ES8601174A1 - Procedimiento para preparar la n-(3-trifluorometilfenil)-n'-propargil-piperazina - Google Patents

Procedimiento para preparar la n-(3-trifluorometilfenil)-n'-propargil-piperazina

Info

Publication number
ES8601174A1
ES8601174A1 ES536412A ES536412A ES8601174A1 ES 8601174 A1 ES8601174 A1 ES 8601174A1 ES 536412 A ES536412 A ES 536412A ES 536412 A ES536412 A ES 536412A ES 8601174 A1 ES8601174 A1 ES 8601174A1
Authority
ES
Spain
Prior art keywords
preparation
trifluoromethyl phenyl
propargyl piperazine
piperazine
propargyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES536412A
Other languages
English (en)
Other versions
ES536412A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim GmbH
Original Assignee
Boehringer Ingelheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim GmbH filed Critical Boehringer Ingelheim GmbH
Publication of ES8601174A1 publication Critical patent/ES8601174A1/es
Publication of ES536412A0 publication Critical patent/ES536412A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE LA N-(3-TRIFLUOROMETILFENIL)-N-PROPARGIL-PIPERAZINA Y DE SUS SALES DE ADICION DE ACIDOS FISIOLOGICAMENTE COMPATIBLES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (I) CON UN COMPUESTO DE FORMULA X-CH2-CH2-X EN LA QUE X ES UN GRUPO FACILMENTE SEPARABLE EN FORMA ANIONICA. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE COMO TOLUENO EVENTUALMENTE EN PRESENCIA DE UN ACEPTOR ACIDO COMO TRIETILAMINA A UNA TEMPERATURA ENTRE LA AMBIENTE Y LA DE EBULLICION DE LA MEZCLA DE REACCION. ESTE COMPUESTO TIENE APLICACIONES FARMACOLOGICAS POR SUS PROPIEDADES ANALGESICAS.
ES536412A 1983-02-28 1984-10-01 Procedimiento para preparar la n-(3-trifluorometilfenil)-n'-propargil-piperazina Granted ES536412A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833306964 DE3306964A1 (de) 1983-02-28 1983-02-28 Neues n-arylpiperazin und verfahren zu seiner herstellung

Publications (2)

Publication Number Publication Date
ES8601174A1 true ES8601174A1 (es) 1985-10-16
ES536412A0 ES536412A0 (es) 1985-10-16

Family

ID=6192038

Family Applications (7)

Application Number Title Priority Date Filing Date
ES530073A Granted ES530073A0 (es) 1983-02-28 1984-02-27 Procedimiento para preparar la n-(3-trifluorometil fenil)-n-propargil-piperazina.
ES536416A Expired ES8603447A1 (es) 1983-02-28 1984-10-01 Procedimiento para preparar la n-(3-trifluorometilfenil)-n'-propargil-piperazina
ES536414A Expired ES8603445A1 (es) 1983-02-28 1984-10-01 Procedimiento para preparar la n-(3-trifluorometilfenil)-n'-propargil-piperazina
ES536413A Granted ES536413A0 (es) 1983-02-28 1984-10-01 Procedimiento para preparar la n-(3-trifluorometilfenil)-n'-propargil-piperazina
ES536411A Expired ES8601173A1 (es) 1983-02-28 1984-10-01 Procedimiento para preparar la n-(3-trifluorometilfenil)-n'-propargil-piperazina
ES536412A Granted ES536412A0 (es) 1983-02-28 1984-10-01 Procedimiento para preparar la n-(3-trifluorometilfenil)-n'-propargil-piperazina
ES536415A Expired ES8603446A1 (es) 1983-02-28 1984-10-01 Procedimiento para preparar la n-(3-trifluorometilfenil)-n'-propargil-piperazina

Family Applications Before (5)

Application Number Title Priority Date Filing Date
ES530073A Granted ES530073A0 (es) 1983-02-28 1984-02-27 Procedimiento para preparar la n-(3-trifluorometil fenil)-n-propargil-piperazina.
ES536416A Expired ES8603447A1 (es) 1983-02-28 1984-10-01 Procedimiento para preparar la n-(3-trifluorometilfenil)-n'-propargil-piperazina
ES536414A Expired ES8603445A1 (es) 1983-02-28 1984-10-01 Procedimiento para preparar la n-(3-trifluorometilfenil)-n'-propargil-piperazina
ES536413A Granted ES536413A0 (es) 1983-02-28 1984-10-01 Procedimiento para preparar la n-(3-trifluorometilfenil)-n'-propargil-piperazina
ES536411A Expired ES8601173A1 (es) 1983-02-28 1984-10-01 Procedimiento para preparar la n-(3-trifluorometilfenil)-n'-propargil-piperazina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES536415A Expired ES8603446A1 (es) 1983-02-28 1984-10-01 Procedimiento para preparar la n-(3-trifluorometilfenil)-n'-propargil-piperazina

Country Status (25)

