ES8604132A1 - Procedimiento para la obtencion de derivados de 1-(4'-alquiltiofenil)-2-amino-1,3-propandiol - Google Patents
Procedimiento para la obtencion de derivados de 1-(4'-alquiltiofenil)-2-amino-1,3-propandiolInfo
- Publication number
- ES8604132A1 ES8604132A1 ES534858A ES534858A ES8604132A1 ES 8604132 A1 ES8604132 A1 ES 8604132A1 ES 534858 A ES534858 A ES 534858A ES 534858 A ES534858 A ES 534858A ES 8604132 A1 ES8604132 A1 ES 8604132A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- propanediol
- opt
- alkylthiophenyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical compound CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE 1-(40ALQUILTIOFENIL)-2-AMINO-1,3-PROPANDIOL Y DE SUS SALES DE ADICION DE ACIDOS FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE A REPRESENTA ALQUILO CON 1 A 6 ATOMOS DE CARBONO; R ES ALQUILO CON 1 A 4 ATOMOS DE CARBONO; R1 Y R2 PUEDEN SER VARIOS TIPOS DE RADICALES; Y N VALE 0 O 1. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (I), EN LA QUE N ES 0, R1 Y R2 SON HIDROGENO Y R TIENE EL SIGNIFICADO INDICADO ANTERIORMENTE, CON UN DERIVADO DE CARBONILO ADECUADO, EN UN DISOLVENTE INERTE, EN PRESENCIA DE UNA BASE; SEGUIDA DE LA REDUCCION DEL COMPUESTO FORMADO POR TRATAMIENTO CON UN HIDRURO, COMO HIDRURO DE LITIO Y ALUMINIO O BOROHIDRURO SODICO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANTIARRITMICOS Y VASODILATADORES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT22451/83A IT1164389B (it) | 1983-08-05 | 1983-08-05 | Derivati n-sostituiti dell'1-(4'-alchiltiofenil)-2-ammino-1,3-propandiolo |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES534858A0 ES534858A0 (es) | 1986-01-16 |
| ES8604132A1 true ES8604132A1 (es) | 1986-01-16 |
Family
ID=11196476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES534858A Expired ES8604132A1 (es) | 1983-08-05 | 1984-08-03 | Procedimiento para la obtencion de derivados de 1-(4'-alquiltiofenil)-2-amino-1,3-propandiol |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4638003A (es) |
| EP (1) | EP0136736B1 (es) |
| JP (1) | JPS60120853A (es) |
| AT (1) | ATE30417T1 (es) |
| AU (1) | AU581856B2 (es) |
| CA (1) | CA1243319A (es) |
| DE (1) | DE3466981D1 (es) |
| ES (1) | ES8604132A1 (es) |
| IT (1) | IT1164389B (es) |
| ZA (1) | ZA845930B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1164387B (it) * | 1983-08-05 | 1987-04-08 | Zambon Spa | Derivati n-sostituiti dell'1-(4'-alchilsulfonilfenil)-2-ammino-1,3-propandiolo |
| IT1205124B (it) * | 1987-06-05 | 1989-03-15 | Simens Soteta Italiana Medicin | Composto attivo nella terapia carciovascolare |
| DE3906540A1 (de) * | 1989-03-02 | 1990-09-13 | Behringwerke Ag | Expressionsvektoren zur synthese von proteinen in der spalthefe schizosaccharomyces pombe |
| IT1237798B (it) * | 1989-10-20 | 1993-06-17 | Zambon Spa | Processo per l'inversione stereochimica di (2s,3s)-2-ammino-3-fenil-1 ,3-propandioli nei corrispondenti enantiomeri (2r,3r). |
| IT1240676B (it) * | 1990-04-24 | 1993-12-17 | Agrimont Spa | Composizioni ad attivita' erbicida |
| US5461148A (en) * | 1993-09-27 | 1995-10-24 | Schering Corporation | Process for preparing benzazepine intermediates for the synthesis of D1 antagonists |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2759970A (en) * | 1956-05-09 | 1956-08-21 | Sterling Drug Inc | Acylamidoaceto-mercaptophenones |
| US3056799A (en) * | 1959-07-20 | 1962-10-02 | Sterling Drug Inc | Processes and intermediate products |
| GB1321701A (en) * | 1969-10-01 | 1973-06-27 | Continental Pharma | Amino-alcohols their salts and process for prepairing the same |
| JPS5245700B2 (es) * | 1972-12-28 | 1977-11-17 | ||
| JPS5245700A (en) * | 1975-10-09 | 1977-04-11 | Showa Denko Kk | Excellent method for preparing ring orening polymers |
| JPS5852640B2 (ja) * | 1977-06-06 | 1983-11-24 | 味の素株式会社 | ペルオキシダ−ゼ活性の測定方法 |
| US4226808A (en) * | 1979-08-17 | 1980-10-07 | Schering Corporation | 1-Aryl-2-dihalogenodeuterioalkanoylamido-1,3-propanediol antibacterial agents |
| EP0066919B1 (en) * | 1981-05-27 | 1985-03-20 | MAGGIONI FARMACEUTICI S.p.A. | 4-alkyl-thiophenyl-ethanolamines, having an activity on the cerebral circulation, the blood platelet-aggregation and the lipemia |
| IT1164387B (it) * | 1983-08-05 | 1987-04-08 | Zambon Spa | Derivati n-sostituiti dell'1-(4'-alchilsulfonilfenil)-2-ammino-1,3-propandiolo |
-
1983
- 1983-08-05 IT IT22451/83A patent/IT1164389B/it active
-
1984
- 1984-07-27 EP EP84201115A patent/EP0136736B1/en not_active Expired
- 1984-07-27 AT AT84201115T patent/ATE30417T1/de not_active IP Right Cessation
- 1984-07-27 DE DE8484201115T patent/DE3466981D1/de not_active Expired
- 1984-07-31 CA CA000460079A patent/CA1243319A/en not_active Expired
- 1984-07-31 ZA ZA845930A patent/ZA845930B/xx unknown
- 1984-08-01 US US06/636,714 patent/US4638003A/en not_active Expired - Lifetime
- 1984-08-02 AU AU31454/84A patent/AU581856B2/en not_active Ceased
- 1984-08-03 ES ES534858A patent/ES8604132A1/es not_active Expired
- 1984-08-06 JP JP59164724A patent/JPS60120853A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE3466981D1 (de) | 1987-12-03 |
| IT8322451A0 (it) | 1983-08-05 |
| ES534858A0 (es) | 1986-01-16 |
| EP0136736B1 (en) | 1987-10-28 |
| US4638003A (en) | 1987-01-20 |
| AU581856B2 (en) | 1989-03-09 |
| CA1243319A (en) | 1988-10-18 |
| ZA845930B (en) | 1985-06-26 |
| EP0136736A1 (en) | 1985-04-10 |
| IT1164389B (it) | 1987-04-08 |
| ATE30417T1 (de) | 1987-11-15 |
| JPS60120853A (ja) | 1985-06-28 |
| AU3145484A (en) | 1985-02-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970519 |