ES8703488A1 - Procedimiento para preparar peptidos - Google Patents

Procedimiento para preparar peptidos

Info

Publication number
ES8703488A1
ES8703488A1 ES548052A ES548052A ES8703488A1 ES 8703488 A1 ES8703488 A1 ES 8703488A1 ES 548052 A ES548052 A ES 548052A ES 548052 A ES548052 A ES 548052A ES 8703488 A1 ES8703488 A1 ES 8703488A1
Authority
ES
Spain
Prior art keywords
cholinergetic
zns
active peptides
denotes
peptides acting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES548052A
Other languages
English (en)
Other versions
ES548052A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES548052A0 publication Critical patent/ES548052A0/es
Publication of ES8703488A1 publication Critical patent/ES8703488A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/695—Corticotropin [ACTH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/68—Melanocyte-stimulating hormone [MSH]
    • C07K14/685—Alpha-melanotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/695—Corticotropin [ACTH]
    • C07K14/6955—Corticotropin [ACTH] with at least 1 amino acid in D-form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR PEPTIDOS. CONSISTE EN TRATAR A UN COMPUESTO DE FORMULA (II) CON ACIDOS ORGANICOS, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES FISIOLOGICAMENTE ACEPTABLES. SIENDO: A5, D-LYS O LYS; A6, FENILALAMINA, N-METILFENILALAMINA, 4-ALCOXI DE C 1 A 4 FENILAMINA; R4, BENCILOXICARBONILO (2), ALCANOILO, DE C 2 A 6, ARIL DE C 6 A 10 Y OTROS; R7, -NH(CH2)N-NH2-GLY-NH-(CH2)-NH2 Y GLY-LIS-R8; R8, 1-PIRIOLIDINILO, 1-PIPARIDINILO-AL-R Y OTROS; R, ALQUILO DE C 1 A 4/ M, UN NUMERO ENTERO DE 2 A 6; Y N, UN NUMERO ENTERO DE 4 A 10. LOS RADICALES R4, A3, A6, R7 DE (II) TIENEN PRESENTES GRUPOS AMINO PRIMARIOS Y SECUNDARIOS Y GRUPOS PROTECTORES DE URETANO SEPARABLES EN CONDICIONES ACIDAS. SE UTILIZA PARA TRATAR LESIONES CEREBRALES POST-TRAUMATICAS.
ES548052A 1984-10-22 1985-10-21 Procedimiento para preparar peptidos Expired ES8703488A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/663,193 US4623715A (en) 1984-10-22 1984-10-22 Novel peptides which are active on the central nervous system and have an action on the cholinergic system

Publications (2)

Publication Number Publication Date
ES548052A0 ES548052A0 (es) 1987-02-16
ES8703488A1 true ES8703488A1 (es) 1987-02-16

Family

ID=24660834

Family Applications (1)

Application Number Title Priority Date Filing Date
ES548052A Expired ES8703488A1 (es) 1984-10-22 1985-10-21 Procedimiento para preparar peptidos

Country Status (13)

