ES8200655A1 - Procedimiento para la preparacion de sulfonamidas - Google Patents

Procedimiento para la preparacion de sulfonamidas

Info

Publication number
ES8200655A1
ES8200655A1 ES498308A ES498308A ES8200655A1 ES 8200655 A1 ES8200655 A1 ES 8200655A1 ES 498308 A ES498308 A ES 498308A ES 498308 A ES498308 A ES 498308A ES 8200655 A1 ES8200655 A1 ES 8200655A1
Authority
ES
Spain
Prior art keywords
compounds
sulphonamides
lower alkyl
preparation
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES498308A
Other languages
English (en)
Other versions
ES498308A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of ES8200655A1 publication Critical patent/ES8200655A1/es
Publication of ES498308A0 publication Critical patent/ES498308A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

PROCEDIMIENTO DE PREPARACION DE SULFONAMIDAS DE FORMULA (I), EN QUE R ES HIDROGENO O UN GRUPO ALCOHILO, ARILO, ARALCOHILO O ARALQUENILO Y W UN ENLACE O UNA CADENA SATURADA O CONTENIENDO UN DOBLE ENLACE. SE OBTIENE POR LA REACCION DE UNA AMINA DE FORMULA (II_), EN QUE Y ES UN GRUPO CARBOXILO, CON UN ACIDO SULFONICO DE FORMULA (III) EN PRESENCIA DE UN AGENTE FIJADOR DE ACIDOS. O BIEN POR TRANSACILACION DEL ACIDO SULFONICO DE FORMULA (III) CON UNA ACILAMINA, EN UN DISOLVENTE POLAR A LA TEMPERATURA DE EBULLICION DEL DISOLVENTE. OPCIONALMENTE, EL COMPUESTO OBTENIDO SE ALCOHILA EN NITROGENO EN PRESENCIA DE UN AGENTE FIJADOR DE ACIDOS. SE USAN COMO AGENTES HIPOLIPIDEMICOS E INHIBIDORES DE LA AGLOMERACION DE TROMBOCITOS.
ES498308A 1980-01-07 1981-01-03 Procedimiento para la preparacion de sulfonamidas Granted ES498308A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803000377 DE3000377A1 (de) 1980-01-07 1980-01-07 Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
ES8200655A1 true ES8200655A1 (es) 1981-12-01
ES498308A0 ES498308A0 (es) 1981-12-01

Family

ID=6091629

Family Applications (1)

Application Number Title Priority Date Filing Date
ES498308A Granted ES498308A0 (es) 1980-01-07 1981-01-03 Procedimiento para la preparacion de sulfonamidas

Country Status (22)

