SE7906287L - NEW INDOL- (2,3-A) -QINOLIZIDINES, TAKEN TO PROVIDE THESE AND THEIR USES AS THERAPEUTIC - Google Patents

NEW INDOL- (2,3-A) -QINOLIZIDINES, TAKEN TO PROVIDE THESE AND THEIR USES AS THERAPEUTIC

Info

Publication number
SE7906287L
SE7906287L SE7906287A SE7906287A SE7906287L SE 7906287 L SE7906287 L SE 7906287L SE 7906287 A SE7906287 A SE 7906287A SE 7906287 A SE7906287 A SE 7906287A SE 7906287 L SE7906287 L SE 7906287L
Authority
SE
Sweden
Prior art keywords
qinolizidines
therapeutic
taken
new
group
Prior art date
Application number
SE7906287A
Other languages
Swedish (sv)
Other versions
SE431650B (en
Original Assignee
Buzas Andre
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Buzas Andre filed Critical Buzas Andre
Publication of SE7906287L publication Critical patent/SE7906287L/en
Publication of SE431650B publication Critical patent/SE431650B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

The invention relates to a multistep preparation process of new indolo(2,3-a)quinolizidines of the general formulae (I) and (II): (I) (II) wherein R stands for -COOC2H5, -COOH, -CN, a primary or secondary methylenamino group, a methylenamido group, or wherein R, together with the ring nitrogen of the indolo ring, represents one of the groupings N-CO-NH-CH2 or N-CO. These compounds of the invention are useful in the field of blood circulation in the brain.
SE7906287A 1977-11-25 1979-07-23 INDOLO (2,3-A) QUINOLIZIDIN AND SET TO MAKE IT SE431650B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4920177 1977-11-25

Publications (2)

Publication Number Publication Date
SE7906287L true SE7906287L (en) 1979-07-23
SE431650B SE431650B (en) 1984-02-20

Family

ID=10451538

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7906287A SE431650B (en) 1977-11-25 1979-07-23 INDOLO (2,3-A) QUINOLIZIDIN AND SET TO MAKE IT
SE8007845A SE435622B (en) 1977-11-25 1980-11-07 THERAPEUTIC COMPOSITION CONTAINING INDOLO (2,3-A) QUINOLIZIDINES

Family Applications After (1)

Application Number Title Priority Date Filing Date
SE8007845A SE435622B (en) 1977-11-25 1980-11-07 THERAPEUTIC COMPOSITION CONTAINING INDOLO (2,3-A) QUINOLIZIDINES

Country Status (28)

Country Link
JP (1) JPS6147838B2 (en)
AR (1) AR218514A1 (en)
AT (1) AT372384B (en)
AU (1) AU529108B2 (en)
BE (1) BE872134A (en)
CA (1) CA1100959A (en)
CH (1) CH641181A5 (en)
DE (1) DE2851028A1 (en)
DK (1) DK154430C (en)
EG (1) EG13683A (en)
ES (1) ES475328A1 (en)
FI (1) FI64372C (en)
FR (2) FR2423492A1 (en)
HK (1) HK60884A (en)
IE (1) IE47518B1 (en)
IN (1) IN151146B (en)
IT (1) IT1160263B (en)
LU (1) LU80576A1 (en)
MX (1) MX5529E (en)
MY (1) MY8500029A (en)
NL (1) NL7811562A (en)
NO (1) NO151288C (en)
NZ (1) NZ188974A (en)
PT (1) PT68825A (en)
SE (2) SE431650B (en)
SG (1) SG61182G (en)
WO (1) WO1979000319A1 (en)
ZA (1) ZA786426B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE25383T1 (en) * 1981-11-18 1987-02-15 Thal Claude INDOLOQUINOLIZIN DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND THEIR THERAPEUTIC APPLICATION.
FR2529552B1 (en) * 1982-07-05 1985-09-27 Centre Nat Rech Scient NOVEL PROCESS FOR THE PREPARATION OF VINDOLINE SYNTHESIS INTERMEDIATES AND SYNTHESIS INTERMEDIATES
HU191454B (en) * 1984-10-05 1987-02-27 Richter Gedeon Vegyeszeti Gyar Rt.,Hu Process for producing amides of oktahydro-indolo/2,3-a/quinolyzin-1-yl-alkanecarboxylic acids and pharmaceutically acceptable acid additional salts thereof
HU194220B (en) * 1985-04-19 1988-01-28 Richter Gedeon Vegyeszet Process for production of derivatives of 1,12 b disubstituated-octahydro-indolo /2,3-a/ quinolisine and medical compounds containing thereof
HU195214B (en) * 1985-04-19 1988-04-28 Richter Gedeon Vegyeszet Process for producing 12b-substituted-1-(hydroxymethyl)-octahydro-indolo /2,3-a/ quinolizine derivatives and pharmaceutical preparations comprising these compounds
FI95572C (en) 1987-06-22 1996-02-26 Eisai Co Ltd Process for the preparation of a medicament useful as a piperidine derivative or its pharmaceutical salt
KR100324040B1 (en) * 1993-06-18 2002-07-22 후지사와 야꾸힝 고교 가부시키가이샤 Process for preparing novel intermediates and aminopiperazine derivatives for use in synthetic applications
FR2713643B1 (en) * 1993-12-14 1996-06-07 Adir New analogs of eburnane, process for their preparation and pharmaceutical compositions containing them.
FR2713644B1 (en) * 1993-12-14 1996-02-09 Adir New analogs of eburnane, process for their preparation and pharmaceutical compositions containing them.
SI1532391T2 (en) † 2002-06-24 2019-06-28 Saint-Gobain Isover Insulation panel for supply duct
FR2911141B1 (en) * 2007-01-05 2009-02-20 Servier Lab NOVEL TRIAZABENZO [A] NAPHTHO [2,1,8-CDE] AZULENE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2911143A1 (en) * 2007-01-05 2008-07-11 Servier Lab Use of neuroprotective compounds to prepare medicaments for treating neurodegenerative diseases
FR2911142A1 (en) * 2007-01-05 2008-07-11 Servier Lab New amino-pyrroloindole and amino-pyridazinoindole derivatives, are tyrosine hydroxylase inducers, useful e.g. for treating anxiety, depression or memory loss

