DK58789A - Proteiner med faktor viii-aktivitet, fremgangsmaade til deres fremstilling ved anvendelse af genetisk konstruerede celler og farmaceutiske kompositioner indeholdende proteinerne - Google Patents
Proteiner med faktor viii-aktivitet, fremgangsmaade til deres fremstilling ved anvendelse af genetisk konstruerede celler og farmaceutiske kompositioner indeholdende proteinerneInfo
- Publication number
- DK58789A DK58789A DK058789A DK58789A DK58789A DK 58789 A DK58789 A DK 58789A DK 058789 A DK058789 A DK 058789A DK 58789 A DK58789 A DK 58789A DK 58789 A DK58789 A DK 58789A
- Authority
- DK
- Denmark
- Prior art keywords
- proteins
- factor viii
- preparation
- procedure
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
- Y10S530/83—Plasma; serum
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP87201121 | 1987-06-12 | ||
EP87201121 | 1987-06-12 | ||
NL8800028 | 1988-06-13 | ||
PCT/NL1988/000028 WO1988009813A1 (en) | 1987-06-12 | 1988-06-13 | Novel proteins with factor viii activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them |
Publications (3)
Publication Number | Publication Date |
---|---|
DK58789D0 DK58789D0 (da) | 1989-02-09 |
DK58789A true DK58789A (da) | 1989-02-09 |
DK172631B1 DK172631B1 (da) | 1999-03-22 |
Family
ID=8197627
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK198900587A DK172631B1 (da) | 1987-06-12 | 1989-02-09 | Proteiner med Faktor VIII-aktivitet, fremgangsmåde til deres fremstilling ved anvendelse af genetisk konstruerede celler og |
Country Status (19)
Country | Link |
---|---|
US (2) | US5171844A (da) |
JP (1) | JP2771827B2 (da) |
KR (1) | KR970002915B1 (da) |
CN (1) | CN1033760C (da) |
AT (2) | ATE142691T1 (da) |
CA (1) | CA1341208C (da) |
DE (2) | DE3855523T2 (da) |
DK (1) | DK172631B1 (da) |
ES (2) | ES2169095T3 (da) |
FI (1) | FI103731B (da) |
GR (1) | GR3021545T3 (da) |
HU (2) | HU213300B (da) |
IE (1) | IE69026B1 (da) |
IL (1) | IL86693A (da) |
NO (1) | NO301121B1 (da) |
NZ (1) | NZ224992A (da) |
PT (1) | PT87721B (da) |
WO (1) | WO1988009813A1 (da) |
ZA (1) | ZA884216B (da) |
Families Citing this family (93)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5595886A (en) | 1986-01-27 | 1997-01-21 | Chiron Corporation | Protein complexes having Factor VIII:C activity and production thereof |
US5422260A (en) * | 1986-05-29 | 1995-06-06 | Genetics Institute, Inc. -Legal Affairs | Human factor VIII:c muteins |
US6060447A (en) * | 1987-05-19 | 2000-05-09 | Chiron Corporation | Protein complexes having Factor VIII:C activity and production thereof |
JPH0387173A (ja) * | 1987-09-10 | 1991-04-11 | Teijin Ltd | ヒト活性化天然型ファクター8cの製造方法及びそれに用いる形質転換体 |
FR2657884B1 (fr) * | 1990-02-05 | 1994-09-02 | Tm Innovation | Procede pour la preparation du facteur viii humain et d'analogues du facteur viii. |
JPH06503710A (ja) * | 1990-09-14 | 1994-04-28 | カイロン コーポレイション | 酵母細胞におけるマクロファージ誘導タンパク質(mip)の発現 |
US20060122376A1 (en) * | 1991-02-07 | 2006-06-08 | Chiron Corporation | Protein complexes having factor VIII:C activity and production thereof |
US5888974A (en) * | 1992-04-07 | 1999-03-30 | Emory University | Hybrid human/animal factor VIII |
US5859204A (en) * | 1992-04-07 | 1999-01-12 | Emory University | Modified factor VIII |
SE504074C2 (sv) * | 1993-07-05 | 1996-11-04 | Pharmacia Ab | Proteinberedning för subkutan, intramuskulär eller intradermal administrering |
