DK9382A - Stabilt d-phenylalanin-l-propyl-l-argininal-dehyd-sulfat dets fremstilling og anvendelse i antikoagulerende virksomme farmaceutika - Google Patents

Stabilt d-phenylalanin-l-propyl-l-argininal-dehyd-sulfat dets fremstilling og anvendelse i antikoagulerende virksomme farmaceutika Download PDF

Info

Publication number
DK9382A
DK9382A DK9382A DK9382A DK9382A DK 9382 A DK9382 A DK 9382A DK 9382 A DK9382 A DK 9382A DK 9382 A DK9382 A DK 9382A DK 9382 A DK9382 A DK 9382A
Authority
DK
Denmark
Prior art keywords
argininal
dehyd
phenylalanin
anticoagulating
sulphate
Prior art date
Application number
DK9382A
Other languages
English (en)
Other versions
DK151341B (da
DK151341C (da
Inventor
S Bajusz
E Szell
E Barabas
D Bagdy
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of DK9382A publication Critical patent/DK9382A/da
Publication of DK151341B publication Critical patent/DK151341B/da
Application granted granted Critical
Publication of DK151341C publication Critical patent/DK151341C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DK009382A 1981-01-13 1982-01-12 Analogifremgangsmaade til fremstilling af d-phenylalanyl-l-prolyl-l-argininaldehydsulfat DK151341C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU7081 1981-01-13
HU8170A HU184368B (en) 1981-01-13 1981-01-13 Process for preparing d-phenyl-alanyl-l-propyl-l-arginine-ald ehyde-shulphate

Publications (3)

Publication Number Publication Date
DK9382A true DK9382A (da) 1982-07-14
DK151341B DK151341B (da) 1987-11-23
DK151341C DK151341C (da) 1988-05-09

Family

ID=10947750

Family Applications (1)

Application Number Title Priority Date Filing Date
DK009382A DK151341C (da) 1981-01-13 1982-01-12 Analogifremgangsmaade til fremstilling af d-phenylalanyl-l-prolyl-l-argininaldehydsulfat

Country Status (23)

