ES8507419A1 - Procedimiento para la preparacion de diesteres del acido fosforico - Google Patents

Procedimiento para la preparacion de diesteres del acido fosforico

Info

Publication number
ES8507419A1
ES8507419A1 ES532872A ES532872A ES8507419A1 ES 8507419 A1 ES8507419 A1 ES 8507419A1 ES 532872 A ES532872 A ES 532872A ES 532872 A ES532872 A ES 532872A ES 8507419 A1 ES8507419 A1 ES 8507419A1
Authority
ES
Spain
Prior art keywords
salts
diesters
producing
compositions containing
acid diesters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES532872A
Other languages
English (en)
Other versions
ES532872A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Senju Pharmaceutical Co Ltd
Original Assignee
Senju Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senju Pharmaceutical Co Ltd filed Critical Senju Pharmaceutical Co Ltd
Publication of ES532872A0 publication Critical patent/ES532872A0/es
Publication of ES8507419A1 publication Critical patent/ES8507419A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DIESTERES DEL ACIDO FOSFORICO.COMPRENDE: A) HACER REACCIONAR ALFA-TOCOFEROL CON UN AGENTE HALOGENOFORILANTE; B) HACER REACCIONAR EL PRODUCTO RESULTANTE DE (A) CON ACIDO ASCORBICO QUE TIENE LOS GRUPOS HIDROXI EN LAS POSICIONES 5- Y 6- PROTEGIDAS CON GRUPOS PROTECTORES; Y C) ELIMINAR LOS GRUPOS PROTECTORES, PARA OBTENER DIESTERES DEL ACIDO FOSFORICO DE FORMULA (I) O SU SAL.SE UTILIZAN COMO AGENTES PROFILACTICOS Y TERAPEUTICOS PARA CATARATAS Y RIESGOS CLIMACTERICOS.
ES532872A 1983-05-30 1984-05-26 Procedimiento para la preparacion de diesteres del acido fosforico Expired ES8507419A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58096428A JPS59219295A (ja) 1983-05-30 1983-05-30 リン酸ジエステルまたはその塩およびそれらの製造法

Publications (2)

Publication Number Publication Date
ES532872A0 ES532872A0 (es) 1985-10-01
ES8507419A1 true ES8507419A1 (es) 1985-10-01

Family

ID=14164718

Family Applications (1)

Application Number Title Priority Date Filing Date
ES532872A Expired ES8507419A1 (es) 1983-05-30 1984-05-26 Procedimiento para la preparacion de diesteres del acido fosforico

Country Status (6)

