ES8206545A1 - Un procedimiento para la preparacion de una solucion concen-trada estable de cisplatin - Google Patents

Un procedimiento para la preparacion de una solucion concen-trada estable de cisplatin

Info

Publication number
ES8206545A1
ES8206545A1 ES500869A ES500869A ES8206545A1 ES 8206545 A1 ES8206545 A1 ES 8206545A1 ES 500869 A ES500869 A ES 500869A ES 500869 A ES500869 A ES 500869A ES 8206545 A1 ES8206545 A1 ES 8206545A1
Authority
ES
Spain
Prior art keywords
pharmaceutical formulations
polyethylene glycol
cisplatin
solvent
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES500869A
Other languages
English (en)
Other versions
ES500869A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES8206545A1 publication Critical patent/ES8206545A1/es
Publication of ES500869A0 publication Critical patent/ES500869A0/es
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Abstract

PROCEDIMIENTO DE PREPARACION DE UNA SOLUCION CONCENTRADA ESTABLE SE CISPLATIN. CONSISTE EN PREPARAR UN DISOLVENTE CONSTITUIDO POR UN 30-95 POR 100 DE POLIETILENGLICOL DE PESO MOLECULAR MEDIO ENTRE 150 Y 9.000, O METOXI POLIETILENGLICOL DE PESO MOLECULAR MEDIO ENTRE 300 Y 6.000, O DE UNA MEZCLA DE AMBOS, CON UN 5-70 POR 100 DE AGUA Y UNA FUENTE NO TOXICA, Y FARMACEUTICMENTE ACEPTABLE DE ION CLORURO EN CANTIDAD EQUIVALENTE A LA DE CISPLATIN, Y DISOLVER EN EL MISMO UNA CANTIDAD DE CISPLATIN SUFIENTE PARA LOGRAR UNA CONCENTRACION DE 2,5 A 25 MG/ML, DE MODO WUE SE PRODUZCA LA CORRESPONDIENTE REACCION DE COMPLEJACION. LA FUENTE DE ION CLORURO PUEDE SER HCI, NACI, CACI, MGCI O UNA MEZCLA DE LOS MISMOS. DIVERSAS VARIANTES SE CONSIGUEN CON DISTINTAS PROPORCIONES Y PESOS MOLECULARES MEDIOS DE LOS COMPONENTES DEL DISOLVENTE, ASI COMA DE LA CANTIDAD DE CISPLATIN
ES500869A 1980-03-31 1981-03-30 Un procedimiento para la preparacion de una solucion concen-trada estable de cisplatin Granted ES500869A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13537380A 1980-03-31 1980-03-31

Publications (2)

Publication Number Publication Date
ES8206545A1 true ES8206545A1 (es) 1982-08-16
ES500869A0 ES500869A0 (es) 1982-08-16

Family

ID=22467813

Family Applications (1)

Application Number Title Priority Date Filing Date
ES500869A Granted ES500869A0 (es) 1980-03-31 1981-03-30 Un procedimiento para la preparacion de una solucion concen-trada estable de cisplatin

Country Status (30)

