ES8305352A1 - Procedimiento para la preparacion de nuevos compuestos de aorilimidazol-2-ona. - Google Patents
Procedimiento para la preparacion de nuevos compuestos de aorilimidazol-2-ona.Info
- Publication number
- ES8305352A1 ES8305352A1 ES510087A ES510087A ES8305352A1 ES 8305352 A1 ES8305352 A1 ES 8305352A1 ES 510087 A ES510087 A ES 510087A ES 510087 A ES510087 A ES 510087A ES 8305352 A1 ES8305352 A1 ES 8305352A1
- Authority
- ES
- Spain
- Prior art keywords
- aroylimidazolones
- novel
- aroylimidazole
- cardiotonics
- ones
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Luminescent Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Saccharide Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE COMPUESTOS DE AROILIMIDAZOL-2-ONA, DE FORMULA GENERAL (I), EN LA QUE Q Y T SON CADA UNO DE ELLOS UN ATOMO DE OXIGENO O UN ATOMO DIVALENTE DE AZUFRE; R ES HIDROGENO, ALQUILO INFERIOR O BENZOILO; R ES HIDROGENO O ALQUILO INFERIOR; Y AR ES PIRIDILO, PIRRILO, TIENILO O FURANILO, Y SUS SALES DE ADICION FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UNA AMINOCETONA DE FORMULA (II), EN LA QUE R Y AR TIENEN LOS SIGNIFICADOS YA INDICADOS, CON UNA SAL DE CIANATO O TIOCIANATO. DE APLICACION COMO CARDIOTONICOS EN EL TRATAMIENTO DE FALLOS CARDIACOS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24088981A | 1981-03-05 | 1981-03-05 | |
US06/314,312 US4405628A (en) | 1981-03-05 | 1981-10-23 | 4-Pyridylimidazolones and method of use |
Publications (2)
Publication Number | Publication Date |
---|---|
ES510087A0 ES510087A0 (es) | 1983-04-16 |
ES8305352A1 true ES8305352A1 (es) | 1983-04-16 |
Family
ID=26933806
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES510087A Expired ES8305352A1 (es) | 1981-03-05 | 1982-03-03 | Procedimiento para la preparacion de nuevos compuestos de aorilimidazol-2-ona. |
ES519254A Expired ES8402827A1 (es) | 1981-03-05 | 1983-01-25 | Procedimiento para la preparacion de nuevos compuestos de aroilimidazol-2-ona. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES519254A Expired ES8402827A1 (es) | 1981-03-05 | 1983-01-25 | Procedimiento para la preparacion de nuevos compuestos de aroilimidazol-2-ona. |
Country Status (18)
Country | Link |
---|---|
US (1) | US4405628A (es) |
EP (1) | EP0059948B1 (es) |
KR (1) | KR890000765B1 (es) |
AT (1) | ATE16489T1 (es) |
AU (1) | AU557590B2 (es) |
CA (1) | CA1190550A (es) |
DE (1) | DE3267352D1 (es) |
DK (1) | DK168627B1 (es) |
ES (2) | ES8305352A1 (es) |
GB (1) | GB2096600B (es) |
GR (1) | GR76518B (es) |
HK (1) | HK61686A (es) |
IE (1) | IE52387B1 (es) |
IL (1) | IL65137A (es) |
MY (1) | MY8600700A (es) |
NO (1) | NO157175C (es) |
NZ (1) | NZ199885A (es) |
PH (1) | PH18345A (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4367236A (en) * | 1981-11-04 | 1983-01-04 | Merrell Dow Pharmaceuticals Inc. | Method for the treatment of cardiac failure with alkanoylimidazol-2-one derivatives |
US4552880A (en) * | 1983-02-15 | 1985-11-12 | Merrell Dow Pharmaceuticals Inc. | Aroylimidazolones |
US4532250A (en) * | 1983-11-23 | 1985-07-30 | American Hospital Supply Corporation | 5-Heteroarylimidazol-2-ones having cardiotonic activity |
US4556665A (en) * | 1984-07-09 | 1985-12-03 | Schering A.G. | Cardiotonic 1,3-dihydro-4-[[(imidazol-1-yl)aryl]carbonyl]imidazol-2-ones |
IL75902A (en) * | 1984-07-30 | 1988-10-31 | Merrell Dow Pharma | Preparation of 1,3-dihydro-4-pyridoyl-2h-imidazol-2-ones |
US4803278A (en) * | 1984-07-30 | 1989-02-07 | Merrell Dow Pharmaceuticals, Inc. | Preparation of 1,3-dihydro-4-pyridoyl-2H-imidazol-2-ones |
ZA881807B (en) * | 1987-03-20 | 1988-09-05 | Merrell Dow Pharmaceuticals Inc. | Method for reducing reperfusion injury with imidazol-2-thiones |
US4999365A (en) * | 1987-03-20 | 1991-03-12 | Merrell Dow Pharmaceuticals Inc. | Method of reducing reperfusion injury with imidazol-2-thiones |
ZA887662B (en) * | 1987-10-19 | 1989-06-28 | Merrell Dow Pharma | Method for reducing reperfusion injury with imidazol-2-thione-carboxamides |