US5576291A (en) * | 1993-09-13 | 1996-11-19 | Baxter International Inc. | Activated factor VIII as a therapeutic agent and method of treating factor VIII deficiency |
AT403167B (de) * | 1994-11-14 | 1997-11-25 | Immuno Ag | Selektion und expression von fremdproteinen mittels eines selektions-amplifikations-systems |
US5641655A (en) * | 1994-11-30 | 1997-06-24 | Zymogenetics, Inc. | Methods for producing thrombopoietin polypeptides using a mammalian tissue plasminogen activator secretory peptide |
AU5989796A (en) * | 1995-06-06 | 1996-12-24 | Board Of Regents Of The University Of Nebraska, by and on behalf of The University Of Nebraska Medical Center, The | Organ function replacement compositions and methods of makin g and using the same |
US7560107B2 (en) * | 1996-06-26 | 2009-07-14 | Emory University | Modified factor VIII |
AU735763B2 (en) | 1997-12-05 | 2001-07-12 | Immune Response Corporation, The | Novel vectors and genes exhibiting increased expression |
US6221349B1 (en) | 1998-10-20 | 2001-04-24 | Avigen, Inc. | Adeno-associated vectors for expression of factor VIII by target cells |
US6200560B1 (en) * | 1998-10-20 | 2001-03-13 | Avigen, Inc. | Adeno-associated virus vectors for expression of factor VIII by target cells |
US6358703B1 (en) | 1998-12-10 | 2002-03-19 | Bayer Corporation | Expression system for factor VIII |
EP1325681A1 (en) * | 2001-12-11 | 2003-07-09 | Société des Produits Nestlé S.A. | Composition for promotion of bone growth and maintenance of bone health |
WO2003100053A1 (en) * | 2002-05-22 | 2003-12-04 | The Children's Hospital Of Philadelphia | Compositions and methods for the treatment of hemophilia a |
TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
WO2005033321A2 (en) | 2003-09-30 | 2005-04-14 | The Trustees Of The University Of Pennsylvania | Adeno-associated virus (aav) clades, sequences, vectors containing same, and uses therefor |
US7566701B2 (en) | 2004-09-07 | 2009-07-28 | Archemix Corp. | Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics |
CA2578046A1 (en) | 2004-09-07 | 2006-03-16 | Archemix Corp. | Aptamer medicinal chemistry |
CA2579374A1 (en) | 2004-09-07 | 2006-03-30 | Archemix Corp. | Aptamers to von willebrand factor and their use as thrombotic disease therapeutics |
DK1824988T3 (da) | 2004-11-12 | 2017-08-07 | Bayer Healthcare Llc | Stedspecifik modificering af fviii |
CN102994549B (zh) | 2005-04-07 | 2015-02-11 | 宾夕法尼亚大学托管会 | 增强腺相关病毒载体功能的方法 |
US7855279B2 (en) | 2005-09-27 | 2010-12-21 | Amunix Operating, Inc. | Unstructured recombinant polymers and uses thereof |
US9359629B2 (en) | 2007-12-27 | 2016-06-07 | Baxalta Incorporated | Cell culture processes |
JP5624891B2 (ja) * | 2007-12-31 | 2014-11-12 | バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated | ヒト血液凝固因子を発現するトランスジェニック非ヒト動物 |
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US9315825B2 (en) | 2010-03-29 | 2016-04-19 | The Trustees Of The University Of Pennsylvania | Pharmacologically induced transgene ablation system |
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CA2826316C (en) | 2011-02-17 | 2021-04-27 | The Trustees Of The University Of Pennsylvania | Compositions and methods for altering tissue specificity and improving aav9-mediated gene transfer |
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CN104427995A (zh) | 2012-06-08 | 2015-03-18 | 比奥根艾迪克Ma公司 | 嵌合凝血因子 |
CN104519897A (zh) | 2012-06-08 | 2015-04-15 | 比奥根艾迪克Ma公司 | 促凝血化合物 |
