ES8307006A1 - Procedimiento de preparar nuevos derivados de aprovincaminol. - Google Patents

Procedimiento de preparar nuevos derivados de aprovincaminol.

Info

Publication number
ES8307006A1
ES8307006A1 ES509419A ES509419A ES8307006A1 ES 8307006 A1 ES8307006 A1 ES 8307006A1 ES 509419 A ES509419 A ES 509419A ES 509419 A ES509419 A ES 509419A ES 8307006 A1 ES8307006 A1 ES 8307006A1
Authority
ES
Spain
Prior art keywords
hydrogen
pharmaceutically acceptable
addition salts
nitro
acid addition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES509419A
Other languages
English (en)
Other versions
ES509419A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU81323A external-priority patent/HU183325B/hu
Priority claimed from HU81322A external-priority patent/HU183324B/hu
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of ES509419A0 publication Critical patent/ES509419A0/es
Publication of ES8307006A1 publication Critical patent/ES8307006A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE APOVINCAMINOL, DE FORMULA GENERAL (I), EN LA QUE TANTO R COMO R SON HIDROGENO O UNO DE ELLOS ES HIDROGENO Y EL OTRO ES NITRO, Y SUS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR APOVINCAMINOL O UNA SAL DE ADICION DE ACIDO DEL MISMO, CON ACIDO 3,4,5-TRIMETOXIBENZOICO O CON UN DERIVADO REACTIVO DEL MISMO CAPAZ DE ACILACION. UNA VEZ TERMINADA LA REACCION SE AISLAN LOS COMPUESTOS DE FORMULA (II) O SE LES CONVIERTE EN SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLES. DE APLICACION EN EL TRATAMIENTO DE ENFERMEDADES DE LA PIEL.
ES509419A 1981-02-11 1982-02-08 Procedimiento de preparar nuevos derivados de aprovincaminol. Expired ES8307006A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU81323A HU183325B (en) 1981-02-11 1981-02-11 Process for preparing new apovincaminol-3',4',5'-trimethoxy-benzoates substituted with a nitro group
HU81322A HU183324B (en) 1981-02-11 1981-02-11 Process for preparing new apovincaminol-3',4',5'-trimethoxy-benzoate and acid addition salts thereof

Publications (2)

Publication Number Publication Date
ES509419A0 ES509419A0 (es) 1983-07-01
ES8307006A1 true ES8307006A1 (es) 1983-07-01

Family

ID=26317194

Family Applications (1)

Application Number Title Priority Date Filing Date
ES509419A Expired ES8307006A1 (es) 1981-02-11 1982-02-08 Procedimiento de preparar nuevos derivados de aprovincaminol.

Country Status (19)

Country Link
AR (1) AR227574A1 (es)
AT (1) AT386203B (es)
AU (1) AU544455B2 (es)
CA (1) CA1202028A (es)
CH (1) CH651038A5 (es)
DD (1) DD202570A5 (es)
DE (1) DE3204509A1 (es)
DK (1) DK151023C (es)
ES (1) ES8307006A1 (es)
FI (1) FI70215C (es)
FR (1) FR2499571B1 (es)
GB (1) GB2094787B (es)
GR (1) GR75857B (es)
IL (1) IL64808A (es)
IT (1) IT1157301B (es)
NL (1) NL8200490A (es)
NO (1) NO820394L (es)
SE (1) SE449863B (es)
SU (1) SU1093249A3 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU192013B (en) * 1984-04-25 1987-04-28 Richter Gedeon Vegyeszet Process for production of new aporincavinol esther derivatives
HU193772B (en) * 1985-06-12 1987-11-30 Richter Gedeon Vegyeszet Process for producing new nitro-bis-indole derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2035784A1 (en) * 1969-03-27 1970-12-24 Olivier Louisette Vincamine derivs with therapeutic propert- - ies
HU170888B (hu) * 1975-06-10 1977-09-28 Richter Gedeon Vegyeszet Sposob poluchenija novykh, opticheski aktivnykh proizvodnykh eburnameninov
HU171662B (hu) * 1975-07-18 1978-02-28 Richter Gedeon Vegyeszet Sposob poluchenija novykh, opticheski aktivnykh proizvodnykh apovinkaminola i ikh kislotnykh adduktov
HU177370B (en) * 1977-07-27 1981-09-28 Richter Gedeon Vegyeszet Process for producing new bracket-cross-bracket-vincaminol-esters

Also Published As

Publication number Publication date
DE3204509A1 (de) 1982-08-26
ES509419A0 (es) 1983-07-01
DK151023B (da) 1987-10-12
FI70215C (fi) 1986-09-15
NO820394L (no) 1982-08-12
ATA26082A (de) 1987-12-15
SE8200248L (sv) 1982-08-12
SU1093249A3 (ru) 1984-05-15
AT386203B (de) 1988-07-25
FR2499571A1 (fr) 1982-08-13
IT8219587A0 (it) 1982-02-10
CH651038A5 (de) 1985-08-30
DK151023C (da) 1988-06-27
IT1157301B (it) 1987-02-11
AR227574A1 (es) 1982-11-15
GB2094787B (en) 1984-10-24
FR2499571B1 (fr) 1986-03-28
FI820339L (fi) 1982-08-12
GB2094787A (en) 1982-09-22
DD202570A5 (de) 1983-09-21
CA1202028A (en) 1986-03-18
IL64808A (en) 1984-12-31
AU8033882A (en) 1982-08-19
DK57782A (da) 1982-08-12
IL64808A0 (en) 1982-03-31
NL8200490A (nl) 1982-09-01
SE449863B (sv) 1987-05-25
FI70215B (fi) 1986-02-28
DE3204509C2 (es) 1990-10-04
GR75857B (es) 1984-08-02
AU544455B2 (en) 1985-05-30

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506