ES473451A1 - Un procedimiento para la preparacion de derivados de imida- zol. - Google Patents
Un procedimiento para la preparacion de derivados de imida- zol.Info
- Publication number
- ES473451A1 ES473451A1 ES473451A ES473451A ES473451A1 ES 473451 A1 ES473451 A1 ES 473451A1 ES 473451 A ES473451 A ES 473451A ES 473451 A ES473451 A ES 473451A ES 473451 A1 ES473451 A1 ES 473451A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- radical
- lower alkyl
- procedure
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/26—Radicals substituted by halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU78140 | 1977-09-19 | ||
| CH814978 | 1978-07-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES473451A1 true ES473451A1 (es) | 1979-05-01 |
Family
ID=25702876
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES473451A Expired ES473451A1 (es) | 1977-09-19 | 1978-09-18 | Un procedimiento para la preparacion de derivados de imida- zol. |
Country Status (36)
| Country | Link |
|---|---|
| US (2) | US4182766A (env) |
| EP (1) | EP0001279B1 (env) |
| JP (1) | JPS5459274A (env) |
| AR (1) | AR224350A1 (env) |
| AT (1) | AT368152B (env) |
| AU (1) | AU519711B2 (env) |
| BG (1) | BG28708A3 (env) |
| BR (1) | BR7806148A (env) |
| CA (1) | CA1106849A (env) |
| DD (1) | DD138210A5 (env) |
| DE (2) | DE2840591A1 (env) |
| DK (1) | DK406578A (env) |
| EG (1) | EG13530A (env) |
| ES (1) | ES473451A1 (env) |
| FI (1) | FI64365C (env) |
| FR (1) | FR2403340A1 (env) |
| GB (1) | GB2004281B (env) |
| GR (1) | GR73069B (env) |
| HU (1) | HU176111B (env) |
| IE (1) | IE47363B1 (env) |
| IL (1) | IL55557A (env) |
| IN (1) | IN148930B (env) |
| IT (1) | IT1098858B (env) |
| MC (1) | MC1213A1 (env) |
| MT (1) | MTP835B (env) |
| NL (1) | NL7809529A (env) |
| NO (1) | NO149962C (env) |
| NZ (1) | NZ188405A (env) |
| OA (1) | OA06054A (env) |
| PH (1) | PH16342A (env) |
| PL (1) | PL114494B1 (env) |
| PT (1) | PT68573A (env) |
| RO (1) | RO75258A (env) |
| SE (1) | SE7809792L (env) |
| SU (1) | SU793390A3 (env) |
| YU (1) | YU216778A (env) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE7804231L (sv) * | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
| US4321372A (en) * | 1980-06-16 | 1982-03-23 | Pfizer Inc. | Antiulcer thiazol-2-ylcarbamoyl-carboxylic acids, esters and amides |
| US4359465A (en) * | 1980-07-28 | 1982-11-16 | The Upjohn Company | Methods for treating gastrointestinal inflammation |
| CH644116A5 (de) * | 1980-08-21 | 1984-07-13 | Hoffmann La Roche | Imidazolderivate. |
| US4368201A (en) * | 1981-07-20 | 1983-01-11 | Usv Pharmaceutical Corporation | Tetrahydronaphthoxazoles |
| IL66340A (en) * | 1981-08-13 | 1986-08-31 | Haessle Ab | Pharmaceutical compositions comprising pyridylmethyl-thiobenzimidazole derivatives,certain such novel derivatives and their preparation |
| HU191756B (en) * | 1983-05-03 | 1987-04-28 | Byk Gulden Lomberg Chem Fab | Process for preparing new fluoro-alkoxy-benzimidazole derivatives |
| ZW4585A1 (en) * | 1984-04-19 | 1985-11-20 | Hoffmann La Roche | Imidazole derivatives |
| EP0174717B1 (en) * | 1984-07-06 | 1992-01-22 | FISONS plc | Benzimidazoles, and their production formulation and use as gastric acid secretion inhibitors |
| GB2161160B (en) * | 1984-07-06 | 1989-05-24 | Fisons Plc | Heterocyclic sulphinyl compounds |
| SE8404065D0 (sv) * | 1984-08-10 | 1984-08-10 | Haessle Ab | Novel biologically active compounds |
| DE3501497A1 (de) * | 1985-01-18 | 1986-07-24 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte |
| US5869513A (en) * | 1985-05-24 | 1999-02-09 | G. D. Searle & Co. | 2- (1H-benzimidazol-2-ylsulfinyl)methyl!benzenamines |
| EP0204215B1 (en) | 1985-05-24 | 1993-08-11 | G.D. Searle & Co. | 2-[(1H-benzimidazol-2-ylsulfinyl)methyl]-benzenamines |
| DK337086A (da) * | 1985-08-12 | 1987-02-13 | Hoffmann La Roche | Benzimidazolderivater |
| SE8505112D0 (sv) * | 1985-10-29 | 1985-10-29 | Haessle Ab | Novel pharmacological compounds |
| SE8600658D0 (sv) * | 1986-02-14 | 1986-02-14 | Haessle Ab | Novel composition of matter |
