ATE61407T1 - Muteine biologisch aktiver proteine mit verringertem cysteingehalt, ihre herstellung, formulierungen, die solche muteine enthalten sowie strukturgene, vektoren und organismen, die zur herstellung der genannten muteine geeignet sind und deren herstellung. - Google Patents
Muteine biologisch aktiver proteine mit verringertem cysteingehalt, ihre herstellung, formulierungen, die solche muteine enthalten sowie strukturgene, vektoren und organismen, die zur herstellung der genannten muteine geeignet sind und deren herstellung.Info
- Publication number
- ATE61407T1 ATE61407T1 AT85109295T AT85109295T ATE61407T1 AT E61407 T1 ATE61407 T1 AT E61407T1 AT 85109295 T AT85109295 T AT 85109295T AT 85109295 T AT85109295 T AT 85109295T AT E61407 T1 ATE61407 T1 AT E61407T1
- Authority
- AT
- Austria
- Prior art keywords
- muteins
- production
- biologically active
- vectors
- formulations containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/565—IFN-beta
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
- Y10S530/809—Fused cells, e.g. hybridoma
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/14—Lymphokine; related peptides
- Y10S930/141—Interleukin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/14—Lymphokine; related peptides
- Y10S930/142—Interferon
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43515482A | 1982-10-19 | 1982-10-19 | |
US48616283A | 1983-04-15 | 1983-04-15 | |
EP85109295A EP0192811B1 (de) | 1982-10-19 | 1983-10-13 | Muteine biologisch aktiver Proteine mit verringertem Cysteingehalt, ihre Herstellung, Formulierungen, die solche Muteine enthalten sowie Strukturgene, Vektoren und Organismen, die zur Herstellung der genannten Muteine geeignet sind und deren Herstellung |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE61407T1 true ATE61407T1 (de) | 1991-03-15 |
Family
ID=27030446
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT83306221T ATE33503T1 (de) | 1982-10-19 | 1983-10-13 | Pharmazeutische und tiermedizinische praeparate von interleukin-2, in dem cystein-125 ausgetauscht worden ist (muteine), sowie deren herstellung. |
AT85109295T ATE61407T1 (de) | 1982-10-19 | 1983-10-13 | Muteine biologisch aktiver proteine mit verringertem cysteingehalt, ihre herstellung, formulierungen, die solche muteine enthalten sowie strukturgene, vektoren und organismen, die zur herstellung der genannten muteine geeignet sind und deren herstellung. |
AT86110595T ATE46539T1 (de) | 1982-10-19 | 1983-10-13 | Cystein-verminderte muteine von interferon-beta, ihre herstellung, zusammensetzungen, die diese muteine enthalten sowie strukturgene, vektoren und organismen geeignet zur verwendung bei der herstellung der genannten muteine und deren herstellung. |
AT87103350T ATE73493T1 (de) | 1982-10-19 | 1983-10-13 | Cysteinverminderte muteine von interleukin-2, ihre herstellung, zusammensetzungen, die diese muteine enthalten sowie gene, vektoren und organismen, geeignet zur verwendung bei der herstellung der genannten muteine. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT83306221T ATE33503T1 (de) | 1982-10-19 | 1983-10-13 | Pharmazeutische und tiermedizinische praeparate von interleukin-2, in dem cystein-125 ausgetauscht worden ist (muteine), sowie deren herstellung. |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT86110595T ATE46539T1 (de) | 1982-10-19 | 1983-10-13 | Cystein-verminderte muteine von interferon-beta, ihre herstellung, zusammensetzungen, die diese muteine enthalten sowie strukturgene, vektoren und organismen geeignet zur verwendung bei der herstellung der genannten muteine und deren herstellung. |