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EA029685B1 (ru) | 2012-07-11 | 2018-04-30 | Амуникс Оперэйтинг Инк. | Комплекс фактора viii с xten и белком фактора фон виллебранда и его применение (варианты) |
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HUE063051T2 (hu) | 2013-02-15 | 2023-12-28 | Bioverativ Therapeutics Inc | Optimalizált VIII. faktor gén |
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TWI629993B (zh) | 2013-03-15 | 2018-07-21 | 美商生物化學醫療公司 | 因子viii多肽調配物 |
US9719106B2 (en) | 2013-04-29 | 2017-08-01 | The Trustees Of The University Of Pennsylvania | Tissue preferential codon modified expression cassettes, vectors containing same, and uses thereof |
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EP3283126B1 (en) | 2015-04-16 | 2019-11-06 | Emory University | Recombinant promoters and vectors for protein expression in liver and use thereof |
TWI741992B (zh) | 2015-08-03 | 2021-10-11 | 美商百歐維拉提夫治療公司 | 因子ix融合蛋白以及其製備及使用方法 |
CN116479001A (zh) | 2015-11-13 | 2023-07-25 | 武田药品工业株式会社 | 用于血友病a的基因治疗的具有增加的表达的编码重组fviii变体的病毒载体 |
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CN109790529A (zh) | 2016-06-24 | 2019-05-21 | 财团法人牧岩生命科学研究所 | 包含FVIII和vWF因子的嵌合蛋白及其用途 |
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CA3188420A1 (en) | 2020-08-07 | 2022-02-10 | Joseph Bauman | Vesicle targeting proteins and uses of same |
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AR126846A1 (es) | 2021-08-23 | 2023-11-22 | Bioverativ Therapeutics Inc | Genes del factor viii optimizados |
CN118019758A (zh) | 2021-09-30 | 2024-05-10 | 比奥维拉迪维治疗股份有限公司 | 编码免疫原性降低的因子viii多肽的核酸 |
WO2024081309A1 (en) | 2022-10-11 | 2024-04-18 | Sigilon Therapeutics, Inc. | Engineered cells and implantable elements for treatment of disease |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4886876A (en) | 1983-03-31 | 1989-12-12 | Scripps Clinic And Research Foundation | Factor VIII coagulant polypeptides |
US4657894A (en) | 1983-03-31 | 1987-04-14 | Scripps Clinic & Research Foundation | New factor VIII coagulant polypeptides |
US4857635A (en) | 1983-03-31 | 1989-08-15 | Scripps Clinic And Research Foundation | Factor VIII coagulant polypeptides and monoclonal antibodies tof them |
US5004804A (en) * | 1984-01-12 | 1991-04-02 | Nordisk Gentofte | Method and composition for preparation of factor VIIIC |
US4965199A (en) * | 1984-04-20 | 1990-10-23 | Genentech, Inc. | Preparation of functional human factor VIII in mammalian cells using methotrexate based selection |
IL74909A (en) * | 1984-04-20 | 1992-01-15 | Genentech Inc | Preparation of functional human factor viii and dna sequences,expression vectors,transformed microorganisms and cell lines used therein |
SE8501050D0 (sv) | 1985-03-05 | 1985-03-05 | Kabivitrum Ab | Biologically active fragments of human antihemophilic factor and method for preparation thereof |
ES8801674A1 (es) * | 1985-04-12 | 1988-02-16 | Genetics Inst | Un procedimiento para la preparacion de una proteina que presenta actividad procoagulante. |
US4769336A (en) | 1985-05-24 | 1988-09-06 | Scripps Clinic And Research Foundation | Treatment of factor VIII inhibitors |
KR910006424B1 (ko) * | 1985-08-21 | 1991-08-24 | 인코텍스 비.브이 | 편성브리프(brief) 제조방법 |
FI98829C (fi) * | 1986-01-27 | 1997-08-25 | Chiron Corp | Menetelmä rekombinoidun proteiinikompleksin valmistamiseksi, jolla on humaanitekijä VIII:C-aktiivisuutta |
