ES8107217A1 - Un procedimiento para preparar un compuesto de 1,8-naftiri- dina - Google Patents

Un procedimiento para preparar un compuesto de 1,8-naftiri- dina

Info

Publication number
ES8107217A1
ES8107217A1 ES495376A ES495376A ES8107217A1 ES 8107217 A1 ES8107217 A1 ES 8107217A1 ES 495376 A ES495376 A ES 495376A ES 495376 A ES495376 A ES 495376A ES 8107217 A1 ES8107217 A1 ES 8107217A1
Authority
ES
Spain
Prior art keywords
compound
formula
hydrogen
image
protective group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES495376A
Other languages
English (en)
Other versions
ES495376A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dainippon Pharmaceutical Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Publication of ES8107217A1 publication Critical patent/ES8107217A1/es
Publication of ES495376A0 publication Critical patent/ES495376A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

PROCEDIMIENTO DE PREPARACION DE UN COMPUESTO DE 1,8-NAFTIRIDINA DE FORMULA (I), DONDE R ES HIDROGENO, METILO, ETILO O PROPILO. SE HACE REACCIONAR A TEMPERATURA DE 20-150GC, EN UN RECIPIENTE CERRADO HERMETICAMENTE, Y OPCIONALMENTE EN PRESENCIA DE UNA BASE, UN COMPUESTO DE FORMULA (I), DONDE Y ES HALOGENO, ALCOHILOXI INFERIOR, ALCOHILITO INFERIOR..., U OTROS, Y R1 ES HIDROGENO O ALCOHILO INFERIOR, Y UN COMPUESTO DE FORMULA (III), DONDE R2 ES HIDROGENO O UN GRUPO PROTECTOR DEL GRUPO AMINO. CASO DE SER R1 Y R2 DIFERENTES DE HIDROGENO, EL PRODUCTO DE LA REACCION SE TRATA CON UN ACIDO O UNA BASE Y/O SE ESCINDE REDUCTORAMENTE. EL PRODUCTO FINAL PUEDE CONVERTIRSE EN UNA SAL POR REACCION CON UN ACIDO O UN HIDROXIDO METALICO. DE APLICACION COMO AGENTE ANTIBACTERIANO CONTRA BACTERIAS GRAM-POSITIVAS Y GRAM-NEGATIVAS. *FORMULA*
ES495376A 1979-09-28 1980-09-26 Un procedimiento para preparar un compuesto de 1,8-naftiri- dina Granted ES495376A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12622379A JPS5649382A (en) 1979-09-28 1979-09-28 6-fluoro-7-cyclic amino-1,8-naphthylidine derivative and its salt

Publications (2)

Publication Number Publication Date
ES8107217A1 true ES8107217A1 (es) 1981-10-01
ES495376A0 ES495376A0 (es) 1981-10-01

Family

ID=14929790

Family Applications (1)

Application Number Title Priority Date Filing Date
ES495376A Granted ES495376A0 (es) 1979-09-28 1980-09-26 Un procedimiento para preparar un compuesto de 1,8-naftiri- dina

Country Status (18)

