ES8608872A1 - Un metodo para preparar una composicion terapeutica a base de un extracto soluble en piridina y una endotoxina destosificada refinada. - Google Patents

Un metodo para preparar una composicion terapeutica a base de un extracto soluble en piridina y una endotoxina destosificada refinada.

Info

Publication number
ES8608872A1
ES8608872A1 ES536167A ES536167A ES8608872A1 ES 8608872 A1 ES8608872 A1 ES 8608872A1 ES 536167 A ES536167 A ES 536167A ES 536167 A ES536167 A ES 536167A ES 8608872 A1 ES8608872 A1 ES 8608872A1
Authority
ES
Spain
Prior art keywords
pyridine
soluble extract
detoxified endotoxin
refined detoxified
endotoxin composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES536167A
Other languages
English (en)
Other versions
ES536167A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ribi Immunochem Research Inc
Original Assignee
Ribi Immunochem Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ribi Immunochem Research Inc filed Critical Ribi Immunochem Research Inc
Publication of ES536167A0 publication Critical patent/ES536167A0/es
Publication of ES8608872A1 publication Critical patent/ES8608872A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/05—Actinobacteria, e.g. Actinomyces, Streptomyces, Nocardia, Bifidobacterium, Gardnerella, Corynebacterium; Propionibacterium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/806—Antigenic peptides or proteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/825—Bacteria

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Mycology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

METODO DE PREPARACION DE COMPOSICIONES A BASE DE EXTRACTOS SOLUBLES EN PIRIDINA Y ENDOTOXINAS DESTOXIFICADAS. COMPRENDE LA PRODUCCION DE UNA PASTA DE CELULAS COMPLETAS DE UNO ENTRE VARIOS MICROORGANISMOS; LAVADO DE LA PASTA Y TRATAMIENTO CON PIRIDINA PARA PRODUCIR UN EXTRACTO Y UN RESIDUO; ELIMINACION DE LA PIRIDINA DEL EXTRACTO Y DIALISIS DEL EXTRACTO SECO. HIDROLISIS DE UN EXTRACTO DE ENDOTOXINA DERIVADA DE ENTEROBACTERIACIAE CON UN ACIDO; LIOFILIZADO DEL HIDROLIZADO; TRATAMIENTO DEL LIPIDO ASI OBTENIDO CON UN DISOLVENTE QUE ELIMINA LOS ACIDOS GRASOS DEL MISMO Y A CONTINUACION CON UN DISOLVENTE QUE DISUELVE EL LIPIDO; SEPARACION CROMATOGRAFICA DEL PRODUCTO DISUELTO PARA OBTENER UNA ENDOTOXINA DEXTOSIFICADA PURA; Y COMBINACION DE ESTA CON EL EXTRACTO SECO Y UN VEHICULO ADECUADO. ESTAS COMPOSICIONES TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE TUMORES CANCEROSOS.
ES536167A 1983-09-23 1984-09-21 Un metodo para preparar una composicion terapeutica a base de un extracto soluble en piridina y una endotoxina destosificada refinada. Expired ES8608872A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/535,037 US4663306A (en) 1983-09-23 1983-09-23 Pyridine-soluble extract-refined detoxified endotoxin composition and use

Publications (2)

Publication Number Publication Date
ES536167A0 ES536167A0 (es) 1986-07-16
ES8608872A1 true ES8608872A1 (es) 1986-07-16

Family

ID=24132594

Family Applications (1)

Application Number Title Priority Date Filing Date
ES536167A Expired ES8608872A1 (es) 1983-09-23 1984-09-21 Un metodo para preparar una composicion terapeutica a base de un extracto soluble en piridina y una endotoxina destosificada refinada.

Country Status (23)

