ES8201972A1 - Un procedimiento para la preparacion de derivados de piridi-na o de pirimidina. - Google Patents
Un procedimiento para la preparacion de derivados de piridi-na o de pirimidina.Info
- Publication number
- ES8201972A1 ES8201972A1 ES495932A ES495932A ES8201972A1 ES 8201972 A1 ES8201972 A1 ES 8201972A1 ES 495932 A ES495932 A ES 495932A ES 495932 A ES495932 A ES 495932A ES 8201972 A1 ES8201972 A1 ES 8201972A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- immunoregulatory
- pyrimidines
- antiinflammatory
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000003110 anti-inflammatory effect Effects 0.000 title abstract 2
- 230000004957 immunoregulator effect Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003230 pyrimidines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 AND AND IS O-PHENYL Chemical class 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical class C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical group O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000008020 evaporation Effects 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical group [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01D—HARVESTING; MOWING
- A01D34/00—Mowers; Mowing apparatus of harvesters
- A01D34/001—Accessories not otherwise provided for
- A01D34/003—Means for cleaning the machine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C33/00—Moulds or cores; Details thereof or accessories therefor
- B29C33/56—Coatings, e.g. enameled or galvanised; Releasing, lubricating or separating agents
- B29C33/60—Releasing, lubricating or separating agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C70/00—Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts
- B29C70/68—Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts by incorporating or moulding on preformed parts, e.g. inserts or layers, e.g. foam blocks
- B29C70/84—Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts by incorporating or moulding on preformed parts, e.g. inserts or layers, e.g. foam blocks by moulding material on preformed parts to be joined
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16C—SHAFTS; FLEXIBLE SHAFTS; ELEMENTS OR CRANKSHAFT MECHANISMS; ROTARY BODIES OTHER THAN GEARING ELEMENTS; BEARINGS
- F16C11/00—Pivots; Pivotal connections
- F16C11/04—Pivotal connections
- F16C11/06—Ball-joints; Other joints having more than one degree of angular freedom, i.e. universal joints
- F16C11/0604—Construction of the male part
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16C—SHAFTS; FLEXIBLE SHAFTS; ELEMENTS OR CRANKSHAFT MECHANISMS; ROTARY BODIES OTHER THAN GEARING ELEMENTS; BEARINGS
- F16C11/00—Pivots; Pivotal connections
- F16C11/04—Pivotal connections
- F16C11/06—Ball-joints; Other joints having more than one degree of angular freedom, i.e. universal joints
- F16C11/068—Special features relating to lubrication
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Environmental Sciences (AREA)
- Composite Materials (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/085,011 US4246263A (en) | 1979-10-15 | 1979-10-15 | Antiinflammatory and immunoregulatory pyrimidines, their method of use and pharmaceutical compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES495932A0 ES495932A0 (es) | 1982-01-16 |
| ES8201972A1 true ES8201972A1 (es) | 1982-01-16 |
Family
ID=22188737
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES495932A Expired ES8201972A1 (es) | 1979-10-15 | 1980-10-14 | Un procedimiento para la preparacion de derivados de piridi-na o de pirimidina. |
| ES505544A Granted ES505544A0 (es) | 1979-10-15 | 1981-09-16 | Un procedimiento para la preparacion de derivados de piridi-na o de pirimidina |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES505544A Granted ES505544A0 (es) | 1979-10-15 | 1981-09-16 | Un procedimiento para la preparacion de derivados de piridi-na o de pirimidina |
Country Status (39)
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4371696A (en) * | 1980-07-14 | 1983-02-01 | Pfizer Inc. | Certain pyridine methylthio acetaldehyde derivatives and non-cyclic and cyclic acetals thereof |
| GB8405896D0 (en) * | 1984-03-07 | 1984-04-11 | Sandoz Ltd | Organic compounds |
| WO1987007842A1 (en) * | 1986-06-17 | 1987-12-30 | Biogen N.V. | Combinations of gamma interferons and anti-inflammatory or anti-pyretic agents and methods for treating diseases |
| WO2003024955A2 (en) * | 2001-09-18 | 2003-03-27 | Sunesis Pharmaceuticals, Inc. | Small molecule inhibitors of caspases |
| CA2599169C (en) * | 2005-02-25 | 2013-10-22 | Temple University - Of The Commonwealth System Of Higher Education | Synthesis of (e)-alpha, beta unsaturated sulfides, sulfones, sulfoxides and sulfonamides |
| JP5287033B2 (ja) * | 2007-08-23 | 2013-09-11 | 住友化学株式会社 | 含フッ素有機硫黄化合物およびその有害節足動物防除剤 |
| CN108530606B (zh) * | 2018-04-19 | 2020-11-20 | 山东师范大学 | 一种pH敏感性医用聚氨酯脲材料及其制备方法 |