Country Link
US (1) US4564686A (es)
EP (1) EP0127471B1 (es)
JP (1) JPS59219295A (es)
CA (1) CA1213284A (es)
DE (1) DE3465997D1 (es)
ES (1) ES8507419A1 (es)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59219295A (ja) * 1983-05-30 1984-12-10 Senjiyu Seiyaku Kk リン酸ジエステルまたはその塩およびそれらの製造法
JPS62205091A (ja) * 1986-03-04 1987-09-09 Senjiyu Seiyaku Kk 新規なリン酸ジエステルならびにその塩、その製造法およびそれを含有する製剤
JPH0781138B2 (ja) * 1986-12-02 1995-08-30 株式会社資生堂 抗酸化剤
JP2526059B2 (ja) * 1987-04-28 1996-08-21 千寿製薬株式会社 抗潰瘍剤
JP2546687B2 (ja) * 1987-09-11 1996-10-23 千寿製薬株式会社 リン酸ジエステルまたはその塩からなる抗酸化剤
PH25859A (en) * 1988-01-11 1991-12-02 Takeda Chemical Industries Ltd Composition for treatment of ischemic disorder
US4939128A (en) * 1988-04-25 1990-07-03 Takeda Chemical Industries, Ltd. Ester of ascorbic acid 2-phosphate and pharmaceutical use
JP2736794B2 (ja) * 1988-12-26 1998-04-02 千寿製薬株式会社 歯垢生成防止剤
UA19385A1 (uk) * 1989-04-27 1997-12-25 Сендзю Фармасьютікал Ко. Лтд. Фофоліпідhі похідhі та композиція, яка має аhтиоксидаhтhу та іhгібуючу активhість щодо пероксидів ліпідів
JP2854631B2 (ja) * 1989-11-21 1999-02-03 千寿製薬株式会社 糖尿病合併症および老化によって引き起こされる疾患の予防・治療剤
FR2657526B1 (fr) * 1990-01-31 1994-10-28 Lvmh Rech Utilisation d'un phosphate d'alpha-tocopherol, ou de l'un de ses derives, pour la preparation de compositions cosmetiques, dermatologiques, ou pharmaceutiques; compositions ainsi obtenues.
EP0506961B1 (en) * 1990-10-26 1995-12-20 Shiseido Company Limited External preparation for skin
JPH05286848A (ja) * 1992-04-10 1993-11-02 Senju Pharmaceut Co Ltd 浴用剤
US5776438A (en) * 1992-06-26 1998-07-07 Shiseido Co., Ltd. External preparation
US5350775A (en) * 1992-07-20 1994-09-27 Showa Denko K.K. Benzopyran derivative, method for producing the same and use thereof
TW262386B (es) * 1992-09-30 1995-11-11 Senju Pharma Co
CA2115606A1 (en) * 1993-02-22 1994-08-23 Takahiro Matsumoto Intraocular irrigating and enucleated eyeball preservative composition
TW252918B (es) * 1993-03-31 1995-08-01 Senju Pharma Co
CA2133784A1 (en) * 1993-10-22 1995-04-23 Kazumi Ogato Deodorant composition
JPH07196516A (ja) * 1993-12-29 1995-08-01 Senju Pharmaceut Co Ltd 痔疾患治療剤
JPH07215801A (ja) * 1994-01-28 1995-08-15 Senju Pharmaceut Co Ltd 肺保存剤および肺保存方法
ES2138674T3 (es) * 1994-04-01 2000-01-16 Senju Pharma Co Produccion de cristales de una sal monopotasica de diester-fosfato.
JPH07277988A (ja) * 1994-04-05 1995-10-24 Senju Pharmaceut Co Ltd 局所用掻痒除去、治療剤
JP3362501B2 (ja) * 1994-04-28 2003-01-07 千寿製薬株式会社 角膜障害治療剤
JPH07330501A (ja) * 1994-06-14 1995-12-19 Senju Pharmaceut Co Ltd 肝保存剤および肝保存方法
CA2152693A1 (en) 1994-08-05 1996-02-06 Kazumi Ogata Therapeutic composition for pancreatitis
US5795912A (en) * 1995-04-26 1998-08-18 Senju Pharmaceutical, Co., Ltd. Therapeutic composition for corneal impairment
US6162450A (en) * 1995-05-15 2000-12-19 Avon Products, Inc. Uses of ascorbyl-phosphoryl-cholesterol and compositions for practicing same
US5951990A (en) * 1995-05-15 1999-09-14 Avon Products, Inc. Ascorbyl-phosphoryl-cholesterol
US5922335A (en) * 1995-05-15 1999-07-13 Avon Products, Inc. Uses for ascorbyl-phosphoryl-cholesterol in topical compositions
US5866147A (en) * 1995-05-15 1999-02-02 Avon Products, Inc. Ascorbyl-phosphoryl-cholesterol
US5607968A (en) * 1995-06-07 1997-03-04 Avon Products, Inc. Topical alkyl-2-O-L-ascorbyl-phosphates
CA2179940A1 (en) * 1995-07-18 1997-01-19 Kazumi Ogata Antiallergic composition comprising a phosphoric diester compound
CA2186654A1 (en) * 1995-10-13 1997-04-14 Masayuki Nakamura Phosphoric diester
WO1997014705A1 (fr) * 1995-10-17 1997-04-24 Showa Denko K.K. Phosphates de tocopherol tres purs, procedes de preparation, techniques d'analyse et produits cosmetiques correspondants
JPH09194375A (ja) * 1996-01-17 1997-07-29 Senju Pharmaceut Co Ltd 免疫抑制作用増強剤
CA2209690A1 (en) * 1996-07-31 1998-01-31 Sachiko Matsuura Therapeutic drug for acne vulgaris
KR100278747B1 (ko) * 1998-03-17 2001-02-01 서경배 아스코르빈산-아미노프로판올인산디에스테르를함유한미백화장료조성물
EP1043322B1 (en) 1997-12-24 2002-05-08 Senju Pharmaceutical Co., Ltd. Vitamin e derivatives
EP1053749A4 (en) * 1998-02-03 2003-01-15 Senju Pharma Co PREVENTION AND MEDICINE FOR NEURODEGENERATIVE DISEASES
EP1086698A1 (en) 1998-06-19 2001-03-28 Senju Pharmaceutical Co., Ltd. Agents for relieving side effects of adrenal cortex hormone
KR100365070B1 (ko) * 2000-08-29 2002-12-16 주식회사 태평양 토코페롤 유도체 및 그의 제조방법
JP4179809B2 (ja) * 2001-06-06 2008-11-12 千寿製薬株式会社 Ｌ−アスコルビン酸−２−Ｏ−マレイン酸−α−トコフェロールジエステル・１−プロパノール付加体及びその製造法
CN1275953C (zh) * 2002-12-18 2006-09-20 高丽雅娜化妆品股份有限公司 新型视黄醇衍生物及包含该视黄醇衍生物的化妆品组合物
UA100841C2 (en) * 2006-02-21 2013-02-11 Мэри Кей, Инк. Normal;heading 1;heading 2;heading 3;STABLE VITAMIN C COMPOSITIONS
JP4879344B1 (ja) * 2010-08-18 2012-02-22 東洋ビューティ株式会社 抗酸化性ポリヒドロキシベンゼン誘導体および抗炎症用皮膚外用剤
JP2013091620A (ja) * 2011-10-26 2013-05-16 Fancl Corp 油中水型乳化組成物
JP5869296B2 (ja) * 2011-10-26 2016-02-24 株式会社ファンケル 油中水型乳化組成物
CN107441046B (zh) * 2017-08-31 2020-07-28 宁波盖济尔医疗科技有限公司 一种复合蛋白质脂质体纳米制剂

