PT68962A - Process for preparing hexahydroazepine piperidine and pyrrolidine derivatives - Google Patents
Process for preparing hexahydroazepine piperidine and pyrrolidine derivativesInfo
- Publication number
- PT68962A PT68962A PT68962A PT6896278A PT68962A PT 68962 A PT68962 A PT 68962A PT 68962 A PT68962 A PT 68962A PT 6896278 A PT6896278 A PT 6896278A PT 68962 A PT68962 A PT 68962A
- Authority
- PT
- Portugal
- Prior art keywords
- hexahydroazepine
- piperidine
- preparing
- pyrrolidine derivatives
- pyrrolidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/04—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/08—Oxygen atoms
- C07D223/10—Oxygen atoms attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB53370/77A GB1593888A (en) | 1977-12-22 | 1977-12-22 | Hexahydroazepine piperidine and pyrrolidine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT68962A true PT68962A (en) | 1979-01-01 |
Family
ID=10467561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT68962A PT68962A (en) | 1977-12-22 | 1978-12-21 | Process for preparing hexahydroazepine piperidine and pyrrolidine derivatives |
Country Status (33)
| Country | Link |
|---|---|
| US (2) | US4197239A (pt) |
| EP (1) | EP0003253B1 (pt) |
| JP (1) | JPS5488286A (pt) |
| AR (1) | AR221710A1 (pt) |
| AT (1) | AT373586B (pt) |
| AU (1) | AU519653B2 (pt) |
| CA (2) | CA1113092A (pt) |
| CS (1) | CS207748B2 (pt) |
| CY (2) | CY1145A (pt) |
| DD (2) | DD149515A5 (pt) |
| DE (1) | DE2862139D1 (pt) |
| DK (1) | DK156302C (pt) |
| EG (1) | EG13745A (pt) |
| ES (2) | ES476160A1 (pt) |
| FI (1) | FI70575C (pt) |
| GB (1) | GB1593888A (pt) |
| GR (1) | GR64029B (pt) |
| HK (2) | HK18182A (pt) |
| HU (1) | HU181997B (pt) |
| IE (1) | IE47631B1 (pt) |
| IL (1) | IL55924A (pt) |
| IN (1) | IN150193B (pt) |
| IT (1) | IT1102761B (pt) |
| KE (2) | KE3207A (pt) |
| MX (1) | MX5628E (pt) |
| MY (2) | MY8200279A (pt) |
| NZ (1) | NZ188863A (pt) |
| PH (2) | PH14412A (pt) |
| PL (1) | PL126008B1 (pt) |
| PT (1) | PT68962A (pt) |
| SU (1) | SU1301311A3 (pt) |
| YU (1) | YU40543B (pt) |
| ZA (1) | ZA786244B (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3069897D1 (en) * | 1979-07-03 | 1985-02-14 | Wyeth John & Brother Ltd | Method of preparing 2-oxo- and 2-unsubstituted-hexahydroazepine derivatives |
| IE54154B1 (en) * | 1981-12-02 | 1989-07-05 | Wyeth John & Brother Ltd | M-hydroxyphenyl substituted compounds |
| US5665754A (en) * | 1993-09-20 | 1997-09-09 | Glaxo Wellcome Inc. | Substituted pyrrolidines |
| SE0001438D0 (sv) * | 2000-04-18 | 2000-04-18 | Axon Chemicals Bv | New chemical compounds and their use in therapy |
| KR100421282B1 (ko) * | 2001-08-22 | 2004-03-09 | 부광약품 주식회사 | 1-메틸헥사히드로-4-아제피논 염산염의 제조방법 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2524643A (en) * | 1947-12-04 | 1950-10-03 | Maltbie Lab Inc | 3-phenyl-2-piperidones |
| US3149123A (en) * | 1961-01-04 | 1964-09-15 | Parke Davis & Co | 1, 3-dialkyl-3-oxyphenylpyrrolidine compounds |
| NL265485A (pt) * | 1961-06-02 | |||
| FR1337793A (fr) * | 1962-06-19 | 1963-09-20 | Parke Davis & Co | Composés de pyrrolidine et procédé de préparation de ces composés |
| GB1285025A (en) * | 1968-08-16 | 1972-08-09 | Wyeth John & Brother Ltd | Hexahydroazepines |
