ES8400418A1 - Un procedimiento para la preparacion de derivados del piroxican. - Google Patents
Un procedimiento para la preparacion de derivados del piroxican.Info
- Publication number
- ES8400418A1 ES8400418A1 ES516208A ES516208A ES8400418A1 ES 8400418 A1 ES8400418 A1 ES 8400418A1 ES 516208 A ES516208 A ES 516208A ES 516208 A ES516208 A ES 516208A ES 8400418 A1 ES8400418 A1 ES 8400418A1
- Authority
- ES
- Spain
- Prior art keywords
- piroxicam
- alkyl
- processes
- intermediates leading
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
- C07D279/08—1,3-Thiazines; Hydrogenated 1,3-thiazines condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
UN PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE PIROXICAM.SE HACE REACCIONAR UN COMPUESTO (II) CON EL COMPUESTO (III) DONDE X ESTA SELECCIONADO ENTRE EL GRUPO FORMADO POR CLORO, BROMO, O YODO. SE EMPLEA UN DISOLVENTE POLAR INERTE A LA REACCION EN PRESENCIA DE UNA BASE SELECCIONADA DE ENTRE EL GRUPO FORMADO POR AL MENOS DOS EQUIVALENTES DE UN HIDRURO METALICO; AL MENOS DOS EQUIVALENTES DE UN ALCOXIDO, AL MENOS DOS EQUIVALENTES DE HEXAMETILDISALAZANO POTASICO Y AL MENOS DOS EQUIVALENTES DE DIISOPROPILAMINA POTASICA. LA TEMPERATURA OSCILA ENTRE 25 Y 70JC. SE OBTIENEN DERIVADOSDE PIROXICAM DE FORMULA (I).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/308,746 US4376204A (en) | 1981-10-05 | 1981-10-05 | 3-Hydroxy 2-methyl benzisothiazolines as intermediates in production of piroxicam |
| US41303682A | 1982-09-02 | 1982-09-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8400418A1 true ES8400418A1 (es) | 1983-11-01 |
| ES516208A0 ES516208A0 (es) | 1983-11-01 |
Family
ID=26976430
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES516208A Granted ES516208A0 (es) | 1981-10-05 | 1982-10-04 | Un procedimiento para la preparacion de derivados del piroxican. |
| ES522788A Expired ES8407034A1 (es) | 1981-10-05 | 1983-05-27 | Un procedimiento para la preparacion de derivados del piroxicam. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES522788A Expired ES8407034A1 (es) | 1981-10-05 | 1983-05-27 | Un procedimiento para la preparacion de derivados del piroxicam. |
Country Status (27)
| Country | Link |
|---|---|
| EP (1) | EP0076643B1 (es) |
| KR (1) | KR850001223B1 (es) |
| AT (1) | ATE11916T1 (es) |
| AU (1) | AU534759B2 (es) |
| BG (2) | BG40812A3 (es) |
| CA (1) | CA1187873A (es) |
| DD (2) | DD216460A5 (es) |
| DE (1) | DE3262440D1 (es) |
| DK (2) | DK154646C (es) |
| EG (1) | EG15847A (es) |
| ES (2) | ES516208A0 (es) |
| FI (1) | FI75342C (es) |
| GR (1) | GR77345B (es) |
| HK (1) | HK52687A (es) |
| HU (1) | HU186977B (es) |
| IE (1) | IE53957B1 (es) |
| IL (1) | IL66921A0 (es) |
| IN (1) | IN159273B (es) |
| MY (1) | MY8700510A (es) |
| NO (1) | NO157140C (es) |
| NZ (1) | NZ202062A (es) |
| PH (2) | PH17991A (es) |
| PL (2) | PL136931B1 (es) |
| PT (1) | PT75642B (es) |
| RO (2) | RO86733B (es) |
| SG (1) | SG22987G (es) |
| YU (2) | YU42804B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001515893A (ja) | 1997-09-05 | 2001-09-25 | ワーナー−ランバート・カンパニー | 特定のベンゾチアジンジオキシドエンドセリンアンタゴニスト類およびその製造方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3591584A (en) * | 1968-08-27 | 1971-07-06 | Pfizer | Benzothiazine dioxides |
| US3853862A (en) * | 1973-04-23 | 1974-12-10 | Pfizer | Production of 4-hydroxy-1,2-benzothiazine-3-carboxamides |
