GB2009749A - Indolo (2,3-a) Quinolizidines, Preparation and Therapeutic Use - Google Patents

Indolo (2,3-a) Quinolizidines, Preparation and Therapeutic Use

Info

Publication number
GB2009749A
GB2009749A GB7846148A GB7846148A GB2009749A GB 2009749 A GB2009749 A GB 2009749A GB 7846148 A GB7846148 A GB 7846148A GB 7846148 A GB7846148 A GB 7846148A GB 2009749 A GB2009749 A GB 2009749A
Authority
GB
United Kingdom
Prior art keywords
indolo
quinolizidines
preparation
therapeutic use
amidomethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7846148A
Other versions
GB2009749B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Pharma SAS
Original Assignee
Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS filed Critical Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Priority to GB7846148A priority Critical patent/GB2009749B/en
Publication of GB2009749A publication Critical patent/GB2009749A/en
Application granted granted Critical
Publication of GB2009749B publication Critical patent/GB2009749B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Indolo (2,3-a) quinolizidines of the formula I and II <IMAGE> in which R=-COOC2H5, -COOH, -CN, aminomethyl, amido or amidomethyl or in which R and the indolo ring nitrogen together provide -N-CO- NH-CH2- or -N-CO-. Also acid addition salts and a process for their preparation starting from 2-aminoethyl-3-indole and 1- chloro-4-(ethoxycarbonyl or cyano)-4- chlorocarbonyl-hexane. The products are useful in the field of cerebral irrigation.
GB7846148A 1977-11-25 1978-11-27 Indolo(1,3-a)quinolizidines Expired GB2009749B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB7846148A GB2009749B (en) 1977-11-25 1978-11-27 Indolo(1,3-a)quinolizidines

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB4920177 1977-11-25
GB7846148A GB2009749B (en) 1977-11-25 1978-11-27 Indolo(1,3-a)quinolizidines

Publications (2)

Publication Number Publication Date
GB2009749A true GB2009749A (en) 1979-06-20
GB2009749B GB2009749B (en) 1982-04-28

Family

ID=26266426

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7846148A Expired GB2009749B (en) 1977-11-25 1978-11-27 Indolo(1,3-a)quinolizidines

Country Status (1)

Country Link
GB (1) GB2009749B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0202774A2 (en) * 1985-04-19 1986-11-26 Richter Gedeon Vegyeszeti Gyar R.T. 1,12b-Disubstituted octahydroindolo [2,3-a]-Quinolizine derivatives
AU679132B2 (en) * 1993-12-14 1997-06-19 Les Laboratoires Servier New eburnane analogues, a process for the preparation thereof and pharmaceutical compositions containing them

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0202774A2 (en) * 1985-04-19 1986-11-26 Richter Gedeon Vegyeszeti Gyar R.T. 1,12b-Disubstituted octahydroindolo [2,3-a]-Quinolizine derivatives
EP0202774A3 (en) * 1985-04-19 1989-03-15 Richter Gedeon Vegyeszeti Gyar R.T. 1,12b-Disubstituted octahydroindolo [2,3-a]-Quinolizine derivatives
AU679132B2 (en) * 1993-12-14 1997-06-19 Les Laboratoires Servier New eburnane analogues, a process for the preparation thereof and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
GB2009749B (en) 1982-04-28

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee