GB2009155A - Pyridine Derivatives - Google Patents

Pyridine Derivatives

Info

Publication number
GB2009155A
GB2009155A GB7843540A GB7843540A GB2009155A GB 2009155 A GB2009155 A GB 2009155A GB 7843540 A GB7843540 A GB 7843540A GB 7843540 A GB7843540 A GB 7843540A GB 2009155 A GB2009155 A GB 2009155A
Authority
GB
United Kingdom
Prior art keywords
compounds
ring system
optionally
alkyl
present compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7843540A
Other versions
GB2009155B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leo Pharma AS
Original Assignee
Leo Pharmaceutical Products Ltd AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharmaceutical Products Ltd AS filed Critical Leo Pharmaceutical Products Ltd AS
Priority to GB7843540A priority Critical patent/GB2009155B/en
Publication of GB2009155A publication Critical patent/GB2009155A/en
Application granted granted Critical
Publication of GB2009155B publication Critical patent/GB2009155B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

This invention relates to new compounds, salts, complexes and acylated derivatives thereof, methods of producing said compounds, pharmaceutical compositions containing the present compounds and methods of producing same, and a method of treating patients using the present compounds, the compounds having the general formula (I> <IMAGE> in which R1 represents hydrogen, alkyl, alkoxy, hydroxy, halogen, trifluoromethyl, or phenyl; R2 represents hydrogen, alkyl, alkoxy, halogen, trifluoromethyl, or hydroxy; R3 represents alkyl, cycloalkyl which can be further mono-or disubstituted with methyl or ethyl, phenyl or phenylalkyl, optionally being further substituted; and R4 represents a 5-or 6-membered heterocyclic ring system containing at least one nitrogen atom and optionally further nitrogen, oxygen and/or sulphur atoms, said ring system optionally being further substituted; or said ring system optionally forming part of a larger fused ring system; and pharmaceutically acceptable, non- toxic salts, complexes and acylated derivatives thereof. Intermediates obtained in the preparation of the above compounds are also described. The present compounds can be used in the therapy of rheumatoid arthritis, osteo-arthritis, and allied conditions in humans and domestic animals by enteral, parenteral or topical administration.
GB7843540A 1977-11-07 1978-11-07 Chemical compounds Expired GB2009155B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB7843540A GB2009155B (en) 1977-11-07 1978-11-07 Chemical compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB4616677 1977-11-07
GB7843540A GB2009155B (en) 1977-11-07 1978-11-07 Chemical compounds

Publications (2)

Publication Number Publication Date
GB2009155A true GB2009155A (en) 1979-06-13
GB2009155B GB2009155B (en) 1982-07-21

Family

ID=26265755

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7843540A Expired GB2009155B (en) 1977-11-07 1978-11-07 Chemical compounds

Country Status (1)

Country Link
GB (1) GB2009155B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6100282A (en) * 1998-01-02 2000-08-08 Hoffman-La Roche Inc. Thiazole derivatives
WO2001056988A1 (en) * 2000-02-01 2001-08-09 Kirin Beer Kabushiki Kaisha Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same
WO2002036568A1 (en) * 2000-11-06 2002-05-10 Astrazeneca Ab N-type calcium channel antagonists for the treatment of pain

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6100282A (en) * 1998-01-02 2000-08-08 Hoffman-La Roche Inc. Thiazole derivatives
US6320054B1 (en) 1998-01-02 2001-11-20 Hoffman-La Roche Inc. Thiazole derivatives
US6344562B1 (en) 1998-01-02 2002-02-05 Hoffmann-La Roche Inc. Thiazole derivatives
WO2001056988A1 (en) * 2000-02-01 2001-08-09 Kirin Beer Kabushiki Kaisha Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same
US7217722B2 (en) 2000-02-01 2007-05-15 Kirin Beer Kabushiki Kaisha Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same
WO2002036568A1 (en) * 2000-11-06 2002-05-10 Astrazeneca Ab N-type calcium channel antagonists for the treatment of pain
US6906193B2 (en) 2000-11-06 2005-06-14 Astrazeneca Ab N-type calcium channel antagonists for the treatment of pain

Also Published As

Publication number Publication date
GB2009155B (en) 1982-07-21

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19921107