RO84510B - Procedeu pentru prepararea unor derivati de 1, 2-benzotiazina - Google Patents
Procedeu pentru prepararea unor derivati de 1, 2-benzotiazinaInfo
- Publication number
- RO84510B RO84510B RO108738A RO10873882A RO84510B RO 84510 B RO84510 B RO 84510B RO 108738 A RO108738 A RO 108738A RO 10873882 A RO10873882 A RO 10873882A RO 84510 B RO84510 B RO 84510B
- Authority
- RO
- Romania
- Prior art keywords
- piroxicam
- alkyl
- hydroxy
- methyl
- benzothiazine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
- C07D279/08—1,3-Thiazines; Hydrogenated 1,3-thiazines condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Cephalosporin Compounds (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Compounds Of Unknown Constitution (AREA)
- Pyridine Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
Inventia se refera la un procedeu pentru prepararea unor derivati de 1,2-benzotiazina, cu formula generala I: (vezi formula) în care Y reprezinta o grupa alcoxi cu 1...4 atomi de carbon, 2-metoxietoxi si 2-piridilimino, constînd din aceea ca un compus cu formula generala II: (vezi formula) se trateaza cu un compus cu formula generala III: (vezi formula) în care Y are semnificatia de mai sus si X este clor sau brom, într-un solvent polar inert, ales dintre dimetilformamida si dimetilsulfoxid, în prezenta unei baze, aleasa dintr-o hidrura de sodiu, un alcoxid de sodiu sau potasiu cu 1...4 atomi de carbon, hexametildisilazan de potasiu si diizopropilamina, folosind un raport molar între compusul II si compusul bazic de 1:2...1:5, la o temperatura cuprinsa între 25 si 55 degree C.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/308,746 US4376204A (en) | 1981-10-05 | 1981-10-05 | 3-Hydroxy 2-methyl benzisothiazolines as intermediates in production of piroxicam |
US41303682A | 1982-09-02 | 1982-09-02 |
Publications (2)
Publication Number | Publication Date |
---|---|
RO84510A RO84510A (ro) | 1984-06-21 |
RO84510B true RO84510B (ro) | 1984-08-30 |
Family
ID=26976430
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RO108738A RO84510B (ro) | 1981-10-05 | 1982-10-04 | Procedeu pentru prepararea unor derivati de 1, 2-benzotiazina |
RO112350A RO86733B (ro) | 1981-10-05 | 1982-10-04 | Procedeu pentru prepararea unor derivati de 1,2-benzotiazina |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RO112350A RO86733B (ro) | 1981-10-05 | 1982-10-04 | Procedeu pentru prepararea unor derivati de 1,2-benzotiazina |
Country Status (27)
Country | Link |
---|---|
EP (1) | EP0076643B1 (ro) |
KR (1) | KR850001223B1 (ro) |
AT (1) | ATE11916T1 (ro) |
AU (1) | AU534759B2 (ro) |
BG (2) | BG40812A3 (ro) |
CA (1) | CA1187873A (ro) |
DD (2) | DD203051A5 (ro) |
DE (1) | DE3262440D1 (ro) |
DK (2) | DK154646C (ro) |
EG (1) | EG15847A (ro) |
ES (2) | ES516208A0 (ro) |
FI (1) | FI75342C (ro) |
GR (1) | GR77345B (ro) |
HK (1) | HK52687A (ro) |
HU (1) | HU186977B (ro) |
IE (1) | IE53957B1 (ro) |
IL (1) | IL66921A0 (ro) |
IN (1) | IN159273B (ro) |
MY (1) | MY8700510A (ro) |
NO (1) | NO157140C (ro) |
NZ (1) | NZ202062A (ro) |
PH (2) | PH17991A (ro) |
PL (2) | PL136540B1 (ro) |
PT (1) | PT75642B (ro) |
RO (2) | RO84510B (ro) |
SG (1) | SG22987G (ro) |
YU (2) | YU42804B (ro) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2221191T3 (es) | 1997-09-05 | 2004-12-16 | Warner-Lambert Company Llc | Ciertos dioxidos de benzotiazina, antagonistas de endotelina y procedimientos para su preparacion. |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3591584A (en) * | 1968-08-27 | 1971-07-06 | Pfizer | Benzothiazine dioxides |