Country Link
US (2) US4399065A (da)
JP (1) JPS57181046A (da)
AT (1) AT383352B (da)
AU (1) AU544492B2 (da)
BE (1) BE891708A (da)
CA (1) CA1182111A (da)
CH (1) CH649305A5 (da)
DE (1) DE3200812C2 (da)
DK (1) DK151341C (da)
ES (1) ES508637A0 (da)
FI (1) FI74024C (da)
FR (1) FR2497799B1 (da)
GB (1) GB2091270B (da)
HU (1) HU184368B (da)
IL (1) IL64761A (da)
IT (1) IT1210842B (da)
MX (1) MX156383A (da)
NL (1) NL8200105A (da)
NO (1) NO158021C (da)
PL (1) PL133451B1 (da)
PT (1) PT74268B (da)
SE (1) SE453509B (da)
SU (1) SU1442078A3 (da)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU184368B (en) * 1981-01-13 1984-08-28 Gyogyszerkutato Intezet Process for preparing d-phenyl-alanyl-l-propyl-l-arginine-ald ehyde-shulphate
WO1984003044A1 (en) * 1983-02-07 1984-08-16 Ferring Ab Enzyme inhibitors
DE3481913D1 (de) * 1983-04-27 1990-05-17 Ici America Inc Prolin-derivate.
HU192646B (en) * 1984-12-21 1987-06-29 Gyogyszerkutato Intezet Process for preparing new n-alkyl-peptide aldehydes
DE3505555A1 (de) * 1985-02-18 1986-09-11 Behringwerke Ag, 3550 Marburg Neue oligopeptidylargininolderivate und deren homologe, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel
DE3606480A1 (de) * 1986-02-28 1987-09-03 Behringwerke Ag Oligopeptidylnitrilderivate, diese enthaltende mittel, verfahren zu ihrer herstellung und ihre verwendung
US5023236A (en) * 1988-04-07 1991-06-11 Corvas, Inc. Factor VII/VIIA active site inhibitors
US5332726A (en) * 1989-09-29 1994-07-26 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antithrombotic peptides and pseudopeptides
US5064814A (en) * 1990-04-05 1991-11-12 Rhone-Poulenc Rorer Pharmaceuticals Inc. Anti-thrombotic peptide and pseudopeptide derivatives
GB2244994B (en) * 1990-06-12 1994-01-19 Richter Gedeon Vegyeszet Improved process for the preparation of tripeptide aldehydes
US5430023A (en) * 1990-09-28 1995-07-04 Eli Lilly And Company Tripeptide antithrombotic agents
CA2075154A1 (en) * 1991-08-06 1993-02-07 Neelakantan Balasubramanian Peptide aldehydes as antithrombotic agents
US5252566A (en) * 1991-11-12 1993-10-12 Eli Lilly And Company Antithrombotic agents
US5416093A (en) * 1991-11-12 1995-05-16 Eli Lilly And Company Antithrombotic agents
US5250660A (en) * 1991-11-12 1993-10-05 Eli Lilly And Company Peptide purification process
DE69314478T2 (de) * 1992-03-04 1999-02-11 Gyogyszerkutato Intezet Neuartige antikoagulierende peptidderivate und arzneimittel die solche enthalten so wie entsprechendes herstellungsverfahren
DE69217934T2 (de) * 1992-08-14 1997-09-04 Procter & Gamble Peptidaldehydhaltige flüssige Waschmittel
US5576283A (en) * 1992-08-14 1996-11-19 The Procter & Gamble Company Liquid detergents containing a peptide aldehyde
US5582762A (en) * 1992-08-14 1996-12-10 The Procter & Gamble Company Liquid detergents containing a peptide trifluoromethyl ketone
US5371072A (en) * 1992-10-16 1994-12-06 Corvas International, Inc. Asp-Pro-Arg α-keto-amide enzyme inhibitors
IL108031A0 (en) * 1992-12-22 1994-04-12 Procter & Gamble Difluoro pentapeptide derivatives and pharmaceutical compositions containing them
JP3466614B2 (ja) * 1993-02-12 2003-11-17 コルバス・インターナショナル、インコーポレイテッド 血栓症のインヒビター
US5436229A (en) * 1994-03-04 1995-07-25 Eli Lilly And Company Bisulfite adducts of arginine aldehydes
US5707966A (en) * 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
US5602101A (en) * 1994-03-04 1997-02-11 Eli Lilly And Company Antithrombotic agents
US5484772A (en) * 1994-03-04 1996-01-16 Eli Lilly And Company Antithrombotic agents
US5885967A (en) * 1994-03-04 1999-03-23 Eli Lilly And Company Antithrombotic agents
US5439888A (en) * 1994-03-04 1995-08-08 Eli Lilly And Company Antithrombotic agents
CA2143533A1 (en) * 1994-03-04 1995-09-05 Kenneth D. Kurz Antithrombotic agents
US5705487A (en) * 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
US5488037A (en) * 1994-03-04 1996-01-30 Eli Lilly And Company Antithrombotic agents
US5726159A (en) * 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
ZA951618B (en) * 1994-03-04 1996-08-27 Lilly Co Eli Antithrombotic agents
