ES8301205A1 - "procedimiento de preparacion de sulfato aldehido d-fenilalanil-l-arginina". - Google Patents

"procedimiento de preparacion de sulfato aldehido d-fenilalanil-l-arginina".

Info

Publication number
ES8301205A1
ES8301205A1 ES508637A ES508637A ES8301205A1 ES 8301205 A1 ES8301205 A1 ES 8301205A1 ES 508637 A ES508637 A ES 508637A ES 508637 A ES508637 A ES 508637A ES 8301205 A1 ES8301205 A1 ES 8301205A1
Authority
ES
Spain
Prior art keywords
phenylalanyl
prolyl
arginine aldehyde
aldehyde sulfate
sulfate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES508637A
Other languages
English (en)
Other versions
ES508637A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of ES508637A0 publication Critical patent/ES508637A0/es
Publication of ES8301205A1 publication Critical patent/ES8301205A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE SULFATO ALDEHIDO DE D-FENILALANIL-L-PROPIL-L-ARGININA. CONSISTE EN SEPARAR DE HEMISULFATO ALDEHIDO DE D-FENILALANIL-L-PROPIL-L-ARGININA O DE ALDEHIDO DE D-FENILALANIL-L-PROPIL-N<041>-CARBOXI-L-ARGININA, QUE CONTIENE UN GRUPO PROTECTOR SENSIBLE A LOS ACIDOS EN SU TERMINAL AMINO, ESTE GRUPO PROTECTOR, O EN SU CASO EL GRUPO N<041>-CARBOXILO, MEDIANTE ACIDO SULFURICO 1 A 12N, QUE SE APLICA EN 1 A 12 CANTIDADES EQUIVALENTES; Y AISLAR EL SULFATO ALDEHIDO TRIPEPTIDO LIBRE. >ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO ANTICOAGULANTES.
ES508637A 1981-01-13 1982-01-12 "procedimiento de preparacion de sulfato aldehido d-fenilalanil-l-arginina". Expired ES8301205A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU8170A HU184368B (en) 1981-01-13 1981-01-13 Process for preparing d-phenyl-alanyl-l-propyl-l-arginine-ald ehyde-shulphate

Publications (2)

Publication Number Publication Date
ES508637A0 ES508637A0 (es) 1982-11-16
ES8301205A1 true ES8301205A1 (es) 1982-11-16

Family

ID=10947750

Family Applications (1)

Application Number Title Priority Date Filing Date
ES508637A Expired ES8301205A1 (es) 1981-01-13 1982-01-12 "procedimiento de preparacion de sulfato aldehido d-fenilalanil-l-arginina".

Country Status (23)

Country Link
US (2) US4399065A (es)
JP (1) JPS57181046A (es)
AT (1) AT383352B (es)
AU (1) AU544492B2 (es)
BE (1) BE891708A (es)
CA (1) CA1182111A (es)
CH (1) CH649305A5 (es)
DE (1) DE3200812C2 (es)
DK (1) DK151341C (es)
ES (1) ES8301205A1 (es)
FI (1) FI74024C (es)
FR (1) FR2497799B1 (es)
GB (1) GB2091270B (es)
HU (1) HU184368B (es)
IL (1) IL64761A (es)
IT (1) IT1210842B (es)
MX (1) MX156383A (es)
NL (1) NL8200105A (es)
NO (1) NO158021C (es)
PL (1) PL133451B1 (es)
PT (1) PT74268B (es)
SE (1) SE453509B (es)
SU (1) SU1442078A3 (es)