Country Link
US (1) US4341784A (es)
EP (1) EP0027752B1 (es)
JP (1) JPS5649382A (es)
AR (1) AR226320A1 (es)
AU (1) AU534288B2 (es)
CA (1) CA1147731A (es)
CS (1) CS215139B2 (es)
DD (1) DD155990A5 (es)
DE (1) DE3065949D1 (es)
DK (1) DK155048C (es)
ES (1) ES495376A0 (es)
FI (1) FI70216C (es)
HU (1) HU183218B (es)
PH (1) PH15907A (es)
PL (1) PL127762B1 (es)
SU (1) SU1060112A3 (es)
YU (1) YU42983B (es)
ZA (1) ZA806007B (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57146775A (en) * 1981-03-06 1982-09-10 Dainippon Pharmaceut Co Ltd 1,8-naphthyridine derivative and its salt
US4382937A (en) * 1981-02-27 1983-05-10 Dainippon Pharmaceutical Co., Ltd. Naphthyridine derivatives and their use as anti-bacterials
JPS5925391A (ja) * 1982-07-30 1984-02-09 Dainippon Pharmaceut Co Ltd ピリジルナフチリジン誘導体およびその塩
US4777175A (en) * 1982-09-09 1988-10-11 Warner-Lambert Company Antibacterial agents
IE55898B1 (en) * 1982-09-09 1991-02-14 Warner Lambert Co Antibacterial agents
US4665079A (en) * 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
US5281612A (en) * 1982-09-09 1994-01-25 Warner-Lambert Company Naphthyridine antibacterial agents
FR2559484B2 (fr) * 1983-07-06 1986-09-26 Provesan Sa Nouveau derive 7-(pyrrol-1-yl) de l'acide 1-ethyl-1,4-dihydro-4-oxo-(1,8-naphtyridin)-3-carboxylique, sa preparation et son application en tant que medicament
CS274601B2 (en) * 1983-07-27 1991-09-15 Dainippon Pharmaceutical Co Method of 1,8-naphthyridine derivative production
JPS60260577A (ja) * 1984-06-06 1985-12-23 Dainippon Pharmaceut Co Ltd １，８−ナフチリジン誘導体
JPS60112790A (ja) * 1983-11-21 1985-06-19 Dainippon Pharmaceut Co Ltd ピリジルナフチリジン誘導体
NZ210847A (en) * 1984-01-26 1988-02-29 Abbott Lab Naphthyridine and pyridopyrimidine derivatives and pharmaceutical compositions
DE3409922A1 (de) * 1984-03-17 1985-09-26 Bayer Ag, 5090 Leverkusen 1,7-diamino-1,4-dihydro-4-oxo-3-(aza)chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie ihre verwendung bei der bekaempfung bakterieller erkrankungen
US4571396A (en) * 1984-04-16 1986-02-18 Warner-Lambert Company Antibacterial agents
US4604401A (en) * 1984-07-20 1986-08-05 Warner-Lambert Company Antibacterial agents III
DE3508816A1 (de) * 1985-01-10 1986-07-10 Bayer Ag, 5090 Leverkusen 6,7-disubstituierte 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphtyridin-3-carbonsaeuren
US4851535A (en) * 1985-01-23 1989-07-25 Toyama Chemical Co., Ltd. Nicotinic acid derivatives
DE3525108A1 (de) * 1985-06-07 1986-12-11 Bayer Ag, 5090 Leverkusen Antibakteriell wirksame chinoloncarbonsaeureester
US4692454A (en) * 1986-02-03 1987-09-08 Warner-Lambert Company Opthalmic use of quinolone antibiotics
ZA877471B (en) * 1986-10-08 1988-04-05 Bristol-Myers Company 1-tertiary-alkyl-substituted naphthyridine-and quinoline-carboxylic acid antibacterial agents
US4954507A (en) * 1986-10-08 1990-09-04 Bristol-Myers Company 1-tertiary-alkyl-substituted naphthyridine carboxylic acid antibacterial agents
US4923879A (en) * 1987-07-31 1990-05-08 Warner-Lambert Company 1,8-Naphthyridines and their use as antibacterial agents
US4962108A (en) * 1987-07-31 1990-10-09 Warner-Lambert Company Antibacterial quinoline compounds
US4920120A (en) * 1988-01-25 1990-04-24 Warner-Lambert Company Antibacterial agents
US5585491A (en) * 1988-01-25 1996-12-17 Otsuka Pharmaceutical Co., Ltd. Antibacterial agents
KR910003630B1 (ko) * 1988-06-17 1991-06-07 한국과학기술원 벤조일 아세틱 에스테르 유도체 및 그 제조방법
US5151267A (en) * 1988-07-15 1992-09-29 University Of Saskatchewan Bovine herpesvirus type 1 polypeptides and vaccines
US5585264A (en) * 1988-07-15 1996-12-17 University Of Saskatchewan Nucleotide sequences encoding recombinant bovine herpesvirus type-1 GI, GIII and GIV polypeptides
IL91648A (en) * 1988-09-22 1997-03-18 Abbott Lab Amino acid quinoline and naphthyridine derivatives, their preparation and pharmaceutical compositions containing them
US5262417A (en) * 1988-12-06 1993-11-16 The Upjohn Company Antibacterial quinolone compounds
US5527910A (en) * 1992-12-30 1996-06-18 Cheil Foods & Chemicals, Inc. Pyridone carboxylic acid compounds and their uses for treating infectious diseases caused by bacteria
JPH08213881A (ja) * 1995-02-02 1996-08-20 Fujitsu Ltd 周波数制御回路
US5994365A (en) * 1997-02-25 1999-11-30 Diazans Limited Substituted diazaanthracene compounds having pharmaceutical utility
DE69840599D1 (de) * 1997-09-15 2009-04-09 Procter & Gamble Antimikrobielle chinolone, ihre zusammensetzungen und ihre verwendungen
US6387928B1 (en) * 1997-09-15 2002-05-14 The Procter & Gamble Co. Antimicrobial quinolones, their compositions and uses
US7528264B2 (en) * 2006-03-28 2009-05-05 The Procter & Gamble Company Hydride reduction process for preparing quinolone intermediates
AU2007230630B2 (en) * 2006-03-28 2012-12-20 Taigen Biotechnology Co., Ltd Malate salts, and polymorphs of (3S,5S)-7-[3-amino-5-methyl-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
KR101084521B1 (ko) * 2006-03-28 2011-11-18 워너 칠콧 컴퍼니 엘엘씨 퀴놀론 중간체를 제조하기 위한 커플링 방법
AR096135A1 (es) 2013-05-02 2015-12-09 Actelion Pharmaceuticals Ltd Derivados de la quinolona

