ES8305352A1 - Procedimiento para la preparacion de nuevos compuestos de aorilimidazol-2-ona. - Google Patents

Procedimiento para la preparacion de nuevos compuestos de aorilimidazol-2-ona.

Info

Publication number
ES8305352A1
ES8305352A1 ES510087A ES510087A ES8305352A1 ES 8305352 A1 ES8305352 A1 ES 8305352A1 ES 510087 A ES510087 A ES 510087A ES 510087 A ES510087 A ES 510087A ES 8305352 A1 ES8305352 A1 ES 8305352A1
Authority
ES
Spain
Prior art keywords
aroylimidazolones
novel
aroylimidazole
cardiotonics
ones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES510087A
Other languages
English (en)
Other versions
ES510087A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of ES8305352A1 publication Critical patent/ES8305352A1/es
Publication of ES510087A0 publication Critical patent/ES510087A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Luminescent Compositions (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE COMPUESTOS DE AROILIMIDAZOL-2-ONA, DE FORMULA GENERAL (I), EN LA QUE Q Y T SON CADA UNO DE ELLOS UN ATOMO DE OXIGENO O UN ATOMO DIVALENTE DE AZUFRE; R ES HIDROGENO, ALQUILO INFERIOR O BENZOILO; R ES HIDROGENO O ALQUILO INFERIOR; Y AR ES PIRIDILO, PIRRILO, TIENILO O FURANILO, Y SUS SALES DE ADICION FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UNA AMINOCETONA DE FORMULA (II), EN LA QUE R Y AR TIENEN LOS SIGNIFICADOS YA INDICADOS, CON UNA SAL DE CIANATO O TIOCIANATO. DE APLICACION COMO CARDIOTONICOS EN EL TRATAMIENTO DE FALLOS CARDIACOS.
ES510087A 1981-03-05 1982-03-03 Procedimiento para la preparacion de nuevos compuestos de aorilimidazol-2-ona. Granted ES510087A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24088981A 1981-03-05 1981-03-05
US06/314,312 US4405628A (en) 1981-03-05 1981-10-23 4-Pyridylimidazolones and method of use

Publications (2)

Publication Number Publication Date
ES8305352A1 true ES8305352A1 (es) 1983-04-16
ES510087A0 ES510087A0 (es) 1983-04-16

Family

ID=26933806

Family Applications (2)

Application Number Title Priority Date Filing Date
ES510087A Granted ES510087A0 (es) 1981-03-05 1982-03-03 Procedimiento para la preparacion de nuevos compuestos de aorilimidazol-2-ona.
ES519254A Expired ES8402827A1 (es) 1981-03-05 1983-01-25 Procedimiento para la preparacion de nuevos compuestos de aroilimidazol-2-ona.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES519254A Expired ES8402827A1 (es) 1981-03-05 1983-01-25 Procedimiento para la preparacion de nuevos compuestos de aroilimidazol-2-ona.

Country Status (18)