AT87103350T ATE73493T1 (de) | 1982-10-19 | 1983-10-13 | Cysteinverminderte muteine von interleukin-2, ihre herstellung, zusammensetzungen, die diese muteine enthalten sowie gene, vektoren und organismen, geeignet zur verwendung bei der herstellung der genannten muteine. |
Country Status (23)
Country | Link |
---|---|
EP (4) | EP0218825B1 (de) |
JP (2) | JPS6128392A (de) |
KR (1) | KR910009900B1 (de) |
AT (4) | ATE33503T1 (de) |
AU (1) | AU563962B2 (de) |
BE (1) | BE898016A (de) |
CA (1) | CA1340861C (de) |
CH (1) | CH669395A5 (de) |
DE (4) | DE3382197D1 (de) |
DK (2) | DK168767B1 (de) |
ES (4) | ES8505717A1 (de) |
FI (1) | FI82266C (de) |
FR (1) | FR2534594B1 (de) |
GB (1) | GB2130219B (de) |
GR (1) | GR79408B (de) |
IE (1) | IE56026B1 (de) |
IL (1) | IL69970A (de) |
LU (3) | LU88761I2 (de) |
NL (2) | NL930119I2 (de) |
NO (1) | NO173740C (de) |
NZ (1) | NZ205922A (de) |
PH (2) | PH20343A (de) |
PT (1) | PT77512B (de) |
Families Citing this family (117)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE56026B1 (en) * | 1982-10-19 | 1991-03-27 | Cetus Corp | Cysteine-depleted muteins of biologically active proteins |
IL71951A0 (en) * | 1983-06-01 | 1984-09-30 | Hoffmann La Roche | Polypeptides having interferon activity,their preparation and pharmaceutical compositions containing them |
WO1985000817A1 (en) * | 1983-08-10 | 1985-02-28 | Amgen | Microbial expression of interleukin ii |
GB8334102D0 (en) * | 1983-12-21 | 1984-02-01 | Searle & Co | Interferons with cysteine pattern |
US4530787A (en) * | 1984-03-28 | 1985-07-23 | Cetus Corporation | Controlled oxidation of microbially produced cysteine-containing proteins |
WO1985004328A1 (en) | 1984-03-28 | 1985-10-10 | Cetus Corporation | Pharmaceutical compositions of microbially produced interleukin-2 |
ATE48641T1 (de) * | 1984-05-08 | 1989-12-15 | Genetics Inst | Ein menschlicher t-zellwachstumsfaktor. |
GB8412564D0 (en) * | 1984-05-17 | 1984-06-20 | Searle & Co | Structure and properties |
IL75318A (en) * | 1984-05-31 | 1994-08-26 | Genentech Inc | Recombinant human memotoxin and methods for its recombinant production |
US5683688A (en) * | 1984-05-31 | 1997-11-04 | Genentech, Inc. | Unglycosylated recombinant human lymphotoxin polypeptides and compositions |
US5672347A (en) * | 1984-07-05 | 1997-09-30 | Genentech, Inc. | Tumor necrosis factor antagonists and their use |
CA1275954C (en) | 1984-08-31 | 1990-11-06 | Hing Cheug Wong | 3'-expression enhancing fragments and method |
WO1986002068A1 (en) * | 1984-09-26 | 1986-04-10 | Takeda Chemical Industries, Ltd. | Mutual separation of proteins |
IL76360A0 (en) | 1984-09-26 | 1986-01-31 | Takeda Chemical Industries Ltd | Mutual separation of proteins |
US4606917A (en) * | 1984-10-03 | 1986-08-19 | Syntex (U.S.A) Inc. | Synergistic antiviral composition |
US4857316A (en) * | 1984-10-03 | 1989-08-15 | Syntex (U.S.A.) Inc. | Synergistic antiviral composition |
US4959314A (en) | 1984-11-09 | 1990-09-25 | Cetus Corporation | Cysteine-depleted muteins of biologically active proteins |
US4572798A (en) * | 1984-12-06 | 1986-02-25 | Cetus Corporation | Method for promoting disulfide bond formation in recombinant proteins |