Country Link
US (1) US4443477A (es)
EP (1) EP0031954B1 (es)
JP (1) JPS56100757A (es)
AT (1) ATE6641T1 (es)
AU (1) AU538993B2 (es)
CA (1) CA1241341A (es)
CS (1) CS238611B2 (es)
DD (1) DD157190A5 (es)
DE (2) DE3000377A1 (es)
ES (1) ES498308A0 (es)
FI (1) FI73667C (es)
GR (1) GR72486B (es)
HK (1) HK68887A (es)
IE (1) IE50657B1 (es)
IL (1) IL61834A (es)
PH (1) PH18739A (es)
PL (1) PL127050B1 (es)
PT (1) PT72305B (es)
SG (1) SG2387G (es)
SU (1) SU1088664A3 (es)
YU (1) YU42995B (es)
ZA (1) ZA8132B (es)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4401663A (en) * 1981-06-30 1983-08-30 The Procter & Gamble Company Novel sulfonamide derivatives
AU567140B2 (en) * 1984-01-06 1987-11-12 Shionogi & Co., Ltd. Sulphonamido-benzamide derivatives
EP0194548A3 (de) * 1985-03-12 1988-08-17 Dr. Karl Thomae GmbH Neue Sulfonylaminoäthylverbindungen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE3535167A1 (de) * 1985-10-02 1987-04-09 Boehringer Mannheim Gmbh Neue sulfonyl-phenyl(alkyl)amine, verfahren zu ihrer herstellung sowie arzneimittel
US4689182A (en) * 1985-12-20 1987-08-25 Warner-Lambert Company Benzoic acid and benzoic acid ester derivatives having anti-inflammatory and analgesic activity
FR2598412B1 (fr) * 1986-03-12 1988-10-21 Sanofi Sa Nouveaux derives de diarylcetones et leurs procedes de preparation et les compositions pharmaceutiques les contenant
IL83230A (en) * 1986-08-06 1992-06-21 Tanabe Seiyaku Co Phenoxyacetic acid derivatives,their preparation and pharmaceutical compositions containing them
DE3629929A1 (de) * 1986-09-03 1988-03-10 Thomae Gmbh Dr K Neue sulfonamido-aethylverbindungen, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
ES2036213T3 (es) * 1986-10-28 1993-05-16 Smith Kline & French Laboratories Limited Procedimiento para preparar derivados tetrahidroisoquinolin-1-ilicos de acidos carboxilicos.
GB8708233D0 (en) * 1987-04-07 1987-05-13 Smith Kline French Lab Pharmaceutically active compounds
KR880012221A (ko) * 1987-04-13 1988-11-26 사노 가즈오 에스테르 또는 아미드를 활성성분으로 함유하는 약제 조성물
CA1294974C (en) * 1987-05-08 1992-01-28 Sanji Hagishita Bicyclic sulfonamide derivatives and process therefor
US4752616A (en) * 1987-06-29 1988-06-21 E. R. Squibb & Sons, Inc. Arylthioalkylphenyl carboxylic acids, compositions containing same and method of use
GB8717374D0 (en) * 1987-07-22 1987-08-26 Smith Kline French Lab Pharmaceutically active compounds
US4752613A (en) * 1987-08-03 1988-06-21 E. R. Squibb & Sons, Inc. Sulphonamidothienylcarboxylic acid compounds
US4783473A (en) * 1987-09-02 1988-11-08 E. R. Squibb & Sons, Inc. Geminally substituted cyclic ether carboxylic acids, derivatives thereof, compositions containing same and method of use
US4931460A (en) * 1987-09-17 1990-06-05 E. R. Squibb & Sons, Inc. Post-ischemic myocardial dysfunction using thromboxane A2 antagonists
JPH01175962A (ja) * 1987-12-28 1989-07-12 Tanabe Seiyaku Co Ltd フェニル酢酸誘導体
DE68909958D1 (de) * 1988-01-19 1993-11-25 Tanabe Seiyaku Co Phenoxyessigsäure-Derivate, ihre Herstellung, pharmazeutische Zusammensetzungen, die sie enthalten, und deren Verwendung.
US5066480A (en) * 1988-04-11 1991-11-19 E. R. Squibb & Sons, Inc. Method of preventing or reducing adverse reactions to protamine using a thromboxane a2 receptor antagonist
DE3819052A1 (de) * 1988-06-04 1989-12-07 Basf Ag Neue sulfonamid-derivate, ihre herstellung und verwendung
DE3829455A1 (de) * 1988-08-31 1990-03-15 Boehringer Mannheim Gmbh Sulfonamidoalkyl-cyclohexan-verbindungen, verfahren zu ihrer herstellung sowie arzneimittel
US4925873A (en) * 1988-09-01 1990-05-15 E. R. Squibb & Sons, Inc. Method of treating skin injuries using thromboxane A2 receptor antagonists
US5280043A (en) * 1988-10-10 1994-01-18 Smith Kline & French Laboratories Ltd. Sulphonamido containing phenylalkanoic acids as thromboxane A2 antagonists
GB8823731D0 (en) * 1988-10-10 1988-11-16 Smith Kline French Lab Biologically active compounds
US5006542A (en) * 1988-10-31 1991-04-09 E. R. Squibb & Sons, Inc. Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same and method of use
US5070099A (en) * 1988-10-31 1991-12-03 E. R. Squibb & Sons, Inc. Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same method of use
US4959383A (en) * 1988-10-31 1990-09-25 E. R. Squibb & Sons, Inc. Phenylsulfone alkenoic acids, derivatives thereof, compositions containing same and method of use
US4975452A (en) * 1989-06-02 1990-12-04 E. R. Squibb & Sons, Inc. Geminally substituted thiaheterocyclic carboxylic acids and derivatives thereof
US5106991A (en) * 1989-06-02 1992-04-21 E. R. Squibb & Sons, Inc. Geminally substituted thiaheterocyclic carboxylic acids and derivatives thereof
US5153214A (en) * 1989-06-28 1992-10-06 Ciba-Geigy Corporation Certain (arylsulfonamido- and imidazolyl-)-substituted carboxylic acids and derivatives thereof and use for suppressing thromboxane activity
