ES481856A1 - Procedimiento para la preparacion de nuevos derivados de 1,3-benzoxacina-2,4-diona con actividad analgesica. - Google Patents
Procedimiento para la preparacion de nuevos derivados de 1,3-benzoxacina-2,4-diona con actividad analgesica.Info
- Publication number
- ES481856A1 ES481856A1 ES481856A ES481856A ES481856A1 ES 481856 A1 ES481856 A1 ES 481856A1 ES 481856 A ES481856 A ES 481856A ES 481856 A ES481856 A ES 481856A ES 481856 A1 ES481856 A1 ES 481856A1
- Authority
- ES
- Spain
- Prior art keywords
- benzoxazine
- preparation
- dione
- derivatives
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
- C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Procedimiento para la preparación de nuevos derivados de 1,3- benzoxacina-2,4-diona con actividad analgésica de fórmula general I **(Fórmula)** en la que R representa un radical alquilo inferior de preferencia de C1 a C4 de cadena normal o ramificada, un grupo orto-fenoxifenil, orto-tiofenoxifenil, orto-tiofenoxifenil, bencilo, funfurilo, o bien 2-piridilo; R'' representa un átomo de hidrógeno, de cloro, de bromo o un radical metoxi; R''` representa un átomo de hidrógeno, de cloro o un radical metilo, y R''`'' representa un átomo de hidrógeno, de cloro o de bromo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7824674A FR2434158A1 (fr) | 1978-08-25 | 1978-08-25 | Nouveaux derives de 1,3-benzoxazine-2,4-dione, leur preparation et leur application en tant que medicaments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES481856A1 true ES481856A1 (es) | 1980-02-16 |
Family
ID=9212085
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES481856A Expired ES481856A1 (es) | 1978-08-25 | 1979-06-06 | Procedimiento para la preparacion de nuevos derivados de 1,3-benzoxacina-2,4-diona con actividad analgesica. |
Country Status (25)
| Country | Link |
|---|---|
| JP (1) | JPS5533484A (es) |
| AR (1) | AR222494A1 (es) |
| AT (1) | AT373591B (es) |
| BE (1) | BE878395A (es) |
| BG (1) | BG30929A3 (es) |
| CA (1) | CA1128511A (es) |
| CH (1) | CH643548A5 (es) |
| CS (1) | CS208131B2 (es) |
| DD (1) | DD145534A5 (es) |
| DE (1) | DE2934166A1 (es) |
| EG (1) | EG14355A (es) |
| ES (1) | ES481856A1 (es) |
| FI (1) | FI68818C (es) |
| FR (1) | FR2434158A1 (es) |
| GB (1) | GB2031410B (es) |
| GR (1) | GR69619B (es) |
| HU (1) | HU182916B (es) |
| IL (1) | IL58096A (es) |
| NL (1) | NL7906408A (es) |
| PL (1) | PL116771B1 (es) |
| PT (1) | PT70107A (es) |
| RO (1) | RO78156A (es) |
| SE (1) | SE446865B (es) |
| SU (1) | SU797576A3 (es) |
| YU (1) | YU40849B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA011719B1 (ru) | 2000-12-18 | 2009-04-28 | Институт Оф Медисинал Молекьюлар Дизайн, Инк. | Ингибитор высвобождения воспалительного цитокина |
| WO2003103665A1 (ja) | 2002-06-06 | 2003-12-18 | 株式会社医薬分子設計研究所 | 抗アレルギー薬 |
| EP1512397B1 (en) * | 2002-06-06 | 2014-10-08 | Institute of Medicinal Molecular Design, Inc. | O-substituted hydroxyaryl derivatives |
| CN108658887B (zh) * | 2018-06-20 | 2022-04-05 | 中南大学 | 苯并[d][1,3]噁嗪-2,4(1H)-二酮衍生物及其合成方法和用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2476559A (en) * | 1946-10-01 | 1949-07-19 | Gen Aniline & Film Corp | Oxazine diones |
