ES8601973A1 - Compuestos azolicos antifungales. - Google Patents

Compuestos azolicos antifungales.

Info

Publication number
ES8601973A1
ES8601973A1 ES530414A ES530414A ES8601973A1 ES 8601973 A1 ES8601973 A1 ES 8601973A1 ES 530414 A ES530414 A ES 530414A ES 530414 A ES530414 A ES 530414A ES 8601973 A1 ES8601973 A1 ES 8601973A1
Authority
ES
Spain
Prior art keywords
alkyl
phenyl
azolyl
substd
opt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES530414A
Other languages
English (en)
Other versions
ES530414A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of ES530414A0 publication Critical patent/ES530414A0/es
Publication of ES8601973A1 publication Critical patent/ES8601973A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/08—Compounds containing oxirane rings with hydrocarbon radicals, substituted by halogen atoms, nitro radicals or nitroso radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Pyridine Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR COMPUESTOS AXOLICOS ANTIFUNGALES.CONSISTE EN HACER REACCIONAR UN EPOXIDO DE FORMULA (II) CON UN AZOL DE FORMULA R9 H, EN PRESENCIA DE UNA BASE FUERTE, COMO KOH O NA OH, PARA OBTENER UN COMPUESTO AZOLICO DE FORMULA (I). SIENDO: R1, RADICAL FENILO OPCIONALMENTE SUBSTITUIDO; R2 Y R3, IGUALES O DIFERENTES, H, O UN RADICAL ALQUILO DE C 1 A 6; R4 Y R5, H, UN RADICAL AMILO O ALQUILO DE C 1 A 6, Y OTROS; AL MENOS UNO DE R2, R3, R4 Y R5 DISTINTO DE H; R8, UN RADICAL DE FORMULA (III) O (IV); R9; UN RADICAL DE FORMULA (V) O (VI) Y X E Y, IGUALES O DIFERENTES, UN RADICAL METILDINO O NITRILO. SE UTILIZA COMO ANTIFUNGAL EN EL TRATAMIENTO DE LA CANDIOSIS E INFECCIONES DERMATOFITICAS EN EL HOMBRE.
ES530414A 1983-03-08 1984-03-08 Compuestos azolicos antifungales. Expired ES8601973A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838306351A GB8306351D0 (en) 1983-03-08 1983-03-08 Azole fungicides

Publications (2)

Publication Number Publication Date
ES530414A0 ES530414A0 (es) 1985-11-16
ES8601973A1 true ES8601973A1 (es) 1985-11-16

Family

ID=10539169

Family Applications (2)

Application Number Title Priority Date Filing Date
ES530414A Expired ES8601973A1 (es) 1983-03-08 1984-03-08 Compuestos azolicos antifungales.
ES537182A Granted ES537182A0 (es) 1983-03-08 1984-10-29 Procedimiento de obtencion de compuestos de 1-aril-2-(3-(4-trifluormetilestiril)-1,2,4-triazol-1-il)-1-c 1,2,4,-triazol-1-il-metil) etanol de efecto antifugal.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES537182A Granted ES537182A0 (es) 1983-03-08 1984-10-29 Procedimiento de obtencion de compuestos de 1-aril-2-(3-(4-trifluormetilestiril)-1,2,4-triazol-1-il)-1-c 1,2,4,-triazol-1-il-metil) etanol de efecto antifugal.

Country Status (19)

Country Link
US (1) US4625036A (es)
EP (1) EP0122693B1 (es)
JP (1) JPS59175475A (es)
AT (1) ATE28194T1 (es)
AU (1) AU563978B2 (es)
DE (1) DE3464605D1 (es)
DK (1) DK164499C (es)
ES (2) ES8601973A1 (es)
FI (1) FI78692C (es)
GB (1) GB8306351D0 (es)
GR (1) GR79780B (es)
HU (1) HU191258B (es)
IE (1) IE56905B1 (es)
IL (1) IL71128A (es)
NO (1) NO162719C (es)
NZ (1) NZ207412A (es)
PT (1) PT78206B (es)
YU (2) YU43666B (es)
ZA (1) ZA841307B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2062941A1 (es) * 1993-03-15 1994-12-16 Uriach & Cia Sa J Nuevos derivados de azol activos por via oral.