Country Link
JP (1) JPS56152415A (es)
KR (1) KR860000841B1 (es)
AR (1) AR225500A1 (es)
AT (1) AT370996B (es)
AU (1) AU541056B2 (es)
BE (1) BE888209A (es)
CA (1) CA1162479A (es)
CH (1) CH647481A5 (es)
CS (1) CS246051B2 (es)
DD (1) DD157762A5 (es)
DE (1) DE3112272A1 (es)
DK (1) DK158564C (es)
ES (1) ES500869A0 (es)
FI (1) FI70670C (es)
FR (1) FR2480605A1 (es)
GB (1) GB2074028B (es)
GR (1) GR72769B (es)
HU (1) HU183379B (es)
IE (1) IE51070B1 (es)
IL (1) IL62517A (es)
IT (1) IT1170838B (es)
LU (1) LU83270A1 (es)
NL (1) NL8101531A (es)
NO (1) NO156675C (es)
NZ (1) NZ196519A (es)
PH (1) PH17152A (es)
PT (1) PT72774B (es)
SE (1) SE455045B (es)
SU (1) SU1056893A3 (es)
ZA (1) ZA812084B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1153974B (it) * 1982-09-23 1987-01-21 Erba Farmitalia Composizioni farmacologiche a base di cisplatino e metodo per il loro ottenimento
NL8303657A (nl) * 1983-10-24 1985-05-17 Pharmachemie Bv Voor injectie geschikte, stabiele, waterige, zoutzuur bevattende oplossing van cisplatine, alsmede werkwijze ter bereiding daarvan.
FI895340A0 (fi) * 1988-11-14 1989-11-09 Bristol Myers Squibb Co Hypertonisk cisplatin-loesning.
AU714992B2 (en) * 1996-08-23 2000-01-13 Alza Corporation Liposomes containing a cisplatin compound
AUPQ641100A0 (en) 2000-03-23 2000-04-15 Australia Nuclear Science & Technology Organisation Methods of synthesis and use of radiolabelled platinum chemotherapeutic ag ents
JP4445304B2 (ja) 2004-03-26 2010-04-07 オンキヨー株式会社 スイッチングアンプ
US8852566B2 (en) * 2009-03-26 2014-10-07 Warsaw Orthopedic, Inc. Compositions and methods for preferential distribution of active agents to injury sites
EP3773498B1 (en) 2018-03-29 2022-06-22 Project Pharmaceutics GmbH Liquid pharmaceutical formulation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4177263A (en) * 1972-02-28 1979-12-04 Research Corporation Anti-animal tumor method
SE445172B (sv) * 1978-05-30 1986-06-09 Bristol Myers Co Stabil, steril vattenlosning av cisplatin i enhetsdoseringsform

Also Published As

Publication number Publication date
NZ196519A (en) 1983-06-17
PT72774B (en) 1982-11-16
NL8101531A (nl) 1981-10-16
IL62517A0 (en) 1981-05-20
DK158564B (da) 1990-06-11
DK158564C (da) 1990-11-05
IT8148090A0 (it) 1981-03-24
KR830004849A (ko) 1983-07-20
AU541056B2 (en) 1984-12-13
HU183379B (en) 1984-04-28
GB2074028B (en) 1983-09-21
FR2480605A1 (fr) 1981-10-23
IL62517A (en) 1984-01-31
IT1170838B (it) 1987-06-03
JPS6360008B2 (es) 1988-11-22
KR860000841B1 (ko) 1986-07-09
NO156675B (no) 1987-07-27
ZA812084B (en) 1982-04-28
CA1162479A (en) 1984-02-21
PH17152A (en) 1984-06-13
SE455045B (sv) 1988-06-20
JPS56152415A (en) 1981-11-26
DE3112272C2 (es) 1990-09-27
GR72769B (es) 1983-12-02
CS246051B2 (en) 1986-10-16
SU1056893A3 (ru) 1983-11-23
BE888209A (fr) 1981-09-30
NO156675C (no) 1987-11-04
GB2074028A (en) 1981-10-28
AR225500A1 (es) 1982-03-31
FR2480605B1 (es) 1984-05-11
ATA150481A (de) 1982-10-15
IE810715L (en) 1981-09-30
DE3112272A1 (de) 1982-04-29
NO811081L (no) 1981-10-01
PT72774A (en) 1981-04-01
AU6816681A (en) 1981-10-08
FI70670B (fi) 1986-06-26
LU83270A1 (fr) 1981-10-29
AT370996B (de) 1983-05-25
DD157762A5 (de) 1982-12-08
CH647481A5 (fr) 1985-01-31
FI810934L (fi) 1981-10-01
ES500869A0 (es) 1982-08-16
DK144281A (da) 1981-10-01
FI70670C (fi) 1986-10-06
IE51070B1 (en) 1986-09-17
SE8101990L (sv) 1981-11-13

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970505