| DE1153375B (de) * | 1960-05-25 | 1963-08-29 | Thomae Gmbh Dr K | Verfahren zur Herstellung von Benzoxazin-(1, 3)-dionen-(2, 4) |
| GB1069367A (en) * | 1964-10-01 | 1967-05-17 | Aspro Nicholas Ltd | Improvements in or relating to the production of 1:3-benzoxazine-2:4-dione |
| CH459211A (de) * | 1965-01-25 | 1968-07-15 | Robapharm Ag | Verfahren zur Herstellung von neuen basischen Derivaten des Dihydro-1,3-benzoxazin-2,4-dions |
-
1978
- 1978-08-25 FR FR7824674A patent/FR2434158A1/fr active Granted
-
1979
- 1979-06-06 ES ES481856A patent/ES481856A1/es not_active Expired
- 1979-08-21 DD DD79215096A patent/DD145534A5/de not_active IP Right Cessation
- 1979-08-22 PL PL1979217893A patent/PL116771B1/pl unknown
- 1979-08-22 CA CA334,287A patent/CA1128511A/fr not_active Expired
- 1979-08-22 HU HU79PO694A patent/HU182916B/hu not_active IP Right Cessation
- 1979-08-22 GR GR52886A patent/GR69619B/el unknown
- 1979-08-22 GB GB7929266A patent/GB2031410B/en not_active Expired
- 1979-08-22 RO RO7998518A patent/RO78156A/ro unknown
- 1979-08-22 BG BG7944725A patent/BG30929A3/xx unknown
- 1979-08-23 IL IL58096A patent/IL58096A/xx not_active IP Right Cessation
- 1979-08-23 SU SU792804596A patent/SU797576A3/ru active
- 1979-08-23 DE DE19792934166 patent/DE2934166A1/de not_active Ceased
- 1979-08-23 AT AT0568379A patent/AT373591B/de not_active IP Right Cessation
- 1979-08-23 PT PT70107A patent/PT70107A/pt unknown
- 1979-08-23 FI FI792632A patent/FI68818C/fi not_active IP Right Cessation
- 1979-08-23 YU YU2073/79A patent/YU40849B/xx unknown
- 1979-08-23 BE BE0/196852A patent/BE878395A/fr not_active IP Right Cessation
- 1979-08-23 AR AR277829A patent/AR222494A1/es active
- 1979-08-23 JP JP10764779A patent/JPS5533484A/ja active Pending
- 1979-08-24 NL NL7906408A patent/NL7906408A/nl not_active Application Discontinuation
- 1979-08-24 CS CS795769A patent/CS208131B2/cs unknown
- 1979-08-24 SE SE7907067A patent/SE446865B/sv not_active IP Right Cessation
- 1979-08-24 CH CH773579A patent/CH643548A5/fr not_active IP Right Cessation
- 1979-08-27 EG EG520/79A patent/EG14355A/xx active
Also Published As
| Publication number | Publication date |
|---|---|
| IL58096A0 (en) | 1979-12-30 |
| FI68818B (fi) | 1985-07-31 |
| CS208131B2 (en) | 1981-08-31 |
| BE878395A (fr) | 1980-02-25 |
| PT70107A (fr) | 1979-09-01 |
| CH643548A5 (fr) | 1984-06-15 |
| ATA568379A (de) | 1983-06-15 |
| FI68818C (fi) | 1985-11-11 |
| NL7906408A (nl) | 1980-02-27 |
| BG30929A3 (en) | 1981-09-15 |
| YU40849B (en) | 1986-06-30 |
| DE2934166A1 (de) | 1980-02-28 |
| EG14355A (en) | 1983-12-31 |
| SE446865B (sv) | 1986-10-13 |
| SU797576A3 (ru) | 1981-01-15 |
| FI792632A (fi) | 1980-02-26 |
| HU182916B (en) | 1984-03-28 |
| PL116771B1 (en) | 1981-06-30 |
| SE7907067L (sv) | 1980-02-26 |
| GB2031410B (en) | 1982-12-01 |
| CA1128511A (fr) | 1982-07-27 |
| GR69619B (es) | 1982-07-06 |
| JPS5533484A (en) | 1980-03-08 |
| AT373591B (de) | 1984-02-10 |
| FR2434158B1 (es) | 1985-05-03 |
| DD145534A5 (de) | 1980-12-17 |
| PL217893A1 (es) | 1980-04-21 |
| AR222494A1 (es) | 1981-05-29 |
| IL58096A (en) | 1982-12-31 |
| RO78156A (ro) | 1982-02-01 |
| YU207379A (en) | 1983-02-28 |
| GB2031410A (en) | 1980-04-23 |
| FR2434158A1 (fr) | 1980-03-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970401 |