ES8505998A1 - Un procedimiento para preparar un derivado de carbostirilo - Google Patents
Un procedimiento para preparar un derivado de carbostiriloInfo
- Publication number
- ES8505998A1 ES8505998A1 ES532536A ES532536A ES8505998A1 ES 8505998 A1 ES8505998 A1 ES 8505998A1 ES 532536 A ES532536 A ES 532536A ES 532536 A ES532536 A ES 532536A ES 8505998 A1 ES8505998 A1 ES 8505998A1
- Authority
- ES
- Spain
- Prior art keywords
- agents
- carbostyril
- carbostyril derivatives
- useful
- hypotensive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR UN DERIVADO DE CARBOSTIRILO, DE FORMULA GENERAL (I), Y SUS SALES DE ADICION FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE CARBOSTIRILO DE FORMULA GENERAL (II) CON UN COMPUESTO DE FORMULA GENERAL (III).DE APLICACION COMO MEDIO PROFILACTICO EN EL TRATAMIENTO DE LA TROMBOSIS Y COMO AGENTE HIPOTENSOR E INHIBIDOR DE FOSFODIESTERASA.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15409082A JPS5962585A (ja) | 1982-09-03 | 1982-09-03 | カルボスチリル誘導体 |
JP57213167A JPS59104378A (ja) | 1982-12-03 | 1982-12-03 | カルボスチリル誘導体 |
JP58114679A JPS606685A (ja) | 1983-06-24 | 1983-06-24 | カルボスチリル誘導体 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8505998A1 true ES8505998A1 (es) | 1985-06-16 |
ES532536A0 ES532536A0 (es) | 1985-06-16 |
Family
ID=27312797
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES525346A Granted ES525346A0 (es) | 1982-09-03 | 1983-09-02 | Un derivado de carbostirilo. |
ES532538A Expired ES8506697A1 (es) | 1982-09-03 | 1984-05-16 | Un procedimiento para preparar un derivado de carbostirilo |
ES532536A Granted ES532536A0 (es) | 1982-09-03 | 1984-05-16 | Un procedimiento para preparar un derivado de carbostirilo |
ES532537A Expired ES8601187A1 (es) | 1982-09-03 | 1984-05-16 | Un procedimiento para preparar un derivado de carbostirilo |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES525346A Granted ES525346A0 (es) | 1982-09-03 | 1983-09-02 | Un derivado de carbostirilo. |
ES532538A Expired ES8506697A1 (es) | 1982-09-03 | 1984-05-16 | Un procedimiento para preparar un derivado de carbostirilo |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES532537A Expired ES8601187A1 (es) | 1982-09-03 | 1984-05-16 | Un procedimiento para preparar un derivado de carbostirilo |
Country Status (11)
Country | Link |
---|---|
US (1) | US4564619A (es) |
KR (1) | KR910000181B1 (es) |
CA (1) | CA1252469A (es) |
CH (1) | CH655110A5 (es) |
DE (1) | DE3331808A1 (es) |
ES (4) | ES525346A0 (es) |
FR (1) | FR2532648B1 (es) |
GB (1) | GB2127402B (es) |
IT (1) | IT1193145B (es) |
NL (1) | NL8303066A (es) |
SE (1) | SE455503B (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ212209A (en) * | 1984-05-29 | 1988-08-30 | Pfizer | Quinolone derivatives and pharmaceutical compositions |
GB8529362D0 (en) * | 1985-11-28 | 1986-01-02 | Pfizer Ltd | Quinolone cardiac stimulants |
KR940000785B1 (ko) * | 1986-04-02 | 1994-01-31 | 오오쓰까세이야꾸 가부시끼가이샤 | 카르보스티릴 유도체 및 그의 염의 제조 방법 |
DK167187A (da) * | 1986-04-02 | 1987-10-03 | Otsuka Pharma Co Ltd | Carbostyrilderivater og salte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddel indeholdende disse |
KR100305515B1 (ko) * | 1999-02-04 | 2001-09-24 | 이순금 | 메주의 제조방법 |
NL1012886C1 (nl) | 1999-08-23 | 2001-02-26 | Rephartox | 1,4-Dihydropyridine-5-carbonzuuresterderivaten en werkwijze voor de bereiding ervan. |
KR100422242B1 (ko) * | 2001-07-20 | 2004-03-12 | 농업회사법인(주)맛가마식품 | 중공봉형상 메주와 이를 이용한 간장 및 된장 제조방법과제조용 장독 |
US20070066619A1 (en) * | 2002-10-07 | 2007-03-22 | Artesian Therapeutics, Inc. | Compounds having simultaneous ability to block L-type calcium channels and to inhibit phosphodiesterase type 3 activity |
PL376405A1 (en) * | 2002-10-07 | 2005-12-27 | Artesian Therapeutics, Inc. | Dihydropyridine compounds having simultaneous ability to block l-type calcium channels and to inhibit phosphodiesterase type 3 activity |
