ES8502974A1 - Procedimiento para la obtencion de nuevos acidos 3-amino 1 benza-zepin-2-on-1-alcanicos. - Google Patents
Procedimiento para la obtencion de nuevos acidos 3-amino 1 benza-zepin-2-on-1-alcanicos.Info
- Publication number
- ES8502974A1 ES8502974A1 ES514856A ES514856A ES8502974A1 ES 8502974 A1 ES8502974 A1 ES 8502974A1 ES 514856 A ES514856 A ES 514856A ES 514856 A ES514856 A ES 514856A ES 8502974 A1 ES8502974 A1 ES 8502974A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- compounds
- hydrogen
- formula
- benzazepin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- AYQMNFRCBKOMIA-UHFFFAOYSA-N 1-benzazepin-2-one Chemical class O=C1C=CC=C2C=CC=CC2=N1 AYQMNFRCBKOMIA-UHFFFAOYSA-N 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 abstract 2
- 102000004270 Peptidyl-Dipeptidase A Human genes 0.000 abstract 2
- 108090000882 Peptidyl-Dipeptidase A Proteins 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29190781A | 1981-08-11 | 1981-08-11 | |
| US31986381A | 1981-11-09 | 1981-11-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES514856A0 ES514856A0 (es) | 1985-02-01 |
| ES8502974A1 true ES8502974A1 (es) | 1985-02-01 |
Family
ID=26967047
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES514856A Expired ES8502974A1 (es) | 1981-08-11 | 1982-08-09 | Procedimiento para la obtencion de nuevos acidos 3-amino 1 benza-zepin-2-on-1-alcanicos. |
| ES526889A Expired ES8604523A1 (es) | 1981-08-11 | 1983-10-28 | Procedimiento para la obtencion de nuevos acidos 3-amino-(1)benzazepin-2-on-1-alcanicos |
| ES526886A Expired ES8601142A1 (es) | 1981-08-11 | 1983-10-28 | Procedimiento para la obtencion de nuevos acidos 3-amino-(1)benzazepin-2-on-1-alcanicos |
| ES526887A Expired ES8606285A1 (es) | 1981-08-11 | 1983-10-28 | Procedimiento para la obtencion de nuevos acidos 3-amino-(1)benzazepin-2-on-1-alcanoicos |
| ES526888A Expired ES8504728A1 (es) | 1981-08-11 | 1983-10-28 | Procedimiento para la obtencion de nuevos acidos 3-amino-(1)benzazepin-2-on-1-alcanicos |
| ES530658A Granted ES530658A0 (es) | 1981-08-11 | 1984-03-15 | Procedimiento para la obtencion de nuevos acidos 3-amino-(1)-benzazepin-2-on-1-alcanicos |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES526889A Expired ES8604523A1 (es) | 1981-08-11 | 1983-10-28 | Procedimiento para la obtencion de nuevos acidos 3-amino-(1)benzazepin-2-on-1-alcanicos |
| ES526886A Expired ES8601142A1 (es) | 1981-08-11 | 1983-10-28 | Procedimiento para la obtencion de nuevos acidos 3-amino-(1)benzazepin-2-on-1-alcanicos |
| ES526887A Expired ES8606285A1 (es) | 1981-08-11 | 1983-10-28 | Procedimiento para la obtencion de nuevos acidos 3-amino-(1)benzazepin-2-on-1-alcanoicos |
| ES526888A Expired ES8504728A1 (es) | 1981-08-11 | 1983-10-28 | Procedimiento para la obtencion de nuevos acidos 3-amino-(1)benzazepin-2-on-1-alcanicos |
| ES530658A Granted ES530658A0 (es) | 1981-08-11 | 1984-03-15 | Procedimiento para la obtencion de nuevos acidos 3-amino-(1)-benzazepin-2-on-1-alcanicos |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0072352B1 (en, 2012) |
| KR (3) | KR890003425B1 (en, 2012) |
| AR (3) | AR240806A1 (en, 2012) |
| AT (1) | ATE18397T1 (en, 2012) |
| AU (1) | AU561395B2 (en, 2012) |
| CA (1) | CA1196636A (en, 2012) |
| CY (1) | CY1403A (en, 2012) |
| DD (1) | DD202546A5 (en, 2012) |
| DE (1) | DE3269625D1 (en, 2012) |
| DK (1) | DK157881C (en, 2012) |
| ES (6) | ES8502974A1 (en, 2012) |
| FI (1) | FI76074C (en, 2012) |
| GB (1) | GB2103614B (en, 2012) |
| GR (1) | GR77256B (en, 2012) |
| HK (1) | HK93387A (en, 2012) |
| HU (1) | HU189628B (en, 2012) |
| IE (1) | IE53668B1 (en, 2012) |
| IL (1) | IL66501A (en, 2012) |
| NL (1) | NL930112I2 (en, 2012) |
| NO (1) | NO161558C (en, 2012) |
| NZ (1) | NZ201555A (en, 2012) |
| PT (1) | PT75395B (en, 2012) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3242599A1 (de) * | 1982-11-18 | 1984-05-24 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel |
| US4473575A (en) * | 1982-07-19 | 1984-09-25 | Ciba-Geigy Corporation | 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids |
