ES8505717A1 - Un procedimiento para preparar una muteina sintetica de una proteina biologicamente activa - Google Patents

Un procedimiento para preparar una muteina sintetica de una proteina biologicamente activa

Info

Publication number
ES8505717A1
ES8505717A1 ES526541A ES526541A ES8505717A1 ES 8505717 A1 ES8505717 A1 ES 8505717A1 ES 526541 A ES526541 A ES 526541A ES 526541 A ES526541 A ES 526541A ES 8505717 A1 ES8505717 A1 ES 8505717A1
Authority
ES
Spain
Prior art keywords
muteins
cystein
interleukin
pharmaceutical
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES526541A
Other languages
English (en)
Other versions
ES526541A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Cetus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27030446&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8505717(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cetus Corp filed Critical Cetus Corp
Publication of ES526541A0 publication Critical patent/ES526541A0/es
Publication of ES8505717A1 publication Critical patent/ES8505717A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y10S530/809—Fused cells, e.g. hybridoma
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/141—Interleukin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/142—Interferon

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR UNA MUTEINA SINTETICA DE UNA PROTEINA BIOLOLGICAMENTE ACTIVA.CONSISTE EN CULTIVAR UNA CELULA U ORGANISMO HOSPEDANTE RECOMBINANTE QUE SE HA TRANSFORMADO CON UN VECTOR DE EXPRESION QUE INCLUYE UN GEN ESTRUCTURAL QUE COFDIFICA LA MUTEINA SINTETICA, O PROGENIE DE DICHA CELULA U ORGANISMO Y RECOGER LA MUTEINA SINTETICA A PARTIR DEL CULTIVO. CONTIENE UN RESTO DE CISTEINA QUE ESTA LIBRE PARA FORMAR UN ENLACE DE DISOLFURO Y NO ES ESENCIAL PARA LA ACTIVIDAD BIOLOGICA, TENIENDO LA MUTEINA UNO DE LOS RESTOS DE CISTEINA SUPRIMIDOS O REEMPLAZADOS POR OTRO AMINOACIDO, TAL COMO SERINA, TREONINA, GLICINA, ALANINA, VALINA, LEUCINA, ISOLEUCINA, HISTIDINA, TIROSINA, FENILALANINA, TRIPTOFANO O METIONINA.
ES526541A 1982-10-19 1983-10-18 Un procedimiento para preparar una muteina sintetica de una proteina biologicamente activa Expired ES8505717A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43515482A 1982-10-19 1982-10-19
US48616283A 1983-04-15 1983-04-15

Publications (2)

Publication Number Publication Date
ES526541A0 ES526541A0 (es) 1985-04-01
ES8505717A1 true ES8505717A1 (es) 1985-04-01

Family

ID=27030446

Family Applications (4)

Application Number Title Priority Date Filing Date
ES526541A Expired ES8505717A1 (es) 1982-10-19 1983-10-18 Un procedimiento para preparar una muteina sintetica de una proteina biologicamente activa
ES533053A Granted ES533053A0 (es) 1982-10-19 1984-06-01 Un procedimiento para preparar una celula u organismo recombinante
ES533054A Expired ES8506801A1 (es) 1982-10-19 1984-06-01 Un metodo para producir un gen que contiene una muteina sintetica de una proteina biologicamente activa
ES542829A Expired ES8608043A1 (es) 1982-10-19 1985-05-03 Un metodo para evitar la formacion de un enlace de disulfuro en una proteina.

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES533053A Granted ES533053A0 (es) 1982-10-19 1984-06-01 Un procedimiento para preparar una celula u organismo recombinante
ES533054A Expired ES8506801A1 (es) 1982-10-19 1984-06-01 Un metodo para producir un gen que contiene una muteina sintetica de una proteina biologicamente activa
ES542829A Expired ES8608043A1 (es) 1982-10-19 1985-05-03 Un metodo para evitar la formacion de un enlace de disulfuro en una proteina.