US5932733A (en) * 1994-06-17 1999-08-03 Corvas International, Inc. 3-amino-2-oxo-1-piperidineacetic derivatives containing an arginine mimic as enzyme inhibitors
US5656645A (en) * 1994-12-13 1997-08-12 Corvas International, Inc. Aromatic heterocyclic derivatives as enzyme inhibitors
US5658930A (en) * 1994-12-13 1997-08-19 Corvas International, Inc. Aromatic heterocyclic derivatives as enzyme inhibitors
US5914319A (en) * 1995-02-27 1999-06-22 Eli Lilly And Company Antithrombotic agents
US5710130A (en) * 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
US6046169A (en) * 1995-06-07 2000-04-04 Cor Therapeutics, Inc. Inhibitors of factor XA
US5721214A (en) * 1995-06-07 1998-02-24 Cor Therapeutics, Inc. Inhibitors of factor Xa
US6022861A (en) * 1995-06-07 2000-02-08 Cor Therapeutics, Inc. Ketoheterocyclic inhibitors of factor Xa
US6069130A (en) 1995-06-07 2000-05-30 Cor Therapeutics, Inc. Ketoheterocyclic inhibitors of factor Xa
US5919765A (en) * 1995-06-07 1999-07-06 Cor Therapeutics, Inc. Inhibitors of factor XA
US6069232A (en) * 1995-10-02 2000-05-30 Hoechst Marion Roussel, Inc. Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors
DE19605039A1 (de) 1996-02-12 1997-08-14 Hoechst Ag Verfahren zur Herstellung von Oligopeptid-Aldehyden
US5739354A (en) * 1996-03-26 1998-04-14 Hoechst Marion Roussel, Inc. Process for the preparation of N-methyl-D-phenylalanyl-N- 1- 3- (aminoiminomethyl)amino!propyl!-3,3-difluoro-2-oxohexyl!-L-prolinamide
US6245743B1 (en) 1996-06-05 2001-06-12 Cor Therapeutics, Inc. Inhibitors of factor Xa
IT1283467B1 (it) * 1996-07-19 1998-04-21 Menarini Farma Ind Derivati di cicloalcani 1,2 sostituiti come inibitori della trombina, procedimento per la loro preparazione e loro impiego in formulazioni
US6162783A (en) * 1996-09-24 2000-12-19 The Procter & Gamble Company Liquid detergents containing proteolytic enzyme and protease inhibitors
US6165966A (en) * 1996-09-24 2000-12-26 The Procter & Gamble Company Liquid detergents containing proteolytic enzyme and protease inhibitors
WO1998013461A1 (en) 1996-09-24 1998-04-02 The Procter & Gamble Company Liquid laundry detergent compositions containing proteolytic enzyme and protease inhibitors
US7090455B2 (en) * 1998-11-13 2006-08-15 Pneutools, Incorporated Stacked assembly of roofing caps
WO2009068926A1 (en) * 2007-11-30 2009-06-04 University Of Debrecen Use of urokinase type plasminogen activator inhibitors for the treatment of corneal disorders
EP2343310A1 (en) * 2010-01-08 2011-07-13 Novozymes A/S Serine hydrolase formulation
CN103649292B (zh) 2011-07-01 2017-11-28 诺维信公司 稳定化的枯草杆菌蛋白酶组合物
EP3164476A1 (en) 2014-07-03 2017-05-10 Novozymes A/S Improved stabilization of non-protease enzyme
DE102015208655A1 (de) 2015-05-11 2016-11-17 Henkel Ag & Co. Kgaa Enzymstabilisatoren
DE102015210828A1 (de) 2015-06-12 2016-12-15 Henkel Ag & Co. Kgaa Phosphatfreies flüssiges Geschirrspülmittel
DE102016209406A1 (de) 2016-05-31 2017-11-30 Henkel Ag & Co. Kgaa Stabilisierte Enzym-haltige Wasch- und Reinigungsmittel
DE102017219993A1 (de) 2017-11-09 2019-05-09 Henkel Ag & Co. Kgaa Enzymhaltiges Wasch- oder Reinigungsmittel
DE102018129277A1 (de) 2018-11-21 2020-05-28 Henkel Ag & Co. Kgaa Mehrkomponenten Wasch- oder Reinigungsmittel enthaltend eine Chinon-Oxidoreduktase
MX2021015894A (es) 2019-07-01 2022-02-03 Basf Se Peptidos acetales para estabilizar enzimas.
EP3770237A1 (de) 2019-07-22 2021-01-27 Henkel AG & Co. KGaA Wasch- und reinigungsmittel mit verbesserter enzym-stabilität
MX2023003275A (es) 2020-09-22 2023-04-12 Basf Se Combinacion mejorada de proteasa e inhibidor de proteasa con enzima secundaria.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3826793A (en) * 1968-10-21 1974-07-30 Bofors Ab Anticoagulant peptides related to fibrino peptides
HU169870B (da) * 1974-06-14 1977-02-28
HU177098B (en) * 1979-01-04 1981-07-28 Gyogyszerkutato Intezet Process for producing new peptidyl-n-carboxy-l-arginin-a
HU184368B (en) * 1981-01-13 1984-08-28 Gyogyszerkutato Intezet Process for preparing d-phenyl-alanyl-l-propyl-l-arginine-ald ehyde-shulphate