NL1028564C2 (nl) * | 2005-03-17 | 2006-09-20 | Rademaker Holding B V | Toepassing van een coumarine-groep omvattende derivaten voor de bereiding van een antiviraal middel, coumarine-group omvattende derivaten, een werkwijze voor de bereiding daarvan, en farmaceutische preparaten die deze bevatten. |
US7678363B2 (en) | 2005-08-26 | 2010-03-16 | Braincells Inc | Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs |
EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
EP1940389A2 (en) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
EP1991212A1 (en) * | 2006-03-08 | 2008-11-19 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
US20100009983A1 (en) * | 2006-05-09 | 2010-01-14 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
EP2021000A2 (en) | 2006-05-09 | 2009-02-11 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
MX2008014320A (es) * | 2006-05-09 | 2009-03-25 | Braincells Inc | Neurogenesis mediada por el receptor de 5-hidroxitriptamina. |
EP2068872A1 (en) * | 2006-09-08 | 2009-06-17 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
EP2066355A2 (en) * | 2006-09-19 | 2009-06-10 | Braincells, Inc. | Combination comprising a peroxisome proliferator activated receptor agent and a second neurogenic agent for treating a nervous system disorder, increasing neurodifferentiation and increasing neurogenesis |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
EP2804603A1 (en) | 2012-01-10 | 2014-11-26 | President and Fellows of Harvard College | Beta-cell replication promoting compounds and methods of their use |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3971797A (en) * | 1973-06-15 | 1976-07-27 | Merck & Co., Inc. | S,S'-bis(pyridylmethyl)-carbonodithioates |
DE2508181A1 (de) * | 1975-02-26 | 1976-09-09 | Bayer Ag | 1,4-dihydropyridincarbonsaeurearal- kylester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
US4081447A (en) * | 1975-04-09 | 1978-03-28 | Abbott Laboratories | 5-[2-Hydroxy-3-(3,4-dimethoxy phenethylamino)]-propoxy-3,4-dihydro carbostyril and pharmaceutically acceptable salts thereof |
DE2659665A1 (de) * | 1976-12-30 | 1978-07-13 | Nattermann A & Cie | Neue 1,4-dihydropyridin-derivate |
JPS5387368A (en) * | 1977-01-12 | 1978-08-01 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
JPS5390270A (en) * | 1977-01-14 | 1978-08-08 | Otsuka Pharmaceut Co Ltd | Carbostryl derivs. |
IE46852B1 (en) * | 1977-06-10 | 1983-10-05 | Otsuka Pharma Co Ltd | Novel carbostyril derivatives |
DE2805404A1 (de) * | 1978-02-09 | 1979-08-16 | Merck Patent Gmbh | 1-aryloxy-3-nitratoalkylamino-2-propanole und verfahren zu ihrer herstellung |
IT1097538B (it) * | 1978-07-17 | 1985-08-31 | Medea Res Srl | Processo per la preparazione del 2,6-dimetil-4-3(3-nitrofenil)-3-metossicarbonil-1,4-didropiridin-5-carbossilati di 2(n-benzil-n-metilammino) |
CA1117117A (en) * | 1978-10-10 | 1982-01-26 | Fujisawa Pharmaceutical Co., Ltd. | 2-methyl-dihydropyridine compound, processes for preparation thereof and pharmaceutical composition comprising the same |
DE3034237A1 (de) * | 1979-09-18 | 1981-04-16 | Otsuka Pharmaceutical Co. Ltd., Tokyo | Carbostyrilderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende, antihistaminisch wirkende mittel |
PH17194A (en) * | 1980-03-06 | 1984-06-19 | Otsuka Pharma Co Ltd | Novel carbostyril derivatives,and pharmaceutical composition containing the same |
JPS5777676A (en) * | 1980-10-31 | 1982-05-15 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
JPS57200386A (en) * | 1981-06-04 | 1982-12-08 | Yoshitomi Pharmaceut Ind Ltd | Novel 1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its salts |
-
1983
- 1983-09-01 CH CH4807/83A patent/CH655110A5/de not_active IP Right Cessation
- 1983-09-02 ES ES525346A patent/ES525346A0/es active Granted
- 1983-09-02 CA CA000435962A patent/CA1252469A/en not_active Expired
- 1983-09-02 FR FR8314115A patent/FR2532648B1/fr not_active Expired
- 1983-09-02 US US06/528,887 patent/US4564619A/en not_active Expired - Fee Related
