ES475328A1 - Procedimiento de preparacion de nuevas indol (2,3-a)quinoli-zidinas - Google Patents

Procedimiento de preparacion de nuevas indol (2,3-a)quinoli-zidinas

Info

Publication number
ES475328A1
ES475328A1 ES475328A ES475328A ES475328A1 ES 475328 A1 ES475328 A1 ES 475328A1 ES 475328 A ES475328 A ES 475328A ES 475328 A ES475328 A ES 475328A ES 475328 A1 ES475328 A1 ES 475328A1
Authority
ES
Spain
Prior art keywords
quinolizidines
indolo
preparation
therapeutic use
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES475328A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Pharma SAS
Original Assignee
Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS filed Critical Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Publication of ES475328A1 publication Critical patent/ES475328A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

Procedimiento de preparación de nuevas indol-(2,3-a)-quinolizidinas de las fórmulas generales (I) y (II) (**Fórmula**) en las que R representa -COOC2H5, -COOH, -CN, un grupo metilenamino primario o secundario, un grupo metilenamido, o en las que R, junto con el nitrógeno cíclico del anillo de indol, representa uno de los grupos N-CO-NH-CH2 ó N-CO-, que comprende condensar juntos 2-aminoetil-3-indol y 1-cloro-4-(A)-4-clorocarbonil-hexano, donde A representa -COOC2H5 ó -CN, para formar la amida correspondiente; someter la amida a condiciones fuertemente básicas para eliminar HC1 y efectuar la formación de anillo en el átomo de nitrógeno del sustituyente 3-indol; efectuar la formación del anillo de quinolizidina del producto por tratamiento del mismo con un agente deshidratante seguido por una sal de perclorato; hidrogenar el perclorato de quinolizidinio resultante, para producir la correspondiente mezcla de isómeros de indol-(2,3a)-quinolizidina y separar los isómeros.
ES475328A 1977-11-25 1978-11-23 Procedimiento de preparacion de nuevas indol (2,3-a)quinoli-zidinas Expired ES475328A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4920177 1977-11-25

Publications (1)

Publication Number Publication Date
ES475328A1 true ES475328A1 (es) 1979-04-01

Family

ID=10451538

Family Applications (1)

Application Number Title Priority Date Filing Date
ES475328A Expired ES475328A1 (es) 1977-11-25 1978-11-23 Procedimiento de preparacion de nuevas indol (2,3-a)quinoli-zidinas

Country Status (28)