| EP0107095B1 (en) * | 1982-09-30 | 1987-09-09 | Merck & Co. Inc. | 1-n-alkylcarboxy-benzofused lactams useful as antihypertensive agents |
| US4575503A (en) * | 1983-02-10 | 1986-03-11 | Ciba-Geigy Corporation | 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids |
| US4564612A (en) * | 1983-04-22 | 1986-01-14 | Takeda Chemical Industries, Ltd. | Condensed, seven-membered ring compounds and their use |
| JPS608284A (ja) * | 1983-06-29 | 1985-01-17 | Mitsui Toatsu Chem Inc | ベンゾチアゼピン誘導体およびその製造法 |
| US4539150A (en) * | 1983-06-29 | 1985-09-03 | Mitsui Toatsu Chemicals, Inc. | Benzothiazepine derivatives and their methods of preparation |
| US4638000A (en) * | 1983-08-12 | 1987-01-20 | Takeda Chemical Industries, Ltd. | Condensed seven-membered ring compounds, their production and use |
| IL72523A (en) * | 1983-08-12 | 1988-06-30 | Takeda Chemical Industries Ltd | 3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine derivatives,their production and pharmaceutical compositions containing them |
| AU570710B2 (en) * | 1983-08-12 | 1988-03-24 | Takeda Chemical Industries Ltd. | 4-oxo-2, 3, 4, 5-tetrahydro-1, 5-benzoxazepine derivatives |
| DE3586445T2 (de) * | 1984-06-26 | 1993-01-14 | Merck & Co Inc | Kondensierte benzo-laktam-verbindungen und deren pharmazeutische zusammensetzungen. |
| CA1266647A (en) * | 1984-06-26 | 1990-03-13 | William H. Parsons | Benzofused lactams useful as antihypertensive agents and as cholecystokinin antagonists |
| EP0166357A3 (en) * | 1984-06-26 | 1988-10-26 | Merck & Co. Inc. | Benzofused lactams and pharmaceutical compositions containing them |
| US4785089A (en) * | 1985-06-13 | 1988-11-15 | Ciba-Geigy Corporation | Novel sulfonic acid esters and their preparation |
| DE3704661A1 (de) * | 1987-02-14 | 1988-08-25 | Hoechst Ag | Annelierte azepinon- und azocinon-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung, sowie zwischenprodukte bei ihrer herstellung |
| EP0322779A3 (en) * | 1987-12-29 | 1991-05-08 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzolactam compounds and pharmaceutical uses thereof |
| TW197945B (en, 2012) * | 1990-11-27 | 1993-01-11 | Hoechst Ag | |
| GB9100028D0 (en) * | 1991-01-02 | 1991-02-20 | Ici Plc | Compounds |
| GB9212308D0 (en) * | 1992-06-10 | 1992-07-22 | Ici Plc | Therapeutic compositions |
| US5504080A (en) * | 1992-10-28 | 1996-04-02 | Bristol-Myers Squibb Co. | Benzo-fused lactams |
| AU685768B2 (en) * | 1992-12-11 | 1998-01-29 | Novartis Ag | Benzazepinone derivatives |
| GB9310075D0 (en) * | 1993-05-17 | 1993-06-30 | Fujisawa Pharmaceutical Co | New mercapto-amide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same |
| GB9311948D0 (en) * | 1993-06-10 | 1993-07-28 | Zeneca Ltd | Substituted nitrogen heterocycles |
| US5801168A (en) * | 1994-06-09 | 1998-09-01 | Zeneca Limited | Substituted nitrogen heterocycles |
| US5597922A (en) * | 1994-07-29 | 1997-01-28 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | Glycine receptor antagonist pharmacophore |
| US6514965B1 (en) * | 1999-11-18 | 2003-02-04 | Antex Pharma Inc. | Substituted 1-benzazepines and derivatives thereof |
| CA2668823A1 (en) | 2000-12-27 | 2002-07-04 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Process for the preparation of .alpha.-aminosubstituted carboxylic acid amides |
| JP2004526735A (ja) | 2001-03-27 | 2004-09-02 | ランバクシー ラボラトリーズ リミテッド | ベナゼプリルの製造方法 |
| AU2002348276A1 (en) | 2001-11-16 | 2003-06-10 | Bristol-Myers Squibb Company | Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein |
| US20050107359A1 (en) * | 2002-07-26 | 2005-05-19 | Van Der Schaaf Paul A. | Crystalline polymorphic and amorphous forms of benazepril hydrochloride |
| KR100710548B1 (ko) * | 2002-12-26 | 2007-04-24 | 에스케이 주식회사 | (ｓ)-3-아미노-2,3,4,5-테트라히드로-2-옥소-1Ｈ-1-벤자제핀-1-아세트산 및 이의 에스테르 화합물의 제조방법 |
| US7459474B2 (en) | 2003-06-11 | 2008-12-02 | Bristol-Myers Squibb Company | Modulators of the glucocorticoid receptor and method |
| US8080579B2 (en) | 2005-10-03 | 2011-12-20 | The Regents Of The University Of Michigan | Compositions and methods for treatment of inflammatory bowel disease |
