ES481125A1 - Un procedimiento para la preparacion de nuevos derivados de 2-oxohexahidroacepina,-piperidina o -pirrolidina. - Google Patents

Un procedimiento para la preparacion de nuevos derivados de 2-oxohexahidroacepina,-piperidina o -pirrolidina.

Info

Publication number
ES481125A1
ES481125A1 ES481125A ES481125A ES481125A1 ES 481125 A1 ES481125 A1 ES 481125A1 ES 481125 A ES481125 A ES 481125A ES 481125 A ES481125 A ES 481125A ES 481125 A1 ES481125 A1 ES 481125A1
Authority
ES
Spain
Prior art keywords
alkyl
hexahydroazepine
piperidine
hydrogen
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES481125A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
John Wyeth and Brother Ltd
Original Assignee
John Wyeth and Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by John Wyeth and Brother Ltd filed Critical John Wyeth and Brother Ltd
Publication of ES481125A1 publication Critical patent/ES481125A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C07D211/76—Oxygen atoms attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/04—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08—Oxygen atoms
    • C07D223/10—Oxygen atoms attached in position 2

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Un procedimiento para la preparación de nuevos derivados de 2- oxo-hexahidroacepina, -piperidina o -pirrolidina, de la fórmula general **(Fórmula I)** en donde n es 2,3 ó 4 R es hidrógeno, alquilo inferior o aril-alquilo inferior y R1 es hidrógeno o alquilo inferior, caracterizado porque se hace reaccionar un derivado de ciclohexeno.
ES481125A 1977-12-22 1979-05-31 Un procedimiento para la preparacion de nuevos derivados de 2-oxohexahidroacepina,-piperidina o -pirrolidina. Expired ES481125A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB53370/77A GB1593888A (en) 1977-12-22 1977-12-22 Hexahydroazepine piperidine and pyrrolidine derivatives

Publications (1)

Publication Number Publication Date
ES481125A1 true ES481125A1 (es) 1980-02-01

Family

ID=10467561

Family Applications (2)

Application Number Title Priority Date Filing Date
ES476160A Expired ES476160A1 (es) 1977-12-22 1978-12-20 Un procedimiento para la preparacion de nuevos derivados de 2-oxo-hexahidroacepina -piperidina o -pirrolidina
ES481125A Expired ES481125A1 (es) 1977-12-22 1979-05-31 Un procedimiento para la preparacion de nuevos derivados de 2-oxohexahidroacepina,-piperidina o -pirrolidina.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES476160A Expired ES476160A1 (es) 1977-12-22 1978-12-20 Un procedimiento para la preparacion de nuevos derivados de 2-oxo-hexahidroacepina -piperidina o -pirrolidina

Country Status (33)

Country Link
US (2) US4197241A (es)
EP (1) EP0003253B1 (es)
JP (1) JPS5488286A (es)
AR (1) AR221710A1 (es)
AT (1) AT373586B (es)
AU (1) AU519653B2 (es)
CA (2) CA1113092A (es)
CS (1) CS207748B2 (es)
CY (2) CY1144A (es)
DD (2) DD149515A5 (es)
DE (1) DE2862139D1 (es)
DK (1) DK156302C (es)
EG (1) EG13745A (es)
ES (2) ES476160A1 (es)
FI (1) FI70575C (es)
GB (1) GB1593888A (es)
GR (1) GR64029B (es)
HK (2) HK18082A (es)
HU (1) HU181997B (es)
IE (1) IE47631B1 (es)
IL (1) IL55924A (es)
IN (1) IN150193B (es)
IT (1) IT1102761B (es)
KE (2) KE3206A (es)
MX (1) MX5628E (es)
MY (2) MY8200279A (es)
NZ (1) NZ188863A (es)
PH (2) PH14517A (es)
PL (1) PL126008B1 (es)
PT (1) PT68962A (es)
SU (1) SU1301311A3 (es)
YU (1) YU40543B (es)
ZA (1) ZA786244B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0021772B1 (en) * 1979-07-03 1985-01-02 JOHN WYETH & BROTHER LIMITED Method of preparing 2-oxo- and 2-unsubstituted-hexahydroazepine derivatives
IE54154B1 (en) * 1981-12-02 1989-07-05 Wyeth John & Brother Ltd M-hydroxyphenyl substituted compounds
US5665754A (en) * 1993-09-20 1997-09-09 Glaxo Wellcome Inc. Substituted pyrrolidines
SE0001438D0 (sv) 2000-04-18 2000-04-18 Axon Chemicals Bv New chemical compounds and their use in therapy
KR100421282B1 (ko) * 2001-08-22 2004-03-09 부광약품 주식회사 1-메틸헥사히드로-4-아제피논 염산염의 제조방법