US5342614A (en) * | 1984-12-21 | 1994-08-30 | Otsuka Pharmaceutical Co., Ltd. | Method of treating arthritus or inflammation with IL-1β or derivatives thereof |
US6107465A (en) * | 1984-12-21 | 2000-08-22 | Otsuka Pharmaceutical Co., Ltd. | IL-1β and derivatives thereof and drugs |
DK172052B1 (da) * | 1984-12-21 | 1997-09-29 | Otsuka Pharma Co Ltd | Antitumor-aktivt stof, fremgangsmåde til dets fremstilling, lægemiddel indeholdende stoffet, gen kodende for stoffet, vektor indeholdende genet samt rekombinant mikroorganisme transformet med en sådan vektor |
DE3500681A1 (de) * | 1985-01-11 | 1986-07-17 | Hoechst Ag, 6230 Frankfurt | Verfahren zur isolierung und reinigung von lymphokinen |
US4863849A (en) * | 1985-07-18 | 1989-09-05 | New York Medical College | Automatable process for sequencing nucleotide |
US4810643A (en) * | 1985-08-23 | 1989-03-07 | Kirin- Amgen Inc. | Production of pluripotent granulocyte colony-stimulating factor |
US6004548A (en) | 1985-08-23 | 1999-12-21 | Amgen, Inc. | Analogs of pluripotent granulocyte colony-stimulating factor |
WO1989000198A1 (en) * | 1987-07-07 | 1989-01-12 | Biotechnology Research Associates, J.V. | Recombinant fibroblast growth factors |
CA1297003C (en) * | 1985-09-20 | 1992-03-10 | Jack H. Nunberg | Composition and method for treating animals |
US5359035A (en) * | 1985-12-21 | 1994-10-25 | Hoechst Aktiengesellschaft | Bifunctional proteins including interleukin-2 (IL-2) and granuloctyte macrophage colony stimulating factor (GM-CSF) |
US5008374A (en) * | 1986-03-14 | 1991-04-16 | Otsuka Pharmaceutical Co., Ltd. | IL-1α derivatives and drugs |
AU595864B2 (en) * | 1986-03-14 | 1990-04-12 | Otsuka Pharmaceutical Co., Ltd. | Il-1 alpha derivatives and drugs |
ATE72582T1 (de) * | 1986-09-05 | 1992-02-15 | Cetus Corp | Oxidationsresistente muteine von beta-interferon, deren herstellung und diese muteine enthaltende praeparate. |
JP2526965B2 (ja) * | 1987-02-24 | 1996-08-21 | 武田薬品工業株式会社 | ムテイン,dnaおよびその用途 |
DK175535B1 (da) * | 1987-03-04 | 2004-11-29 | Daiichi Suntory Pharma Co Ltd | Fremgangsmåde til fremstilling af et fysiologisk aktivt cysteinholdigt peptid |
JP2602968B2 (ja) * | 1987-11-04 | 1997-04-23 | カリフォルニア バイオテクノロジー インコーポレイテッド | 肺胞の界面活性タンパク類 |
DE68929273T2 (de) * | 1988-08-24 | 2001-07-05 | American Cyanamid Co | Stabilisierung von Somatotropinen durch Modifikation von Cystein-Resten durch orts-spezifische Mutagenese oder chemische Derivatisierung |
US5079230A (en) * | 1988-09-12 | 1992-01-07 | Pitman-Moore, Inc. | Stable bioactive somatotropins |
CA2003886A1 (en) * | 1988-12-16 | 1990-06-16 | Anthony F. Purchio | Cloning and expression of simian transforming growth factor-beta 1 |
AU620673B2 (en) * | 1989-01-31 | 1992-02-20 | Pharmacia & Upjohn Company | Somatotropin analogs |
DK0383599T3 (da) * | 1989-02-17 | 1996-08-05 | Merck & Co Inc | Protein-anticancermiddel |
US5621078A (en) * | 1989-03-22 | 1997-04-15 | Merck & Co., Inc. | Modified pseudomonas exotoxin PE40 |
WO1990012877A1 (en) * | 1989-04-19 | 1990-11-01 | Cetus Corporation | Multifunctional m-csf proteins and genes encoding therefor |
US6207798B1 (en) | 1989-08-03 | 2001-03-27 | Merck & Co., Inc. | Modified PE40 toxin fusion proteins |
US5173297A (en) * | 1991-07-01 | 1992-12-22 | Quest International Flavors & Food Ingredients Company Division Of Indopco, Inc. | Bacteriocin from lactococcus lactis subspecies lactis |
IL98528A0 (en) * | 1990-06-21 | 1992-07-15 | Merck & Co Inc | Pharmaceutical compositions containing hybrid for killing bladder cancer cells |
