GB1284379A - Substituted 4,5-diphenyloxazoles - Google Patents
Substituted 4,5-diphenyloxazolesInfo
- Publication number
- GB1284379A GB1284379A GB2290071A GB2290071A GB1284379A GB 1284379 A GB1284379 A GB 1284379A GB 2290071 A GB2290071 A GB 2290071A GB 2290071 A GB2290071 A GB 2290071A GB 1284379 A GB1284379 A GB 1284379A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- compound
- carbon atoms
- radical containing
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
1284379 Substituted 3,4-diphenyloxazoles ISTITUTO FARMACOLOGICO SERONO SpA 19 April 1971 [21 Feb 1970] 22900/71 Heading C2C Novel compounds of Formula I wherein n is 1 or 2 and each of R and R<SP>1</SP>, which may represent the same or different radicals, represents a hydrogen atom, an alkyl, acyl or hydroxyalkyl radical which contains 1 to 4 carbon atoms, a cycloalkyl radical containing 5 or 6 carbon atoms in its ring, a phenylalkyl radical containing 1 to 3 carbon atoms in its alkyl chain, an acetoxyalkyl radical containing 1 to 4 carbon atoms in its alkyl chain, a dialkyaminoalkyl radical in which each alkyl group contains 1 to 4 carbon atoms; or a carbalkoxy radical containing 1 to 4 carbon atoms in its alkyl chain; or R and R<SP>1</SP> form, together with the nitrogen atom, a 5- or 6-membered heterocyclic ring are prepared either by reaction of a compound HNRR1 where R and R<SP>1</SP> are not acyl, with a compound of Formula IV or by cyclization of a compound of Formula VI optionally followed in both cases by acylation. Intermediates of Formula IV above are prepared by cyclization of a compound of Formula III and intermediates of Formula VI above are prepared by reaction of a compound of Formula III above with a compound of formula RHNR<SP>1</SP>. Pharmaceutical preparations having antiphlogistic, analgesic and antihistaminic properties comprise an above novel compound and a physiologically tolerable carrier or diluent.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2094670A IT1033040B (en) | 1970-02-21 | 1970-02-21 | 4 5 DIPHENYLOXZOLES 2 AMINOMETHYL AND 2.2 AMINOETHYL SUBSTITUTED |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1284379A true GB1284379A (en) | 1972-08-09 |
Family
ID=11174442
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2290071A Expired GB1284379A (en) | 1970-02-21 | 1971-04-19 | Substituted 4,5-diphenyloxazoles |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS504662B1 (en) |
| CH (1) | CH554360A (en) |
| DE (1) | DE2108437A1 (en) |
| FR (1) | FR2081532B1 (en) |
| GB (1) | GB1284379A (en) |
| IT (1) | IT1033040B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999047529A1 (en) * | 1998-03-18 | 1999-09-23 | Ariad Pharmaceuticals, Inc. | Heterocyclic signal transduction inhibitors, compositions containing them |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2012716A1 (en) * | 1989-03-22 | 1990-09-22 | Akito Tanaka | Thiazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same |
| FR2677477B1 (en) * | 1991-06-06 | 1993-08-20 | Bellon Labor Sa Roger | NEW OXAZOLE DERIVATIVES, THEIR PREPARATION, THEIR USE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
| FR2677355B1 (en) * | 1991-06-06 | 1993-08-20 | Bellon Labor Sa Roger | NEW OXAZOLE DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
| DK0582164T3 (en) * | 1992-07-31 | 1999-08-23 | Bristol Myers Squibb Co | Adenosine reuptake inhibitory derivatives of diphenyloxazoles, thiazoles and imidazoles |
| JPH10509713A (en) * | 1994-11-23 | 1998-09-22 | グラクソ、ウェルカム、インコーポレーテッド | Oxazole derivatives as antagonists of the alpha-1C adrenergic receptor |
| FR2894578B1 (en) * | 2005-12-12 | 2008-02-01 | Sanofi Aventis Sa | HETEROCYCLIC DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE. |
| EP3162798B1 (en) | 2007-09-28 | 2021-04-14 | Takeda Pharmaceutical Company Limited | 5-membered heterocyclic compound |
-
1970
- 1970-02-21 IT IT2094670A patent/IT1033040B/en active
-
1971
- 1971-02-19 CH CH247471A patent/CH554360A/en not_active IP Right Cessation
- 1971-02-22 FR FR7105916A patent/FR2081532B1/fr not_active Expired
- 1971-02-22 DE DE19712108437 patent/DE2108437A1/en active Pending
- 1971-02-22 JP JP807071A patent/JPS504662B1/ja active Pending
- 1971-04-19 GB GB2290071A patent/GB1284379A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999047529A1 (en) * | 1998-03-18 | 1999-09-23 | Ariad Pharmaceuticals, Inc. | Heterocyclic signal transduction inhibitors, compositions containing them |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2108437A1 (en) | 1971-11-11 |
| FR2081532A1 (en) | 1971-12-03 |
| FR2081532B1 (en) | 1974-04-12 |
| IT1033040B (en) | 1979-07-10 |
| CH554360A (en) | 1974-09-30 |
| JPS504662B1 (en) | 1975-02-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |