ES2094111T3 - Proteinas con actividad de factor viii, procedimiento para su produccion que utilizan celulas modificadas por ingenieria genetica y composiciones farmaceuticas que las contienen. - Google Patents

Proteinas con actividad de factor viii, procedimiento para su produccion que utilizan celulas modificadas por ingenieria genetica y composiciones farmaceuticas que las contienen.

Info

Publication number
ES2094111T3
ES2094111T3 ES88201209T ES88201209T ES2094111T3 ES 2094111 T3 ES2094111 T3 ES 2094111T3 ES 88201209 T ES88201209 T ES 88201209T ES 88201209 T ES88201209 T ES 88201209T ES 2094111 T3 ES2094111 T3 ES 2094111T3
Authority
ES
Spain
Prior art keywords
factor viii
activity
proteins
procedure
contain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88201209T
Other languages
English (en)
Inventor
Ooyen Albert Johannes Jose Van
Hans Pannekoek
Martinus Philippus Verbeet
Leen Robert Willem Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oesterreichisches Institut fuer Haemoderivate
Original Assignee
Immuno AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immuno AG filed Critical Immuno AG
Application granted granted Critical
Publication of ES2094111T3 publication Critical patent/ES2094111T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y10S530/83—Plasma; serum

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

SE DAN NUEVOS POLIPEPTIDOS DE ACTIVIDAD DE FACTOR VIII ASI COMO COMPOSICIONES Y METODOS PARA SU PREPARACION. LOS POLIPEPTIDOS COMPRENDEN DERIVADOS Y FRAGMENTOS DE FACTOS VIII Y TIENEN SECUENCIAS SUSTANCIALMENTE SIMILARES A PORCIONES DE FACTOR VIII NATURALMENTE PRESENTE. LOS POLIPEPTIDOS SON UTILES EN EL TRATAMIENTO DE LA HEMOPHILIA A.
ES88201209T 1987-06-12 1988-06-13 Proteinas con actividad de factor viii, procedimiento para su produccion que utilizan celulas modificadas por ingenieria genetica y composiciones farmaceuticas que las contienen. Expired - Lifetime ES2094111T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP87201121 1987-06-12

Publications (1)

Publication Number Publication Date
ES2094111T3 true ES2094111T3 (es) 1997-01-16

Family

ID=8197627

Family Applications (2)

Application Number Title Priority Date Filing Date
ES95110468T Expired - Lifetime ES2169095T3 (es) 1987-06-12 1988-06-13 Proteinas con actividad de factor viii, procedimiento para su produccion utilizando celulas modificadas por ingenieria genetica y composiciones farmaceuticas que los contienen.
ES88201209T Expired - Lifetime ES2094111T3 (es) 1987-06-12 1988-06-13 Proteinas con actividad de factor viii, procedimiento para su produccion que utilizan celulas modificadas por ingenieria genetica y composiciones farmaceuticas que las contienen.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES95110468T Expired - Lifetime ES2169095T3 (es) 1987-06-12 1988-06-13 Proteinas con actividad de factor viii, procedimiento para su produccion utilizando celulas modificadas por ingenieria genetica y composiciones farmaceuticas que los contienen.

Country Status (19)

Country Link
US (2) US5171844A (es)
JP (1) JP2771827B2 (es)
KR (1) KR970002915B1 (es)
CN (1) CN1033760C (es)
AT (2) ATE209679T1 (es)
CA (1) CA1341208C (es)
DE (2) DE3856505T2 (es)
DK (1) DK172631B1 (es)
ES (2) ES2169095T3 (es)
FI (1) FI103731B (es)
GR (1) GR3021545T3 (es)
HU (2) HU213300B (es)
IE (1) IE69026B1 (es)
IL (1) IL86693A (es)
NO (1) NO301121B1 (es)
NZ (1) NZ224992A (es)
PT (1) PT87721B (es)
WO (1) WO1988009813A1 (es)
ZA (1) ZA884216B (es)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
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US6060447A (en) * 1987-05-19 2000-05-09 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
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US20060122376A1 (en) * 1991-02-07 2006-06-08 Chiron Corporation Protein complexes having factor VIII:C activity and production thereof
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US5576291A (en) * 1993-09-13 1996-11-19 Baxter International Inc. Activated factor VIII as a therapeutic agent and method of treating factor VIII deficiency
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PT87721A (pt) 1988-07-01
JPH02500484A (ja) 1990-02-22
ATE209679T1 (de) 2001-12-15
CN1030609A (zh) 1989-01-25
NO890587D0 (no) 1989-02-10
IL86693A0 (en) 1988-11-30
ZA884216B (en) 1989-02-22
HU213300B (en) 1997-05-28
US5171844A (en) 1992-12-15
ATE142691T1 (de) 1996-09-15
NZ224992A (en) 1991-07-26
CA1341208C (en) 2001-03-27
IL86693A (en) 1994-06-24
NO890587L (no) 1989-02-10
DE3855523D1 (de) 1996-10-17
DE3856505T2 (de) 2002-08-08
DK58789D0 (da) 1989-02-09
KR890701739A (ko) 1989-12-21
DK58789A (da) 1989-02-09
PT87721B (pt) 1992-10-30
US6316226B1 (en) 2001-11-13
DE3856505D1 (de) 2002-01-10
FI103731B1 (fi) 1999-08-31
ES2169095T3 (es) 2002-07-01
JP2771827B2 (ja) 1998-07-02
NO301121B1 (no) 1997-09-15
IE69026B1 (en) 1996-08-07
DE3855523T2 (de) 1997-02-06
CN1033760C (zh) 1997-01-08
FI103731B (fi) 1999-08-31
GR3021545T3 (en) 1997-02-28
WO1988009813A1 (en) 1988-12-15
IE881755L (en) 1988-12-12
FI890643A (fi) 1989-02-10
FI890643A0 (fi) 1989-02-10
DK172631B1 (da) 1999-03-22
KR970002915B1 (ko) 1997-03-12
HU211503A9 (en) 1995-11-28

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