ES474900A1 - Metodo para producir nues n''-4-quinolilguanidinas n,n'-di- sustituidas para la terapia de la artritis reumatoide, os- teo-artritis y estados relacionados - Google Patents
Metodo para producir nues n''-4-quinolilguanidinas n,n'-di- sustituidas para la terapia de la artritis reumatoide, os- teo-artritis y estados relacionadosInfo
- Publication number
- ES474900A1 ES474900A1 ES474900A ES474900A ES474900A1 ES 474900 A1 ES474900 A1 ES 474900A1 ES 474900 A ES474900 A ES 474900A ES 474900 A ES474900 A ES 474900A ES 474900 A1 ES474900 A1 ES 474900A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- ring system
- phenyl
- optionally
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
Método para producir nuevos N''`-4-quinolilguanidinas N,N''-disustituidas para la terapia de la artritis reumatoide, osteo-artritis y estados relacionados, que responden a la fórmula general I: ** (Ver fórmula I) ** en la que R1 representa el hidrógeno, alquilo en C1-C6, alcoxi en C1-C6, hidroxi, halógeno, trifluorometilo, o fenilo; R2 representa el hidrógeno, alquilo en C1-C6, alcoxi en C1-C6, halógeno, trifluorometilo, o hidroxi; R3 representa alquilo en C1- C18, o cicloalquilo en C3-C8 que puede ser además mono- o di-sustituido con metilo o etilo, o fenilo o fenil-alquilo en C1-C3 que puede además ser sustituido con metilo, metoxi, halo o trifluorometilo; y R4 representa un sistema de anillo heterocíclico de 5 ó 6 miembros que contiene al menos un átomo de nitrógeno y conteniendo además opcionalmente átomos de nitrógeno, oxígeno y/o azufre, estando sustituido opcionalmente dicho sistema de anillo con alquilo en C1-C3, carboxi, carbalcoxi, halógeno, trifluorometilo, hidroxi y/o mercapto; oformando parte opcionalmente dicho sistema de anillo de un sistema de anillo fundido más grande; y las sales, complejos o derivados acilados farmacéuticamente aceptables no tóxicos del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4616677 | 1977-11-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES474900A1 true ES474900A1 (es) | 1980-04-16 |
Family
ID=10440127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES474900A Expired ES474900A1 (es) | 1977-11-07 | 1978-11-07 | Metodo para producir nues n''-4-quinolilguanidinas n,n'-di- sustituidas para la terapia de la artritis reumatoide, os- teo-artritis y estados relacionados |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US4293549A (es) |
| JP (1) | JPS5473784A (es) |
| AT (1) | AT366368B (es) |
| AU (1) | AU517670B2 (es) |
| BE (1) | BE871807A (es) |
| CA (1) | CA1120929A (es) |
| CH (1) | CH645354A5 (es) |
| DE (1) | DE2847792A1 (es) |
| DK (1) | DK153950C (es) |
| ES (1) | ES474900A1 (es) |
| FI (1) | FI69463C (es) |
| FR (1) | FR2407930A1 (es) |
| GR (1) | GR65010B (es) |
| IE (1) | IE47458B1 (es) |
| IT (1) | IT1100075B (es) |
| LU (1) | LU80476A1 (es) |
| NL (1) | NL7811035A (es) |
| NZ (1) | NZ188770A (es) |
| PH (1) | PH16296A (es) |
| PT (1) | PT68750A (es) |
| SE (1) | SE446267B (es) |
| SU (1) | SU828967A3 (es) |
| YU (1) | YU41129B (es) |
| ZA (1) | ZA786175B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6306846B1 (en) * | 1972-05-31 | 2001-10-23 | John R. J. Sorenson | Anti-inflammatory and anti-ulcer compounds and process |
| IT1205640B (it) * | 1983-04-06 | 1989-03-23 | Yason Srl | Nuovi composti ad attivita' antiinfiammatoria,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono |
| US4563460A (en) * | 1984-01-13 | 1986-01-07 | William H. Rorer, Inc. | Quinoline and quinazoline derivatives for treating gastrointestinal motility dysfunctions |
| HU195487B (en) * | 1985-06-04 | 1988-05-30 | Egyt Gyogyszervegyeszeti Gyar | Process for producing quinoline derivatives |
| EP0259085B1 (en) * | 1986-08-29 | 1991-08-21 | Pfizer Inc. | 2-guanidino-4-arylthiazoles for treatment of peptic ulcers |
| US6100260A (en) * | 1997-04-21 | 2000-08-08 | Sumitomo Pharmaceutical Company, Limited | Isoxazole derivatives |
| EP0928793B1 (en) * | 1998-01-02 | 2002-05-15 | F. Hoffmann-La Roche Ag | Thiazole derivatives |
| BR9909666A (pt) * | 1998-03-26 | 2001-09-11 | Japan Tobacco Inc | Derivados de amida e antagonistas de nociceptina |