Country Link
US (2) US4623715A (es)
EP (1) EP0179332B1 (es)
JP (1) JPH075632B2 (es)
AT (1) ATE84544T1 (es)
AU (1) AU579593B2 (es)
CA (1) CA1267996A (es)
CS (1) CS408391A3 (es)
DE (1) DE3586979D1 (es)
DK (1) DK170649B1 (es)
ES (1) ES8703488A1 (es)
GR (1) GR852541B (es)
IE (1) IE59724B1 (es)
PT (1) PT81345B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565606A (en) * 1986-10-21 1996-10-15 Hoechst Aktiengesellschaft Synthesis of peptide aminoalkylamides and peptide hydrazides by the solid-phase method
ATE63821T1 (de) * 1987-08-14 1991-06-15 Akzo Nv Praeparat zur verhuetung oder bekaempfung von komplikationen bei diabetes.
US4945999A (en) * 1989-04-06 1990-08-07 The Charles Machine Works, Inc. Directional rod pusher
DE3931788A1 (de) * 1989-09-23 1991-04-04 Hoechst Ag Neue zns-aktive hexapeptide mit antiamnestischer wirkung
IE912091A1 (en) * 1990-07-18 1992-01-29 Akzo Nv Use of a centrally acting atch analog in the manufacture of a¹medicament
US5444042A (en) * 1990-12-28 1995-08-22 Cortex Pharmaceuticals Method of treatment of neurodegeneration with calpain inhibitors
US5190924A (en) * 1991-02-13 1993-03-02 Boc Health Care, Inc. Peptide amides and amide dimers useful as muscle relaxants
US6579968B1 (en) * 1999-06-29 2003-06-17 Palatin Technologies, Inc. Compositions and methods for treatment of sexual dysfunction
US7176279B2 (en) * 2000-06-28 2007-02-13 Palatin Technologies, Inc. Cyclic peptide compositions and methods for treatment of sexual dysfunction
GB0010183D0 (en) * 2000-04-26 2000-06-14 Ferring Bv Inhibitors of dipeptidyl peptidase IV
JP4663233B2 (ja) * 2001-11-09 2011-04-06 エンゾン，インコーポレーテッド ベンジル脱離系を利用する高分子チオール結合プロドラッグ
US6974187B2 (en) * 2004-01-28 2005-12-13 Tachi-S Co., Ltd. Vehicle seat structure
CA2939164A1 (en) 2014-02-12 2015-08-20 Iteos Therapeutics Novel 3-(indol-3-yl)-pyridine derivatives, pharmaceutical compositions and methods for use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3042064A (en) * 1957-04-02 1962-07-03 Rockwell Mfg Co Gas pressure regulator
BE795788A (nl) 1972-02-22 1973-08-22 Akzo Nv Werkwijze ter bereiding van peptiden en peptide-derivaten en de toepassing hiervan
US3856770A (en) 1972-03-08 1974-12-24 Akzona Inc Psychopharmacologically active tetra-, penta-, hexa-, and heptapeptides
NL175174C (nl) 1972-03-31 1984-10-01 Akzo Nv Werkwijze ter bereiding van een farmaceutisch preparaat met psychofarmacologische werking, dat een peptide of peptide-derivaat als actief bestanddeel bevat, alsmede een werkwijze ter bereiding van deze peptiden.
NL175618C (nl) 1972-07-15 1984-12-03 Akzo Nv Werkwijze ter bereiding van een farmaceutisch preparaat met psychofarmacologische werking, dat een peptide of peptide-derivaat bevat, alsmede een werkwijze ter bereiding van dergelijke peptiden.
NL7607684A (nl) 1976-07-12 1978-01-16 Akzo Nv Werkwijze ter bereiding van nieuwe peptiden en peptide-derivaten en de toepassing hiervan.
IE56254B1 (en) 1982-11-10 1991-06-05 Akzo Nv Peptides

Also Published As

Publication number Publication date
EP0179332A3 (en) 1989-02-08
ES548052A0 (es) 1987-02-16
DK482185A (da) 1986-04-23
ATE84544T1 (de) 1993-01-15
PT81345B (pt) 1987-12-30
US4623715A (en) 1986-11-18
IE852596L (en) 1986-04-22
EP0179332B1 (de) 1993-01-13
US4696913A (en) 1987-09-29
DK482185D0 (da) 1985-10-21
IE59724B1 (en) 1994-03-23
JPH075632B2 (ja) 1995-01-25
AU579593B2 (en) 1988-12-01
CA1267996A (en) 1990-04-17
EP0179332A2 (de) 1986-04-30
JPS61100596A (ja) 1986-05-19
CS408391A3 (en) 1992-06-17
DK170649B1 (da) 1995-11-20
AU3539484A (en) 1986-05-01
GR852541B (es) 1986-02-18
PT81345A (de) 1985-11-01
DE3586979D1 (de) 1993-02-25

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20061121