US5595886A (en) | 1986-01-27 | 1997-01-21 | Chiron Corporation | Protein complexes having Factor VIII:C activity and production thereof |
US5451521A (en) | 1986-05-29 | 1995-09-19 | Genetics Institute, Inc. | Procoagulant proteins |
US5422260A (en) | 1986-05-29 | 1995-06-06 | Genetics Institute, Inc. -Legal Affairs | Human factor VIII:c muteins |
EP0251843A1 (fr) | 1986-06-06 | 1988-01-07 | Transgene S.A. | Procédé de préparation de facteur VIII à partir de cellules de mammifères |
US5543502A (en) | 1986-06-24 | 1996-08-06 | Novo Nordisk A/S | Process for producing a coagulation active complex of factor VIII fragments |
IL83192A (en) * | 1986-07-18 | 1992-11-15 | Gist Brocades Nv | Method for the preparation of proteins with factor viii activity by microbial host cells;expression vectors,host cells,antibodies |
IL84168A0 (en) * | 1986-10-15 | 1988-03-31 | Rorer Int Overseas | Human factor viii-c analogs,process for the preparation thereof and pharmaceutical compositions containing the same |
US4980456A (en) * | 1987-04-06 | 1990-12-25 | Scripps Clinic And Research Foundation | Recombinant factor VIIIC derived fragments |
FR2619314B1 (fr) | 1987-08-11 | 1990-06-15 | Transgene Sa | Analogue du facteur viii, procede de preparation et composition pharmaceutique le contenant |
JPH025890A (ja) | 1988-06-24 | 1990-01-10 | Chemo Sero Therapeut Res Inst | ニワトリのβ−アクチンプロモーターを用いたヒトファクター8Cの製造方法 |
SE465222C5 (sv) | 1989-12-15 | 1998-02-10 | Pharmacia & Upjohn Ab | Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning |
-
1988
- 1988-06-10 IE IE175588A patent/IE69026B1/en not_active IP Right Cessation
- 1988-06-10 US US07/205,226 patent/US5171844A/en not_active Expired - Lifetime
- 1988-06-10 IL IL8669388A patent/IL86693A/en not_active IP Right Cessation
- 1988-06-11 CN CN88103482A patent/CN1033760C/zh not_active Expired - Fee Related
- 1988-06-13 CA CA000569359A patent/CA1341208C/en not_active Expired - Lifetime
- 1988-06-13 WO PCT/NL1988/000028 patent/WO1988009813A1/en active IP Right Grant
- 1988-06-13 DE DE3855523T patent/DE3855523T2/de not_active Expired - Fee Related
- 1988-06-13 AT AT88201209T patent/ATE142691T1/de not_active IP Right Cessation
- 1988-06-13 KR KR1019890700238A patent/KR970002915B1/ko not_active IP Right Cessation
- 1988-06-13 ES ES95110468T patent/ES2169095T3/es not_active Expired - Lifetime
- 1988-06-13 ZA ZA884216A patent/ZA884216B/xx unknown
- 1988-06-13 NZ NZ224992A patent/NZ224992A/xx unknown
- 1988-06-13 HU HU883818A patent/HU213300B/hu not_active IP Right Cessation
- 1988-06-13 DE DE3856505T patent/DE3856505T2/de not_active Expired - Fee Related
- 1988-06-13 JP JP63504632A patent/JP2771827B2/ja not_active Expired - Fee Related
- 1988-06-13 ES ES88201209T patent/ES2094111T3/es not_active Expired - Lifetime
- 1988-06-13 AT AT95110468T patent/ATE209679T1/de not_active IP Right Cessation
- 1988-06-14 PT PT87721A patent/PT87721B/pt not_active IP Right Cessation
-
1989
- 1989-02-09 DK DK198900587A patent/DK172631B1/da not_active IP Right Cessation
- 1989-02-10 FI FI890643A patent/FI103731B/fi not_active IP Right Cessation
- 1989-02-10 NO NO890587A patent/NO301121B1/no not_active IP Right Cessation
-
1995
- 1995-04-03 US US08/416,532 patent/US6316226B1/en not_active Expired - Lifetime
- 1995-07-04 HU HU95P/P00758P patent/HU211503A9/hu unknown
-
1996
- 1996-11-06 GR GR960402919T patent/GR3021545T3/el unknown
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