Country Status (23)

Country Link
EP (4) EP0192811B1 (es)
JP (2) JPS6128392A (es)
KR (1) KR910009900B1 (es)
AT (4) ATE33503T1 (es)
AU (1) AU563962B2 (es)
BE (1) BE898016A (es)
CA (1) CA1340861C (es)
CH (1) CH669395A5 (es)
DE (4) DE3382528D1 (es)
DK (2) DK168767B1 (es)
ES (4) ES8505717A1 (es)
FI (1) FI82266C (es)
FR (1) FR2534594B1 (es)
GB (1) GB2130219B (es)
GR (1) GR79408B (es)
IE (1) IE56026B1 (es)
IL (1) IL69970A (es)
LU (3) LU88761I2 (es)
NL (2) NL930119I2 (es)
NO (1) NO173740C (es)
NZ (1) NZ205922A (es)
PH (2) PH20343A (es)
PT (1) PT77512B (es)

Families Citing this family (118)

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FI833681A (fi) 1984-04-20
FR2534594A1 (fr) 1984-04-20
AU563962B2 (en) 1987-07-30
IE56026B1 (en) 1991-03-27
FI82266B (fi) 1990-10-31
PH20343A (en) 1986-12-04
JPH0568480B2 (es) 1993-09-29
ATE33503T1 (de) 1988-04-15
IL69970A0 (en) 1984-01-31
NL930119I1 (nl) 1993-11-01
DK105892A (da) 1992-08-26
GR79408B (es) 1984-10-22
EP0234599A1 (en) 1987-09-02
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CA1340861C (en) 1999-12-28
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ES8506089A1 (es) 1985-06-16
DK481383D0 (da) 1983-10-19
DE3376271D1 (en) 1988-05-19
CH669395A5 (es) 1989-03-15
NO173740C (no) 1994-01-26
LU90413I2 (fr) 1999-09-07
FI82266C (fi) 1991-02-11
PT77512B (en) 1987-11-24
PT77512A (en) 1983-11-01
EP0234599B1 (en) 1992-03-11
NL960013I2 (nl) 1997-03-03
DE3380598D1 (en) 1989-10-26
BE898016A (fr) 1984-02-15
NO173740B (no) 1993-10-18
LU88761I2 (fr) 1996-11-05
PH23702A (en) 1989-09-27
EP0218825A1 (en) 1987-04-22
ES526541A0 (es) 1985-04-01
ATE61407T1 (de) 1991-03-15
LU88357I2 (fr) 1994-05-04
EP0218825B1 (en) 1989-09-20
AU2008683A (en) 1984-05-03
ATE73493T1 (de) 1992-03-15
ES533054A0 (es) 1985-08-01
NL930119I2 (nl) 1995-01-16
DK105892D0 (da) 1992-08-26
DE3382197D1 (de) 1991-04-11
JPS6420096A (en) 1989-01-24
KR910009900B1 (ko) 1991-12-03
NZ205922A (en) 1987-11-27
IL69970A (en) 1991-05-12
DK168767B1 (da) 1994-06-06
ES8506801A1 (es) 1985-08-01
GB2130219B (en) 1986-01-29
FR2534594B1 (fr) 1987-06-19
ES542829A0 (es) 1986-06-01
ES533053A0 (es) 1985-06-16
FI833681A0 (fi) 1983-10-10
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DK481383A (da) 1984-04-20
EP0109748A1 (en) 1984-05-30
NO833793L (no) 1984-04-24
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EP0109748B1 (en) 1988-04-13
IE832380L (en) 1984-04-19
EP0192811B1 (en) 1991-03-06
ES8608043A1 (es) 1986-06-01
DE3382528D1 (de) 1992-04-16
ATE46539T1 (de) 1989-10-15
KR840006369A (ko) 1984-11-29
NL960013I1 (nl) 1996-10-01

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