ES8708235A1 - Un procedimiento para la preparacion de derivados de androstendiona 4-sustituida - Google Patents

Un procedimiento para la preparacion de derivados de androstendiona 4-sustituida

Info

Publication number
ES8708235A1
ES8708235A1 ES557215A ES557215A ES8708235A1 ES 8708235 A1 ES8708235 A1 ES 8708235A1 ES 557215 A ES557215 A ES 557215A ES 557215 A ES557215 A ES 557215A ES 8708235 A1 ES8708235 A1 ES 8708235A1
Authority
ES
Spain
Prior art keywords
amino
androstendione
derivatives
preparation
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557215A
Other languages
English (en)
Other versions
ES557215A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Publication of ES8708235A1 publication Critical patent/ES8708235A1/es
Publication of ES557215A0 publication Critical patent/ES557215A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0027—Azides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE ANDROSTENDIONA 4-SUSTITUIDA. CONSISTENTE EN REDUCIR UN COMPUESTO DE FORMULA (II) CON PROPANO-1,3-DIETIOL EN TRIETILAMINA, PARA OBTENER EL COMPUESTO DE FORMULA (I). SIENDO: R, GRUPO -NHCOR5, -NHSO2R6, Y OTROS; R5, H, ALCOXI DE C 1 A 3 Y OTROS; R6, COMO R5, EXCEPTO H. POR SU EFECTO INHIBIDOR DE AROMATASA ESTEROIDAL, SE UTILIZAN EN EL TRATAMIENTO DE TUMORES DE HORMONAS AVANZADOS. *FORMULA* M
ES557215A 1985-02-15 1986-11-20 Un procedimiento para la preparacion de derivados de androstendiona 4-sustituida Expired ES8708235A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858503940A GB8503940D0 (en) 1985-02-15 1985-02-15 4-substituted androstendione derivatives

Publications (2)

Publication Number Publication Date
ES8708235A1 true ES8708235A1 (es) 1987-10-01
ES557215A0 ES557215A0 (es) 1987-10-01

Family

ID=10574550

Family Applications (2)

Application Number Title Priority Date Filing Date
ES552052A Expired ES8706165A1 (es) 1985-02-15 1986-02-14 Un procedimiento para la preparacion de derivados de androstendiona 4-sustituida.
ES557215A Expired ES8708235A1 (es) 1985-02-15 1986-11-20 Un procedimiento para la preparacion de derivados de androstendiona 4-sustituida

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES552052A Expired ES8706165A1 (es) 1985-02-15 1986-02-14 Un procedimiento para la preparacion de derivados de androstendiona 4-sustituida.

Country Status (28)