Country Link
US (1) US4663306A (es)
JP (1) JPS60120817A (es)
KR (1) KR870000843B1 (es)
AT (1) AT385659B (es)
AU (1) AU566234B2 (es)
BE (1) BE900650A (es)
CA (1) CA1244765A (es)
CH (1) CH664897A5 (es)
DE (1) DE3434766A1 (es)
DK (1) DK446684A (es)
ES (1) ES8608872A1 (es)
FI (1) FI843716L (es)
FR (1) FR2552326B1 (es)
GB (1) GB2149301B (es)
HU (1) HU192585B (es)
IL (1) IL73034A (es)
IN (1) IN157240B (es)
IT (1) IT1179444B (es)
NL (1) NL8402902A (es)
NO (1) NO843776L (es)
NZ (1) NZ209635A (es)
SE (1) SE8404707L (es)
ZA (1) ZA847405B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4844894A (en) * 1984-07-12 1989-07-04 Ribi Immunochem Research Inc. Method of inhibiting the onset of septicemia and endotoxemia
US4877611A (en) * 1986-04-15 1989-10-31 Ribi Immunochem Research Inc. Vaccine containing tumor antigens and adjuvants
US4806352A (en) * 1986-04-15 1989-02-21 Ribi Immunochem Research Inc. Immunological lipid emulsion adjuvant
US4929604A (en) * 1986-05-28 1990-05-29 Board Of Regents, The University Of Texas System Lipopolysaccharides of reduced toxicity and the production thereof
ATE210989T1 (de) * 1993-08-27 2002-01-15 Vetrepharm Inc Zusammensetzung und verfahren zur stimulation der reproduzierenden leistung
BE1007823A3 (fr) * 1993-12-10 1995-10-31 Anda Biolog Sa Utilisation d'une composition comprenant au moins un antigene et/ou un ou plusieurs fragments de cet antigene pour l'obtention d'un medicament destine au traitement et/ou a la prevention du cancer.
US6090385A (en) * 1993-12-10 2000-07-18 Maes; Hubert Method of treating cancer
US5976580A (en) 1995-06-07 1999-11-02 Novus International, Inc. Nutrient formulation and process for enhancing the health, livability, cumulative weight gain or feed efficiency in poultry and other animals
DE19710255A1 (de) * 1997-03-13 1998-09-17 Henkel Ecolab Gmbh & Co Ohg Verwendung einer Lösung zur Desaktivierung von Endotoxinen
DE69809561T2 (de) 1997-08-05 2003-09-25 Bioniche Life Science Inc Zusammensetzung und verfahren zur regulierung von zellproliferation und zelltod
US6019985A (en) * 1998-02-27 2000-02-01 Munova Corporation Immunostimulation methods for providing disease protection in poultry
CA2337445A1 (en) * 1998-07-16 2000-01-27 Sumitomo Pharmaceuticals Co., Ltd. Preparations for immunotherapy for cancer having bacterial somatic constituent as the active ingredient
DK1238070T3 (da) * 1999-12-13 2007-12-03 Bioniche Life Sciences Inc Terapeutisk anvendelige syntetiske oligonucleotider
US7125858B2 (en) * 1999-12-28 2006-10-24 Bioniche Life Sciences Inc. Hyaluronic acid in the treatment of cancer
LU90996B1 (en) * 2000-07-11 2003-01-08 Bayer Ag Use of the strains of the parapox ovis virus against fibrosis
KR100820521B1 (ko) * 2002-03-05 2008-04-07 셀 메디신 가부시키가이샤 고체화 조직 면역아쥬반트
JP4726485B2 (ja) * 2002-08-02 2011-07-20 大日本住友製薬株式会社 細菌細胞壁骨格成分製剤
FR2848223B1 (fr) * 2002-12-09 2005-02-25 Centre Nat Rech Scient Nouveau procede d'isolement des endotoxines.
AU2003261624A1 (en) * 2003-09-05 2005-03-29 Shenyang Sunbellcom Bio-Pharmaceutical Co., Ltd. A red nocardia cell wall skeleton preparation process and its therapeutic use on treating cervical erosion
WO2005102369A1 (ja) * 2004-04-22 2005-11-03 Dainippon Sumitomo Pharma Co., Ltd. 細菌細胞壁骨格成分を含有する製剤
EA032326B1 (ru) 2013-04-18 2019-05-31 Иммьюн Дизайн Корп. Монотерапия gla для применения в лечении рака
US9463198B2 (en) 2013-06-04 2016-10-11 Infectious Disease Research Institute Compositions and methods for reducing or preventing metastasis
WO2015195845A1 (en) 2014-06-17 2015-12-23 Xycrobe Therapeutics, Inc. Genetically modified bacteria and methods for genetic modification of bacteria
WO2017147507A1 (en) 2016-02-24 2017-08-31 Xycrobe Therapeutics, Inc. Skin probiotic formulation

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7308450A (es) * 1972-06-20 1973-12-27
FR2269962B1 (es) * 1974-05-06 1978-02-03 Anvar
JPS58874B2 (ja) * 1979-08-30 1983-01-08 株式会社 目黒研究所 糖蛋白ｗｅｎａｃ及びその製造法
US4435386A (en) * 1982-05-26 1984-03-06 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product
US4436728A (en) * 1982-05-26 1984-03-13 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product
US4436727A (en) * 1982-05-26 1984-03-13 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product
CA1206415A (en) * 1982-06-30 1986-06-24 John L. Cantrell Pyridine soluble extract of a microorganism
CA1206416A (en) * 1982-06-30 1986-06-24 John L. Cantrell Pyridine soluble extract of a microorganism
CA1209504A (en) * 1982-06-30 1986-08-12 John L. Cantrell Pyridine soluble extract of a microorganism

Also Published As

Publication number Publication date
CA1244765A (en) 1988-11-15
ZA847405B (en) 1985-05-29
ES536167A0 (es) 1986-07-16
KR870000843B1 (ko) 1987-04-25
DE3434766C2 (es) 1987-05-14
DK446684D0 (da) 1984-09-19
CH664897A5 (de) 1988-04-15
HUT35521A (en) 1985-07-29
NL8402902A (nl) 1985-04-16
IT1179444B (it) 1987-09-16
JPS6254775B2 (es) 1987-11-17
FI843716A0 (fi) 1984-09-21
DK446684A (da) 1985-03-24
FR2552326B1 (fr) 1988-05-13
US4663306A (en) 1987-05-05
BE900650A (fr) 1985-03-21
SE8404707L (sv) 1985-03-24
AU3340084A (en) 1985-03-28
ATA302384A (de) 1987-10-15
FI843716L (fi) 1985-03-24
IN157240B (es) 1986-02-15
HU192585B (en) 1987-06-29
FR2552326A1 (fr) 1985-03-29
AU566234B2 (en) 1987-10-15
JPS60120817A (ja) 1985-06-28
KR850002404A (ko) 1985-05-13
NO843776L (no) 1985-03-25
GB2149301A (en) 1985-06-12
GB2149301B (en) 1988-06-22
GB8423993D0 (en) 1984-10-31
IL73034A (en) 1988-11-15
DE3434766A1 (de) 1986-04-30
IT8448894A0 (it) 1984-09-24
NZ209635A (en) 1989-01-27
SE8404707D0 (sv) 1984-09-20
AT385659B (de) 1988-05-10

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