Country Link
US (1) US4405628A (es)
EP (1) EP0059948B1 (es)
KR (1) KR890000765B1 (es)
AT (1) ATE16489T1 (es)
AU (1) AU557590B2 (es)
CA (1) CA1190550A (es)
DE (1) DE3267352D1 (es)
DK (1) DK168627B1 (es)
ES (2) ES510087A0 (es)
GB (1) GB2096600B (es)
GR (1) GR76518B (es)
HK (1) HK61686A (es)
IE (1) IE52387B1 (es)
IL (1) IL65137A (es)
MY (1) MY8600700A (es)
NO (1) NO157175C (es)
NZ (1) NZ199885A (es)
PH (1) PH18345A (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4367236A (en) * 1981-11-04 1983-01-04 Merrell Dow Pharmaceuticals Inc. Method for the treatment of cardiac failure with alkanoylimidazol-2-one derivatives
US4552880A (en) * 1983-02-15 1985-11-12 Merrell Dow Pharmaceuticals Inc. Aroylimidazolones
US4532250A (en) * 1983-11-23 1985-07-30 American Hospital Supply Corporation 5-Heteroarylimidazol-2-ones having cardiotonic activity
US4556665A (en) * 1984-07-09 1985-12-03 Schering A.G. Cardiotonic 1,3-dihydro-4-[[(imidazol-1-yl)aryl]carbonyl]imidazol-2-ones
CA1262732C (en) * 1984-07-30 1989-11-07 PREPARATION OF 1,3-DIHYDRO-4-PYRIDOYL-2H-IMIDAZOL-2-ONES
US4803278A (en) * 1984-07-30 1989-02-07 Merrell Dow Pharmaceuticals, Inc. Preparation of 1,3-dihydro-4-pyridoyl-2H-imidazol-2-ones
US4999365A (en) * 1987-03-20 1991-03-12 Merrell Dow Pharmaceuticals Inc. Method of reducing reperfusion injury with imidazol-2-thiones
ZA881807B (en) * 1987-03-20 1988-09-05 Merrell Dow Pharmaceuticals Inc. Method for reducing reperfusion injury with imidazol-2-thiones
ZA887662B (en) * 1987-10-19 1989-06-28 Merrell Dow Pharma Method for reducing reperfusion injury with imidazol-2-thione-carboxamides
EP0536279A1 (en) * 1990-06-29 1993-04-14 The Upjohn Company Substituted 1-(alkoxyphenyl)piperazines with cns and antihypertensive activity
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
CA2688161C (en) 2007-06-04 2020-10-20 Kunwar Shailubhai Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CA2726917C (en) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP2011528375A (ja) 2008-07-16 2011-11-17 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
WO2012118972A2 (en) 2011-03-01 2012-09-07 Synegy Pharmaceuticals Inc. Process of preparing guanylate cyclase c agonists
AU2014218599C1 (en) 2013-02-25 2018-09-06 Bausch Health Ireland Limited Guanylate cyclase receptor agonists for use in colonic cleansing
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
CN105764916B (zh) 2013-06-05 2021-05-18 博士医疗爱尔兰有限公司 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法
IL280864B2 (en) 2013-08-09 2024-03-01 Ardelyx Inc Compounds and methods for inhibiting phosphate transport
CN114340631A (zh) 2019-05-21 2022-04-12 阿德利克斯股份有限公司 用于降低患者的血清磷酸盐的组合

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2441933A (en) * 1945-07-30 1948-05-18 Hoffmann La Roche Substituted imidazolones and process of making them
US3538104A (en) * 1969-02-28 1970-11-03 Geigy Chem Corp Pyridyl-2-imidazolones
NZ193935A (en) * 1979-06-18 1985-05-31 Richardson Merrell Inc 4-aroyl-imidazol-2-one derivatives;pharmaceutical compositions
ZA803332B (en) * 1979-06-18 1981-01-28 Richardson Merrell Inc Novel 4-aroylimidazol-2-ones
PH18106A (en) * 1981-02-18 1985-03-21 Merrell Dow Pharma Novel-4-aroylimidazol-2-ones

Also Published As

Publication number Publication date
GR76518B (es) 1984-08-10
PH18345A (en) 1985-06-05
ATE16489T1 (de) 1985-11-15
EP0059948A1 (en) 1982-09-15
KR890000765B1 (ko) 1989-04-05
KR830009046A (ko) 1983-12-17
NZ199885A (en) 1985-04-30
IE820491L (en) 1982-09-05
EP0059948B1 (en) 1985-11-13
NO157175C (no) 1988-02-03
ES519254A0 (es) 1984-03-01
DE3267352D1 (en) 1985-12-19
AU8103782A (en) 1982-09-09
DK95482A (da) 1982-09-06
CA1190550A (en) 1985-07-16
NO820686L (no) 1982-09-06
ES8402827A1 (es) 1984-03-01
AU557590B2 (en) 1986-12-24
IL65137A (en) 1987-02-27
IE52387B1 (en) 1987-10-14
NO157175B (no) 1987-10-26
HK61686A (en) 1986-08-29
US4405628A (en) 1983-09-20
DK168627B1 (da) 1994-05-09
GB2096600A (en) 1982-10-20
IL65137A0 (en) 1982-05-31
MY8600700A (en) 1986-12-31
ES510087A0 (es) 1983-04-16
GB2096600B (en) 1985-06-05

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20020304