FR2671554A1 (fr) * | 1991-01-11 | 1992-07-17 | Clonatec Sa | Peptides synthetiques derivant de l'antigene hbc du virus de l'hepatite b, leurs applications a la detection d'une infection par ce virus et a la vaccination contre l'hepatite b. |
US5545723A (en) * | 1994-03-15 | 1996-08-13 | Biogen Inc. | Muteins of IFN-β |
US5814485A (en) * | 1995-06-06 | 1998-09-29 | Chiron Corporation | Production of interferon-β (IFN-β) in E. coli |
DE19544167A1 (de) * | 1995-11-17 | 1997-05-22 | Schering Ag | Verwendung von Interferon-ß zur Behandlung von Bronchialkarzinom bei Bestrahlungstherapie |
AU6399996A (en) * | 1996-06-19 | 1998-01-07 | Chiron Corporation | Bacterial production of interferon-beta using low levels of sodium and potassium ions |
CN1100875C (zh) * | 1998-03-06 | 2003-02-05 | 上海华晨生物技术研究所 | 新型重组人白细胞介素2的制备方法及其表达载体和工程菌 |
JP2003530838A (ja) | 2000-04-12 | 2003-10-21 | ヒューマン ゲノム サイエンシズ インコーポレイテッド | アルブミン融合タンパク質 |
EP1935431A3 (de) | 2000-05-15 | 2008-08-13 | Health Research, Inc. | Krebsbehandlungen unter Verwendung einer Kombination aus einem HER2-Antikörper und Interleukin-2 |
DE10112825A1 (de) | 2001-03-16 | 2002-10-02 | Fresenius Kabi De Gmbh | HESylierung von Wirkstoffen in wässriger Lösung |
US6887462B2 (en) | 2001-04-09 | 2005-05-03 | Chiron Corporation | HSA-free formulations of interferon-beta |
US20030082138A1 (en) * | 2001-09-18 | 2003-05-01 | Chiron Corporation | Methods for treating multiple sclerosis |
KR100511749B1 (ko) * | 2001-11-06 | 2005-09-02 | 선바이오(주) | 변형된 인터페론-베타, 및 이의 화학적으로 변형된 배합체 |
CA2471363C (en) | 2001-12-21 | 2014-02-11 | Human Genome Sciences, Inc. | Albumin fusion proteins |
DE10209822A1 (de) | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid |
DE10209821A1 (de) | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Kopplung von Proteinen an ein modifiziertes Polysaccharid |
CA2496317C (en) | 2002-09-11 | 2014-02-18 | Fresenius Kabi Deutschland Gmbh | Method of producing hydroxyalkyl starch derivatives |
AU2003273413A1 (en) | 2002-10-08 | 2004-05-04 | Fresenius Kabi Deutschland Gmbh | Pharmaceutically active oligosaccharide conjugates |
WO2005014655A2 (en) | 2003-08-08 | 2005-02-17 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyalkyl starch and a protein |
EP1682178B8 (de) | 2003-11-04 | 2010-09-01 | Novartis Vaccines and Diagnostics, Inc. | Verfahren zur behandlung von krebs mit expression des cd40-antigens |
WO2005091956A2 (en) * | 2004-03-05 | 2005-10-06 | Chiron Corporation | In vitro test system for predicting patient tolerability of therapeutic agents |
SG151261A1 (en) | 2004-03-11 | 2009-04-30 | Fresenius Kabi De Gmbh | Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination |
WO2006015165A2 (en) * | 2004-07-26 | 2006-02-09 | Enzon Pharmaceuticals, Inc. | Optimized interferon-beta gene |
GB0523282D0 (en) | 2005-11-15 | 2005-12-21 | Isis Innovation | Methods using pores |
GB2453377A (en) | 2007-10-05 | 2009-04-08 | Isis Innovation | Transmembrane protein pores and molecular adapters therefore. |
EP2070950A1 (de) | 2007-12-14 | 2009-06-17 | Fresenius Kabi Deutschland GmbH | Hydroxyalkylstärkederivate und deren Herstellungsverfahren |
ATE548052T1 (de) | 2008-01-17 | 2012-03-15 | Philogen Spa | Kombination aus einem anti-edb-fibronectin- antikörper-il-2-fusionsprotein und einem b-zellen bindenden molekül, b-zellen-vorläufern und/oder deren krebserregendem gegenspieler |
JP2011527191A (ja) | 2008-07-07 | 2011-10-27 | オックスフォード ナノポア テクノロジーズ リミテッド | 塩基検出細孔 |
CN103695530B (zh) | 2008-07-07 | 2016-05-25 | 牛津纳米孔技术有限公司 | 酶-孔构建体 |
US9077937B2 (en) * | 2008-11-06 | 2015-07-07 | Alcatel Lucent | Method and apparatus for fast channel change |
GB0820927D0 (en) | 2008-11-14 | 2008-12-24 | Isis Innovation | Method |
JP2012516145A (ja) | 2009-01-30 | 2012-07-19 | オックスフォード ナノポア テクノロジーズ リミテッド | ハイブリダイゼーションリンカー |
AU2010209528B2 (en) | 2009-01-30 | 2015-10-01 | Oxford Nanopore Technologies Limited | Adaptors for nucleic acid constructs in transmembrane sequencing |
GB0905140D0 (en) | 2009-03-25 | 2009-05-06 | Isis Innovation | Method |
US9751915B2 (en) | 2011-02-11 | 2017-09-05 | Oxford Nanopore Technologies Ltd. | Mutant pores |
PL2683395T3 (pl) | 2011-03-11 | 2019-04-30 | Assist Publique Hopitaux De Paris | Zastosowanie małych dawek il-2 do leczenia cukrzycy typu 1 |
AU2012288629B2 (en) | 2011-07-25 | 2017-02-02 | Oxford Nanopore Technologies Limited | Hairpin loop method for double strand polynucleotide sequencing using transmembrane pores |
GB201119244D0 (en) | 2011-11-08 | 2011-12-21 | British American Tobacco Co | Smoking article |
WO2013153359A1 (en) | 2012-04-10 | 2013-10-17 | Oxford Nanopore Technologies Limited | Mutant lysenin pores |
EP2875154B1 (de) | 2012-07-19 | 2017-08-23 | Oxford Nanopore Technologies Limited | SSB-Verfahren zur Charakterisierung einer Nukleinsäure |
GB201314695D0 (en) | 2013-08-16 | 2013-10-02 | Oxford Nanopore Tech Ltd | Method |
JP6408494B2 (ja) | 2013-03-08 | 2018-10-17 | オックスフォード ナノポール テクノロジーズ リミテッド | 酵素停止法 |
GB201313477D0 (en) | 2013-07-29 | 2013-09-11 | Univ Leuven Kath | Nanopore biosensors for detection of proteins and nucleic acids |
EP3013355B1 (de) | 2013-06-25 | 2019-08-07 | ICM - Institut du Cerveau et da la Moelle Epinière | Il-2 zur verwendung in der behandlung von alzheimer-krankheit und verwandten erkrankungen |
GB201403096D0 (en) | 2014-02-21 | 2014-04-09 | Oxford Nanopore Tech Ltd | Sample preparation method |
EP2918285A1 (de) | 2014-03-11 | 2015-09-16 | Université Pierre et Marie Curie (Paris 6) | Interleukin-2 zur Behandlung einer Lebensmittelallergie |
WO2015166276A1 (en) | 2014-05-02 | 2015-11-05 | Oxford Nanopore Technologies Limited | Method of improving the movement of a target polynucleotide with respect to a transmembrane pore |
WO2016034591A2 (en) | 2014-09-01 | 2016-03-10 | Vib Vzw | Mutant pores |
WO2016055778A1 (en) | 2014-10-07 | 2016-04-14 | Oxford Nanopore Technologies Limited | Mutant pores |
GB201418159D0 (en) | 2014-10-14 | 2014-11-26 | Oxford Nanopore Tech Ltd | Method |
US10801023B2 (en) * | 2015-04-24 | 2020-10-13 | University Of Florida Research Foundation, Inc. | Methods of identifying biologically active random peptides in plants and libraries of plants expressing candidate biologically active random peptides |
WO2016172445A2 (en) * | 2015-04-24 | 2016-10-27 | The University Of Florida Research Foundation, Inc. | Methods of identifying biologically active random peptides in plants and libraries of plants expressing candidate biologically active random peptides |
US10876109B2 (en) | 2015-04-24 | 2020-12-29 | University Of Florida Research Foundation, Inc. | Methods of identifying biologically active random peptides in prokaryotic cells and libraries of prokaryotic cells expressing candidate biologically active random peptides |