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HU184368B (en) * 1981-01-13 1984-08-28 Gyogyszerkutato Intezet Process for preparing d-phenyl-alanyl-l-propyl-l-arginine-ald ehyde-shulphate
EP0118223A1 (en) * 1983-02-07 1984-09-12 Aktiebolaget Hässle Enzyme inhibitors
DE3481913D1 (de) * 1983-04-27 1990-05-17 Ici America Inc Prolin-derivate.
HU192646B (en) * 1984-12-21 1987-06-29 Gyogyszerkutato Intezet Process for preparing new n-alkyl-peptide aldehydes
DE3505555A1 (de) * 1985-02-18 1986-09-11 Behringwerke Ag, 3550 Marburg Neue oligopeptidylargininolderivate und deren homologe, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel
DE3606480A1 (de) * 1986-02-28 1987-09-03 Behringwerke Ag Oligopeptidylnitrilderivate, diese enthaltende mittel, verfahren zu ihrer herstellung und ihre verwendung
US5023236A (en) * 1988-04-07 1991-06-11 Corvas, Inc. Factor VII/VIIA active site inhibitors
US5332726A (en) * 1989-09-29 1994-07-26 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antithrombotic peptides and pseudopeptides
US5064814A (en) * 1990-04-05 1991-11-12 Rhone-Poulenc Rorer Pharmaceuticals Inc. Anti-thrombotic peptide and pseudopeptide derivatives
GB2244994B (en) * 1990-06-12 1994-01-19 Richter Gedeon Vegyeszet Improved process for the preparation of tripeptide aldehydes
US5430023A (en) * 1990-09-28 1995-07-04 Eli Lilly And Company Tripeptide antithrombotic agents
CA2075154A1 (en) * 1991-08-06 1993-02-07 Neelakantan Balasubramanian Peptide aldehydes as antithrombotic agents
US5250660A (en) * 1991-11-12 1993-10-05 Eli Lilly And Company Peptide purification process
US5416093A (en) * 1991-11-12 1995-05-16 Eli Lilly And Company Antithrombotic agents
US5252566A (en) * 1991-11-12 1993-10-12 Eli Lilly And Company Antithrombotic agents
US5492895A (en) * 1992-02-14 1996-02-20 Corvas International, Inc. Inhibitors of thrombosis
AU663169B2 (en) * 1992-03-04 1995-09-28 Gyogyszerkutato Intezet Kft New anticoagulant peptide derivatives and pharmaceutical compositions containing the same as well as a process for the preparation thereof
EP0583534B1 (en) * 1992-08-14 1997-03-05 The Procter & Gamble Company Liquid detergents containing a peptide aldehyde
US5576283A (en) * 1992-08-14 1996-11-19 The Procter & Gamble Company Liquid detergents containing a peptide aldehyde
US5582762A (en) * 1992-08-14 1996-12-10 The Procter & Gamble Company Liquid detergents containing a peptide trifluoromethyl ketone
US5371072A (en) * 1992-10-16 1994-12-06 Corvas International, Inc. Asp-Pro-Arg α-keto-amide enzyme inhibitors
IL108031A0 (en) * 1992-12-22 1994-04-12 Procter & Gamble Difluoro pentapeptide derivatives and pharmaceutical compositions containing them
US5707966A (en) * 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
US5885967A (en) * 1994-03-04 1999-03-23 Eli Lilly And Company Antithrombotic agents
US5488037A (en) * 1994-03-04 1996-01-30 Eli Lilly And Company Antithrombotic agents
US5436229A (en) * 1994-03-04 1995-07-25 Eli Lilly And Company Bisulfite adducts of arginine aldehydes
US5484772A (en) * 1994-03-04 1996-01-16 Eli Lilly And Company Antithrombotic agents
CA2143533A1 (en) * 1994-03-04 1995-09-05 Kenneth D. Kurz Antithrombotic agents
US5726159A (en) * 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
ZA951618B (en) * 1994-03-04 1996-08-27 Lilly Co Eli Antithrombotic agents
US5439888A (en) * 1994-03-04 1995-08-08 Eli Lilly And Company Antithrombotic agents
US5602101A (en) * 1994-03-04 1997-02-11 Eli Lilly And Company Antithrombotic agents
US5705487A (en) * 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
US5932733A (en) * 1994-06-17 1999-08-03 Corvas International, Inc. 3-amino-2-oxo-1-piperidineacetic derivatives containing an arginine mimic as enzyme inhibitors
US5656645A (en) * 1994-12-13 1997-08-12 Corvas International, Inc. Aromatic heterocyclic derivatives as enzyme inhibitors
US5658930A (en) * 1994-12-13 1997-08-19 Corvas International, Inc. Aromatic heterocyclic derivatives as enzyme inhibitors
US5914319A (en) * 1995-02-27 1999-06-22 Eli Lilly And Company Antithrombotic agents
US5710130A (en) * 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
US6046169A (en) * 1995-06-07 2000-04-04 Cor Therapeutics, Inc. Inhibitors of factor XA
US5721214A (en) * 1995-06-07 1998-02-24 Cor Therapeutics, Inc. Inhibitors of factor Xa
US5919765A (en) * 1995-06-07 1999-07-06 Cor Therapeutics, Inc. Inhibitors of factor XA
US6022861A (en) * 1995-06-07 2000-02-08 Cor Therapeutics, Inc. Ketoheterocyclic inhibitors of factor Xa
US6069130A (en) 1995-06-07 2000-05-30 Cor Therapeutics, Inc. Ketoheterocyclic inhibitors of factor Xa
US6069232A (en) * 1995-10-02 2000-05-30 Hoechst Marion Roussel, Inc. Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors
DE19605039A1 (de) 1996-02-12 1997-08-14 Hoechst Ag Verfahren zur Herstellung von Oligopeptid-Aldehyden
US5739354A (en) * 1996-03-26 1998-04-14 Hoechst Marion Roussel, Inc. Process for the preparation of N-methyl-D-phenylalanyl-N- 1- 3- (aminoiminomethyl)amino!propyl!-3,3-difluoro-2-oxohexyl!-L-prolinamide
US6245743B1 (en) 1996-06-05 2001-06-12 Cor Therapeutics, Inc. Inhibitors of factor Xa
IT1283467B1 (it) * 1996-07-19 1998-04-21 Menarini Farma Ind Derivati di cicloalcani 1,2 sostituiti come inibitori della trombina, procedimento per la loro preparazione e loro impiego in formulazioni
BR9712111A (pt) * 1996-09-24 1999-08-31 Procter & Gamble Detergentes líquidos contendo enzima proteolítica e inibidores da protease.
US6165966A (en) * 1996-09-24 2000-12-26 The Procter & Gamble Company Liquid detergents containing proteolytic enzyme and protease inhibitors
CN1238003A (zh) 1996-09-24 1999-12-08 普罗格特-甘布尔公司 含有蛋白酶和蛋白酶抑制剂的液体洗衣洗涤剂组合物
US7090455B2 (en) * 1998-11-13 2006-08-15 Pneutools, Incorporated Stacked assembly of roofing caps
EP2224949B1 (en) * 2007-11-30 2012-10-17 University of Debrecen Use of urokinase type plasminogen activator inhibitors for the treatment of corneal disorders
EP2343310A1 (en) * 2010-01-08 2011-07-13 Novozymes A/S Serine hydrolase formulation
KR101956895B1 (ko) 2011-07-01 2019-03-12 노보자임스 에이/에스 안정화된 서브틸리신 조성물
CN106471110A (zh) 2014-07-03 2017-03-01 诺维信公司 改进的非蛋白酶类酶稳定化
DE102015208655A1 (de) 2015-05-11 2016-11-17 Henkel Ag & Co. Kgaa Enzymstabilisatoren
DE102015210828A1 (de) 2015-06-12 2016-12-15 Henkel Ag & Co. Kgaa Phosphatfreies flüssiges Geschirrspülmittel
DE102016209406A1 (de) 2016-05-31 2017-11-30 Henkel Ag & Co. Kgaa Stabilisierte Enzym-haltige Wasch- und Reinigungsmittel
DE102017219993A1 (de) 2017-11-09 2019-05-09 Henkel Ag & Co. Kgaa Enzymhaltiges Wasch- oder Reinigungsmittel
DE102018129277A1 (de) 2018-11-21 2020-05-28 Henkel Ag & Co. Kgaa Mehrkomponenten Wasch- oder Reinigungsmittel enthaltend eine Chinon-Oxidoreduktase
JP2022538360A (ja) 2019-07-01 2022-09-01 ビーエーエスエフ ソシエタス・ヨーロピア 酵素を安定化するためのペプチドアセタール
EP3770237A1 (de) 2019-07-22 2021-01-27 Henkel AG & Co. KGaA Wasch- und reinigungsmittel mit verbesserter enzym-stabilität
BR112023005128A2 (pt) 2020-09-22 2023-04-25 Basf Se Composição, composição de detergente, método para prover uma composição de detergente com estabilidade e/ou desempenho de lavagem melhorados, e, uso de uma composição