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2524643A (en) * 1947-12-04 1950-10-03 Maltbie Lab Inc 3-phenyl-2-piperidones
US3149123A (en) * 1961-01-04 1964-09-15 Parke Davis & Co 1, 3-dialkyl-3-oxyphenylpyrrolidine compounds
NL265485A (es) * 1961-06-02
FR1337793A (fr) * 1962-06-19 1963-09-20 Parke Davis & Co Composés de pyrrolidine et procédé de préparation de ces composés
GB1285025A (en) * 1968-08-16 1972-08-09 Wyeth John & Brother Ltd Hexahydroazepines
CH526534A (de) * 1970-02-05 1972-08-15 Sandoz Ag Verfahren zur Herstellung neuer Pyrrolidin-1-carboxamidinderivate
CH526535A (de) * 1970-02-05 1972-08-15 Sandoz Ag Verfahren zur Herstellung neuer Pyrrolidin-1-carboxamidinderivate
CH526536A (de) * 1970-02-05 1972-08-15 Sandoz Ag Verfahren zur Herstellung neuer 3-Phenylpyrrolidinderivate
US3729465A (en) * 1971-02-03 1973-04-24 Wyeth John & Brother Ltd Hexahydroazepines
JPS4911844A (es) * 1972-05-09 1974-02-01
BE850777A (fr) * 1976-01-28 1977-07-26 Sandoz Sa Nouveaux derives de la pyrrolidine

Also Published As

Publication number Publication date
EG13745A (en) 1983-03-31
DE2862139D1 (en) 1983-01-27
AT373586B (de) 1984-02-10
AR221710A1 (es) 1981-03-13
PT68962A (en) 1979-01-01
CY1145A (en) 1982-09-10
MY8200279A (en) 1982-12-31
CA1113092A (en) 1981-11-24
FI70575B (fi) 1986-06-06
EP0003253B1 (en) 1982-12-22
PH14412A (en) 1981-07-09
CA1113465A (en) 1981-12-01
DK546578A (da) 1979-06-23
IT7831286A0 (it) 1978-12-22
YU40543B (en) 1986-02-28
MY8200278A (en) 1982-12-31
US4197241A (en) 1980-04-08
PL126008B1 (en) 1983-06-30
GR64029B (en) 1980-01-19
CS207748B2 (en) 1981-08-31
IL55924A (en) 1982-01-31
KE3206A (en) 1982-05-21
HU181997B (en) 1983-11-28
IE782252L (en) 1979-06-22
EP0003253A1 (en) 1979-08-08
PL211970A1 (es) 1980-02-25
GB1593888A (en) 1981-07-22
IL55924A0 (en) 1979-01-31
PH14517A (en) 1981-08-26
MX5628E (es) 1983-11-15
US4197239A (en) 1980-04-08
IT1102761B (it) 1985-10-07
DK156302B (da) 1989-07-31
AU4147978A (en) 1979-06-28
YU299778A (en) 1983-12-31
ZA786244B (en) 1980-06-25
CY1144A (en) 1982-09-10
IN150193B (es) 1982-08-14
HK18082A (en) 1982-05-07
FI783922A (fi) 1979-06-23
ATA898578A (de) 1983-06-15
NZ188863A (en) 1982-03-16
JPS5488286A (en) 1979-07-13
DK156302C (da) 1989-12-11
AU519653B2 (en) 1981-12-17
IE47631B1 (en) 1984-05-16
KE3207A (en) 1982-05-21
JPS64392B2 (es) 1989-01-06
ES476160A1 (es) 1979-11-16
HK18182A (en) 1982-05-07
SU1301311A3 (ru) 1987-03-30
FI70575C (fi) 1986-09-24
DD141308A5 (de) 1980-04-23
DD149515A5 (de) 1981-07-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000202