DK154139C - Fremgangsmaade til fremstilling af 4-hydroxy-2-methyl-2h-1,2-benzothiazin-1,1-dioxid-3-carboxylsyrederivater, der kan omdannes til piroxicam - Google Patents

Fremgangsmaade til fremstilling af 4-hydroxy-2-methyl-2h-1,2-benzothiazin-1,1-dioxid-3-carboxylsyrederivater, der kan omdannes til piroxicam

Info

Publication number
DK154139C
DK154139C DK204888A DK204888A DK154139C DK 154139 C DK154139 C DK 154139C DK 204888 A DK204888 A DK 204888A DK 204888 A DK204888 A DK 204888A DK 154139 C DK154139 C DK 154139C
Authority
DK
Denmark
Prior art keywords
piroxicam
hydroxy
methyl
benzothiazine
conversible
Prior art date
Application number
DK204888A
Other languages
English (en)
Other versions
DK204888D0 (da
DK154139B (da
DK204888A (da
Inventor
Paul Douglas Weeks
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/308,746 external-priority patent/US4376204A/en
Application filed by Pfizer filed Critical Pfizer
Publication of DK204888D0 publication Critical patent/DK204888D0/da
Publication of DK204888A publication Critical patent/DK204888A/da
Publication of DK154139B publication Critical patent/DK154139B/da
Application granted granted Critical
Publication of DK154139C publication Critical patent/DK154139C/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D279/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/041,3-Thiazines; Hydrogenated 1,3-thiazines
    • C07D279/081,3-Thiazines; Hydrogenated 1,3-thiazines condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/75Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D275/00Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D279/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/021,2-Thiazines; Hydrogenated 1,2-thiazines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Pyridine Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
DK204888A 1981-10-05 1988-04-14 Fremgangsmaade til fremstilling af 4-hydroxy-2-methyl-2h-1,2-benzothiazin-1,1-dioxid-3-carboxylsyrederivater, der kan omdannes til piroxicam DK154139C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US30874681 1981-10-05
US06/308,746 US4376204A (en) 1981-10-05 1981-10-05 3-Hydroxy 2-methyl benzisothiazolines as intermediates in production of piroxicam
US41303682A 1982-09-02 1982-09-02
US41303682 1982-09-02

Publications (4)

Publication Number Publication Date
DK204888D0 DK204888D0 (da) 1988-04-14
DK204888A DK204888A (da) 1988-04-14
DK154139B DK154139B (da) 1988-10-17
DK154139C true DK154139C (da) 1989-03-06

Family

ID=26976430

Family Applications (2)

Application Number Title Priority Date Filing Date
DK439482A DK154646C (da) 1981-10-05 1982-10-04 Fremgangsmaade til fremstilling af piroxicam og mellemprodukter, der foerer til denne forbindelse
DK204888A DK154139C (da) 1981-10-05 1988-04-14 Fremgangsmaade til fremstilling af 4-hydroxy-2-methyl-2h-1,2-benzothiazin-1,1-dioxid-3-carboxylsyrederivater, der kan omdannes til piroxicam

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK439482A DK154646C (da) 1981-10-05 1982-10-04 Fremgangsmaade til fremstilling af piroxicam og mellemprodukter, der foerer til denne forbindelse

Country Status (27)

Country Link
EP (1) EP0076643B1 (da)
KR (1) KR850001223B1 (da)
AT (1) ATE11916T1 (da)
AU (1) AU534759B2 (da)
BG (2) BG40812A3 (da)
CA (1) CA1187873A (da)
DD (2) DD216460A5 (da)
DE (1) DE3262440D1 (da)
DK (2) DK154646C (da)
EG (1) EG15847A (da)
ES (2) ES8400418A1 (da)
FI (1) FI75342C (da)
GR (1) GR77345B (da)
HK (1) HK52687A (da)
HU (1) HU186977B (da)
IE (1) IE53957B1 (da)
IL (1) IL66921A0 (da)
IN (1) IN159273B (da)
MY (1) MY8700510A (da)
NO (1) NO157140C (da)
NZ (1) NZ202062A (da)
PH (2) PH17991A (da)
PL (2) PL136931B1 (da)
PT (1) PT75642B (da)
RO (2) RO84510B (da)
SG (1) SG22987G (da)
YU (2) YU42804B (da)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL338983A1 (en) * 1997-09-05 2000-12-04 Warner Lambert Co Some dioxides of benzothiazine as antagonists of endothelin and methods of obtaining them