| CH526534A (de) * | 1970-02-05 | 1972-08-15 | Sandoz Ag | Verfahren zur Herstellung neuer Pyrrolidin-1-carboxamidinderivate |
| CH526535A (de) * | 1970-02-05 | 1972-08-15 | Sandoz Ag | Verfahren zur Herstellung neuer Pyrrolidin-1-carboxamidinderivate |
| CH526536A (de) * | 1970-02-05 | 1972-08-15 | Sandoz Ag | Verfahren zur Herstellung neuer 3-Phenylpyrrolidinderivate |
| US3729465A (en) * | 1971-02-03 | 1973-04-24 | Wyeth John & Brother Ltd | Hexahydroazepines |
| JPS4911844A (pt) * | 1972-05-09 | 1974-02-01 | ||
| BE850777A (fr) * | 1976-01-28 | 1977-07-26 | Sandoz Sa | Nouveaux derives de la pyrrolidine |
-
1977
- 1977-12-22 GB GB53370/77A patent/GB1593888A/en not_active Expired
-
1978
- 1978-05-30 CY CY1145A patent/CY1145A/xx unknown
- 1978-05-30 CY CY1144A patent/CY1144A/xx unknown
- 1978-11-06 ZA ZA786244A patent/ZA786244B/xx unknown
- 1978-11-08 NZ NZ188863A patent/NZ188863A/xx unknown
- 1978-11-09 CA CA316,049A patent/CA1113092A/en not_active Expired
- 1978-11-09 CA CA316,048A patent/CA1113465A/en not_active Expired
- 1978-11-10 IL IL55924A patent/IL55924A/xx unknown
- 1978-11-10 AU AU41479/78A patent/AU519653B2/en not_active Expired
- 1978-11-15 US US05/961,086 patent/US4197239A/en not_active Expired - Lifetime
- 1978-11-15 IE IE2252/78A patent/IE47631B1/en unknown
- 1978-11-15 US US05/961,087 patent/US4197241A/en not_active Expired - Lifetime
- 1978-11-20 IN IN1249/CAL/78A patent/IN150193B/en unknown
- 1978-11-28 AR AR274561A patent/AR221710A1/es active
- 1978-11-30 DK DK546578A patent/DK156302C/da not_active IP Right Cessation
- 1978-11-30 MX MX787562U patent/MX5628E/es unknown
- 1978-12-06 DE DE7878300753T patent/DE2862139D1/de not_active Expired
- 1978-12-06 EP EP78300753A patent/EP0003253B1/en not_active Expired
- 1978-12-08 PH PH21913A patent/PH14412A/en unknown
- 1978-12-08 PH PH21914A patent/PH14517A/en unknown
- 1978-12-15 AT AT0898578A patent/AT373586B/de not_active IP Right Cessation
- 1978-12-19 YU YU2997/78A patent/YU40543B/xx unknown
- 1978-12-19 GR GR57927A patent/GR64029B/el unknown
- 1978-12-20 SU SU782699100A patent/SU1301311A3/ru active
- 1978-12-20 DD DD78219713A patent/DD149515A5/de unknown
- 1978-12-20 PL PL1978211970A patent/PL126008B1/pl unknown
- 1978-12-20 FI FI783922A patent/FI70575C/fi not_active IP Right Cessation
- 1978-12-20 DD DD78209990A patent/DD141308A5/de unknown
- 1978-12-20 ES ES476160A patent/ES476160A1/es not_active Expired
- 1978-12-20 EG EG724/78A patent/EG13745A/xx active
- 1978-12-21 JP JP15695778A patent/JPS5488286A/ja active Granted
- 1978-12-21 PT PT68962A patent/PT68962A/pt unknown
- 1978-12-21 CS CS788756A patent/CS207748B2/cs unknown
- 1978-12-21 HU HU78WI298A patent/HU181997B/hu unknown
- 1978-12-22 IT IT31286/78A patent/IT1102761B/it active
-
1979
- 1979-05-31 ES ES481125A patent/ES481125A1/es not_active Expired
-
1982
- 1982-04-06 KE KE3207A patent/KE3207A/xx unknown
- 1982-04-06 KE KE3206A patent/KE3206A/xx unknown
- 1982-04-29 HK HK181/82A patent/HK18182A/xx not_active IP Right Cessation
- 1982-04-29 HK HK180/82A patent/HK18082A/xx not_active IP Right Cessation
- 1982-12-30 MY MY279/82A patent/MY8200279A/xx unknown
- 1982-12-30 MY MY278/82A patent/MY8200278A/xx unknown
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