CA3001429C (en) | 2015-10-22 | 2023-07-11 | Iltoo Pharma | Pharmaceutical compositions of il-2 |
GB201609220D0 (en) | 2016-05-25 | 2016-07-06 | Oxford Nanopore Tech Ltd | Method |
JP7206190B2 (ja) | 2016-06-22 | 2023-01-17 | ダヴィド・クラッツマン | 遺伝的に修飾されたtリンパ球 |
AU2018234810B2 (en) | 2017-03-15 | 2023-05-11 | Pandion Operations, Inc. | Targeted immunotolerance |
SG11201909949XA (en) | 2017-05-24 | 2019-11-28 | Pandion Therapeutics Inc | Targeted immunotolerance |
US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
US10174092B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
US11534479B2 (en) | 2018-02-16 | 2022-12-27 | Iltoo Pharma | Use of interleukin 2 for treating Sjögren's syndrome |
GB201807793D0 (en) | 2018-05-14 | 2018-06-27 | Oxford Nanopore Tech Ltd | Method |
US20220403001A1 (en) | 2018-06-12 | 2022-12-22 | Obsidian Therapeutics, Inc. | Pde5 derived regulatory constructs and methods of use in immunotherapy |
WO2020007937A1 (en) | 2018-07-03 | 2020-01-09 | Iltoo Pharma | Use of interleukin-2 for treating systemic sclerosis |
EP3836954A1 (de) | 2018-08-13 | 2021-06-23 | Iltoo Pharma | Kombination von interleukin-2 mit einem interleukin-1-inhibitor, konjugate und therapeutische verwendungen davon |
EP3880838A4 (de) | 2018-11-15 | 2022-11-02 | The Board of Trustees of the Leland Stanford Junior University | Zusammensetzungen und verfahren zur prognose und klassifizierung von präeklampsie |
TW202110885A (zh) | 2019-05-20 | 2021-03-16 | 美商潘迪恩治療公司 | 靶向MAdCAM之免疫耐受性 |
WO2021116444A1 (en) | 2019-12-12 | 2021-06-17 | Iltoo Pharma | Interleukin 2 chimeric constructs |
EP4107187A1 (de) | 2020-02-21 | 2022-12-28 | Pandion Operations, Inc. | Gewebegezielte immuntoleranz mit einem cd39-effektor |
JP2023516774A (ja) | 2020-03-06 | 2023-04-20 | サントル、オスピタリエ、ユニヴェルシテール、ド、ニーム | 筋萎縮性側索硬化症の治療のための低用量ヒトインターロイキン-2 |
CN115989239A (zh) * | 2020-04-29 | 2023-04-18 | 瑷备恩有限公司 | 具有双重突变的人干扰素β变体和用于改善人干扰素β变体的稳定性的方法 |
WO2021221470A1 (ko) * | 2020-04-29 | 2021-11-04 | (주) 제노팜 | 인터페론-베타 변이체와 항체가 융합된 재조합 단백질 및 이를 포함하는 약학 조성물 |
AU2022360645A1 (en) | 2021-10-06 | 2024-05-02 | Assistance Publique - Hôpitaux De Paris | Interleukin 2 chimeric constructs with targeting specificity to inflamed tissues |
WO2024056154A1 (en) | 2022-09-12 | 2024-03-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Interleukin-2 for use in treating autism spectrum disorder |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5359688A (en) * | 1976-11-11 | 1978-05-29 | Tanpakushitsu Kenkiyuu Shiyour | Production of novel polypeptide |
US4399216A (en) * | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
ES500966A0 (es) * | 1980-04-03 | 1982-12-16 | Biogen Nv | Un metodo de producir un polipeptido que muestra una actividad immunologica obiologica de interferon de fibroblasto hu- mano. |
JPS58110548A (ja) * | 1981-12-24 | 1983-07-01 | Asahi Chem Ind Co Ltd | 新規な生理活性ペプチド |
US6936694B1 (en) * | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
IE56026B1 (en) * | 1982-10-19 | 1991-03-27 | Cetus Corp | Cysteine-depleted muteins of biologically active proteins |
IL71951A0 (en) * | 1983-06-01 | 1984-09-30 | Hoffmann La Roche | Polypeptides having interferon activity,their preparation and pharmaceutical compositions containing them |
WO1985000817A1 (en) * | 1983-08-10 | 1985-02-28 | Amgen | Microbial expression of interleukin ii |
US4959314A (en) * | 1984-11-09 | 1990-09-25 | Cetus Corporation | Cysteine-depleted muteins of biologically active proteins |
-
1983