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4992454A (en) * 1983-03-16 1991-02-12 Pfizer Inc. Antifungal 1,3-bis (1H-1,2,4-triazol-1-yl)-2-aryl butan-2-ols and derivatives thereof
DK159205C (da) * 1983-03-16 1991-03-04 Pfizer Bis(triazol)alkanol-forbindelser, anvendelse af disse, farmaceutiske praeparater og landbrugsfungicider indeholdende disse og fremgangsmaade til behandling af planter eller froe, som har en svampeinfektion
GB8313235D0 (en) * 1983-05-13 1983-06-22 Pfizer Ltd Antifungal agents
DE3325313A1 (de) * 1983-07-13 1985-01-31 Bayer Ag, 5090 Leverkusen Fungizide mittel, deren herstellung und verwendung
IE58738B1 (en) * 1984-09-05 1993-11-03 Ici Plc Antifungal azole compounds
DE3440117A1 (de) * 1984-11-02 1986-05-15 Bayer Ag, 5090 Leverkusen Substituierte azolylcyclopropyl-azolylmethyl-carbinol-derivate
GB8614712D0 (en) * 1986-06-17 1986-07-23 Ici Plc Heterocyclic compounds
US5272167A (en) * 1986-12-10 1993-12-21 Schering Corporation Pharmaceutically active compounds
EP0285893B1 (en) * 1987-03-27 1992-03-18 Kumiai Chemical Industry Co., Ltd. Phenyltriazole derivative and insecticide
DE3730871A1 (de) * 1987-09-15 1989-03-23 Bayer Ag Bisazolyl-hydroxyalkyl-derivate
DE3737984A1 (de) * 1987-11-09 1989-08-03 Bayer Ag 3-cyano-4-phenyl-pyrrole
DE3806089A1 (de) * 1988-02-26 1989-09-07 Basf Ag Azolylmethyloxirane und diese enthaltende fungizide
FI97382C (fi) * 1988-03-04 1996-12-10 Sankyo Co Menetelmä lääkeaineina käyttökelpoisten 1,2,4-triatsolijohdannaisten valmistamiseksi
US5212194A (en) * 1988-07-29 1993-05-18 Basf Aktiengesellschaft Phenoxyalkyl-substituted heteroaromatics and a method for controlling pests
GB8819308D0 (en) * 1988-08-13 1988-09-14 Pfizer Ltd Triazole antifungal agents
DE3837463A1 (de) * 1988-11-04 1990-05-10 Bayer Ag Substituierte bisazole, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
GB9002375D0 (en) * 1990-02-02 1990-04-04 Pfizer Ltd Triazole antifungal agents
ES2024332A6 (es) * 1990-10-08 1992-02-16 Uriach & Cia Sa J Procedimiento para la obtencion de nuevas sulfonamidas.
TW212798B (es) * 1991-11-25 1993-09-11 Takeda Pharm Industry Co Ltd
TW218017B (es) * 1992-04-28 1993-12-21 Takeda Pharm Industry Co Ltd
JPH069624A (ja) * 1992-06-24 1994-01-18 Ikeda Mohandou:Kk トリアゾール誘導体
DE4302703C2 (de) * 1993-02-01 1997-02-13 Schulman A Gmbh Flammfeste, halogenfreie Polyamidmasse und Verfahren zu ihrer Herstellung
JPH06340636A (ja) * 1993-05-31 1994-12-13 Ss Pharmaceut Co Ltd トリアゾール誘導体又はその塩、及びこれを含有する抗真菌剤
TW297813B (es) * 1993-09-24 1997-02-11 Takeda Pharm Industry Co Ltd
NZ270418A (en) * 1994-02-07 1997-09-22 Eisai Co Ltd Polycyclic triazole & imidazole derivatives, antifungal compositions
TW318841B (es) 1995-02-17 1997-11-01 Takeda Pharm Industry Co Ltd
WO2010068287A2 (en) * 2008-12-11 2010-06-17 Angion Biomedica Corp. Small molecule modulators of hepatocyte growth factor (scatter factor) activity
EP2630133A1 (de) 2010-10-22 2013-08-28 Bayer Intellectual Property GmbH Neue heterocylische verbindungen als schädlingsbekämpfungsmittel

