ES8601213A1 - Derivados de cefalosporina - Google Patents

Derivados de cefalosporina

Info

Publication number
ES8601213A1
ES8601213A1 ES533084A ES533084A ES8601213A1 ES 8601213 A1 ES8601213 A1 ES 8601213A1 ES 533084 A ES533084 A ES 533084A ES 533084 A ES533084 A ES 533084A ES 8601213 A1 ES8601213 A1 ES 8601213A1
Authority
ES
Spain
Prior art keywords
alkyl
alkoxy
cooh
cycloalkyl
addn
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES533084A
Other languages
English (en)
Other versions
ES533084A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca SAS
Original Assignee
ICI Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ICI Pharma SA filed Critical ICI Pharma SA
Publication of ES533084A0 publication Critical patent/ES533084A0/es
Publication of ES8601213A1 publication Critical patent/ES8601213A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/57—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with a further substituent in position 7, e.g. cephamycines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE CEFALOSPORINA Y DE SUS SALES DE ADICION DE ACIDO O DE BASE FISIOLOGICAMENTE COMPATIBLES DE FORMULA (I) EN LA QUE X R1 R2 R3 Y R4 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) EN LA QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE ENLA FORMULA (I) POR ADICION DEL GRUPO AMINO A UN ENLACE CFC O CFN ACTIVADO QUE LLEVA SOBRE EL CARBONO EL RADICAL R50 SIENDO R50 UN RADICAL DESPLAZABLE; SEGUIDO DE LA ELIMINACION DE HR50 DEL PRODUCTO FORMADO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIBACTERIAL.
ES533084A 1983-06-03 1984-06-01 Derivados de cefalosporina Expired ES8601213A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP83401135 1983-06-03

Publications (2)

Publication Number Publication Date
ES533084A0 ES533084A0 (es) 1985-10-16
ES8601213A1 true ES8601213A1 (es) 1985-10-16

Family

ID=8191406

Family Applications (1)

Application Number Title Priority Date Filing Date
ES533084A Expired ES8601213A1 (es) 1983-06-03 1984-06-01 Derivados de cefalosporina

Country Status (19)

Country Link
US (1) US4678781A (es)
EP (1) EP0127992B1 (es)
JP (1) JPH0633283B2 (es)
KR (1) KR910008352B1 (es)
AU (1) AU585831B2 (es)
CA (1) CA1272188A (es)
DE (1) DE3486033T2 (es)
DK (1) DK271584A (es)
ES (1) ES8601213A1 (es)
FI (1) FI80043C (es)
GB (1) GB8413152D0 (es)
GR (1) GR81617B (es)
HU (1) HU196811B (es)
IL (1) IL71969A (es)
NO (1) NO164301C (es)
NZ (1) NZ208360A (es)
PH (1) PH22334A (es)
PT (1) PT78685B (es)
ZA (1) ZA844052B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4855420A (en) * 1983-06-03 1989-08-08 Ici Pharma Cephalosporin derivatives
FI851934L (fi) * 1984-05-30 1985-12-01 Ici Plc Kefalosporinderivat.
EP0182633A3 (en) * 1984-11-20 1987-09-02 Ici Pharma Cephalosporin derivatives
EP0187456A1 (en) * 1984-11-29 1986-07-16 Ici Pharma Cephalosporin derivatives
US4840945A (en) * 1985-04-01 1989-06-20 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
GB8626245D0 (en) * 1985-11-27 1986-12-03 Ici Pharma Cephalosporin compounds
US4684722A (en) * 1986-01-06 1987-08-04 E. R. Squibb & Sons, Inc. Monosulfactams
GB8611823D0 (en) * 1986-05-15 1986-06-25 Ici Plc Process
ZA877987B (en) * 1986-11-12 1988-08-31 Ici Pharma Antibiotic compounds
DE3750673T2 (de) * 1986-11-21 1995-03-16 Ici Pharma Cephalosporine, Verfahren zu ihrer Herstellung und pharmazeutische Präparate.
US5262410A (en) * 1986-12-23 1993-11-16 Ici Pharma 3-heterocyclic thiomethyl cephalosporins
EP0272827A3 (en) * 1986-12-23 1990-02-07 ZENECA Pharma S.A. 3-heterocyclicthiomethyl cephalosphorins
EP0304155B1 (en) * 1987-07-23 1995-11-15 ZENECA Pharma S.A. Cephalosporin compounds, process for their preparation and their pharmaceutical compositions
DE3854804T2 (de) * 1987-07-23 1996-06-13 Zeneca Pharma Sa Cephalosporinverbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
US5232918A (en) * 1987-07-23 1993-08-03 Imperial Chemical Industries Plc Cephalosporin derivatives
GB8816519D0 (en) * 1987-07-23 1988-08-17 Ici Plc Antibiotic compounds
AT395854B (de) * 1991-05-24 1993-03-25 Biochemie Gmbh Neues verfahren zur herstellung von 7-amino-3azidomethyl-3-cephem-4-carbonsaeure und deren derivate
US5817520A (en) * 1991-12-20 1998-10-06 Oxis International S.A. Spectrophotometric methods for assaying total mercaptans, reduced glutathione (GSH) and mercaptans other than GSH in an aqueous medium reagents and kits for implementing same
DE19647413A1 (de) * 1996-11-15 1998-05-20 Hoechst Schering Agrevo Gmbh Substituierte Stickstoff-Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel
DE10225537A1 (de) * 2002-06-10 2003-12-18 Bayer Ag N-alkylierte Thiazoliumsalze und Verfahren zu deren Herstellung
WO2012121973A1 (en) 2011-03-04 2012-09-13 Life Technologies Corporation Compounds and methods for conjugation of biomolecules
JP7158717B2 (ja) * 2017-11-22 2022-10-24 国立大学法人九州工業大学 求電子的アジド化剤又はジアゾ化剤