| US4687775A (en) * | 1986-07-17 | 1987-08-18 | G. D. Searle & Co. | 2-[(Imidazo[1,2-a]pyridinylmethyl)sulfinyl]-1H-benzimidazoles |
| US4772619A (en) * | 1986-07-17 | 1988-09-20 | G. D. Searle & Co. | [(1H-benzimidazol-2-ylsulfinyl)methyl]-2-pyridinamines |
| US4721718A (en) * | 1986-08-18 | 1988-01-26 | G. D. Searle & Co. | 2-[(imidazo[1,2-a]pyridin-3-ylmethyl)sulfinyl]-1H-benzimidazoles useful in the treatment and prevention of ulcers |
| SE8604566D0 (sv) * | 1986-10-27 | 1986-10-27 | Haessle Ab | Novel compunds |
| NZ234564A (en) | 1986-11-21 | 1991-04-26 | Haessle Ab | 1-substituted benzimidazoles and pharmaceutical compositions |
| SE8604998D0 (sv) | 1986-11-21 | 1986-11-21 | Haessle Ab | Novel pharmacological compounds |
| FI91754C (fi) * | 1986-12-02 | 1994-08-10 | Tanabe Seiyaku Co | Analogiamenetelmä lääkeaineena käyttökelpoisen imidatsolijohdannaisen valmistamiseksi |
| DE3701277A1 (de) * | 1987-01-17 | 1988-07-28 | Boehringer Mannheim Gmbh | Neue tricyclische benzimidazole, verfahren zu ihrer herstellung und verwendung als arzneimittel |
| US4931557A (en) * | 1988-10-17 | 1990-06-05 | Eli Lilly And Company | Method of resolving cis 3-amino-4-(2-furyl)vinyl)-1-methoxycarbonylmethyl-azetidin-2-one and di-p-toluoyl-tartaric acid salts thereof |
| SE8804628D0 (sv) | 1988-12-22 | 1988-12-22 | Ab Haessle | New compounds |
| SE8804629D0 (sv) | 1988-12-22 | 1988-12-22 | Ab Haessle | New therapeutically active compounds |
| EG19302A (en) * | 1988-12-22 | 1994-11-30 | Haessle Ab | Compound with gastric acid inhibitory effect and process for its preparation |
| US4965269A (en) * | 1989-12-20 | 1990-10-23 | Ab Hassle | Therapeutically active chloro substituted benzimidazoles |
| US5274099A (en) * | 1989-12-20 | 1993-12-28 | Aktiebolaget Hassle | Therapeutically active fluoro substituted benzimidazoles |
| US5049674A (en) | 1989-12-20 | 1991-09-17 | Aktiebolaget Hassle | Therapeutically active fluoro substituted benzimidazoles |
| SE9002043D0 (sv) * | 1990-06-07 | 1990-06-07 | Astra Ab | Improved method for synthesis |
| SE9002206D0 (sv) | 1990-06-20 | 1990-06-20 | Haessle Ab | New compounds |
| PL307026A1 (en) * | 1992-07-08 | 1995-05-02 | Monsanto Co | Method of producing ppaliative effect in respect to swine gastric ulcers |
| WO1995029897A1 (en) * | 1994-04-29 | 1995-11-09 | G.D. Searle & Co. | METHOD OF USING (H+/K+) ATPase INHIBITORS AS ANTIVIRAL AGENTS |
| DK1308159T3 (da) * | 1995-09-21 | 2005-02-14 | Pharma Pass Ii Llc | Farmaceutisk sammensætning indeholdende en syre-labil omeprazol og fremgangsmåde til fremstilling deraf |
| US6645988B2 (en) | 1996-01-04 | 2003-11-11 | Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| US6489346B1 (en) | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
| US6699885B2 (en) * | 1996-01-04 | 2004-03-02 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and methods of using same |
| KR100463031B1 (ko) * | 1997-05-26 | 2005-04-06 | 동아제약주식회사 | 5-메톡시-2-[3,5-디메틸-4-메톡시피리딜메틸)설피닐]-1h-벤즈이미다졸의신규제조방법 |
| US6096340A (en) * | 1997-11-14 | 2000-08-01 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
| US6174548B1 (en) | 1998-08-28 | 2001-01-16 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
| US6733778B1 (en) * | 1999-08-27 | 2004-05-11 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
| WO2003063840A2 (en) * | 2002-01-25 | 2003-08-07 | Santarus, Inc. | Transmucosal delivery of proton pump inhibitors |
| EP1603537A4 (en) * | 2003-02-20 | 2009-11-04 | Santarus Inc | NOVEL FORMULATION, ANTICIPATED COMPLEX IMMEDIATE RELEASE FOR A FAST AND CONTINUOUS SUPPRESSION OF MAGIC ACID |
| US8993599B2 (en) * | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| TWI337877B (en) * | 2003-07-18 | 2011-03-01 | Santarus Inc | Pharmaceutical formulation and method for treating acid-caused gastrointestinal disorders |
| AR045062A1 (es) * | 2003-07-18 | 2005-10-12 | Santarus Inc | Formulaciones farmaceuticas para inhibir la secrecion de acido y metodos para preparar y utilizarlas |