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4038404A (en) * 1972-09-26 1977-07-26 Bayer Aktiengesellschaft 1,2,4-triazole antimycotic compositions and use thereof
DE2324424A1 (de) * 1973-05-15 1974-12-05 Bayer Ag Antimikrobielle mittel
DE2623129C3 (de) * 1976-05-22 1980-04-10 Nordmark-Werke Gmbh, 2000 Hamburg U-Diphenyl-3-(imidazol-l-yl) -propan-2-ole, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
GB2078719B (en) * 1980-06-02 1984-04-26 Ici Ltd Heterocyclic compounds
GB2104065B (en) * 1981-06-04 1985-11-06 Ciba Geigy Ag Heterocyclyl-substituted mandelic acid compounds and mandelonitriles and their use for combating microorganisms
DE3262386D1 (en) * 1981-06-06 1985-03-28 Pfizer Ltd Antifungal agents, processes for their preparation, and pharmaceutical compositions containing them
US4510148A (en) * 1982-06-12 1985-04-09 Pfizer Inc. 2-Heterocyclic-1,3-bis(1H-1,2,4-triazol-1-yl)-propan-2-ols as antifungal agents
FI834141A (fi) * 1982-11-16 1984-05-17 Ciba Geigy Ag Foerfarande foer framstaellning av nya arylfenyleterderivat.
DE3307218A1 (de) * 1983-03-02 1984-09-06 Bayer Ag, 5090 Leverkusen Substituierte diazolylalkyl-carbinole, verfahren zu ihrer herstellung und ihre verwendung als antimykotische mittel
DK159205C (da) * 1983-03-16 1991-03-04 Pfizer Bis(triazol)alkanol-forbindelser, anvendelse af disse, farmaceutiske praeparater og landbrugsfungicider indeholdende disse og fremgangsmaade til behandling af planter eller froe, som har en svampeinfektion
DE3313073A1 (de) * 1983-04-12 1984-10-18 Bayer Ag, 5090 Leverkusen 1-azolyl-3-pyrazolyl-2-propanol-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide
GB8313235D0 (en) * 1983-05-13 1983-06-22 Pfizer Ltd Antifungal agents
DE3319845A1 (de) * 1983-06-01 1984-12-06 Basf Ag, 6700 Ludwigshafen Arylalkylimidazolium- und -triazoliumsalze, verfahren zu ihrer herstellung und ihre verwendung als mikrozide
US4483863A (en) * 1984-01-20 1984-11-20 Pfizer Inc. Triazole antifungal agents

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2062941A1 (es) * 1993-03-15 1994-12-16 Uriach & Cia Sa J Nuevos derivados de azol activos por via oral.

Also Published As

Publication number Publication date
DE3464605D1 (de) 1987-08-13
FI840892A0 (fi) 1984-03-06
GB8306351D0 (en) 1983-04-13
DK164499B (da) 1992-07-06
JPS59175475A (ja) 1984-10-04
FI840892A (fi) 1984-09-09
ES8603470A1 (es) 1985-12-16
YU41284A (en) 1986-12-31
AU563978B2 (en) 1987-07-30
ES537182A0 (es) 1985-12-16
NZ207412A (en) 1987-01-23
JPH0542434B2 (es) 1993-06-28
DK100684D0 (da) 1984-02-24
YU43599B (en) 1989-08-31
NO840861L (no) 1984-09-10
HU191258B (en) 1987-01-28
YU57086A (en) 1986-12-31
ES530414A0 (es) 1985-11-16
US4625036A (en) 1986-11-25
EP0122693B1 (en) 1987-07-08
IE56905B1 (en) 1992-01-29
IL71128A0 (en) 1984-06-29
NO162719B (no) 1989-10-30
IE840393L (en) 1984-09-08
ATE28194T1 (de) 1987-07-15
YU43666B (en) 1989-10-31
EP0122693A1 (en) 1984-10-24
PT78206B (en) 1986-08-05
NO162719C (no) 1990-02-07
HUT34169A (en) 1985-02-28
AU2507684A (en) 1984-09-13
IL71128A (en) 1988-12-30
DK164499C (da) 1992-11-16
GR79780B (es) 1984-10-31
FI78692B (fi) 1989-05-31
DK100684A (da) 1984-09-09
FI78692C (fi) 1989-09-11
PT78206A (en) 1984-04-01
ZA841307B (en) 1984-11-28

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