- 1983-09-02 KR KR1019830004144A patent/KR910000181B1/ko not_active IP Right Cessation
- 1983-09-02 GB GB08323542A patent/GB2127402B/en not_active Expired
- 1983-09-02 NL NL8303066A patent/NL8303066A/nl not_active Application Discontinuation
- 1983-09-02 DE DE19833331808 patent/DE3331808A1/de not_active Withdrawn
- 1983-09-02 SE SE8304737A patent/SE455503B/sv not_active IP Right Cessation
- 1983-09-05 IT IT67922/83A patent/IT1193145B/it active
-
1984
- 1984-05-16 ES ES532538A patent/ES8506697A1/es not_active Expired
- 1984-05-16 ES ES532536A patent/ES532536A0/es active Granted
- 1984-05-16 ES ES532537A patent/ES8601187A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
GB2127402B (en) | 1987-01-14 |
GB8323542D0 (en) | 1983-10-05 |
SE455503B (sv) | 1988-07-18 |
CA1252469A (en) | 1989-04-11 |
IT8367922A0 (it) | 1983-09-05 |
CH655110A5 (de) | 1986-03-27 |
ES532538A0 (es) | 1985-07-16 |
ES532537A0 (es) | 1985-10-16 |
ES8506697A1 (es) | 1985-07-16 |
SE8304737L (sv) | 1984-03-04 |
US4564619A (en) | 1986-01-14 |
ES8502686A1 (es) | 1985-01-16 |
KR910000181B1 (ko) | 1991-01-21 |
NL8303066A (nl) | 1984-04-02 |
ES532536A0 (es) | 1985-06-16 |
ES8601187A1 (es) | 1985-10-16 |
SE8304737D0 (sv) | 1983-09-02 |
DE3331808A1 (de) | 1984-03-08 |
ES525346A0 (es) | 1985-01-16 |
GB2127402A (en) | 1984-04-11 |
KR850000402A (ko) | 1985-02-27 |
FR2532648B1 (fr) | 1989-07-21 |
FR2532648A1 (fr) | 1984-03-09 |
IT1193145B (it) | 1988-06-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES8505998A1 (es) | Un procedimiento para preparar un derivado de carbostirilo | |
RU94013439A (ru) | Гетероциклические соединения, способ их получения, фармацевтическая композиция и способ лечения | |
IE781478L (en) | IMIDAZO £2,1-b| QUINAZOLINES | |
ES8104278A1 (es) | Un procedimiento para la preparacion de derivados del indol. | |
EP0201188A3 (en) | 5-Substituted pyrazolo[4,3-d] pyrimidine-7-ones, process for preparing the compounds and pharmaceutical compositions comprising the compounds | |
ATE307585T1 (de) | Substituierte phenylpyrimidine derivate, für die behandlung oder prevention von zns-erkrankungen | |
IL72354A (en) | Imidazole derivatives and imidazolium salt derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same | |
ES8305352A1 (es) | Procedimiento para la preparacion de nuevos compuestos de aorilimidazol-2-ona. | |
CA2280727A1 (en) | Bicyclic amino acids | |
KR900700435A (ko) | 신규아민류 및 그 용도 | |
CA2072233A1 (en) | Triazolopyrimidine derivatives which are angiotensin ii receptor antagonists; processes for preparing them and pharmaceutical compositions containing them | |
ES8700850A1 (es) | 1,4-dihidropiridin-carboxiamidas. | |
DE3462894D1 (de) | 3-indolecarboxamide compounds | |
ES8705382A1 (es) | Un procedimiento para la preparacion de nuevos derivados de carbaciclina. | |
HUT44515A (en) | Process for producing isoquinolinol compounds of heart activity increasing, phosphodiesterase iii inhibiting and/or renal vasodilating activity and pharmaceutical composition containing them | |
DK478485A (da) | 4-oxo-pyrido(2,3-d)pyrimidin-derivater, deres fremstilling og anvendelse | |
IE781226L (en) | Antithrombatic compound | |
JPS5780321A (en) | Cardiotonic agent | |
DE3889532T2 (de) | Dihydropyridin-Verbindung zur Verbesserung der Adernausdehnung und Hemmung der Herzhypertrophie. | |
US2252390A (en) | X ii ii ii ii | |
DK232885A (da) | Immunosuppressivt praeparat | |
ES8203380A1 (es) | Un procedimiento de preparacion de 4-(1-piperazinil)-fu- ro(3,2-c)piridinas | |
IT8421753A0 (it) | Agenti terapeutici per il trattamento di disturbi cardiaci edella circolazione, delle dislipidemie e delle deficienze delle prestazioni muscolari, procedimento per la loro preparazione e relative composizioni farmaceutiche. | |
DE3887005T2 (de) | Mittel zur Behandlung von Nierenbeschwerden. | |
WO1999010371A3 (de) | Cyclopeptidderivate als adhäsionsinhibitoren |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970203 |