| CA3115629A1 (en) | 2018-10-08 | 2020-04-16 | Ecolab Usa Inc. | Sulfide-based compounds and uses thereof |
| CN110483740B (zh) * | 2019-08-12 | 2021-08-27 | 山东师范大学 | 一种聚合物、pH敏感性纳米囊泡及制备方法与应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3409626A (en) * | 1963-09-17 | 1968-11-05 | Neisler Lab Inc | Indolylethyl pyridinium quaternary ammonium compounds |
| NL144484B (nl) * | 1967-07-26 | 1975-01-15 | Merck & Co Inc | Werkwijze ter bereiding van een geneesmiddel met anti-anflammatoire werking, alsmede werkwijze ter bereiding van de anti-inflammatoir werkzame aralkylmercaptoaminozuren. |
| US3558640A (en) * | 1967-12-20 | 1971-01-26 | Merck & Co Inc | Certain pyridyl and thiazolyl methylthiopropionic acids and derivatives |
| US3636074A (en) * | 1968-08-05 | 1972-01-18 | Hooker Chemical Corp | Novel mercaptophenol derivatives |
| US3591584A (en) | 1968-08-27 | 1971-07-06 | Pfizer | Benzothiazine dioxides |
| US3818009A (en) * | 1969-12-29 | 1974-06-18 | Lilly Co Eli | Alpha, alpha-disubstituted-5-pyrimidinemethanes |
| US3676463A (en) | 1970-10-15 | 1972-07-11 | Pfizer | Oxobenzofuran carboxamides |
| US3707475A (en) | 1970-11-16 | 1972-12-26 | Pfizer | Antiinflammatory imidazoles |
| JPS52125170A (en) * | 1976-04-12 | 1977-10-20 | Yoshitomi Pharmaceut Ind Ltd | Pyridine derivatives |
-
1979
- 1979-10-15 US US06/085,011 patent/US4246263A/en not_active Expired - Lifetime
-
1980
- 1980-08-16 IN IN597/DEL/80A patent/IN154554B/en unknown
- 1980-09-24 DK DK403080A patent/DK152427C/da not_active IP Right Cessation
- 1980-10-09 AR AR282823A patent/AR226864A1/es active
- 1980-10-10 CA CA000362238A patent/CA1156231A/en not_active Expired
- 1980-10-11 GR GR63147A patent/GR70311B/el unknown
- 1980-10-13 DE DE19803038593 patent/DE3038593A1/de active Granted
- 1980-10-13 AT AT0508980A patent/AT377513B/de not_active IP Right Cessation
- 1980-10-13 NZ NZ195246A patent/NZ195246A/en unknown
- 1980-10-13 YU YU2626/80A patent/YU41740B/xx unknown
- 1980-10-13 GB GB8137997A patent/GB2092133B/en not_active Expired
- 1980-10-13 LU LU82844A patent/LU82844A1/fr unknown
- 1980-10-13 IL IL61261A patent/IL61261A/xx unknown
- 1980-10-13 GB GB8032971A patent/GB2061928B/en not_active Expired
- 1980-10-14 EG EG80638A patent/EG14676A/xx active
- 1980-10-14 SU SU802993951A patent/SU1083907A3/ru active
- 1980-10-14 NL NL8005652A patent/NL8005652A/nl not_active Application Discontinuation
- 1980-10-14 IT IT25324/80A patent/IT1195269B/it active
- 1980-10-14 ES ES495932A patent/ES8201972A1/es not_active Expired
- 1980-10-14 DD DD80224544A patent/DD154816B3/de not_active IP Right Cessation
- 1980-10-14 IE IE2125/80A patent/IE50665B1/en unknown
- 1980-10-14 FR FR8021931A patent/FR2467199A1/fr active Granted
- 1980-10-14 PH PH24725A patent/PH18277A/en unknown
- 1980-10-14 AU AU63240/80A patent/AU517763B2/en not_active Ceased
- 1980-10-14 BE BE0/202467A patent/BE885709A/fr not_active IP Right Cessation
- 1980-10-14 HU HU802494A patent/HU183233B/hu not_active IP Right Cessation
- 1980-10-14 JP JP14357280A patent/JPS5663962A/ja active Granted
- 1980-10-14 FI FI803239A patent/FI75560C/fi not_active IP Right Cessation
- 1980-10-14 SE SE8007193A patent/SE437023B/sv not_active IP Right Cessation
- 1980-10-14 NO NO803073A patent/NO156566C/no unknown
- 1980-10-14 PT PT71917A patent/PT71917B/pt unknown
- 1980-10-14 HU HU83101A patent/HU191824B/hu not_active IP Right Cessation
- 1980-10-14 ZA ZA00806306A patent/ZA806306B/xx unknown
- 1980-10-15 PL PL1980227307A patent/PL125314B1/pl unknown
- 1980-10-15 KR KR1019800003966A patent/KR840001614B1/ko not_active Expired
- 1980-10-15 CH CH771980A patent/CH646425A5/fr not_active IP Right Cessation
- 1980-10-15 CS CS806985A patent/CS226020B2/cs unknown
- 1980-10-15 PL PL1980231782A patent/PL125402B1/pl unknown
-
1981
- 1981-09-08 CS CS816610A patent/CS226034B2/cs unknown
- 1981-09-16 ES ES505544A patent/ES505544A0/es active Granted
- 1981-11-04 SU SU813349450A patent/SU1144617A3/ru active
-
1982
- 1982-01-18 DD DD82236826A patent/DD202543A5/de not_active IP Right Cessation
- 1982-02-18 AR AR288463A patent/AR227089A1/es active
- 1982-02-18 AR AR288464A patent/AR227576A1/es active
- 1982-12-01 YU YU2668/82A patent/YU42059B/xx unknown
-
1983
- 1983-07-22 AT AT0268783A patent/AT379801B/de not_active IP Right Cessation
-
1984
- 1984-06-05 IN IN464/DEL/84A patent/IN163553B/en unknown
- 1984-08-13 SG SG563/84A patent/SG56384G/en unknown
- 1984-08-22 KR KR1019840005076A patent/KR840001615B1/ko not_active Expired
- 1984-09-24 KE KE3461A patent/KE3461A/xx unknown
- 1984-09-25 SG SG691/84A patent/SG69184G/en unknown
- 1984-10-05 KE KE3466A patent/KE3466A/xx unknown
-
1985
- 1985-01-03 HK HK11/85A patent/HK1185A/xx unknown
- 1985-12-30 MY MY323/85A patent/MY8500323A/xx unknown
- 1985-12-30 MY MY325/85A patent/MY8500325A/xx unknown
-
1987
- 1987-09-17 HK HK668/87A patent/HK66887A/xx unknown
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