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1584713A (es) * 1967-01-18 1970-01-02
GB1478055A (en) * 1973-07-27 1977-06-29 Erba Carlo Spa Cephalosporin compounds
DE2760484C2 (es) * 1976-04-14 1992-12-03 Takeda Chemical Industries, Ltd., Osaka, Jp
FR2432521A1 (fr) 1978-03-31 1980-02-29 Roussel Uclaf Nouvelles oximes o-substituees derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
DE2818263A1 (de) * 1978-04-26 1979-11-08 Bayer Ag Beta-lactamantibiotika
GB2058791B (en) * 1978-05-26 1982-11-24 Glaxo Group Ltd Cephalosporin antibiotics
GB1604724A (en) * 1978-05-26 1981-12-16 Glaxo Operations Ltd 7-(2-aminothiazol-4-yl)-2-oxymino-acedamido)-cephem derivatives
GB2036738B (en) * 1978-11-17 1983-01-19 Glaxo Group Ltd Cephalosporin antibiotics
GB2046261B (en) * 1979-03-22 1983-07-20 Glaxo Group Ltd Cephalosporin antibiotics
DE3071707D1 (en) * 1979-04-27 1986-09-25 Merck & Co Inc 7-n-heterocyclyl cephalosporins, a process for preparing and a pharmaceutical composition comprising the same
JPS57167993A (en) * 1981-04-09 1982-10-16 Yamanouchi Pharmaceut Co Ltd Novel 3-((4-carboxy-3-hydroxyisothiazole-5-yl) thiomethyl)-delta3-cephem derivative
GB2103205A (en) * 1981-06-15 1983-02-16 Fujisawa Pharmaceutical Co New cephem compounds
ZA824094B (en) * 1981-06-19 1983-07-27 Ici Plc A process for the manufacture of cephalosporin derivative
JPS5876088A (ja) * 1981-10-27 1983-05-09 Nippon Paint Co Ltd 固定化植物組織
US4401668A (en) * 1981-10-02 1983-08-30 Eli Lilly And Company Pyrazinium substituted cephalosporins
FR2516515A1 (fr) * 1981-11-16 1983-05-20 Sanofi Sa Nouveaux derives de pyridinium thiomethyl cephalosporines, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2530248A1 (fr) * 1982-07-13 1984-01-20 Sanofi Sa Nouveaux derives des cephalosporines, leur procede de preparation et medicaments antibiotiques contenant lesdits derives
HU188874B (en) * 1983-04-19 1986-05-28 Biogal Gyogyszergyar,Hu Process for producing new 7-acylamido-3-acylaminomethyl-ceph-3-eme-4-carboxylic acid derivatives and pharmaceutically acceptable salts thereof
US4560749A (en) * 1983-11-18 1985-12-24 Eli Lilly And Company Cephem-3-imidates and 3-amidines
FI851934L (fi) * 1984-05-30 1985-12-01 Ici Plc Kefalosporinderivat.

Also Published As

Publication number Publication date
FI80043C (fi) 1990-04-10
AU585831B2 (en) 1989-06-29
EP0127992A3 (en) 1985-11-21
DE3486033D1 (de) 1993-02-25
HUT34499A (en) 1985-03-28
DK271584D0 (da) 1984-06-01
DE3486033T2 (de) 1993-05-06
ZA844052B (en) 1985-01-30
EP0127992A2 (en) 1984-12-12
AU2894384A (en) 1984-12-06
CA1272188A (en) 1990-07-31
KR910008352B1 (ko) 1991-10-12
IL71969A (en) 1988-03-31
JPS6045584A (ja) 1985-03-12
HU196811B (en) 1989-01-30
NO164301C (no) 1990-09-19
PT78685A (es) 1984-06-01
FI80043B (fi) 1989-12-29
ES533084A0 (es) 1985-10-16
GR81617B (es) 1984-12-11
US4678781A (en) 1987-07-07
JPH0633283B2 (ja) 1994-05-02
IL71969A0 (en) 1984-09-30
FI842211A (fi) 1984-12-04
NZ208360A (en) 1988-01-08
PT78685B (en) 1986-10-21
DK271584A (da) 1984-12-04
GB8413152D0 (en) 1984-06-27
EP0127992B1 (en) 1993-01-13
PH22334A (en) 1988-08-12
FI842211A0 (fi) 1984-06-01
KR850000458A (ko) 1985-02-27
NO842214L (no) 1984-12-04
NO164301B (no) 1990-06-11

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000201