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3067210A (en) * 1959-12-01 1962-12-04 Bayer Ag Cumarin phosphoric esters and processes for the production thereof
US3064009A (en) * 1961-05-05 1962-11-13 Dow Chemical Co O-coumaryl o-alkyl phosphoramidates and phosphoramidothioates
US3294636A (en) * 1961-12-01 1966-12-27 Cooper Mcdougall & Robertson Coumarinyl phosphate intestingal nematocides and the method for using same
GB1041521A (en) * 1963-11-20 1966-09-07 Cooper Mcdougall & Robertson New thiophosphoric acid esters and pesticidal formulations containing them
FR1489249A (fr) * 1965-06-19 1967-07-21 Takeda Chemical Industries Ltd Sels métalliques de l'acide ascorbique phosphorylé et produits cosmétiques obtenus à partir de ces sels
JPS6041677B2 (ja) * 1979-06-27 1985-09-18 クミアイ化学工業株式会社 有機リン酸エステル誘導体、その製造法および殺虫、殺ダニ剤
JPS59219295A (ja) * 1983-05-30 1984-12-10 Senjiyu Seiyaku Kk リン酸ジエステルまたはその塩およびそれらの製造法

Also Published As

Publication number Publication date
CA1213284A (en) 1986-10-28
DE3465997D1 (en) 1987-10-15
EP0127471A2 (en) 1984-12-05
US4564686A (en) 1986-01-14
ES532872A0 (es) 1985-10-01
EP0127471B1 (en) 1987-09-09
JPH0244478B2 (es) 1990-10-04
JPS59219295A (ja) 1984-12-10
EP0127471A3 (en) 1985-08-14

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20041102