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU167366B (en) * 1972-09-06 1975-09-27
BE802387A (en) * 1973-07-16 1973-11-16 Omnium Chimique Sa PROCESS FOR PREPARING VINCAMONE AND EPI-21 VINCAMONE FROM TABERSONIN AND NEW INDOLIC DERIVATIVES.
HU169916B (en) * 1974-09-27 1977-02-28
HU171165B (en) * 1974-11-26 1977-11-28 Richter Gedeon Vegyeszet Process for producing oktahydro-indolo-bracket-2,3-a-bracket closed-quinolizine derivatives
FR2315277A1 (en) * 1975-06-25 1977-01-21 Anvar NEW PENTACYCLIC DERIVATIVES, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM

Also Published As

Publication number Publication date
FI64372C (en) 1983-11-10
IT1160263B (en) 1987-03-11
IE47518B1 (en) 1984-04-04
MY8500029A (en) 1985-12-31
DK154430C (en) 1989-04-17
FR2423492A1 (en) 1979-11-16
AU4187478A (en) 1979-05-31
FR2409755A1 (en) 1979-06-22
AU529108B2 (en) 1983-05-26
ZA786426B (en) 1979-10-31
ATA837478A (en) 1983-02-15
AT372384B (en) 1983-09-26
IE782328L (en) 1979-05-25
SE435622B (en) 1984-10-08
DK524978A (en) 1979-05-26
DE2851028C2 (en) 1990-05-03
SG61182G (en) 1985-02-15
NO151288B (en) 1984-12-03
NL7811562A (en) 1979-05-29
IN151146B (en) 1983-02-26
CH641181A5 (en) 1984-02-15
DK154430B (en) 1988-11-14
FR2409755B1 (en) 1980-08-01
LU80576A1 (en) 1979-03-22
PT68825A (en) 1978-12-01
EG13683A (en) 1982-09-30
FI783581A (en) 1979-05-26
FR2423492B1 (en) 1980-12-05
AR218514A1 (en) 1980-06-13
SE431650B (en) 1984-02-20
BE872134A (en) 1979-03-16
SE8007845L (en) 1980-11-07
ES475328A1 (en) 1979-04-01
HK60884A (en) 1984-08-10
JPS54500053A (en) 1979-11-08
IT7830171A0 (en) 1978-11-24
CA1100959A (en) 1981-05-12
WO1979000319A1 (en) 1979-06-14
DE2851028A1 (en) 1979-05-31
NZ188974A (en) 1989-10-27
NO783958L (en) 1979-05-28
MX5529E (en) 1983-09-23
JPS6147838B2 (en) 1986-10-21
NO151288C (en) 1985-03-13
FI64372B (en) 1983-07-29

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