns Hopkins University Derivatives of rufinamide and their use in inhibtion of the activation of human voltage-gated sodium channels
JP7016169B2 (ja) 2015-12-11 2022-02-04 オーフス ウニベルシテット 筋強直症の治療における使用のためのルフィナミド
WO2021099481A1 (en) 2019-11-20 2021-05-27 Medichem, S.A. Solid composition containing rufinamide

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1511195A (en) * 1976-10-18 1978-05-17 Ici America Inc Triazole derivatives
FI834666A (fi) * 1982-12-23 1984-06-24 Ciba Geigy Ag Foerfarande foer framstaellning av nya aralkyltriazolfoereningar.

Also Published As

Publication number Publication date
CY1751A (en) 1994-06-03
DE3677626D1 (de) 1991-04-04
FI93544C (fi) 1995-04-25
HUT40792A (en) 1987-02-27
ES554024A0 (es) 1987-10-16
KR860008152A (ko) 1986-11-12
JPS61243068A (ja) 1986-10-29
PT82400B (pt) 1988-08-17
NZ215871A (en) 1989-01-27
ES8800176A1 (es) 1987-10-16
ES8802501A1 (es) 1988-07-01
KR900008810B1 (ko) 1990-11-30
FI861573A0 (fi) 1986-04-14
JPH0564949B2 (fi) 1993-09-16
DK169720B1 (da) 1995-01-23
ZA862873B (en) 1986-12-30
PH22568A (en) 1988-10-17
CA1272201A (en) 1990-07-31
FI93544B (fi) 1995-01-13
DD245874A5 (de) 1987-05-20
PT82400A (en) 1986-05-01
AU599024B2 (en) 1990-07-12
GR861004B (en) 1986-08-12
NO861486L (no) 1986-10-20
IL78510A0 (en) 1986-08-31
EP0199262A3 (en) 1987-08-26
HK1494A (en) 1994-01-14
EP0199262B1 (de) 1991-02-27
IE58472B1 (en) 1993-09-22
IE861015L (en) 1986-10-18
IL78510A (en) 1992-05-25
ES557641A0 (es) 1988-07-01
HU203327B (en) 1991-07-29
DK175686D0 (da) 1986-04-17
EP0199262A2 (de) 1986-10-29
MX9203628A (es) 1992-09-01
DK175686A (da) 1986-10-19
AU5631986A (en) 1986-10-23
NO164295C (no) 1990-09-19
NO164295B (no) 1990-06-11

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Owner name: NOVARTIS AG

FG Patent granted

Owner name: NOVARTIS AG

MA Patent expired