US3853862A (en) * | 1973-04-23 | 1974-12-10 | Pfizer | Production of 4-hydroxy-1,2-benzothiazine-3-carboxamides |
US3891637A (en) * | 1974-10-01 | 1975-06-24 | Pfizer | Process for the production of carboxamides of oxo-1,2-benzothiazine-1,1-dioxides |
US3892740A (en) * | 1974-10-15 | 1975-07-01 | Pfizer | Process for the production of carboxamides of oxo-1,2-benzothiazine-1,1-dioxides |
US3960856A (en) * | 1975-06-20 | 1976-06-01 | Warner-Lambert Company | Process for the preparation of 4-hydroxy-3-(5-methyl-3-isoxazolylcarbamoyl)-2-methyl-2H-1,2-benzothiazine 1,1-dioxide |
SE421792B (sv) * | 1976-01-12 | 1982-02-01 | Pfizer | Forfarande for framstellning av n-(2-pyridyl)-4-hydroxi-2-metyl-2h-1,2-benso-tiazin-3-karboxamid-1,1-dioxid |
US4074048A (en) * | 1976-05-10 | 1978-02-14 | Warner-Lambert Company | Process for the preparation of 4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides |
US4100347A (en) * | 1976-06-10 | 1978-07-11 | Pfizer Inc. | 3,4-Dihydro-2-methyl-4-oxo-2H-1,2-benzothiazine-3-carboxylic acid-1,1-dioxide |
US4289879A (en) * | 1980-09-29 | 1981-09-15 | Pfizer Inc. | Synthetic method and intermediate for piroxicam |
-
1982
- 1982-09-22 IN IN719/DEL/82A patent/IN159273B/en unknown
- 1982-09-29 EP EP82305174A patent/EP0076643B1/en not_active Expired
- 1982-09-29 AT AT82305174T patent/ATE11916T1/de not_active IP Right Cessation
- 1982-09-29 DE DE8282305174T patent/DE3262440D1/de not_active Expired
- 1982-09-30 AU AU88917/82A patent/AU534759B2/en not_active Ceased
- 1982-09-30 IL IL66921A patent/IL66921A0/xx not_active IP Right Cessation
- 1982-10-01 GR GR69420A patent/GR77345B/el unknown
- 1982-10-01 PT PT75642A patent/PT75642B/pt not_active IP Right Cessation
- 1982-10-01 NZ NZ202062A patent/NZ202062A/en unknown
- 1982-10-04 ES ES516208A patent/ES516208A0/es active Granted
- 1982-10-04 IE IE2393/82A patent/IE53957B1/en not_active IP Right Cessation
- 1982-10-04 NO NO823330A patent/NO157140C/no unknown
- 1982-10-04 DK DK439482A patent/DK154646C/da not_active IP Right Cessation
- 1982-10-04 FI FI823366A patent/FI75342C/fi not_active IP Right Cessation
- 1982-10-04 YU YU2228/82A patent/YU42804B/xx unknown
- 1982-10-04 RO RO108738A patent/RO84510B/ro unknown
- 1982-10-04 RO RO112350A patent/RO86733B/ro unknown
- 1982-10-04 CA CA000412724A patent/CA1187873A/en not_active Expired
- 1982-10-04 BG BG058162A patent/BG40812A3/xx unknown
- 1982-10-04 PH PH27950A patent/PH17991A/en unknown
- 1982-10-04 BG BG061608A patent/BG40811A3/xx unknown
- 1982-10-05 PL PL1982244761A patent/PL136540B1/pl unknown
- 1982-10-05 DD DD82243802A patent/DD203051A5/de not_active IP Right Cessation
- 1982-10-05 KR KR8204482A patent/KR850001223B1/ko active
- 1982-10-05 DD DD82257459A patent/DD216460A5/de not_active IP Right Cessation
- 1982-10-05 EG EG594/82A patent/EG15847A/xx active
- 1982-10-05 PL PL1982238506A patent/PL136931B1/pl unknown
- 1982-10-05 HU HU823194A patent/HU186977B/hu not_active IP Right Cessation
-
1983
- 1983-05-27 ES ES522788A patent/ES522788A0/es active Granted
-
1984
- 1984-06-07 PH PH30790-AA patent/PH19297A/en unknown
- 1984-09-10 YU YU1560/84A patent/YU42903B/xx unknown
-
1987
- 1987-03-09 SG SG229/87A patent/SG22987G/en unknown
- 1987-07-09 HK HK526/87A patent/HK52687A/xx unknown
- 1987-12-30 MY MY510/87A patent/MY8700510A/xx unknown
-
1988
- 1988-04-14 DK DK204888A patent/DK154139C/da not_active IP Right Cessation
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