Country Link
US (1) US4757061A (es)
JP (1) JPS61189295A (es)
KR (1) KR930005994B1 (es)
AT (1) AT396239B (es)
AU (1) AU577667B2 (es)
BE (1) BE904226A (es)
CA (1) CA1319362C (es)
CH (1) CH669199A5 (es)
CZ (1) CZ413691A3 (es)
DE (1) DE3604179A1 (es)
DK (1) DK167221B1 (es)
ES (2) ES8706165A1 (es)
FI (1) FI84272C (es)
FR (1) FR2577556B1 (es)
GB (2) GB8503940D0 (es)
GR (1) GR860430B (es)
HK (1) HK94090A (es)
HU (1) HU194909B (es)
IE (1) IE58864B1 (es)
IT (1) IT1190335B (es)
MY (1) MY102038A (es)
NL (1) NL8600383A (es)
NZ (1) NZ215163A (es)
PT (1) PT82030B (es)
SE (2) SE468515B (es)
SG (1) SG80890G (es)
SU (1) SU1574178A3 (es)
ZA (1) ZA861118B (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8622330D0 (en) * 1986-09-17 1986-10-22 Erba Farmitalia 4-substituted 6-alkylidenandrostene-3,17-dione derivatives
GB8624251D0 (en) * 1986-10-09 1986-11-12 Erba Farmitalia "1,2-beta-methylene-4-substituted androstene-3,17 dione derivatives
DE3711772A1 (de) * 1987-04-08 1988-10-27 Schering Ag 4- und 15-disubstituierte 4-androsten-3,17-dione und verfahren zu deren herstellung
GB8711579D0 (en) * 1987-05-15 1987-06-17 Erba Farmitalia 4-amino-androstenedione derivatives
US5595985A (en) 1989-03-10 1997-01-21 Endorecherche Inc. Combination therapy for prophylaxis and/or treatment of benign prostatic hyperplasia
AU643445B2 (en) * 1989-07-07 1993-11-18 Endorecherche Inc. Combination therapy for prophylaxis and/or treatment of benign prostatic hyperplasia
US5120840A (en) * 1990-08-01 1992-06-09 Merrell Dow Pharmaceuticals Inc. 4-amino-4-ene-steroids and their use as 5α-reductase inhibitors
US5318961A (en) * 1990-08-01 1994-06-07 Merrell Dow Pharmaceuticals Inc. 4-amino-Δ4-steroids and their use as 5α-reductase inhibitors
US5143909A (en) * 1991-03-19 1992-09-01 Merrell Dow Pharmaceuticals Inc. Aminosteroids in a method for inhibiting c17-20 lyase
US5218110A (en) * 1990-08-01 1993-06-08 Merrell Dow Pharmaceuticals 4-amino-Δ4 -steroids and their use as 5α-reductase inhibitors
NZ239142A (en) * 1990-08-01 1994-05-26 Merrell Dow Pharma 4-amino-delta-4-steroids; preparatory processes and pharmaceutical compositions
AU642757B2 (en) * 1990-08-01 1993-10-28 Merrell Dow Pharmaceuticals Inc. 4-amino-delta4, 6-steroids and their use as 5alpha-reductase inhibitors
US5130424A (en) * 1990-08-01 1992-07-14 Merrell Dow Pharmaceuticals Inc. 4-amino-delta-4,6-steroids and their use as 5 alpha-reductase inhibitors
US5162337A (en) * 1990-10-05 1992-11-10 Merck & Co., Inc. Animal growth promotion
US5189032A (en) * 1991-03-19 1993-02-23 Merrell Dow Pharmaceuticals Inc. 4-amino-Δ4,6 -steroids and their use as 5α-reductase inhibitors
AU652038B2 (en) * 1991-03-28 1994-08-11 Teikoku Hormone Mfg. Co., Ltd. Novel oxa- or azasteroid derivative
CH683151A5 (de) * 1991-04-24 1994-01-31 Ciba Geigy Ag Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
GB9111260D0 (en) * 1991-05-24 1991-07-17 Erba Carlo Spa Process for the preparation of 4-amino-unsaturated androstanedione derivatives
GB9217035D0 (en) * 1992-08-11 1992-09-23 Erba Carlo Spa Androst-4-eno(4,5-b)pyrrole derivatives and process for their preparation
NZ256130A (en) * 1992-09-30 1996-05-28 Teikoku Hormone Mfg Co Ltd 7-substituted oxasteroid derivatives; pharmaceutical compositions
PL305757A1 (en) * 1993-02-18 1995-02-06 Erba Carlo Spa Fluorinated derivatives of 4-amino androstadienone and method of obtaining them
US5486511A (en) * 1993-05-25 1996-01-23 Merrell Dow Pharmaceuticals Inc. 4-amino-17β-(cyclopropyloxy)androst-4-en-3-one, 4-amino-17β-(cyclopropylamino)androst-4-en-3-one and related compounds as C17-20 lyase and 5α-reductase
US6407082B1 (en) * 1996-09-13 2002-06-18 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a vitamin D compound
GB2284605A (en) * 1993-12-09 1995-06-14 Erba Carlo Spa 6-or 7-substituted 4-aminoandrostadienone derivatives
CN1042540C (zh) * 1994-05-02 1999-03-17 默里尔药物公司 通过4－硝基－△4－3－酮甾类化合物制备4－氨基－△4－3－酮甾类化合物的方法
US6365597B1 (en) 1996-02-14 2002-04-02 Aventis Pharmaceuticals Inc. 4-aza steroids
US6511970B1 (en) 1996-09-13 2003-01-28 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
US6765002B2 (en) 2000-03-21 2004-07-20 Gustavo Rodriguez Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
US6034074A (en) 1996-09-13 2000-03-07 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a Vitamin D compound
US6028064A (en) 1996-09-13 2000-02-22 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of progestin products
US20010044431A1 (en) * 2000-03-21 2001-11-22 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
US7435757B2 (en) * 2004-07-02 2008-10-14 Schering Ag 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17β-hydroxy steroid dehydrogenase type 1