| US3891637A (en) * | 1974-10-01 | 1975-06-24 | Pfizer | Process for the production of carboxamides of oxo-1,2-benzothiazine-1,1-dioxides |
| US3892740A (en) * | 1974-10-15 | 1975-07-01 | Pfizer | Process for the production of carboxamides of oxo-1,2-benzothiazine-1,1-dioxides |
| US3960856A (en) * | 1975-06-20 | 1976-06-01 | Warner-Lambert Company | Process for the preparation of 4-hydroxy-3-(5-methyl-3-isoxazolylcarbamoyl)-2-methyl-2H-1,2-benzothiazine 1,1-dioxide |
| SE421792B (sv) * | 1976-01-12 | 1982-02-01 | Pfizer | Forfarande for framstellning av n-(2-pyridyl)-4-hydroxi-2-metyl-2h-1,2-benso-tiazin-3-karboxamid-1,1-dioxid |
| US4074048A (en) * | 1976-05-10 | 1978-02-14 | Warner-Lambert Company | Process for the preparation of 4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides |
| US4100347A (en) * | 1976-06-10 | 1978-07-11 | Pfizer Inc. | 3,4-Dihydro-2-methyl-4-oxo-2H-1,2-benzothiazine-3-carboxylic acid-1,1-dioxide |
| US4289879A (en) * | 1980-09-29 | 1981-09-15 | Pfizer Inc. | Synthetic method and intermediate for piroxicam |
-
1982
- 1982-09-22 IN IN719/DEL/82A patent/IN159273B/en unknown
- 1982-09-29 DE DE8282305174T patent/DE3262440D1/de not_active Expired
- 1982-09-29 EP EP82305174A patent/EP0076643B1/en not_active Expired
- 1982-09-29 AT AT82305174T patent/ATE11916T1/de not_active IP Right Cessation
- 1982-09-30 IL IL66921A patent/IL66921A0/xx not_active IP Right Cessation
- 1982-09-30 AU AU88917/82A patent/AU534759B2/en not_active Ceased
- 1982-10-01 NZ NZ202062A patent/NZ202062A/en unknown
- 1982-10-01 PT PT75642A patent/PT75642B/pt not_active IP Right Cessation
- 1982-10-01 GR GR69420A patent/GR77345B/el unknown
- 1982-10-04 RO RO112350A patent/RO86733B/ro unknown
- 1982-10-04 BG BG8258162A patent/BG40812A3/xx unknown
- 1982-10-04 IE IE2393/82A patent/IE53957B1/en not_active IP Right Cessation
- 1982-10-04 ES ES516208A patent/ES516208A0/es active Granted
- 1982-10-04 BG BG8361608A patent/BG40811A3/xx unknown
- 1982-10-04 YU YU2228/82A patent/YU42804B/xx unknown
- 1982-10-04 FI FI823366A patent/FI75342C/fi not_active IP Right Cessation
- 1982-10-04 PH PH27950A patent/PH17991A/en unknown
- 1982-10-04 RO RO108738A patent/RO84510B/ro unknown
- 1982-10-04 NO NO823330A patent/NO157140C/no unknown
- 1982-10-04 CA CA000412724A patent/CA1187873A/en not_active Expired
- 1982-10-04 DK DK439482A patent/DK154646C/da not_active IP Right Cessation
- 1982-10-05 DD DD82257459A patent/DD216460A5/de not_active IP Right Cessation
- 1982-10-05 EG EG594/82A patent/EG15847A/xx active
- 1982-10-05 PL PL1982238506A patent/PL136931B1/pl unknown
- 1982-10-05 PL PL1982244761A patent/PL136540B1/pl unknown
- 1982-10-05 KR KR8204482A patent/KR850001223B1/ko active
- 1982-10-05 HU HU823194A patent/HU186977B/hu not_active IP Right Cessation
- 1982-10-05 DD DD82243802A patent/DD203051A5/de not_active IP Right Cessation
-
1983
- 1983-05-27 ES ES522788A patent/ES8407034A1/es not_active Expired
-
1984
- 1984-06-07 PH PH30790-AA patent/PH19297A/en unknown
- 1984-09-10 YU YU1560/84A patent/YU42903B/xx unknown
-
1987
- 1987-03-09 SG SG229/87A patent/SG22987G/en unknown
- 1987-07-09 HK HK526/87A patent/HK52687A/xx unknown
- 1987-12-30 MY MY510/87A patent/MY8700510A/xx unknown
-
1988
- 1988-04-14 DK DK204888A patent/DK154139C/da not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970303 |