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3591584A (en) * 1968-08-27 1971-07-06 Pfizer Benzothiazine dioxides
US3853862A (en) * 1973-04-23 1974-12-10 Pfizer Production of 4-hydroxy-1,2-benzothiazine-3-carboxamides
US3891637A (en) * 1974-10-01 1975-06-24 Pfizer Process for the production of carboxamides of oxo-1,2-benzothiazine-1,1-dioxides
US3892740A (en) * 1974-10-15 1975-07-01 Pfizer Process for the production of carboxamides of oxo-1,2-benzothiazine-1,1-dioxides
US3960856A (en) * 1975-06-20 1976-06-01 Warner-Lambert Company Process for the preparation of 4-hydroxy-3-(5-methyl-3-isoxazolylcarbamoyl)-2-methyl-2H-1,2-benzothiazine 1,1-dioxide
SE421792B (sv) * 1976-01-12 1982-02-01 Pfizer Forfarande for framstellning av n-(2-pyridyl)-4-hydroxi-2-metyl-2h-1,2-benso-tiazin-3-karboxamid-1,1-dioxid
US4074048A (en) * 1976-05-10 1978-02-14 Warner-Lambert Company Process for the preparation of 4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides
US4100347A (en) * 1976-06-10 1978-07-11 Pfizer Inc. 3,4-Dihydro-2-methyl-4-oxo-2H-1,2-benzothiazine-3-carboxylic acid-1,1-dioxide
US4289879A (en) * 1980-09-29 1981-09-15 Pfizer Inc. Synthetic method and intermediate for piroxicam

Also Published As

Publication number Publication date
PH19297A (en) 1986-03-05
DK154646B (da) 1988-12-05
RO86733A (ro) 1985-04-17
PL136931B1 (en) 1986-04-30
FI823366L (fi) 1983-04-06
DD203051A5 (de) 1983-10-12
PT75642B (en) 1985-12-09
NO157140B (no) 1987-10-19
CA1187873A (en) 1985-05-28
HU186977B (en) 1985-10-28
EG15847A (en) 1987-04-30
GR77345B (da) 1984-09-11
DD216460A5 (de) 1984-12-12
YU42804B (en) 1988-12-31
ES516208A0 (es) 1983-11-01
PL238506A1 (en) 1984-04-09
PL244761A1 (en) 1984-07-16
DK204888D0 (da) 1988-04-14
DK154139B (da) 1988-10-17
AU534759B2 (en) 1984-02-16
ES8407034A1 (es) 1984-09-01
DK154646C (da) 1989-05-08
BG40812A3 (en) 1987-02-16
SG22987G (en) 1987-07-10
BG40811A3 (en) 1987-02-16
DE3262440D1 (en) 1985-03-28
IE822393L (en) 1983-04-05
ATE11916T1 (de) 1985-03-15
KR850001223B1 (ko) 1985-08-23
HK52687A (en) 1987-07-17
YU222882A (en) 1985-04-30
PT75642A (en) 1982-11-01
NZ202062A (en) 1985-08-30
DK439482A (da) 1983-04-06
AU8891782A (en) 1983-04-14
IN159273B (da) 1987-04-25
RO84510B (ro) 1984-08-30
IL66921A0 (en) 1982-12-31
YU42903B (en) 1988-12-31
ES522788A0 (es) 1984-09-01
FI75342C (fi) 1988-06-09
RO86733B (ro) 1985-05-01
PL136540B1 (en) 1986-02-28
FI823366A0 (fi) 1982-10-04
DK204888A (da) 1988-04-14
FI75342B (fi) 1988-02-29
YU156084A (en) 1985-04-30
NO157140C (no) 1988-02-03
KR840001963A (ko) 1984-06-07
PH17991A (en) 1985-02-28
EP0076643B1 (en) 1985-02-20
NO823330L (no) 1983-04-06
MY8700510A (en) 1987-12-31
ES8400418A1 (es) 1983-11-01
EP0076643A1 (en) 1983-04-13
RO84510A (ro) 1984-06-21
IE53957B1 (en) 1989-04-26

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