Also Published As

Publication number Publication date
NL8200105A (nl) 1982-08-02
FI820086L (fi) 1982-07-14
DE3200812C2 (de) 1986-09-18
SE8200135L (sv) 1982-07-14
CH649305A5 (de) 1985-05-15
CA1182111A (en) 1985-02-05
FI74024C (fi) 1987-12-10
AU7944682A (en) 1982-07-22
AU544492B2 (en) 1985-05-30
AT383352B (de) 1987-06-25
IT1210842B (it) 1989-09-29
MX156383A (es) 1988-08-16
DK151341B (da) 1987-11-23
IL64761A0 (en) 1982-03-31
IT8219074A0 (it) 1982-01-12
US4478745A (en) 1984-10-23
US4399065A (en) 1983-08-16
PT74268B (en) 1983-06-27
FR2497799B1 (fr) 1985-06-28
FI74024B (fi) 1987-08-31
JPH0251920B2 (da) 1990-11-08
ATA9782A (de) 1986-11-15
JPS57181046A (en) 1982-11-08
PT74268A (en) 1982-02-01
ES8301205A1 (es) 1982-11-16
SE453509B (sv) 1988-02-08
GB2091270A (en) 1982-07-28
NO158021C (no) 1988-06-29
NO158021B (no) 1988-03-21
PL234696A1 (da) 1982-09-13
PL133451B1 (en) 1985-06-29
DE3200812A1 (de) 1982-08-12
BE891708A (fr) 1982-07-07
SU1442078A3 (ru) 1988-11-30
FR2497799A1 (fr) 1982-07-16
GB2091270B (en) 1984-08-22
DK151341C (da) 1988-05-09
NO820083L (no) 1982-07-14
IL64761A (en) 1985-01-31
ES508637A0 (es) 1982-11-16
HU184368B (en) 1984-08-28

Similar Documents

Publication Publication Date Title
DK9382A (da) Stabilt d-phenylalanin-l-propyl-l-argininal-dehyd-sulfat dets fremstilling og anvendelse i antikoagulerende virksomme farmaceutika
DK158126C (da) Flydende roegkoncentrat, dets fremstilling og anvendelse
IT1151875B (it) Anilide-composto e suo impiego
DK468685A (da) Liposom-gel-materiale og dets anvendelse
DK522383A (da) Aluminium-n-phosphonomethylglycin og dets anvendelse som herbicid
DK109584D0 (da) Acrylsyreamider,deres fremstilling og anvendelse
DK609689A (da) Folielaminat og dets anvendelse
DK395582A (da) Opakiserende polymerpartikler og deres anvendelse
DK157914C (da) Glasfibre og anvendelse heraf
ES534446A0 (es) Perfeccionamientos en fonocardiografos y electrocardiografos
DK232579A (da) Filter og filterelement til brug i filteret
DK546284D0 (da) Antidiuretisk middel og dets anvendelse
DK321784A (da) Korrosionshindrende middel og dets anvendelse
DK299783D0 (da) Monoklont antistof, dets fremstilling og anvendelse
NO843294L (no) Monokloklonat antistoff, dets fremstilling og anvendelse
DK462981A (da) 10-substituerede 1,8-dihydroxy-9-antroner og deres anvendelse
DK579182A (da) Flydende hudrensemiddel og anvendelsen deraf
DK216380A (da) Fungicidt middel dets fremstilling og anvendelse
FI820427L (fi) Foerbindning foer in i varandra gripande metall- eller plastprofiler
DK158844C (da) Saltsyrepraeparater og anvendelse heraf
DK439982A (da) Fortykkelsesmiddel og dets anvendelse i trykpastaer
DK285182A (da) Nematodicidt praeparat, dets fremstilling og anvendelse
DK144084A (da) Makrolid, dets fremstilling og anvendelse
DK146982A (da) Oximphosphatforbindelser og anvendelse deraf i insecticider,acaricider og nematodicider
DK249481A (da) Herbicid dets fremstilling og anvendelse ved ukrudtsbekaempelse

Legal Events

Date Code Title Description
PBP Patent lapsed