US5025025A (en) * 1989-06-28 1991-06-18 Ciba-Geigy Corporation (Arylsulfonamido- and pyridyl-)-substituted carboxylic acids and derivatives thereof and use for suppressing thromboxane activity
DE4010536A1 (de) * 1990-04-02 1991-10-10 Boehringer Mannheim Gmbh Pharmazeutische waessrige loesung von 4-(2-(benzolsulfonylamino)-ethyl)-phenoxyessigsaeure
FR2665440B1 (fr) * 1990-07-31 1994-02-04 Lipha Nouveaux cycloalkylsulfonamides substitues, procedes de preparation et medicaments les contenant.
US5189211A (en) * 1990-08-01 1993-02-23 Taisho Pharmaceutical Co., Ltd. Sulfonamide derivatives
US5409959A (en) * 1991-01-29 1995-04-25 Genelabs Incorporated Antithrombotic treatment with calix(n)arene compounds
DE4109735A1 (de) * 1991-03-25 1992-10-01 Boehringer Mannheim Gmbh Neue sulfonamide, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
US5280034A (en) * 1991-08-23 1994-01-18 E. R. Squibb & Sons, Inc. Bis-heterocyclic prostaglandin analogs
US5827868A (en) * 1991-10-07 1998-10-27 E. R. Squibb & Sons, Inc. Prostaglandin analogs
TW219358B (es) * 1991-12-20 1994-01-21 Hokuriku Pharmaceutical
GB9220137D0 (en) * 1992-09-23 1992-11-04 Pfizer Ltd Therapeutic agents
JPH0753505A (ja) * 1992-10-01 1995-02-28 Hokuriku Seiyaku Co Ltd ベンゼンスルホンアミド誘導体及びその用途
EP0896533B1 (en) * 1996-02-22 2003-09-10 Tularik, Inc. Pentafluorobenzenesulfonamides and analogs
JP3421350B2 (ja) * 1996-07-19 2003-06-30 テュラリク インコーポレイテッド ペンタフルオロベンゼンスルホンアミドおよび類縁体
GB9702194D0 (en) 1997-02-04 1997-03-26 Lilly Co Eli Sulphonide derivatives
FR2760235B1 (fr) * 1997-02-28 1999-04-09 Adir Nouveaux derives de benzenesulfonylamine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
UA67754C2 (uk) 1997-10-10 2004-07-15 Пфайзер, Інк. Агоністи простагландину, фармацевтична композиція на їх основі (варіанти), спосіб нарощення та збереження кісткової маси у хребетних та спосіб лікування (варіанти)
US6693137B1 (en) * 1998-07-31 2004-02-17 Eli Lilly And Company Sulphonamide derivatives
AP2002002555A0 (en) 1999-12-22 2002-06-30 Pfizer Prod Inc EP4 Receptor selective agonists in the treatment of osteoporosis.
US20050250854A1 (en) * 2000-11-03 2005-11-10 Amgen Inc. Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents
US6822001B2 (en) 2000-11-03 2004-11-23 Tularik Inc. Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents
AU2005300150A1 (en) * 2004-10-29 2006-05-04 Astrazeneca Ab Novel sulphonamide derivatives as glucocorticoid receptor modulators for the treatment of inflammatory diseases
TW200829578A (en) 2006-11-23 2008-07-16 Astrazeneca Ab Chemical compounds 537
JO2754B1 (en) 2006-12-21 2014-03-15 استرازينكا ايه بي Amylendazoleil derivatives for the treatment of glucocorticoid-mediated disorders
BRPI0810609A2 (pt) * 2007-04-27 2014-10-21 Tibotec Pharm Ltd Métodos para a preparação de derivados de n-isobutil-n-(2-hidróxi-a-amino-4-fenilbutil)-p-nitrobe nzenossulfonilamida
UY31831A (es) 2008-05-20 2010-01-05 Astrazeneca Ab Derivados de indazoles sustituidos con fenilo o piridinilo
MX2011000051A (es) * 2008-07-07 2011-07-28 Fasgen Inc Nuevos compuestos, composiciones farmaceuticas que contienen los mismos, metodos para usar los mismos, y metodos para preparar los mismos.
KR101992929B1 (ko) * 2012-09-20 2019-06-25 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 치환된 알킬 디아릴 유도체, 제조방법 및 용도
JP6273072B2 (ja) 2014-05-16 2018-01-31 カンバーランド ファーマシューティカルズ，インコーポレーテッド イフェトロバンにより心臓線維症を治療する組成物及び方法
US20170000771A1 (en) 2015-06-30 2017-01-05 Cumberland Pharmaceuticals, Inc. Thromboxane Receptor Antagonists in AERD/Asthma
US10383831B2 (en) 2015-08-03 2019-08-20 Temple University—Of the Commonwealth System of Higher Education 2,4,6-trialkoxystryl aryl sulfones, sulfonamides and carboxamides, and methods of preparation and use
CN109152767B (zh) 2016-05-11 2022-10-21 坎伯兰医药品股份有限公司 用血栓烷-a2受体拮抗剂治疗肌营养不良的组合物和方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE542184A (es) * 1954-10-21
US3027405A (en) * 1959-07-29 1962-03-27 Geigy Chem Corp Nu-(alkylarylsulfonyl)-amino acids and salts thereof
US3991106A (en) * 1974-09-13 1976-11-09 Merck & Co., Inc. 16-Ethers of 8-aza-9-dioxothia-11,12-seco-prostaglandins
DK148576A (da) * 1975-04-18 1976-10-19 Boehringer Mannheim Gmbh Fenylalkankarbonsyrederivater og fremgangsmade til deres fremstilling
US4112236A (en) * 1977-04-04 1978-09-05 Merck & Co., Inc. Interphenylene 8-aza-9-dioxothia-11,12-secoprostaglandins
GB1572201A (en) * 1977-04-05 1980-07-23 Bristol Myers Co Cephalosporins
DE2809377A1 (de) * 1978-03-04 1979-09-13 Boehringer Mannheim Gmbh Phenoxyalkylcarbonsaeure-derivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
DE3000519A1 (de) * 1979-02-01 1980-08-14 Byk Gulden Lomberg Chem Fab Sulfonamido-alkansaeuren, ihre verwendung und herstellung sowie sie enthaltende arzneimittel