EP0536279A1 (en) * | 1990-06-29 | 1993-04-14 | The Upjohn Company | Substituted 1-(alkoxyphenyl)piperazines with cns and antihypertensive activity |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
US7879802B2 (en) | 2007-06-04 | 2011-02-01 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
US20100120694A1 (en) | 2008-06-04 | 2010-05-13 | Synergy Pharmaceuticals, Inc. | Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
EP2321341B1 (en) | 2008-07-16 | 2017-02-22 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
MX357121B (es) | 2011-03-01 | 2018-06-27 | Synergy Pharmaceuticals Inc Star | Proceso de preparacion de agonistas c de guanilato ciclasa. |
CA2902348C (en) | 2013-02-25 | 2021-11-30 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
EP2970384A1 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
BR112015030326A2 (pt) | 2013-06-05 | 2017-08-29 | Synergy Pharmaceuticals Inc | Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos |
WO2015021358A2 (en) | 2013-08-09 | 2015-02-12 | Dominique Charmot | Compounds and methods for inhibiting phosphate transport |
US20200368223A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Methods for inhibiting phosphate transport |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2441933A (en) * | 1945-07-30 | 1948-05-18 | Hoffmann La Roche | Substituted imidazolones and process of making them |
US3538104A (en) * | 1969-02-28 | 1970-11-03 | Geigy Chem Corp | Pyridyl-2-imidazolones |
ZA803332B (en) * | 1979-06-18 | 1981-01-28 | Richardson Merrell Inc | Novel 4-aroylimidazol-2-ones |
NZ193935A (en) * | 1979-06-18 | 1985-05-31 | Richardson Merrell Inc | 4-aroyl-imidazol-2-one derivatives;pharmaceutical compositions |
PH18106A (en) * | 1981-02-18 | 1985-03-21 | Merrell Dow Pharma | Novel-4-aroylimidazol-2-ones |
-
1981
- 1981-10-23 US US06/314,312 patent/US4405628A/en not_active Expired - Lifetime
-
1982
- 1982-03-01 CA CA000397351A patent/CA1190550A/en not_active Expired
- 1982-03-01 IL IL65137A patent/IL65137A/xx not_active IP Right Cessation
- 1982-03-01 PH PH26929A patent/PH18345A/en unknown
- 1982-03-02 GR GR67455A patent/GR76518B/el unknown
- 1982-03-02 NZ NZ199885A patent/NZ199885A/en unknown
- 1982-03-02 AU AU81037/82A patent/AU557590B2/en not_active Ceased
- 1982-03-03 ES ES510087A patent/ES8305352A1/es not_active Expired
- 1982-03-04 AT AT82101706T patent/ATE16489T1/de active
- 1982-03-04 DK DK095482A patent/DK168627B1/da not_active IP Right Cessation
- 1982-03-04 DE DE8282101706T patent/DE3267352D1/de not_active Expired
- 1982-03-04 KR KR8200933A patent/KR890000765B1/ko active
- 1982-03-04 IE IE491/82A patent/IE52387B1/en not_active IP Right Cessation
- 1982-03-04 EP EP82101706A patent/EP0059948B1/en not_active Expired
- 1982-03-04 NO NO820686A patent/NO157175C/no unknown
- 1982-03-04 GB GB8206412A patent/GB2096600B/en not_active Expired
-
1983
- 1983-01-25 ES ES519254A patent/ES8402827A1/es not_active Expired
-
1986
- 1986-08-21 HK HK616/86A patent/HK61686A/xx not_active IP Right Cessation
- 1986-12-30 MY MY700/86A patent/MY8600700A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
IL65137A (en) | 1987-02-27 |
KR890000765B1 (ko) | 1989-04-05 |
EP0059948A1 (en) | 1982-09-15 |
ES510087A0 (es) | 1983-04-16 |
US4405628A (en) | 1983-09-20 |
AU8103782A (en) | 1982-09-09 |
ES519254A0 (es) | 1984-03-01 |
IE52387B1 (en) | 1987-10-14 |
PH18345A (en) | 1985-06-05 |
NO820686L (no) | 1982-09-06 |
DK168627B1 (da) | 1994-05-09 |
GR76518B (es) | 1984-08-10 |
HK61686A (en) | 1986-08-29 |
IE820491L (en) | 1982-09-05 |
CA1190550A (en) | 1985-07-16 |
DK95482A (da) | 1982-09-06 |
AU557590B2 (en) | 1986-12-24 |
GB2096600A (en) | 1982-10-20 |
GB2096600B (en) | 1985-06-05 |
DE3267352D1 (en) | 1985-12-19 |
ATE16489T1 (de) | 1985-11-15 |
NZ199885A (en) | 1985-04-30 |
NO157175C (no) | 1988-02-03 |
IL65137A0 (en) | 1982-05-31 |
ES8402827A1 (es) | 1984-03-01 |
KR830009046A (ko) | 1983-12-17 |
NO157175B (no) | 1987-10-26 |
MY8600700A (en) | 1986-12-31 |
EP0059948B1 (en) | 1985-11-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20020304 |