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3149104A (en) * 1961-01-03 1964-09-15 Sterling Drug Inc 4-hydroxy-7-styryl-1, 8-naphthyridine-3-carboxylic acids and esters
US3673193A (en) * 1970-05-11 1972-06-27 Sterling Drug Inc 4-oxo-1,8-naphthyridine-3-carboxylates and derivatives thereof
US3786043A (en) * 1972-06-19 1974-01-15 Sterling Drug Inc 7-methyl-4-chloro (or -4-lower-alkoxy)-1,8-naphthyridine-3-carboxylates
JPS5637232B2 (es) * 1973-04-17 1981-08-29
US4024255A (en) * 1973-04-05 1977-05-17 Allen & Hanburys Limited Tetrazole containing naphthyridine-3-carboxamides
JPS587626B2 (ja) * 1974-02-13 1983-02-10 大日本製薬株式会社 ナフチリジン オヨビ キノリンユウドウタイノセイホウ
HU173573B (hu) * 1975-02-18 1979-06-28 Chinoin Gyogyszer Es Vegyeszet Sposob poluchenija novykh proizvodnykh 1,8-naftridina
DE2607012A1 (de) * 1976-02-18 1977-08-25 Schering Ag Neue 1,5-naphthyridincarbonsaeurederivate und verfahren zu ihrer herstellung
IL51092A0 (en) * 1976-12-10 1977-02-28 Abic Ltd Naphthyridine derivatives and their preparation
JPS543095A (en) * 1977-06-09 1979-01-11 Daito Koeki Preparation of 1*88naphthyridine derivative
SE444566B (sv) * 1977-09-20 1986-04-21 Bellon Labor Sa Roger 7-dialkylamin-6-halogen-4-oxo-1,4-dihydrokinolin-3-karboxylsyra, forfarande for framstellning derav och farmaceutiskt preparat derav
AR223983A1 (es) * 1978-08-25 1981-10-15 Dainippon Pharmaceutical Co Un procedimiento para-preparar derivados de acido 6-halogeno-4-oxo-7-(1-piperazinil)-1,8-naftiridin-3-carboxilico

Also Published As

Publication number Publication date
EP0027752A1 (en) 1981-04-29
US4341784A (en) 1982-07-27
DK408580A (da) 1981-03-29
HU183218B (en) 1984-04-28
JPS6113717B2 (es) 1986-04-15
FI70216C (fi) 1986-09-15
SU1060112A3 (ru) 1983-12-07
DE3065949D1 (en) 1984-01-26
FI70216B (fi) 1986-02-28
PL127762B1 (en) 1983-11-30
DK155048C (da) 1989-06-26
AU534288B2 (en) 1984-01-19
FI803042A (fi) 1981-03-29
ZA806007B (en) 1981-10-28
AU6257080A (en) 1981-04-09
ES495376A0 (es) 1981-10-01
JPS5649382A (en) 1981-05-02
EP0027752B1 (en) 1983-12-21
DD155990A5 (de) 1982-07-21
PH15907A (en) 1983-04-15
DK155048B (da) 1989-01-30
YU42983B (en) 1989-02-28
CS215139B2 (en) 1982-07-30
CA1147731A (en) 1983-06-07
YU236480A (en) 1983-02-28
AR226320A1 (es) 1982-06-30
PL226951A1 (es) 1981-10-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303