Country Link
JP (1) JPS6147838B2 (es)
AR (1) AR218514A1 (es)
AT (1) AT372384B (es)
AU (1) AU529108B2 (es)
BE (1) BE872134A (es)
CA (1) CA1100959A (es)
CH (1) CH641181A5 (es)
DE (1) DE2851028A1 (es)
DK (1) DK154430C (es)
EG (1) EG13683A (es)
ES (1) ES475328A1 (es)
FI (1) FI64372C (es)
FR (2) FR2409755A1 (es)
HK (1) HK60884A (es)
IE (1) IE47518B1 (es)
IN (1) IN151146B (es)
IT (1) IT1160263B (es)
LU (1) LU80576A1 (es)
MX (1) MX5529E (es)
MY (1) MY8500029A (es)
NL (1) NL7811562A (es)
NO (1) NO151288C (es)
NZ (1) NZ188974A (es)
PT (1) PT68825A (es)
SE (2) SE431650B (es)
SG (1) SG61182G (es)
WO (1) WO1979000319A1 (es)
ZA (1) ZA786426B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0079411B1 (fr) * 1981-11-18 1987-02-04 Thal, Claude Dérivés d'indoloquinolizine, leur procédé de préparation et leur application en thérapeutique
FR2529552B1 (fr) * 1982-07-05 1985-09-27 Centre Nat Rech Scient Nouveau procede de preparation d'intermediaires de synthese de la vindoline et intermediaires de synthese
HU191454B (en) * 1984-10-05 1987-02-27 Richter Gedeon Vegyeszeti Gyar Rt.,Hu Process for producing amides of oktahydro-indolo/2,3-a/quinolyzin-1-yl-alkanecarboxylic acids and pharmaceutically acceptable acid additional salts thereof
HU195214B (en) * 1985-04-19 1988-04-28 Richter Gedeon Vegyeszet Process for producing 12b-substituted-1-(hydroxymethyl)-octahydro-indolo /2,3-a/ quinolizine derivatives and pharmaceutical preparations comprising these compounds
HU194220B (en) * 1985-04-19 1988-01-28 Richter Gedeon Vegyeszet Process for production of derivatives of 1,12 b disubstituated-octahydro-indolo /2,3-a/ quinolisine and medical compounds containing thereof
FI95572C (fi) 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
ATE204264T1 (de) * 1993-06-18 2001-09-15 Fujisawa Pharmaceutical Co Zwischenprodukt zur verwendung in der synthese und verfahren zur herstellung eines aminopiperazinderivates
FR2713644B1 (fr) * 1993-12-14 1996-02-09 Adir Nouveaux analogues de l'éburnane, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
FR2713643B1 (fr) * 1993-12-14 1996-06-07 Adir Nouveaux analogues de l'éburnane, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
WO2004001277A1 (fr) † 2002-06-24 2003-12-31 Saint-Gobain Isover Panneau d'isolation pour conduit de distribution
FR2911141B1 (fr) * 2007-01-05 2009-02-20 Servier Lab Nouveaux derives triazabenzo[a]naphtho[2,1,8-cde]azulene, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2911143A1 (fr) * 2007-01-05 2008-07-11 Servier Lab Utilisation de composes neuroprotecteurs pour l'obtention de medicaments destines au traitement de maladies neurodegeneratives.
FR2911142A1 (fr) * 2007-01-05 2008-07-11 Servier Lab Nouveaux derives aminopyrrolo[1,2-a]indole et aminopyridazino[1,6-a]indole,leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU167366B (es) * 1972-09-06 1975-09-27
BE802387A (fr) * 1973-07-16 1973-11-16 Omnium Chimique Sa Procede de preparation de la vincamone et de l'epi-21 vincamone a partir de la tabersonine et derives indoliques nouveaux.
HU169916B (es) * 1974-09-27 1977-02-28
HU171165B (hu) * 1974-11-26 1977-11-28 Richter Gedeon Vegyeszet Sposob poluchenija proizvodnykh oktagidro-indolo-skobka-2,3-a-skobka zakryta-kinolizina
FR2315277A1 (fr) * 1975-06-25 1977-01-21 Anvar Nouveaux derives pentacycliques, leur preparation et les compositions qui les contiennent

Also Published As

Publication number Publication date
JPS6147838B2 (es) 1986-10-21
NO783958L (no) 1979-05-28
ATA837478A (de) 1983-02-15
FR2423492A1 (fr) 1979-11-16
FI64372C (fi) 1983-11-10
NO151288C (no) 1985-03-13
MY8500029A (en) 1985-12-31
CA1100959A (en) 1981-05-12
SE435622B (sv) 1984-10-08
SE7906287L (sv) 1979-07-23
FR2409755B1 (es) 1980-08-01
WO1979000319A1 (fr) 1979-06-14
FI783581A (fi) 1979-05-26
AU4187478A (en) 1979-05-31
DK154430C (da) 1989-04-17
NL7811562A (nl) 1979-05-29
FR2409755A1 (fr) 1979-06-22
DE2851028C2 (es) 1990-05-03
HK60884A (en) 1984-08-10
DK524978A (da) 1979-05-26
SE8007845L (sv) 1980-11-07
SE431650B (sv) 1984-02-20
IN151146B (es) 1983-02-26
JPS54500053A (es) 1979-11-08
NO151288B (no) 1984-12-03
MX5529E (es) 1983-09-23
IE47518B1 (en) 1984-04-04
DK154430B (da) 1988-11-14
BE872134A (fr) 1979-03-16
PT68825A (en) 1978-12-01
EG13683A (en) 1982-09-30
AR218514A1 (es) 1980-06-13
IE782328L (en) 1979-05-25
FI64372B (fi) 1983-07-29
IT7830171A0 (it) 1978-11-24
DE2851028A1 (de) 1979-05-31
NZ188974A (en) 1989-10-27
ZA786426B (en) 1979-10-31
FR2423492B1 (es) 1980-12-05
AT372384B (de) 1983-09-26
IT1160263B (it) 1987-03-11
AU529108B2 (en) 1983-05-26
LU80576A1 (fr) 1979-03-22
SG61182G (en) 1985-02-15
CH641181A5 (fr) 1984-02-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19990201