Also Published As

Publication number Publication date
ATE6641T1 (de) 1984-03-15
DE3067068D1 (en) 1984-04-19
IE810006L (en) 1981-07-07
JPS6352625B2 (es) 1988-10-19
IL61834A0 (en) 1981-01-30
JPS56100757A (en) 1981-08-12
YU881A (en) 1983-10-31
EP0031954B1 (de) 1984-03-14
EP0031954A2 (de) 1981-07-15
FI73667C (fi) 1987-11-09
PL229072A1 (es) 1982-04-26
SG2387G (en) 1987-11-13
DD157190A5 (de) 1982-10-20
PL127050B1 (en) 1983-09-30
PH18739A (en) 1985-09-16
AU6597481A (en) 1981-07-16
FI804085L (fi) 1981-07-08
SU1088664A3 (ru) 1984-04-23
DE3000377A1 (de) 1981-07-09
PT72305B (de) 1981-12-17
GR72486B (es) 1983-11-14
EP0031954A3 (en) 1981-11-11
PT72305A (de) 1981-02-01
CA1241341A (en) 1988-08-30
FI73667B (fi) 1987-07-31
CS238611B2 (en) 1985-12-16
US4443477A (en) 1984-04-17
IL61834A (en) 1984-06-29
YU42995B (en) 1989-02-28
HK68887A (en) 1987-10-02
ES498308A0 (es) 1981-12-01
ZA8132B (en) 1982-02-24
IE50657B1 (en) 1986-06-11
AU538993B2 (en) 1984-09-06

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20010201