- 1983-10-10 IE IE2380/83A patent/IE56026B1/en active Protection Beyond IP Right Term
- 1983-10-10 FI FI833681A patent/FI82266C/fi not_active IP Right Cessation
- 1983-10-11 NZ NZ205922A patent/NZ205922A/en unknown
- 1983-10-12 CA CA000438878A patent/CA1340861C/en not_active Expired - Lifetime
- 1983-10-12 PH PH29685A patent/PH20343A/en unknown
- 1983-10-12 AU AU20086/83A patent/AU563962B2/en not_active Expired
- 1983-10-13 AT AT83306221T patent/ATE33503T1/de not_active IP Right Cessation
- 1983-10-13 DE DE8585109295T patent/DE3382197D1/de not_active Expired - Lifetime
- 1983-10-13 AT AT85109295T patent/ATE61407T1/de not_active IP Right Cessation
- 1983-10-13 GB GB08327490A patent/GB2130219B/en not_active Expired
- 1983-10-13 DE DE8686110595T patent/DE3380598D1/de not_active Expired
- 1983-10-13 EP EP86110595A patent/EP0218825B1/de not_active Expired
- 1983-10-13 AT AT86110595T patent/ATE46539T1/de active
- 1983-10-13 AT AT87103350T patent/ATE73493T1/de not_active IP Right Cessation
- 1983-10-13 DE DE8787103350T patent/DE3382528D1/de not_active Expired - Lifetime
- 1983-10-13 EP EP87103350A patent/EP0234599B1/de not_active Expired - Lifetime
- 1983-10-13 EP EP85109295A patent/EP0192811B1/de not_active Expired - Lifetime
- 1983-10-13 EP EP83306221A patent/EP0109748B1/de not_active Expired
- 1983-10-13 DE DE8383306221T patent/DE3376271D1/de not_active Expired
- 1983-10-13 LU LU88761C patent/LU88761I2/fr unknown
- 1983-10-14 IL IL69970A patent/IL69970A/xx not_active IP Right Cessation
- 1983-10-17 PT PT77512A patent/PT77512B/pt unknown
- 1983-10-17 GR GR72712A patent/GR79408B/el unknown
- 1983-10-18 NO NO833793A patent/NO173740C/no not_active IP Right Cessation
- 1983-10-18 ES ES526541A patent/ES8505717A1/es not_active Expired
- 1983-10-18 KR KR1019830004927A patent/KR910009900B1/ko not_active IP Right Cessation
- 1983-10-18 BE BE0/211722A patent/BE898016A/fr not_active IP Right Cessation
- 1983-10-18 CH CH5667/83A patent/CH669395A5/fr not_active IP Right Cessation
- 1983-10-18 FR FR8316543A patent/FR2534594B1/fr not_active Expired
- 1983-10-19 DK DK481383A patent/DK168767B1/da not_active IP Right Cessation
-
1984
- 1984-06-01 ES ES533054A patent/ES533054A0/es active Granted
- 1984-06-01 ES ES533053A patent/ES8506089A1/es not_active Expired
- 1984-09-08 JP JP18730184A patent/JPS6128392A/ja active Granted
-
1985
- 1985-05-03 ES ES542829A patent/ES8608043A1/es not_active Expired
-
1986
- 1986-03-13 PH PH33519A patent/PH23702A/en unknown
-
1988
- 1988-03-14 JP JP63058544A patent/JPS6420096A/ja active Pending
-
1992
- 1992-08-26 DK DK105892A patent/DK171681B1/da not_active IP Right Cessation
-
1993
- 1993-06-30 NL NL930119C patent/NL930119I2/nl unknown
- 1993-07-01 LU LU88357C patent/LU88357I2/fr unknown
-
1996
- 1996-05-29 NL NL960013C patent/NL960013I2/nl unknown
-
1999
- 1999-07-07 LU LU90413C patent/LU90413I2/fr unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE61407T1 (de) | Muteine biologisch aktiver proteine mit verringertem cysteingehalt, ihre herstellung, formulierungen, die solche muteine enthalten sowie strukturgene, vektoren und organismen, die zur herstellung der genannten muteine geeignet sind und deren herstellung. | |
ATE246246T1 (de) | Herstellung von hämoglobin und analogen davon in nicht-erythrozytzellen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
EEIH | Change in the person of patent owner | ||
EELA | Cancelled due to lapse of time |