IE782328L - INDOLO (2,3-a) QUINOLIZIDINES - Google Patents

INDOLO (2,3-a) QUINOLIZIDINES

Info

Publication number
IE782328L
IE782328L IE782328A IE232878A IE782328L IE 782328 L IE782328 L IE 782328L IE 782328 A IE782328 A IE 782328A IE 232878 A IE232878 A IE 232878A IE 782328 L IE782328 L IE 782328L
Authority
IE
Ireland
Prior art keywords
indolo
quinolizidines
radical
group
methylenamido
Prior art date
Application number
IE782328A
Other versions
IE47518B1 (en
Original Assignee
Sod Conseils Rech Applic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic
Publication of IE782328L publication Critical patent/IE782328L/en
Publication of IE47518B1 publication Critical patent/IE47518B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

New indolo (2, 3-a) quinolizidines having the following formulae (I) and (II) (FORMULA) wherein R is a radical -COOC2H5, -COOH, -CN, a primary or secondary methylenamino radical, a group methylenamido or, with the nitrogen of the indolo nucleus, a group N-CO-NH-CH2 or N-CO-, as well as the salts of acid addition, therapeutically acceptable of these bodies. Also, a process for preparing the compounds.[WO7900319A1]
IE2328/78A 1977-11-25 1978-11-24 Indolo (2,3-a) quinolizidines,preparation and therapeutic use IE47518B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4920177 1977-11-25

Publications (2)

Publication Number Publication Date
IE782328L true IE782328L (en) 1979-05-25
IE47518B1 IE47518B1 (en) 1984-04-04

Family

ID=10451538

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2328/78A IE47518B1 (en) 1977-11-25 1978-11-24 Indolo (2,3-a) quinolizidines,preparation and therapeutic use

Country Status (28)

Country Link
JP (1) JPS6147838B2 (en)
AR (1) AR218514A1 (en)
AT (1) AT372384B (en)
AU (1) AU529108B2 (en)
BE (1) BE872134A (en)
CA (1) CA1100959A (en)
CH (1) CH641181A5 (en)
DE (1) DE2851028A1 (en)
DK (1) DK154430C (en)
EG (1) EG13683A (en)
ES (1) ES475328A1 (en)
FI (1) FI64372C (en)
FR (2) FR2409755A1 (en)
HK (1) HK60884A (en)
IE (1) IE47518B1 (en)
IN (1) IN151146B (en)
IT (1) IT1160263B (en)
LU (1) LU80576A1 (en)
MX (1) MX5529E (en)
MY (1) MY8500029A (en)
NL (1) NL7811562A (en)
NO (1) NO151288C (en)
NZ (1) NZ188974A (en)
PT (1) PT68825A (en)
SE (2) SE431650B (en)
SG (1) SG61182G (en)
WO (1) WO1979000319A1 (en)
ZA (1) ZA786426B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE25383T1 (en) * 1981-11-18 1987-02-15 Thal Claude INDOLOQUINOLIZIN DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND THEIR THERAPEUTIC APPLICATION.
FR2529552B1 (en) * 1982-07-05 1985-09-27 Centre Nat Rech Scient NOVEL PROCESS FOR THE PREPARATION OF VINDOLINE SYNTHESIS INTERMEDIATES AND SYNTHESIS INTERMEDIATES
HU191454B (en) * 1984-10-05 1987-02-27 Richter Gedeon Vegyeszeti Gyar Rt.,Hu Process for producing amides of oktahydro-indolo/2,3-a/quinolyzin-1-yl-alkanecarboxylic acids and pharmaceutically acceptable acid additional salts thereof
HU195214B (en) * 1985-04-19 1988-04-28 Richter Gedeon Vegyeszet Process for producing 12b-substituted-1-(hydroxymethyl)-octahydro-indolo /2,3-a/ quinolizine derivatives and pharmaceutical preparations comprising these compounds
HU194220B (en) * 1985-04-19 1988-01-28 Richter Gedeon Vegyeszet Process for production of derivatives of 1,12 b disubstituated-octahydro-indolo /2,3-a/ quinolisine and medical compounds containing thereof
FI95572C (en) 1987-06-22 1996-02-26 Eisai Co Ltd Process for the preparation of a medicament useful as a piperidine derivative or its pharmaceutical salt
PT704439E (en) * 1993-06-18 2001-12-28 Fujisawa Pharmaceutical Co A NEW INTERMEDIARY FOR SYNTHETIC USE AND PROCESS FOR THE PREPARATION OF AMINOPIPERAZINE DERIVATIVES
FR2713643B1 (en) * 1993-12-14 1996-06-07 Adir New analogs of eburnane, process for their preparation and pharmaceutical compositions containing them.
FR2713644B1 (en) * 1993-12-14 1996-02-09 Adir New analogs of eburnane, process for their preparation and pharmaceutical compositions containing them.
EP1532391B2 (en) † 2002-06-24 2019-03-06 Saint-Gobain Isover Insulation panel for supply duct
FR2911143A1 (en) * 2007-01-05 2008-07-11 Servier Lab Use of neuroprotective compounds to prepare medicaments for treating neurodegenerative diseases
FR2911142A1 (en) * 2007-01-05 2008-07-11 Servier Lab New amino-pyrroloindole and amino-pyridazinoindole derivatives, are tyrosine hydroxylase inducers, useful e.g. for treating anxiety, depression or memory loss
FR2911141B1 (en) * 2007-01-05 2009-02-20 Servier Lab NOVEL TRIAZABENZO [A] NAPHTHO [2,1,8-CDE] AZULENE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU167366B (en) * 1972-09-06 1975-09-27
BE802387A (en) * 1973-07-16 1973-11-16 Omnium Chimique Sa PROCESS FOR PREPARING VINCAMONE AND EPI-21 VINCAMONE FROM TABERSONIN AND NEW INDOLIC DERIVATIVES.
HU169916B (en) * 1974-09-27 1977-02-28
HU171165B (en) * 1974-11-26 1977-11-28 Richter Gedeon Vegyeszet Process for producing oktahydro-indolo-bracket-2,3-a-bracket closed-quinolizine derivatives
FR2315277A1 (en) * 1975-06-25 1977-01-21 Anvar NEW PENTACYCLIC DERIVATIVES, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM

Also Published As

Publication number Publication date
DK524978A (en) 1979-05-26
FR2409755A1 (en) 1979-06-22
PT68825A (en) 1978-12-01
LU80576A1 (en) 1979-03-22
AU529108B2 (en) 1983-05-26
SG61182G (en) 1985-02-15
NL7811562A (en) 1979-05-29
DK154430C (en) 1989-04-17
ES475328A1 (en) 1979-04-01
WO1979000319A1 (en) 1979-06-14
MX5529E (en) 1983-09-23
FI783581A (en) 1979-05-26
IN151146B (en) 1983-02-26
JPS6147838B2 (en) 1986-10-21
IT1160263B (en) 1987-03-11
SE8007845L (en) 1980-11-07
FR2423492B1 (en) 1980-12-05
AT372384B (en) 1983-09-26
NO783958L (en) 1979-05-28
AR218514A1 (en) 1980-06-13
ATA837478A (en) 1983-02-15
AU4187478A (en) 1979-05-31
DE2851028C2 (en) 1990-05-03
IT7830171A0 (en) 1978-11-24
BE872134A (en) 1979-03-16
SE435622B (en) 1984-10-08
NO151288B (en) 1984-12-03
SE7906287L (en) 1979-07-23
DE2851028A1 (en) 1979-05-31
FI64372C (en) 1983-11-10
FR2423492A1 (en) 1979-11-16
EG13683A (en) 1982-09-30
NZ188974A (en) 1989-10-27
FI64372B (en) 1983-07-29
FR2409755B1 (en) 1980-08-01
SE431650B (en) 1984-02-20
MY8500029A (en) 1985-12-31
JPS54500053A (en) 1979-11-08
IE47518B1 (en) 1984-04-04
HK60884A (en) 1984-08-10
DK154430B (en) 1988-11-14
NO151288C (en) 1985-03-13
CA1100959A (en) 1981-05-12
CH641181A5 (en) 1984-02-15
ZA786426B (en) 1979-10-31

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