| US7592461B2 (en) | 2005-12-21 | 2009-09-22 | Bristol-Myers Squibb Company | Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
| EP2099767A1 (en) | 2006-11-01 | 2009-09-16 | Brystol-Myers Squibb Company | Modulators of glucocorticoid receptor, ap-1, and/or nf- b activity and use thereof |
| EP2089355A2 (en) | 2006-11-01 | 2009-08-19 | Brystol-Myers Squibb Company | Modulators of glucocorticoid receptor, ap-1, and/or nf- kappa b activity and use thereof |
| US8034782B2 (en) | 2008-07-16 | 2011-10-11 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| DK2170930T3 (da) | 2007-06-04 | 2012-11-05 | Synergy Pharmaceuticals Inc | Agonister af guanylatcyclase, anvendelige til behandlingen af gastrointestinale sygdomme, inflammation, cancer og andre sygdomme |
| US7828840B2 (en) | 2007-11-15 | 2010-11-09 | Med Institute, Inc. | Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists |
| EP2328910B1 (en) | 2008-06-04 | 2014-08-06 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| WO2009158380A1 (en) | 2008-06-24 | 2009-12-30 | Bristol-Myers Squibb Company | Cyclopentathiophene modulators of the glucocorticoid receptor, ap-1, and/or nf-kappa b activity and use thereof |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| EP2970384A1 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| AU2014235209B2 (en) | 2013-03-15 | 2018-06-14 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists combined with other drugs |
| KR102272746B1 (ko) | 2013-06-05 | 2021-07-08 | 보슈 헬스 아일랜드 리미티드 | 구아닐레이트 사이클라제 c의 초순수 작용제, 및 이의 제조 및 사용 방법 |
| US9593113B2 (en) | 2013-08-22 | 2017-03-14 | Bristol-Myers Squibb Company | Imide and acylurea derivatives as modulators of the glucocorticoid receptor |
| CN113292495B (zh) * | 2021-06-18 | 2022-09-13 | 迪嘉药业集团有限公司 | 一种 (s)-氨基化合物的合成方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3395150A (en) * | 1965-02-26 | 1968-07-30 | Squibb & Sons Inc | Benzothiazepine carboxamides and derivatives thereof |
| GB1305278A (en, 2012) * | 1970-03-12 | 1973-01-31 |
-
1982
- 1982-08-05 GB GB08222564A patent/GB2103614B/en not_active Expired
- 1982-08-05 DE DE8282810329T patent/DE3269625D1/de not_active Expired
- 1982-08-05 EP EP82810329A patent/EP0072352B1/de not_active Expired
- 1982-08-05 AT AT82810329T patent/ATE18397T1/de active
- 1982-08-05 CY CY140382A patent/CY1403A/en unknown
- 1982-08-09 ES ES514856A patent/ES8502974A1/es not_active Expired
- 1982-08-09 PT PT75395A patent/PT75395B/pt unknown
- 1982-08-09 IL IL66501A patent/IL66501A/xx not_active IP Right Cessation
- 1982-08-09 FI FI822770A patent/FI76074C/fi not_active IP Right Cessation
- 1982-08-09 CA CA000409019A patent/CA1196636A/en not_active Expired
- 1982-08-09 GR GR68996A patent/GR77256B/el unknown
- 1982-08-10 DD DD82242400A patent/DD202546A5/de not_active IP Right Cessation
- 1982-08-10 KR KR8203588A patent/KR890003425B1/ko not_active Expired
- 1982-08-10 DK DK358682A patent/DK157881C/da active
- 1982-08-10 HU HU822585A patent/HU189628B/hu unknown
- 1982-08-10 NZ NZ201555A patent/NZ201555A/en unknown
- 1982-08-10 AU AU87014/82A patent/AU561395B2/en not_active Expired
- 1982-08-10 NO NO822722A patent/NO161558C/no not_active IP Right Cessation
- 1982-08-10 IE IE1929/82A patent/IE53668B1/en not_active IP Right Cessation
- 1982-08-11 AR AR290295A patent/AR240806A1/es active
-
1983
- 1983-10-28 ES ES526889A patent/ES8604523A1/es not_active Expired
- 1983-10-28 ES ES526886A patent/ES8601142A1/es not_active Expired
- 1983-10-28 ES ES526887A patent/ES8606285A1/es not_active Expired
- 1983-10-28 ES ES526888A patent/ES8504728A1/es not_active Expired
-
1984
- 1984-02-28 AR AR295866A patent/AR240807A1/es active
- 1984-02-28 AR AR84295865A patent/AR241222A1/es active
- 1984-03-15 ES ES530658A patent/ES530658A0/es active Granted
-
1987
- 1987-12-10 HK HK933/87A patent/HK93387A/xx not_active IP Right Cessation
-
1989
- 1989-05-13 KR KR8906486A patent/KR900001190B1/ko not_active Expired
- 1989-05-13 KR KR1019890006487A patent/KR900001191B1/ko not_active Expired
-
1993
- 1993-06-29 NL NL930112C patent/NL930112I2/nl unknown
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Effective date: 20041116 |