Country Link
US (1) US4699910A (es)
EP (1) EP0117531B1 (es)
JP (1) JPS59210074A (es)
KR (1) KR910005413B1 (es)
AT (1) ATE22289T1 (es)
AU (1) AU562643B2 (es)
CA (1) CA1240327A (es)
CS (1) CS240997B2 (es)
DD (1) DD218096A5 (es)
DE (2) DE3306964A1 (es)
DK (1) DK158729C (es)
ES (7) ES530073A0 (es)
FI (1) FI77658C (es)
GB (1) GB2135997B (es)
GR (1) GR79822B (es)
HU (1) HU190546B (es)
IE (1) IE56938B1 (es)
IL (1) IL71068A (es)
NO (1) NO158803C (es)
NZ (1) NZ207289A (es)
PH (1) PH21982A (es)
PL (1) PL141275B1 (es)
PT (1) PT78155B (es)
SU (1) SU1223844A3 (es)
ZA (1) ZA841418B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03176457A (ja) * 1989-12-04 1991-07-31 Nippon Paint Co Ltd 新規プロパルギル化合物、その製法ならびに該化合物を含む被覆材
JPH05255089A (ja) * 1991-12-18 1993-10-05 Sanwa Kagaku Kenkyusho Co Ltd 抗ウイルス剤
US5661163A (en) 1995-06-07 1997-08-26 Merck & Co., Inc. Alpha-1a adrenergic receptor antagonists
USRE46117E1 (en) 1999-12-22 2016-08-23 Teva Pharmaceuticals International Gmbh Modulators of dopamine neurotransmission
EA027748B1 (ru) 2012-04-04 2017-08-31 Тева Фармасьютикалз Интернэшнл Гмбх Применение придопидина в комбинации с тетрабеназином для лечения двигательных нарушений и ожирения

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2993899A (en) * 1958-03-31 1961-07-25 Miles Lab Acetylenically unsaturated piperazine derivatives
NL6607959A (es) * 1965-06-10 1966-12-12
DE1545561A1 (de) * 1965-08-23 1969-12-11 Acraf Verfahren zur Herstellung von pharmakologisch aktiven N,N-disubstituierten 1-Aryl-3-aminopropinen
FR2187311B1 (es) * 1972-06-02 1975-06-20 Bouchara Emile
GB1560271A (en) * 1977-01-14 1980-02-06 Joullie International Sa Therapeutically useful m-trifluoromethylphenylpiperazine derivatives
US4180574A (en) * 1978-12-26 1979-12-25 Abbott Laboratories Certain ovicidal piperazines
US4518712A (en) * 1980-06-30 1985-05-21 Taiho Pharmaceutical Company Limited Piperazine derivative and analgesic composition containing the same

Also Published As

Publication number Publication date
FI77658B (fi) 1988-12-30
ES536414A0 (es) 1985-12-16
ES536411A0 (es) 1985-10-16
ES536415A0 (es) 1985-12-16
FI77658C (fi) 1989-04-10
IE56938B1 (en) 1992-02-12
PT78155B (de) 1986-07-17
ES8601173A1 (es) 1985-10-16
DK158729B (da) 1990-07-09
KR910005413B1 (ko) 1991-07-29
FI840743A (fi) 1984-08-29
ES8603445A1 (es) 1985-12-16
ES8603444A1 (es) 1985-12-16
HU190546B (en) 1986-09-29
CS127484A2 (en) 1985-06-13
JPS59210074A (ja) 1984-11-28
NO158803B (no) 1988-07-25
IL71068A (en) 1988-05-31
DD218096A5 (de) 1985-01-30
PH21982A (en) 1988-05-02
NO158803C (no) 1988-11-09
DK102084A (da) 1984-08-29
PL141275B1 (en) 1987-07-31
IE840460L (en) 1984-08-28
IL71068A0 (en) 1984-05-31
ZA841418B (en) 1985-11-27
NO840732L (no) 1984-08-29
ES8603446A1 (es) 1985-12-16
EP0117531B1 (de) 1986-09-17
EP0117531A1 (de) 1984-09-05
SU1223844A3 (ru) 1986-04-07
CA1240327A (en) 1988-08-09
DK102084D0 (da) 1984-02-24
KR840007875A (ko) 1984-12-11
US4699910A (en) 1987-10-13
ES536412A0 (es) 1985-10-16
GB2135997A (en) 1984-09-12
AU562643B2 (en) 1987-06-18
GR79822B (es) 1984-10-31
GB8405113D0 (en) 1984-04-04
ES536416A0 (es) 1985-12-16
NZ207289A (en) 1986-07-11
ES8504754A1 (es) 1985-04-16
PL246418A1 (en) 1985-07-02
DK158729C (da) 1990-11-19
JPH056545B2 (es) 1993-01-26
ES8603447A1 (es) 1985-12-16
DE3306964A1 (de) 1984-09-06
AU2508584A (en) 1984-09-06
PT78155A (de) 1984-03-01
FI840743A0 (fi) 1984-02-23
ES536413A0 (es) 1985-12-16
DE3460733D1 (en) 1986-10-23
ATE22289T1 (de) 1986-10-15
CS240997B2 (en) 1986-03-13
ES530073A0 (es) 1985-04-16
GB2135997B (en) 1986-02-19

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303