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Publication number Priority date Publication date Assignee Title
US3826793A (en) * 1968-10-21 1974-07-30 Bofors Ab Anticoagulant peptides related to fibrino peptides
HU169870B (es) * 1974-06-14 1977-02-28
HU177098B (en) * 1979-01-04 1981-07-28 Gyogyszerkutato Intezet Process for producing new peptidyl-n-carboxy-l-arginin-a
HU184368B (en) * 1981-01-13 1984-08-28 Gyogyszerkutato Intezet Process for preparing d-phenyl-alanyl-l-propyl-l-arginine-ald ehyde-shulphate

Also Published As

Publication number Publication date
GB2091270A (en) 1982-07-28
PT74268A (en) 1982-02-01
IL64761A (en) 1985-01-31
CH649305A5 (de) 1985-05-15
IT8219074A0 (it) 1982-01-12
US4399065A (en) 1983-08-16
DE3200812A1 (de) 1982-08-12
BE891708A (fr) 1982-07-07
CA1182111A (en) 1985-02-05
FI74024C (fi) 1987-12-10
NO158021B (no) 1988-03-21
NL8200105A (nl) 1982-08-02
PL234696A1 (es) 1982-09-13
JPH0251920B2 (es) 1990-11-08
DK151341B (da) 1987-11-23
SE8200135L (sv) 1982-07-14
FI74024B (fi) 1987-08-31
NO158021C (no) 1988-06-29
AU7944682A (en) 1982-07-22
GB2091270B (en) 1984-08-22
US4478745A (en) 1984-10-23
HU184368B (en) 1984-08-28
PL133451B1 (en) 1985-06-29
SU1442078A3 (ru) 1988-11-30
ES508637A0 (es) 1982-11-16
NO820083L (no) 1982-07-14
AT383352B (de) 1987-06-25
IT1210842B (it) 1989-09-29
FR2497799A1 (fr) 1982-07-16
DK151341C (da) 1988-05-09
AU544492B2 (en) 1985-05-30
DK9382A (da) 1982-07-14
IL64761A0 (en) 1982-03-31
FR2497799B1 (fr) 1985-06-28
ATA9782A (de) 1986-11-15
FI820086L (fi) 1982-07-14
DE3200812C2 (de) 1986-09-18
MX156383A (es) 1988-08-16
SE453509B (sv) 1988-02-08
PT74268B (en) 1983-06-27
JPS57181046A (en) 1982-11-08

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