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1042291A (en) * 1961-11-08 1966-09-14 Organon Labor Ltd í¸-6ª‡-amino steroids and the preparation thereof
DE1203768B (de) * 1962-02-01 1965-10-28 Merck Ag E Verfahren zur Herstellung von N-substituierten 4-Aminosteroiden der Testosteronreiheund Saeureadditionssalzen derselben
DK120154B (da) * 1968-02-29 1971-04-19 Schering Ag Fremgangsmåde til fremstilling af N-substituerede 4-amino-3-oxosteroid-4,6-diener af androstan- eller pregnanrækken eller deres ammoniumsalte.
DE1668690C3 (de) * 1968-02-29 1978-09-14 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von N-substituierten 4-Aminosteroiden der Androstan-Pregnan- und Cholestanreihe
US3780070A (en) * 1972-09-21 1973-12-18 Schering Corp 4-azido-17alpha-alkinyl-4-gonen-17beta-ol-3-ones and method for their preparation
CA1154008A (en) * 1979-05-02 1983-09-20 Thomas R. Blohm STEROID 5.alpha.-REDUCTASE INHIBITORS

Also Published As

Publication number Publication date
US4757061A (en) 1988-07-12
SE8600668L (sv) 1986-08-16
GB2171100B (en) 1988-11-30
KR860006485A (ko) 1986-09-11
DE3604179A1 (de) 1986-08-21
SE8600668D0 (sv) 1986-02-14
FR2577556A1 (fr) 1986-08-22
ATA38886A (de) 1992-11-15
PT82030A (en) 1986-03-01
FI84272C (fi) 1991-11-11
HUT40454A (en) 1986-12-28
FI84272B (fi) 1991-07-31
CZ413691A3 (en) 1994-03-16
PT82030B (pt) 1988-07-01
IT1190335B (it) 1988-02-16
CA1319362C (en) 1993-06-22
MY102038A (en) 1992-02-29
KR930005994B1 (ko) 1993-07-01
JPH0469638B2 (es) 1992-11-06
GB8603265D0 (en) 1986-03-19
GB8503940D0 (en) 1985-03-20
FI860672A (fi) 1986-08-16
BE904226A (fr) 1986-08-14
FI860672A0 (fi) 1986-02-13
GR860430B (en) 1986-06-12
HU194909B (en) 1988-03-28
ES8706165A1 (es) 1987-06-01
DK71486D0 (da) 1986-02-14
AU577667B2 (en) 1988-09-29
SG80890G (en) 1990-11-23
JPS61189295A (ja) 1986-08-22
IE58864B1 (en) 1993-11-17
AT396239B (de) 1993-07-26
IE860413L (en) 1986-08-15
ZA861118B (en) 1986-10-29
ES552052A0 (es) 1987-06-01
NL8600383A (nl) 1986-09-01
DK167221B1 (da) 1993-09-20
DK71486A (da) 1986-08-16
ES557215A0 (es) 1987-10-01
GB2171100A (en) 1986-08-20
AU5343386A (en) 1986-08-21
SE468515B (sv) 1993-02-01
SU1574178A3 (ru) 1990-06-23
IT8619361A1 (it) 1987-08-11
IT8619361A0 (it) 1986-02-11
HK94090A (en) 1990-11-23
FR2577556B1 (fr) 1988-01-08
NZ215163A (en) 1988-02-29
CH669199A5 (de) 1989-02-28

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519