| US20070292498A1 (en) * | 2003-11-05 | 2007-12-20 | Warren Hall | Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers |
| US8906940B2 (en) * | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| US8815916B2 (en) * | 2004-05-25 | 2014-08-26 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| US20060024362A1 (en) * | 2004-07-29 | 2006-02-02 | Pawan Seth | Composition comprising a benzimidazole and process for its manufacture |
| GB2444593B (en) | 2006-10-05 | 2010-06-09 | Santarus Inc | Novel formulations for immediate release of proton pump inhibitors and methods of using these formulations |
| US20090092658A1 (en) * | 2007-10-05 | 2009-04-09 | Santarus, Inc. | Novel formulations of proton pump inhibitors and methods of using these formulations |
| MX2009004475A (es) | 2006-10-27 | 2009-08-12 | Univ Missouri | Composiciones que comprenden agentes acido labiles que inhiben la bomba de protones, por lo menos otro agente farmaceuticamente activo y metodos de uso de las misma. |
| JP2025532389A (ja) | 2022-10-04 | 2025-09-29 | ザビリュク，アルセニー | 大動脈弁の石灰化の抑制 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2985661A (en) * | 1956-02-06 | 1961-05-23 | American Cyanamid Co | Preparation of 2(omicron-aminophenyl)-benzimidazole |
| GB1234058A (env) * | 1968-10-21 | 1971-06-03 | ||
| SE418966B (sv) * | 1974-02-18 | 1981-07-06 | Haessle Ab | Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan |
| SE416649B (sv) * | 1974-05-16 | 1981-01-26 | Haessle Ab | Forfarande for framstellning av foreningar som paverkar magsyrasekretionen |
-
1978
- 1978-08-30 IN IN949/CAL/78A patent/IN148930B/en unknown
- 1978-08-31 MC MC781323A patent/MC1213A1/fr unknown
- 1978-09-11 US US05/941,343 patent/US4182766A/en not_active Expired - Lifetime
- 1978-09-12 IL IL55557A patent/IL55557A/xx unknown
- 1978-09-13 EG EG554/78A patent/EG13530A/xx active
- 1978-09-13 BG BG040865A patent/BG28708A3/xx unknown
- 1978-09-13 NZ NZ188405A patent/NZ188405A/xx unknown
- 1978-09-13 CA CA311,181A patent/CA1106849A/en not_active Expired
- 1978-09-13 AU AU39817/78A patent/AU519711B2/en not_active Expired
- 1978-09-14 DK DK406578A patent/DK406578A/da not_active Application Discontinuation
- 1978-09-14 OA OA56607A patent/OA06054A/xx unknown
- 1978-09-14 FR FR7826420A patent/FR2403340A1/fr active Granted
- 1978-09-14 PH PH21603A patent/PH16342A/en unknown
- 1978-09-14 YU YU02167/78A patent/YU216778A/xx unknown
- 1978-09-15 DD DD78207858A patent/DD138210A5/xx unknown
- 1978-09-18 GB GB7837156A patent/GB2004281B/en not_active Expired
- 1978-09-18 JP JP11371578A patent/JPS5459274A/ja active Pending
- 1978-09-18 ES ES473451A patent/ES473451A1/es not_active Expired
- 1978-09-18 FI FI782847A patent/FI64365C/fi not_active IP Right Cessation
- 1978-09-18 NO NO783155A patent/NO149962C/no unknown
- 1978-09-18 DE DE19782840591 patent/DE2840591A1/de not_active Withdrawn
- 1978-09-18 MT MT835A patent/MTP835B/xx unknown
- 1978-09-18 SE SE7809792A patent/SE7809792L/xx unknown
- 1978-09-18 SU SU782664651A patent/SU793390A3/ru active
- 1978-09-18 PT PT68573A patent/PT68573A/pt unknown
- 1978-09-18 AT AT0673378A patent/AT368152B/de not_active IP Right Cessation
- 1978-09-18 IE IE1878/78A patent/IE47363B1/en unknown
- 1978-09-18 EP EP78100923A patent/EP0001279B1/de not_active Expired
- 1978-09-18 GR GR57249A patent/GR73069B/el unknown
- 1978-09-18 HU HU78HO2102A patent/HU176111B/hu unknown
- 1978-09-18 DE DE7878100923T patent/DE2861237D1/de not_active Expired
- 1978-09-19 RO RO7895228A patent/RO75258A/ro unknown
- 1978-09-19 NL NL7809529A patent/NL7809529A/xx not_active Application Discontinuation
- 1978-09-19 IT IT27861/78A patent/IT1098858B/it active
- 1978-09-19 PL PL1978209693A patent/PL114494B1/pl unknown
- 1978-09-19 AR AR273765A patent/AR224350A1/es active
- 1978-09-19 BR BR7806148A patent/BR7806148A/pt unknown
-
1979
- 1979-07-02 US US06/054,210 patent/US4248880A/en not_active Expired - Lifetime
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19850207 |