| JP2003513064A (ja) * | 1999-11-05 | 2003-04-08 | ユニバーシティ カレッジ ロンドン | 可溶性グアニル酸シクラーゼのアクチベーター |
| WO2004063181A1 (en) * | 2003-01-03 | 2004-07-29 | Genzyme Corporation | Urea derivatives and their use as anti-inflammatory agents |
| WO2004064730A2 (en) * | 2003-01-14 | 2004-08-05 | Cytokinetics, Inc. | Compounds, compositions and methods |
| GB0404434D0 (en) * | 2004-02-27 | 2004-03-31 | Novartis Ag | Organic compounds |
| WO2007022964A2 (de) * | 2005-08-24 | 2007-03-01 | Abbott Gmbh & Co. Kg | Hetaryl substituierte guanidinverbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren |
| CN117677386A (zh) * | 2021-07-23 | 2024-03-08 | 瓦伦塔有限责任公司 | 具有亲溶酶体和抗病毒活性的化合物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB889282A (en) * | 1957-05-07 | 1962-02-14 | Air Reduction | Preparation of hexafluorodiethyl ether and medicinal compositions containing it |
| GB889262A (en) * | 1959-07-03 | 1962-02-14 | Ciba Ltd | Quinoline compounds |
| US3159676A (en) * | 1962-02-07 | 1964-12-01 | Smith Kline French Lab | Naphthyl containing guanidines |
| US3852293A (en) | 1972-06-21 | 1974-12-03 | Uniroyal Inc | 4-phenyl-2-(3-pyridyl)-thiazole carboxamides |
| US4000279A (en) * | 1974-10-29 | 1976-12-28 | Armour Pharmaceutical Company | Pharmaceutical preparations containing 5'-(8'-hydroxyquinolyl)guanidine compounds and methods of using same |
-
1978
- 1978-10-20 IE IE2084/78A patent/IE47458B1/en not_active IP Right Cessation
- 1978-10-26 GR GR57518A patent/GR65010B/el unknown
- 1978-10-27 US US05/955,228 patent/US4293549A/en not_active Expired - Lifetime
- 1978-10-30 NZ NZ188770A patent/NZ188770A/en unknown
- 1978-10-30 AT AT0773278A patent/AT366368B/de not_active IP Right Cessation
- 1978-10-31 CA CA000315384A patent/CA1120929A/en not_active Expired
- 1978-11-01 FI FI783327A patent/FI69463C/fi not_active IP Right Cessation
- 1978-11-02 PH PH21790A patent/PH16296A/en unknown
- 1978-11-02 ZA ZA00786175A patent/ZA786175B/xx unknown
- 1978-11-03 CH CH1136378A patent/CH645354A5/de not_active IP Right Cessation
- 1978-11-03 DE DE19782847792 patent/DE2847792A1/de active Granted
- 1978-11-04 SU SU782685598A patent/SU828967A3/ru active
- 1978-11-06 BE BE191566A patent/BE871807A/xx not_active IP Right Cessation
- 1978-11-06 PT PT68750A patent/PT68750A/pt unknown
- 1978-11-06 DK DK493378A patent/DK153950C/da not_active IP Right Cessation
- 1978-11-06 AU AU41376/78A patent/AU517670B2/en not_active Expired
- 1978-11-06 SE SE7811457A patent/SE446267B/sv not_active IP Right Cessation
- 1978-11-06 LU LU80476A patent/LU80476A1/xx unknown
- 1978-11-06 YU YU2575/78A patent/YU41129B/xx unknown
- 1978-11-06 NL NL7811035A patent/NL7811035A/xx not_active Application Discontinuation
- 1978-11-06 FR FR7831339A patent/FR2407930A1/fr active Granted
- 1978-11-06 JP JP13723578A patent/JPS5473784A/ja active Granted
- 1978-11-07 IT IT29514/78A patent/IT1100075B/it active
- 1978-11-07 ES ES474900A patent/ES474900A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| NL7811035A (nl) | 1979-05-09 |
| FI69463B (fi) | 1985-10-31 |
| FI783327A (fi) | 1979-05-08 |
| YU257578A (en) | 1983-01-21 |
| FR2407930A1 (fr) | 1979-06-01 |
| FI69463C (fi) | 1986-02-10 |
| PH16296A (en) | 1983-09-05 |
| US4293549A (en) | 1981-10-06 |
| ATA773278A (de) | 1981-08-15 |
| AT366368B (de) | 1982-04-13 |
| BE871807A (fr) | 1979-05-07 |
| IT1100075B (it) | 1985-09-28 |
| DK493378A (da) | 1979-05-08 |
| CH645354A5 (de) | 1984-09-28 |
| SE446267B (sv) | 1986-08-25 |
| AU4137678A (en) | 1979-05-17 |
| YU41129B (en) | 1986-12-31 |
| ZA786175B (en) | 1979-10-31 |
| PT68750A (en) | 1978-12-01 |
| CA1120929A (en) | 1982-03-30 |
| DK153950B (da) | 1988-09-26 |
| FR2407930B1 (es) | 1983-03-18 |
| DK153950C (da) | 1989-02-20 |
| DE2847792C2 (es) | 1988-02-04 |
| SE7811457L (sv) | 1979-05-08 |
| NZ188770A (en) | 1984-07-31 |
| DE2847792A1 (de) | 1979-05-10 |
| GR65010B (en) | 1980-06-12 |
| IT7829514A0 (it) | 1978-11-07 |
| LU80476A1 (fr) | 1979-06-15 |
| IE782084L (en) | 1979-05-07 |
| JPS5473784A (en) | 1979-06-13 |
| AU517670B2 (en) | 1981-08-20 |
| JPS6348873B2 (es) | 1988-09-30 |
| IE47458B1 (en) | 1984-03-21 |
| SU828967A3 (ru) | 1981-05-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19990201 |